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Contribution to the Study of Antibiotic Sensitivity of Streptococcus pneumoniae Strains in Spinal Cerebral Fluids in Bangui from 2017 to 2022

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Journal of Biomedical Science and Engineering 2023年第7期16卷 95-106页

作者： Zéphirin-Dalengat Vogbia Ernest Lango Yaya Marie Colette-Nganda Banguet Jean de Dieu Longo Clotaire -Rafaï maurel anicet adonis ouoko fa-tigbia Christian Diamant Mossoro Gérard Gresenguet Ministry of Health Epidemiology and National Reference Center for Sexually Transmitted Infections and Anti-Retroviral Therapy Research Service Bangui Central African Republic faculty of Health Sciences University of Bangui Bangui Central African Republic Ministry of Health National Laboratory of Clinical Biology and Public Health Bangui Central African Republic Emergency Department at the Pediatric University Complex Bangui Central African Republic Ministry of Health Training Project Manager and Head of Public Department Bangui Central African Republic

A prospective and analytical study was carried out from January 2017 to Decem-ber 2022, at the National Laboratory of Clinical Biology and Public Health (LNBCSP) in Bangui. 352 samples of cerebrospinal fluid (CSF) were confirmed out of 2065, coming from the four hospitals in Bangui. This study aimed to evalu-ate the evolution of antibiotic sensitivity to strains of Streptococcus pneumoniae. CSF had been collected from patients who presented with meningeal syndromes. Based on the leukocyte count (White blood cells ≥ 5 mm3), an aliquot was trans-ferred to trans-isolate medium and sent to the LNBCSP for confirmatory testing, culture and determination of antibiotic sensitivity. The antibiotic sensitivity of Streptococcus pneumoniae strains was tested according to the methods recom-mended by the Antibiogram Committee of the French Society of Microbiology. The data collected was entered into Excel 2010 to be analyzed with Epi Info 7.2. Ficher’s exact test, chi2 at the 5% threshold (p < 0.05) was used to compare pro-portions and analyze associations between variables. The average sensitivity rate to β-lactams was 74.43%. The sensitivity rate of Fluoroquinolones was 54.54%. That of levofloxacin was 87%. The average rate of sensitivity to β-lactams for the age group under 5 years old was 79.25%. That of fluoroquinolones was 52.59%. Levofloxacin had 90.37%. The average sensitivity rate to β-lactams for the age group over 5 years old was 76.03%. Fluoroquinolones had 45.16%. Levofloxacin had 69.58%. The average sensitivity rate to β-lactams for males was 76.68%. Fluoroquinolones had 54.26%. That of levofloxacin was 83.40%. The sensitivity rate to β-lactams for females was 74.41%. That of fluoroquinolones was 51.16%. Levofloxacin had 67.44%. Cyclins had 28.68%. The study noted an association between age and sensitivity (p < 0.05;CI [1.05-2.57]). Strains of Streptococcus pneumoniae were always detected in the CSF. The average rate of sensitivity to macrolides was 36.93%;aminoglyc

关键词： Streptococcus pneumoniae Sensitivity Antibiotics Central African Republic

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Contribution to the Study of the Incidence of Post-Streptococcal Complications in Republic Central African Republic from 2015 to 2018

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Open Journal of Epidemiology 2024年第1期14卷 110-121页

作者： Zéphirin Dalengat Vogbia Ernest Lango Yaya Jean De Dieu Longo Augustin Balekouzou Gaspard Tekpa Christian Maucler Pamaticka Stéphanie Judith N’Yetobouko maurel anicet adonis ouoko fatigbia Christian Diamant Mossoro Kpindet Gérard Gresenguet Epidemiology and Research Service National Reference Center for Sexually Transmitted Infections and Anti-Retroviral Therapy Ministry of Health Bangui Central African Republic Direction of National Laboratory of Clinical Biology and Public Health Ministry of Health Bangui Central African Republic Training Project Manager and Heald of Public Departement Ministry of Health Bangui Central African Republic faculty of Health Sciences Doctoral School of Human and Veterinary Health Sciences University of Bangui Bangui Central African Republic National Committee for the Fight against AIDS Primature Bangui Central African Republic Infectious Disease Department The Sino Central African Friendship University Hospital Center Bangui Central African Republic Epidemiology Department Bangui National University Hospital Center Bangui Central African Republic

Introduction: Acute rheumatic fever (AAR) is a non-suppurative complication of late infection by group A. Infections due to streptococci remain a public health problem in the Central African Republic. The present study aims to determine the incidence rate of AAR cases and its complications. Methodology: This was a retrospective and analytical study over a period of 4 years (from January 2015 to December 2018) at the National Laboratory of Clinical Biology and Public Health (LNBCSP) in Bangui. It focused on samples concerning the diagnosis of AAR and patient files seen in consultation in the capital’s reference health establishments. Laboratory registers and patient consultation files were used to collect data. They were entered into Excel 2010 to be analyzed with Epi Info 7. A univariate analysis by logistic regression, Ficher’s exact test, and chi2 at the 5% threshold (p Results: We analyzed 94 cases meeting Jones’s criteria. The ages of the patients ranged from 18 to 85 years (mean age 52 years and mode 45 years). The incidence rate of AAR for the female sex was higher than that of the male sex during the study period (p > 0.05). It went from 166.6 in 2015 to 200 in 2016 and 2018 cases of AAR per 1000 people per year. The average incidence rate was 296.18 cases of AAR per 1000 people per year. The average incidence rate was 223.5 cases of AAR per 1000 people per year for joint damage. Joint damage represented 80.85% (RR = 0.62;Chi2 = 4.88;95% CI [0.39-0.97];p Conclusion: The study allowed data on the impact rate and complications of the AAR in Bangui. Special attention to data management will help produce a complete result on the problem. Joint complications predominated. Sustaining an effective surveillance system and preventing infection would help reduce the risk of AAR occurrence.

关键词： Incidence Acute Joint Rheumatism Central African Republic

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Contribution of Genomic Surveillance in the Detection and Monitoring of SARS-CoV-2 Variants during the 6 Pandemic Waves in the Central African Republic from 2020 to 2023

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Journal of Tuberculosis Research 2024年第3期12卷 151-164页

作者： Clotaire Donatien Rafaï Ernest Lango-Yaya Marie Roseline Darnicka Belizaire ouoko fa-Ti-Gbia maurel Annicet adonis Marcel Mbeko Simaleko Jean-Baptiste Roungou Oscar Senzongo Karl G. Njuwa fai Boniface Koffi National Laboratory of Clinical Biology and Public Health of Bangui Bangui Republic Central African University of Bangui Bangui Central African Republic World Health Organization Geneva Switzerland Ministry of Health and Population Bangui Central African Republic Africa CDC Addis-Abeba Ethiopia Homegrown Solutions for Health Yaounde Cameroon

Objective: The COVID-19 pandemic has highlighted the need to strengthen diagnosis and genomic surveillance capacities. In 2021, Central African managed five waves of COVID-19 by integrating genomic surveillance into their health monitoring system. This study sought to report surveillance data from the National Laboratory of Clinical Biology and Public Health and describe the circulation of SARS-CoV-2 variants. Materials and Methods: This retrospective, descriptive observational study spans three years, from April 2020 to November 2023. It was conducted on a population of consenting volunteers from across the Central African Republic, who were tested using RT-PCR on nasopharyngeal samples. Data with sufficient information were obtained from the National Laboratory of Clinical Biology and Public Health (LNBCSP) databases. Sequencing was largely carried out at the National Institute of Biomedical Research (INRB) in Kinshasa until May 2023, and subsequently at the LNBCSP. Results and Discussion: Out of 97,864 RT-PCR tests performed, 9,764 were positive, resulting in a prevalence of 9.98%. The average age of the patients was 39.97 years ± 13.76, and the male-to-female sex ratio was 2.12. RT-PCR test positivity was significantly associated with age (p = 0.001), sex (p = 0.013) and clinical manifestations. Ten variants circulated during the five recorded waves, with Omicron (B.1.1.529), Delta (B.1.617.2) variants being predominant. Notably, the B.1.620 and B.640 variants were prominent during the second wave. Conclusion: This retrospective study provides key insights into the COVID-19 pandemic in the CAR. It identifies risk factors and details the circulation of various SARS-CoV-2 variants. Enhancing national genomic surveillance capacities would enable the country to better respond to future pandemic challenges.

关键词： SARS-CoV-2 Variants Central African Republic RT-PCR

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Cerebral fat embolism following autologous fat injection in facial reconstruction:A case report

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World Journal of Clinical Cases 2025年第2期13卷 50-58页

作者： Xiu-Ying Chen fa Shen Chang Cheng Yu-Han Wang Wen-Chao Cheng De-Zhi Yuan Wen Huang Department of Neurology Chongqing Emergency Medical CenterChongqing University Central HospitalChongqing 400000China Department of Neurology Xinqiao HospitalThe Army Medical University(Third Military Medical University)Chongqing 400000China

BACKGROUND Autologous fat injection in facial reconstruction is a common cosmetic *** cerebral fat embolism(CFE)as a complication is rare,it carries serious health *** SUMMARY We present a case of a 29-year-old female patient who developed acute CFE following facial fat filling *** the surgery,the patient experienced symptoms including headache,nausea,vomiting,and difficulty breathing,which was followed by neurological symptoms such as slurred speech and left-sided *** physical examination and auxiliary investigations,including blood tests,head and neck computed tomography angiography,and cranial magnetic resonance diffusion-weighted imaging,were performed upon *** clinical diagnosis was acute cerebral embolism following facial fat filling *** included measures to improve cerebral circulation,dehydration for intracranial pressure reduction,nutritional support,and rehabilitation therapy for left limb *** patient showed a significant improvement in symptoms after 2 weeks of *** recovered left limb muscle strength to grade 5,had clear speech,and experienced complete relief of *** Our case highlights the potential occurrence of severe complications in patients undergoing fat injection in facial *** prevent these complications,plastic surgeons should enhance their professional knowledge and skills.

关键词： Cerebral fat embolism Mechanical thrombectomy Thrombolysis Steroid therapy Symptomatic treatment Case report

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A Transmission and Transformation fault Detection Algorithm Based on Improved YOLOv5

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Computers, Materials & Continua 2023年第9期76卷 2997-3011页

作者： Xinliang Tang Xiaotong Ru Jingfang Su Gabriel adonis School of Information Science and Engineering Hebei University of Science and TechnologyShijiazhuang050000China Department of Computer Science and Information Systems Birkbeck Institute for Data AnalyticsLondonB100ABWC1E 7HXUK

On the transmission line,the invasion of foreign objects such as kites,plastic bags,and balloons and the damage to electronic components are common transmission line *** these faults is of great significance for the safe operation of power ***,a YOLOv5 target detection method based on a deep convolution neural network is *** this paper,Mobilenetv2 is used to replace Cross Stage Partial(CSP)-Darknet53 as the *** structure uses depth-wise separable convolution to reduce the amount of calculation and parameters;improve the detection *** the same time,to compensate for the detection accuracy,the Squeeze-and-Excitation Networks(SENet)attention model is fused into the algorithm framework and a new detection scale suitable for small targets is added to improve the significance of the fault target area in the *** pictures of foreign matters such as kites,plastic bags,balloons,and insulator defects of transmission lines,and sort theminto a data *** experimental results on datasets show that themean Accuracy Precision(mAP)and recall rate of the algorithm can reach 92.1%and 92.4%,*** the same time,by comparison,the detection accuracy of the proposed algorithm is higher than that of other methods.

关键词： Transmission line YOLOv5 multi-scale integration SENet

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Epigenetic interventions for brain rejuvenation：anchoring age-related transposons

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Neural Regeneration Research 2018年第4期13卷 635-636页

作者： adonis Sfera Lisa fayard Carolina Osorio Amy Price Department of Psychiatry Patton State HospitalPattonCAUSA Department of Psychiatry Loma Linda UniversityLoma LindaCAUSA Evidence-Based Medicine University of OxfordOxfordUK

Highlights：*** and homocysteine accumulation in aging neurons alter genomic *** altered methylome reactivates neuronal cell cycle,enabling transposable element *** R29/p53 axis restores age-related methylation shifts... 详细信息

关键词： Epigenetic interventions for brain rejuvenation:anchoring age-related transposons PUfas DNA Figure TE cycle

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β-Ga_(2)O_(3)热电性能的第一性原理计算

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原子与分子物理学报 2025年第1期42卷 180-188页

作者：邓南发周贤中广东工业大学集成电路学院广州510006

通过使用第一性原理计算方法和玻尔兹曼输运理论,计算了β-Ga_(2)O_(3)的电学、热学和热电性质,并得出了热电性能因子随载流子浓度和温度的变化规律.此外,还考虑了声子散射和极性光学声子散射对平均电子弛豫时间的影响,并详细描述了不... 详细信息

通过使用第一性原理计算方法和玻尔兹曼输运理论,计算了β-Ga_(2)O_(3)的电学、热学和热电性质,并得出了热电性能因子随载流子浓度和温度的变化规律.此外,还考虑了声子散射和极性光学声子散射对平均电子弛豫时间的影响,并详细描述了不同载流子浓度和温度下β-Ga_(2)O_(3)的Seebeck系数、电导率、电热导率和功率因数的计算结果.最后,给出了β-Ga_(2)O_(3)的热电性能因子随载流子浓度和温度的变化趋势.结果表明,在高载流子浓度和高温下,β-Ga_(2)O_(3)具有较高的热电性能因子.

关键词： Ga_(2)O_(3) 第一性原理计算波尔兹曼输运理论热电性质

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LONG-TIME BEHAVIOR OF FINITE DIFFERENCE SOLUTIONS OF THREE-DIMENSIONAL NONLINEAR SCHRODINGER EQUATION WITH WEAKLY DAMPED

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Journal of Computational Mathematics 2004年第4期22卷 593-604页

作者： fa-yongZhang DepartmentofMathematics HeilongjiangUniversityHarbin150080China

The three-dimensional nonlinear SchrSdinger equation with weakly damped that possesses a global attractor are considered. The dynamical properties of the discrete dynamical system which generate by a class of finite d... 详细信息

关键词： Finite difference method Global attractor Nonlinear Schr?dinger equation

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Nonalcoholic fatty liver disease in lean subjects:Prognosis,outcomes and management

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World Journal of Gastroenterology 2020年第42期26卷 6514-6528页

作者： Lampros Chrysavgis Eleftheria Ztriva adonis Protopapas Konstantinos Tziomalos Evangelos Cholongitas First Department of Internal Medicine Medical SchoolNational and Kapodistrian University of AthensLaiko General HospitalAthens 11527Greece First Propedeutic Department of Internal Medicine Medical SchoolAristotle University of ThessalonikiAHEPA HospitalThessaloniki 54636Greece

Nonalcoholic fatty liver disease(NAFLD)accounts for most cases of chronic liver disease worldwide,with an estimated global prevalence of approximately 25%and ranges from simple steatosis to nonalcoholic steatohepatitis and *** is strongly connected to metabolic syndrome,and for many years,fatty liver was considered to be an exclusive feature of obese ***,recent studies have highlighted the presence of NAFLD in non-obese subjects,with or without increased visceral fat or even in lean subjects without increased waist circumference.“Lean NAFLD”is a relatively new concept and there is significant scientific interest in understanding the differences in pathophysiology,prognosis and management compared with NAFLD in overweight/obese *** the present editorial,we discuss the clinical and metabolic profiles and outcomes of lean NAFLD compared with both obese NAFLD and lean healthy individuals from Asian and Western ***,we shed light to the challenging topic of management of NAFLD in lean subjects since there are no specific guidelines for this ***,we discuss open questions and issues to be addressed in the future in order to categorize NAFLD patients into lean and nonlean cohorts.

关键词： Lean nonalcoholic fatty liver disease Non-obese nonalcoholic fatty liver disease Clinical outcomes Metabolic outcomes Disease management Lifestyle interventions

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Algebraic Conditions for Classifying the Positional Relationships Between TwoConies and Their Applications

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Journal of Computer Science & Technology 2004年第5期19卷 665-673页

作者： YangLiu fa-LaiChen DepartmentofComputerScience TheUniversityofHongKongHongKongSpecialAdministrativeRegionP.R.China DepartmentofMathematics UniversityofScienceandTechnologyofChinaHefei230026P.R.China

In many fields of computer science such as computer animation, computergraphics, computer aided geometric design and robotics, it is a common problem to detect thepositional relationships of several entities. Based on generalized characteristic polynomials andprojective transformations, algebraic conditions are derived for detecting the various positionalrelationships between two planar conies, namely, outer separation, exterior contact, intersection,interior contact and inclusion. Then the results are applied to detecting the positionalrelationships between a cylinder (or a cone) and a quadric. The criteria is very effective andeasier to use than other known methods.

关键词： collision detection projective transformation generalized characteristicpolynomial positional relationship

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