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Rule based vs Optimization based Workload Control with and without Exogenous Lead Times:An Assessment by Simulation

Journal of Systems Science and Systems Engineering 2023年第5期32卷 553-570页

作者： Mingze Yuan Ting Qu matthias thürer Lin Ma Lei Liu School of Management Jinan UniversityGuangzhou510632China GBA and B&R International Joint Research Center for Smart Logistics Jinan UniversityZhuhai519070China School of Intelligent Systems Science and Engineering Jinan UniversityZhuhai519070China Institute of Physical Internet Jinan UniversityZhuhai519070China Factory Planning and Intralogistics Chemnitz University of TechnologyChemnitz09125Germany Department of Industrial and Systems Engineering The Hong Kong Polytechnic UniversityHong Kong999077China

Order release is a key production planning and control function,specifically in high variety contexts.A large literature on release methods that balance the workload consequently *** Workload Control methods can be rule based,using a simple greedy heuristic,optimization based or optimization based with lead times that are *** all three types of methods have the same objective,their performance has never been *** simulation,this study shows that a better on time delivery performance of jobs can be achieved by the two optimization based release *** importantly,optimization based methods that assume lead times to be exogenous significantly outperform alternative methods in terms of tardiness *** based and optimization based Workload Control without exogenous lead times overemphasize average lateness reduction,which leads to sequence deviations that offset performance improvements through *** contrast,Workload Control methods that assume lead times to be exogenous limit sequence deviations,which leads to a significant reduction in dispersion of *** has important implication for the future design of order release methods,and managerial practice.

关键词： Workload control order release production planning production control make-to-order production

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双渠道多级分销网络选址—库存问题

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计算机集成制造系统 2021年第11期27卷 3305-3317页

作者：孙姣屈挺聂笃宪 matthias thürer 李从东黄国全暨南大学管理学院广东广州510632 暨南大学智能科学与工程学院广东珠海519070 暨南大学物联网与物流工程研究院广东珠海519070 华南农业大学数学与信息学院广东广州510642 香港大学工业与制造系统工程系中国香港999077

针对分销网络中各节点独立决策与全局最优并存的现实需求,引入目标级联法用于解决双渠道多级分销网络选址—库存问题。构建了多层级、多节点、多主体的三层级问题求解模型,并采用底层先收敛、局部用遗传算法的协调策略进行求解,实现选... 详细信息

针对分销网络中各节点独立决策与全局最优并存的现实需求,引入目标级联法用于解决双渠道多级分销网络选址—库存问题。构建了多层级、多节点、多主体的三层级问题求解模型,并采用底层先收敛、局部用遗传算法的协调策略进行求解,实现选址决策、库存决策与线上需求分配决策。以某红酒企业的双渠道分销网络运作模式为案例,对选址—库存模型进行求解与结果分析,并与传统的一体化优化方法的求解效果进行对比,验证了目标级联法在求解选址—库存问题的有效性;通过对需求方差的变化进行敏感性分析表明,为降低需求不确定性对企业物流总成本的影响,应及时优化供应链结构,调整线上需求分配的层级。

关键词：双渠道多级分销网络选址—库存问题目标级联法

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Small extrachromosomal circular DNA in amyotrophic lateral sclerosis matter

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Neural Regeneration Research 2025年第5期20卷 1411-1413页

作者： Marcos J.Arauzo-Bravo Daniela Gerovska matthias Schwab Alexandra Kretz Computational Biology and Systems Biomedicine Biodonostia Health Research InstituteSan SebastianSpain Basque Foundation for Science IKERBASQUEBilbaoSpainMax Planck Institute for Molecular BiomedicineComputational Biology and Bioinformatics GroupMünsterNorth Rhine-WestphaliaGermany Department of Cell Biology and Histology Faculty of Medicine and NursingUniversity of Basque Country(UPV/EHU)LeioaSpain Department of Neurology Jena University HospitalJenaThuringiaGermany

Comprehensive studies identify motor neuron spectrum disorders including amyotrophic lateral sclerosis(ALS)as globally rising fatal disorders with the highest prevalence in aging populations,influenced by ethnicity and ancestry(GBD 2016 Motor Neuron Disease Colla borators,2018).While~10% of diagnoses involve a family history(fALS),most cases are considered sporadic(sALS).However,population-based studies suggest that even cases without a common index mutation impart heritability(Ryan et al.,2019),indicating a crucial role of rare and as yet unknown genetic denominators.

关键词： amyotrophic sclerosis

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双渠道多级分销网络库存整合优化配置

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工业工程 2021年第4期24卷 134-142页

作者：林瀚盛屈挺徐素秀 thÜrer matthias 郭洪飞黄国全暨南大学管理学院广东广州510632 暨南大学智能科学与工程学院广东珠海519070 暨南大学物联网研究院广东珠海519070 香港大学工业与制造系统工程系中国香港999077

针对拥有线下、线上销售渠道的实体零售企业分销网络运作成本居高不下的现状,研究综合渠道整合和线上订单履行问题下的双渠道库存优化配置问题。在“双渠道库存独立管理、线上订单分散履行”和“双渠道库存整合管理、线上订单集中履行”... 详细信息

针对拥有线下、线上销售渠道的实体零售企业分销网络运作成本居高不下的现状,研究综合渠道整合和线上订单履行问题下的双渠道库存优化配置问题。在“双渠道库存独立管理、线上订单分散履行”和“双渠道库存整合管理、线上订单集中履行”2种不同分销网络运作模式下分别建立数学模型,并利用基于实数编码的遗传算法进行求解。通过对比这2种不同运作模式下的运作成本,同时在需求波动率增加条件下对运作成本进行敏感性分析,发现渠道库存整合、线上订单集中履行方法能够将库存总费用降低17.25%,能够将库存总费用从中下游往上游转移,减缓中下游节点的库存总费用。

关键词：库存优化配置渠道整合线上订单履行

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Review of Sodic Soil Reclamation with a Snapshot of Current Research Activity

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Chinese Geographical Science 2022年第6期32卷 1099-1109页

作者： TÓth Tibor Institute for Soil Sciences Centre for Agricultural ResearchBudapest 1022Hungary

For centuries, reclamation of sodic soils has been an essential part of cropping practices in several parts of the world. Parallel to increasing population, the need for new cropland constantly re-evaluates land suitability concepts. therefore, the importance of sodic soils as potential croplands is increasing worldwide. Although theoretically farmers can choose from a wide variety of reclamation options, according to profitability, business plans, and human and financial resources, in practice, few reclamation methods are applied at large scale. this article touches on the early history, 20th Century intensive research, and current trends of sodic soil reclamation. New approaches such as leaching, chemical amendments, addition of organic material, and biological and microbial improvements are discussed, and also brand-new approaches are reviewed. the early history is reviewed using historical books, the achievements of the last hundred years using basic technical literature, mostly books, and the current approaches of our time with fresh publications, mostly papers and two very recent conferences published in English.

关键词： gypsuming liming chemical reclamation new technology sodic soil

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Manipulating the Gut Microbiome to Alleviate Steatotic Liver Disease:Current Progress and Challenges

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Engineering 2024年第9期40卷 51-60页

作者： Ernesto Saenz Nathally Espinosa Montagut Baohong Wang Christoph Stein-thöringer Kaicen Wang Honglei Weng matthias Ebert Kai Markus Schneider Lanjuan Li Andreas Teufel Division of Hepatology Division of Clinical BioinformaticsDepartment of Medicine ⅡMedical Faculty MannheimHeidelberg UniversityMannheim 68167Germany Clinical Cooperation Unit Healthy Metabolism Center for Preventive Medicine and Digital HealthMedical Faculty MannheimHeidelberg UniversityMannheim 68167Germany School of Medicine Universidad de Los AndesBogotá111711Colombia State Key Laboratory for Diagnosis and Treatment of Infectious Diseases National Clinical Research Center for Infectious DiseasesCollaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesThe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Internal MedicineⅠ University Clinic Tuebingen&CoE CMFI(Controlling Microbes to Fight Infections)Tuebingen 72074Germany Department of MedicineⅡ Medical Faculty MannheimHeidelberg UniversityMannheim 68167Germany DKFZ Hector Cancer Institute at the University Medical Center Mannheim 69120Germany Molecular Medicine Partnership Unit European Molecular Biology LaboratoryHeidelberg 69117Germany Department of MedicineⅢ University Hospital RWTH AachenAachen 52074Germany

the prevalence of metabolic-dysfunction-associated steatotic liver disease(MASLD)is alarmingly high;it is estimated to affect up to a quarter of the global population,making it the most common liver disorder *** is characterized by excessive hepatic fat accumulation and is commonly associated with comorbidities such as obesity,dyslipidemia,and insulin resistance;however,it can also manifest in lean ***,it is crucial to develop effective therapies for this complex ***,there are no approved medications for MASLD treatment,so there is a pressing need to investigate alternative *** research has characterized MASLD as a multifaceted disease,frequently linked to metabolic disorders that stem from dietary *** suggests that changes in the gut microbiome play a fundamental role in the development and progression of MASLD from simple steatosis to steatohepatitis and even hepatocellular carcinoma(HCC).In this review,we critically examine the literature on the emerging field of gut-microbiota-based therapies for MASLD and metabolicdysfunction-associated steatohepatitis(MASH),including interventions such as fecal microbiota transplantation(FMT),probiotics,prebiotics,short-chain fatty acids,antibiotics,metabolic pathway targeting,and immune checkpoint kinase blockade.

关键词： Microbiome Fecal microbiota transplantation Metabolic-dysfunction-associated steatotic liver disease Fatty liver

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Search for 2D Ferromagnets:Molecular Beam Epitaxy is a Critical Tool

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Chinese Physics Letters 2020年第8期37卷 1-2页

作者： matthias Batzill Affiliations Department of Physics University of South FloridaTampaFL 33620USA

Van der Waals materials with ferromagnetic properties have attracted recent interest because of their promise to enable combination of materials with atomically sharp interfaces,facilitating spin transport and spin in... 详细信息

关键词： Epitaxy enable Tool

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the Role of Host-derived Dentinal Matrix Metalloproteinases in Reducing Dentin Bonding of Resin Adhesives

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International Journal of Oral Science 2009年第4期1卷 163-176页

作者： matthias Kern Department of Prosthodontics Propaedeutics and Dental Materials Christians-Albrechts UniversityKiel Germany

Dentin matrix metalloproteinases （MMPs） are a family of host-derived proteolytic enzymes trapped within mineralized dentin matrix, which have the ability to hydrolyze the organic matrix of demineralized dentin. After bonding with resins to dentin there are usually some exposed collagen fibrils at the bottom of the hybrid layer owing to imperfect resin impregnation of the demineralized dentin matrix. Exposed collagen fibrils might be affected by MMPs inducing hydrolytic degradation, which might result in reduced bond strength.Most MMPs are synthesized and released from odontoblasts in the form of proenzymes, requiring activation to degrade extracellular matrix components. Unfortunately, they can be activated by modem self-etch and etch-and-rinse adhe- sives. the aim of this review is to summarize the current knowledge of the role of dentinal host-derived MMPs in dentin matrix degradation. We also discuss various available MMP inhibitors, especially chlorhexidine, and suggest that they could provide a potential pathway for inhibiting collagen degradation in bonding interfaces thereby increasing dentin bonding durability.

关键词： bonding matrix metalloproteinases(MMPs) MMP inhibitors chlorhexidine

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Information schema constructs for defining warehouse databases of genotypes and phenotypes of system manifestation features

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Frontiers of Information Technology & Electronic Engineering 2016年第9期17卷 862-884页

作者： Shahab POURTALEBI Imre HORVáth Faculty of Industrial Design Engineering Delft University of Technology

Our long-term objective is to develop a software toolbox for pre-embodiment design of complex and heterogeneous systems, such as cyber-physical systems. the novelty of this toolbox is that it uses system manifestation features(SMFs) for transdisciplinary modeling of these systems. the main challenges of implementation of the toolbox are functional design- and language-independent computational realization of the warehouses, and systematic development and management of the various evolving implements of SMFs(genotypes, phenotypes, and instances). therefore, an information schema construct(ISC) based approach is proposed to create the schemata of the associated warehouse databases and the above-mentioned SMF implements. ISCs logically arrange the data contents of SMFs in a set of relational tables of varying semantics. In this article we present the ISCs necessary for creation of genotypes and phenotypes. they increase the efficiency of the database development process and make the data relationships transparent. Our follow-up research focuses on the elaboration of the SMF instances based system modeling methodology.

关键词： Cyber-physical systems Software toolbox Pre-embodiment design System manifestation features(SMFs) Warehouses Database schemata SMF genotypes SMF phenotypes SMF instances Information schema constructs

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the Glacial(MIS 3-2)Outlet Glacier of the Marsyandi Nadi-icestream-network with its Ngadi Khola Tributary Glacier(Manaslu-and Lamjung Himalaya):the Reconstructed Lowering of the Marsyandi Nadi Ice Stream Tongue down in to the Southern Himalaya Foreland

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Journal of Mountain Science 2014年第1期11卷 236-287页

作者： matthias KUHLE Department of Geography and High Mountain Geomorphology University of Gottingen

For the reconstruction of past climate variations,investigations on the history of glaciers are *** the Himalaya,investigations like these have a rather short tradition in comparison with other mountains on *** the same time,this area on the southern margin of Tibet is of special interest because of the question as to the monsoon-influence that is connected with the ***,the climate of High Asia is of global *** for the further and regionally intensifying answer to this question,a glacial glacier reconstruction is submitted from the CentralHimalaya,more exactly from the *** on down-valley from the glacial-historical investigations of 1977 in the upper Marsyandi Khola(Nadi) and the partly already published results of field campaigns in the middle Marsyandi Khola and the Damodar- and Manaslu Himal in the years 1995,2000,2004 and 2007,new geomorphological and geological field- and laboratory data are introduced here from the Ngadi(Nadi) Khola and the lower Marsyandi Nadi from the inflow of the Ngadi(Nadi) Khola down to the southern mountain *** has existed a connected ice-stream-network drained down to the south by a 2,100-2,200 m thick and 120 km long Marsyandi Nadi main valley *** a height of the valley bottom of c.1,000 m *** Ngadi Khola glacier joined the still c.1,300 m thick Marsyandi parent glacier from the Himalchuli-massif(Nadi(Ngadi) Chuli) – the south spur of the Manaslu *** here the united glacier tongue flowed down about a further 44 km to the south up to c.400 m a.s.l.(27°57'38 "N/84°24'56" E) into the Himalaya fore-chains and thus reached one of or the lowest past ice margin position of the *** glacial(LGP(Last glacial period),LGM(Last glacial maximum) Würm,Stage 0,MIS 3-2) climatic snowline(ELA = equilibrium line altitude) has run at 3,900 to 4,000 m *** thus c.1,500 altitude meters below the current ELA(Stage XII) at 5,400-5,500 m *** r

关键词： Ice Age Glaciation Himalaya Manaslu Ngadi Khola Icestream network Last Glacial period

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