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Effects of progesterone on T-type-Ca^(2+)-channel expression in Purkinje cells

Neural Regeneration Research 2022年第11期17卷 2465-2471页

作者： Annika Eickhoff Jonas Tjaden Sarah Stahlke matthias Vorgerd Verena Theis Veronika Matschke Carsten Theiss Department of Cytology Institute of AnatomyRuhr-University BochumBochumGermany Department of Neurology Neuromuscular Center RuhrgebietUniversity Hospital BergmannsheilRuhr-Universität BochumBochumGermany

Plasticity of cerebellar Purkinje cells(PC)is influenced by progeste rone via the classical progeste rone receptors PR-A and PR-B by stimulating dendritogenesis,spinogenesis,and synaptogenesis in these *** PC cultures were used to analyze progeste rone effects at a molecular level on the voltage-gated T-type-Ca^(2+)-channels Ca_(v)3.1,Ca_(v)3.2,and Ca_(v)3.3 as they helped determine neuronal plasticity by regulating Ca^(2+)-influx in neuronal *** results showed direct effects of progesterone on the mRNA expression of T-type-Ca^(2+)-channels,as well as on the protein kinases A and C being involved in downstream signaling pathways that play an important role in neuronal *** the mRNA expression studies of T-type-Ca^(2+)-channels and protein kinases of the signaling cascade,laser microdissection and purified PC cultures of diffe rent maturation stages were *** staining was also performed to characte rize the localization of T-type-Ca^(2+)-channels in *** rimental progesterone treatment was performed on the purified PC culture for 24 and 48 *** results show that progesterone increases the expression of Ca_(v)3.1 and Ca_(v)3.3 and associated protein kinases A and Cin PC at the mRNA level within 48 hours after treatment at *** effects extend the current knowledge of the function of progesterone in the central nervous system and provide an explanatory approach for its influence on neuronal plasticity.

关键词： Ca_(v)3.1 Ca_(v)3.2 Ca_(v)3.3 neuronal plasticity progesterone protein kinase A protein kinase C Purkinje cells rat cerebellum T-type-Ca^(2+)-channels

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Fundamentals of Design and Technology of Rolling Element Bearings

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Chinese Journal of Aeronautics 2010年第1期23卷 123-136页

作者： franz-Josef Ebert FAG Aerospace GmbH & Co.KG D-97421 SchweinfurtGermany

This article presents an overview of fundamentals of rolling element bearing designs and technologies. The aim is to outline the complex interrelation of all fundamentals with the rolling contact fatigue and the attainable bearing life. Such fundamentals include, amongst others, bearing stressing and life capability. The article shows the different types of rolling bearing stressing and the analysis of the stress distribution （principal stresses and equivalent stresses） in the material under the rolling contact area. It becomes obvious that the contamination of the bearing with foreign particles leads to a drastic reduction in bearing life. Furthermore, it demonstrates the impact of the bearing lubrication and coating as well as the effect of additives on the attainable life and wear. Further fundamentals of rolling element bearing de- sign are the materials, the material cleanliness and the heat treatment. The article reveals the importance of the clean- liness of bearing steels as well as different types of inclusions and their effect on rolling contact fatigue. Additionally the article describes how to optimize the material properties （strength, toughness and residual stress） by the heat treat- nlent processes. The outcome of these investigations is that endurance life of a rolling element bearing can be achieved if specific operating conditions, an adequate lubrication, good system cleanliness and specific bearing stressing are met. The article provides a guideline for bearing engineers on how designs and technologies can be applied to optimizing a bearing for a particular industry or aerospace application.

关键词： aerospace rolling contact fatigue endurance life materials heat treatment lubrication reliability

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Estimation of radiation-induced health hazards from a“dirty bomb”attack with radiocesium under different assault and rescue conditions

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Military Medical Research 2022年第1期9卷 106-125页

作者： Alexis Rump Stefan Eder Cornelius Hermann Andreas Lamkowski Patrick Ostheim Michael Abend matthias Port Bundeswehr Institute of Radiobiology Neuherberg Str.1180937 MunichGermany

In the case of a terrorist attack by a“dirty bomb”,blast injuries,external irradiation and the incorporation of radioactivity are to be *** from information about the radiological attack scenario with cesium-137 in the *** Scenario Planning Guide,we estimated the radiological doses *** calculations were performed for a smaller plume size and a detonation in a *** conditions as described in the ***,the committed effective dose amounted to a maximum of 848 mSv,even for very unfavorable *** bone marrow equivalent doses are insufcient to induce acute radiation sickness(ARS).In the case of a smaller plume size,the ARS threshold may be exceeded in some *** a subway bombing,doses are much higher and the occurrence of ARS should be *** health hazards from a dirty bomb attack will depend on the location and the explosive *** derived Haddon matrix indicates that preparing for such an event includes education of all the medical staff about radiation effects,the time lines of radiation damages and the treatment *** determinants of the outcome include rapid evacuation even from difficult locations,the availability of a specific triage tool to rapidly identify victims at risk for ARS,the availability of an antidote stockpile and dedicated hospital beds to treat seriously irradiated victims.

关键词： Medical NRBC protection Terrorism Radiological emergency Dirty bomb Combined injuries Triage Acute radiation sickness Radionuclide incorporation

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Health and safety perspectives of graphene in wearables and hybrid materials

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Journal of Materials Science & Technology 2023年第24期155卷 10-32页

作者： Premika Govindaraj Azadeh Mirabedini Xing Jin Dennis Antiohos Nisa Salim Phil Aitchison Jake Parker franz Konstantin Fuss Nishar Hameed Faculty of Science Engineering and Technology Swinburne University of Technology Hawthorn Melbourne VIC 3122 Australia Aerospace Engineering and Aviation School of Engineering RMIT University Bundoora Melbourne VIC 3083 Australia Institute for Frontier Materials Deakin University Geelong VIC 3216 Australia Imagine Intelligent Materials Sydney NSW 2018 Australia Sparc Technologies Kent Town South Australia 5067 Australia Chair of Biomechanics Faculty of Engineering Science University of Bayreuth Bayreuth D-95440 Germany

The growing demand for smart wearables, coupled with the omnipresence of graphene due to its array of outstanding thermal, electrical, and mechanical properties, have driven the industry-led initiatives to develop lightweight, smart, and robust graphene-based wearable technologies. The substantial research and the increase in technology readiness levels (TRLs) of graphene-based technologies have led to the adoption of graphene in many industries. Graphene-based wearables are one such technology that involves closer interaction of graphene by the end-user. Despite this, understanding the toxicological risks associated with using graphene-based wearables is still in the fundamental stage. Herein, graphene-based wearables and industrial-scale fabrication techniques for the development of graphene-based wearables are reviewed. The main goal of the review is to initially evaluate the likelihood of user exposure to graphene from the wearable device and the potential health effects. The subsequent health risks based on graphene's physicochemical characteristics are also discussed. A framework to elucidate the risk is presented in terms of crucial exposure routes, possible graphene interactions, recent exposure assessments, detection removal techniques from the human body, and risk management protocols. It is hoped that this review may aid towards establishing a reasonable practice concerning the safe integration of graphene materials into wearables and facilitate their commercialization.

关键词： Graphene Wearables Composites Nanomaterials Smart materials Health and safety

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Deep learning for geometric and semantic tasks in photogrammetry and remote sensing

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Geo-Spatial Information Science 2020年第1期23卷 10-19页

作者： Christian Heipke franz Rottensteiner Institute of Photogrammetry and GeoInformation(PI) Leibniz University HannoverHannoverGermany

During the last few years,artificial intelligence based on deep learning,and particularly based on convolutional neural networks,has acted as a game changer in just about all tasks related to photogrammetry and remote *** have shown partly significant improvements in many projects all across the photogrammetric processing chain from image orientation to surface reconstruction,scene classification as well as change detection,object extraction and object tracking and recognition in image *** paper summarizes the foundations of deep learning for photogrammetry and remote sensing before illustrating,by way of example,different projects being carried out at the Institute of Photogrammetry and GeoInformation,Leibniz University Hannover,in this exciting and fast moving field of research and development.

关键词： Deep learning machine learning convolutional neural networks(CNN) example project from IPI

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Management of cataract surgery in Lowe syndrome

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International Journal of Ophthalmology(English edition) 2022年第7期15卷 1198-1202页

作者： Katharina Eibenberger Sandra Rezar-Dreindl franz Pusch Ursula Schmidt-Erfurth Eva Stifter Department of Ophthalmology and Optometry Medical University of ViennaVienna 1090Austria Department of Anesthesiology Medical University of ViennaVienna 1090Austria

AIM: To evaluate the ophthalmic and anesthesiologic management of cataract surgery in children with Lowe syndrome receiving lens removal, the development and management of secondary ***: This retrospective case series included 12 eyes of 6 children with genetically verified Lowe syndrome receiving cataract removal. Information regarding the type and duration of surgery and total anesthesia time were recorded. Additionally, intra-and postoperative complications were noted as well as clinical examinations such as visual acuity and funduscopy. RESULTS: All children received simultaneous bilateral cataract surgery at the mean age of 8.98±3.58 wk. Lensectomy combined with posterior capsulotomy and anterior vitrectomy was performed in all children. The mean time for cataract surgery per eye was 35.83±8.86 min, whereas the total time of surgery was 153.33±22.11 min. The mean extubation time and duration at recovery room was 42.33±22.60 min and 130.00±64.37 min, respectively. During surgery, a decrease of oxygen saturation below 93% was found in only one child. During the postoperative followup, nystagmus(6 children) and strabismus(5 children) was commonly found in contrast to no case of visual axis opacification. Secondary glaucoma developed in five eyes of three children, which was treated with topical eye drops in only one child. A trabeculectomy was performed in both eyes of one child, whereas removal of syechia and an iridectomy in one eye of one child. CONCLUSION: Bilateral simultaneous cataract surgery under general anesthesia is a safe surgical procedure in Lowe syndrome children. The glaucoma screening with intraocular pressure measurements is crucial in the postoperative management of Lowe syndrome patients to avoid additional visual impairment.

关键词： Lowe syndrome congenital cataract pediatric cataract surgery

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Identification of a female murder victim found in Burgenland,Austria in 1993

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Forensic Sciences Research 2022年第2期7卷 308-318页

作者： Christine Lehn Andreas Rossmann matthias Graw Gareth R.Davies Institute of Legal Medicine Ludwig-Maximilians-University of MunichMunichGermany Laboratory for Stable Isotope Analytics Isolab GmbHSchweitenkirchenGermany Faculty of Earth and Life Sciences Vrije Universiteit AmsterdamAmsterdamThe Netherlands

In 1993,the skeletal remains of a female corpse were found in Burgenland,*** identification of the approximately 25–35-year-old female appeared impossible,but the case was reopened 23 years *** applying biogeochemical isotope methods to her body tissues,the geographical origin of the unknown corpse could be *** results of the C,N,S,H,Sr,and Pb isotope analyses suggested that the female did not originate from Europe and most likely spent her youth in the northern *** these findings,the police were able to identify the woman within 2 *** female came from the Dominican Republic and resided in Austria for only a short period before she was *** case shows that isotope biogeochemistry investigations can provide the police with crucial information that enables unknown persons to be identified.

关键词： Forensic sciences forensic anthropology human identification provenance stable isotope analysis bio-elements geo-elements

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Spatially Resolved Photoelectric Performance of Axial GaAs Nanowire pn-Diodes

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Nano Research 2011年第10期4卷 987-995页

作者： Andrey Lysov Sasa Vinaji matthias Offer Christoph Gutsche Ingo Regolin Wolfgang Mertin Martin Geller Werner Prost Gerd Bacher franz-Josef Tegude Center for Nanointegration Duisburg-Essen University of Duisburg-Essen 47048 Duisburg Germany

一根单个轴的 GaAs nanowire pn 二极管的空间地解决的光电的反应与扫描光电流和凯尔文探查力量显微镜学被调查了。在结的搬运人的光产生被显示了统治 photoresponse。88 pA， 0.56 V 的开的电路电压和 69% 的一个 fill 因素的光电流在 ... 详细信息

一根单个轴的 GaAs nanowire pn 二极管的空间地解决的光电的反应与扫描光电流和凯尔文探查力量显微镜学被调查了。在结的搬运人的光产生被显示了统治 photoresponse。88 pA， 0.56 V 的开的电路电压和 69% 的一个 fill 因素的光电流在 AM 1.5 G 条件下面被获得。光电流与 0.24 A/W 跟随了增加的 photoexcitation 直到至少 90 W/cm2 的照明密度，它为在选矿厂太阳能电池的潜在的应用是重要的。

关键词：空间分辨二极管纳米线光电性能轴向砷化镓 Kelvin探针光生载流子

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Hydroclimate changes related to thermal state of the tropical Pacific in the northern coast of the South China Sea since~8000 cal yr B.P.

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Journal of Palaeogeography 2022年第3期11卷 410-426页

作者： Yue-Qin Wu Xiao-Qiang Yang Jian Yin franz TFürsich Ting-Wei Zhang Chun-Lian Liu Guangdong Provincial Key Laboratory of Geodynamics and Geohazards School of Earth Sciences and EngineeringSun Yat-Sen UniversityZhuhai 519082Guangdong ProvinceChina Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai) Zhuhai 519082Guangdong ProvinceChina FG Paläoumwelt GeoZentrum Nordbayern der Friedrich-Alexander-Universität Erlangen-NürnbergErlangen 91054Germany

Under the complex influences including the monsoonal climates and tropical hydrological cycle,the features and forcing mechanisms of precipitation changes in the tropical monsoon regions remain *** northern coast of the South China Sea(NCSCS),connecting the South China Sea(SCS)and the Pearl River Estuary(PRE),is a critical area providing reliable tropical precipitation records and probing the possible forcing mechanism of tropical precipitation,benefitted from its high deposition rate and hydroclimatic ***,δ^(18)O variations of planktonic(δ^(18)O_(G).ruber)and benthic foraminifera(δ^(18)O_(C).lobatulus)were investigated respectively to reconstruct a high-resolution low-latitude precipitation record from the core 17NH-NC3 in the *** results show a distinctδ^(18)O difference betweenδ^(18)O_(G).ruber andδ^(18)O_(C).lobatulus,not only with respect to values,but also with respect to trends in some time *** clear difference between the planktonic and benthic foraminifera(Δδ^(18)O_(b-p))illustrates the significant vertical salinity *** the temporal trend ofΔδ^(18)O_(b-p) indicates the degree of salinity stratification variated since the *** assume that the degree of stratification in the NCSCS was mainly controlled by tropical precipitation ***,the trend ofΔδ^(18)O_(b-p) values could indicate the temporal change of the tropical *** precipitation record of our research area is closely related to the tropical atmosphere–ocean dynamics stimulated by sea surface temperature(SST)changes of the tropical Pacific zone,analogous to the El Niño–Southern Oscillation(ENSO)*** the mid-Holocene(from 8260 to 5180 cal yr B.P.),the sustainable higherΔδ^(18)O_(b-p) values(>1.23‰)suggested a large amount of precipitation,pointing to a sustained state of La Niña-like,which is associated with lasted higher difference between Western SST and Eastern SST(W-E SST gradient)in the equatorial Pacif

关键词： Stable oxygen isotope Globigerinoides ruber Cibicides lobatulus Low-latitude precipitation ENSO Mid-Holocene

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Cellular heterogeneity in pancreatic cancer: the different faces of gremlin action

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Signal Transduction and Targeted Therapy 2022年第11期7卷 3992-3994页

作者： Aristidis Moustakas J.matthias Löhr Rainer L.Heuchel Department of Medical Biochemistry and Microbiology Uppsala UniversityUppsalaSweden Department of Clinical Intervention and Technology(CLINTEC) Karolinska InstitutetStockholmSweden

A recent publication in Nature by Lan et al.,presented GREM1(gremlin 1)as an important regulatory node of cellular plasticity in pancreatic ductal adenocarcinoma(PDAC).1 Knockout experiments in mice point to an important role of Grem1 in retaining an epithelial,differentiated phenotype of pancreatic cancer cells presumably by inhibiting BMP signalling.

关键词： al. cancer inhibiting

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