Cellular heterogeneity in pancreatic cancer: the different faces of gremlin action

作     者：Aristidis Moustakas J.Matthias Löhr Rainer L.Heuchel 

作者机构：Department of Medical Biochemistry and MicrobiologyUppsala UniversityUppsalaSweden Department of Clinical Intervention and Technology(CLINTEC)Karolinska InstitutetStockholmSweden 

出 版 物：《Signal Transduction and Targeted Therapy》 (信号转导与靶向治疗（英文）)

年 卷 期：2022年第7卷第11期

页      面：3992-3994页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：CancerFonden(RLH 201356 PjF,AM CAN2021/1506Pj01H) Radiumhemmets Foksningsfonder/RahFo(JML 191213) 

主　　题：al. cancer inhibiting 

摘      要：A recent publication in Nature by Lan et al.,presented GREM1(gremlin 1)as an important regulatory node of cellular plasticity in pancreatic ductal adenocarcinoma(PDAC).1 Knockout experiments in mice point to an important role of Grem1 in retaining an epithelial,differentiated phenotype of pancreatic cancer cells presumably by inhibiting BMP signalling.