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Structure-Preserving Finite-Element Schemes for the Euler-Poisson Equations

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Communications in Computational Physics 2023年第3期33卷 647-691页

作者： matthias Maier John N.Shadid Ignacio Tomas Department of Mathematics Texas A&M University3368 TAMUCollege StationTX 77843USA Sandia National Laboratories P.O.Box 5800MS 1320AlbuquerqueNM 87185USA Department of Mathematics and Statistics University of New MexicoMSC011115AlbuquerqueNM 87131USA Department of Mathematics&Statistics Texas Tech University2500 BroadwayLubbockTX 79409USA.

We discuss structure-preserving numerical discretizations for repulsive and attractive Euler-Poisson equations that find applications in fluid-plasma and selfgravitation *** scheme is fully discrete and structure preserving in the sense that it maintains a discrete energy law,as well as hyperbolic invariant domain properties,such as positivity of the density and a minimum principle of the specific entropy.A detailed discussion of algorithmic details is given,as well as proofs of the claimed *** present computational experiments corroborating our analytical findings and demonstrating the computational capabilities of the scheme.

关键词： Euler-Poisson equations operator splitting invariant domain preservation discrete energy balance.

Characterising acute ischaemic stroke thrombi:insights from histology,imaging and emerging impedance-based technologies

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Stroke & Vascular Neurology 2022年第4期7卷 353-363页

作者： Smita Patil Jean Darcourt Pierluca Messina franz Bozsak Christophe Cognard Karen Doyle CÚRAM SFI Research Centre for Medical DevicesNational University of Ireland GalwayGalwayIreland Neuroradiology CHU de ToulouseToulouseFrance Sensome MassyFrance Physiology National University of Ireland GalwayGalwayIreland

Treatment of acute ischaemic stroke(AIS)focuses on rapid recanalisation of the occluded *** recent years,advent of mechanical thrombectomy devices and new procedures have accelerated the analysis of thrombi retrieved during the endovascular thrombectomy *** ongoing developments and progress in AIS imaging techniques,it is not yet possible to conclude definitively regarding thrombus characteristics that could advise on the probable efficacy of thrombolysis or thrombectomy in advance of *** devices with dignostic capabilities or new clinical imaging approaches are needed for better treatment of AIS *** this review,what is known about the composition of the thrombi that cause strokes and the evidence that thrombus composition has an impact on success of acute stroke treatment has been *** review also discusses the evidence that AIS thrombus composition varies with aetiology,questioning if suspected aetiology could be a useful indicator to stroke physicians to help decide the best acute course of ***,this review discusses the evidence that current widely used radiological imaging tools can predict thrombus *** use of new emerging technologies based on bioimpedance,as imaging modalities for diagnosing AIS and new medical device tools for detecting thrombus composition in situ has been *** bioimpedance would be beneficial for gaining new insights into in situ thrombus composition that could guide choice of optimum treatment approach is also reviewed.

关键词： throm acute impedance

Accelerating materials-space exploration for thermal insulators by mapping materials properties via artificial intelligence

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npj Computational Materials 2023年第1期9卷 1204-1215页

作者： Thomas A.R.Purcel matthias Scheffler Luca M.Ghiringhelli Christian Carbogno The NOMAD Laboratory at Fritz-Haber-Institut der Max-Planck-Gesellschaft and IRIS-Adlershof of the Humboldt-Universität zu Berlin Faradayweg 4-6D-14195 BerlinGermany Physics Department and IRIS Adlershof Humboldt Universität zu Berlin BerlinGermany

Reliable artificial-intelligence models have the potential to accelerate the discovery of materials with optimal properties for various applications,including superconductivity,catalysis,and *** in this field are often hindered by the scarcity and quality of available data and the significant effort required to acquire new *** such applications,reliable surrogate models that help guide materials space exploration using easily accessible materials properties are urgently ***,we present a general,data-driven framework that provides quantitative predictions as well as qualitative rules for steering data creation for all datasets via a combination of symbolic regression and sensitivity *** demonstrate the power of the framework by generating an accurate analytic model for the lattice thermal conductivity using only 75 experimentally measured *** extracting the most influential material properties from this model,we are then able to hierarchically screen 732 materials and find 80 ultra-insulating materials.

关键词： artificial thermal properties

Unconventional bound states in the continuum from metamaterial-induced electron acoustic waves

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Advanced Photonics 2023年第5期5卷 77-85页

作者： Wenhui Wang Antonio Günzler Bodo D.Wilts Ullrich Steiner matthias Saba University of Fribourg Adolphe Merkle InstituteFribourgSwitzerland University of Salzburg Department of Chemistry and Physics of MaterialsSalzburgAustria

Photonic bound states in the continuum(BICs)are spatially localized modes with infinitely long lifetimes,which exist within a radiation continuum at discrete energy *** states have been explored in various systems,including photonic and phononic crystal slabs,metasurfaces,waveguides,and integrated *** and availability of the BICs are important aspects for fully taming the BICs toward practical ***,we propose a generic mechanism to realize BICs that exist by first principles free of fine parameter tuning based on non-Maxwellian double-net metamaterials(DNMs).An ideal warm hydrodynamic double plasma(HDP)fluid model provides a homogenized description of DNMs and explains the robustness of the BICs found *** the HDP model,these are standing wave formations made of electron acoustic waves(EAWs),which are pure charge oscillations with vanishing electromagnetic *** BICs have various advantages,such as(i)frequency-comb-like collection of BICs free from normal resonances;(ii)robustness to symmetry-breaking perturbations and formation of quasi-BICs with an ultrahigh Q-factor even if subject to disorder;and(iii)giving rise to subwavelength microcavity resonators hosting quasi-BIC modes with an ultrahigh Q-factor.

关键词： bound states in the continuum double-net metamaterial metamaterial electron acoustic wave hydrodynamical plasma

Six forests in one:Tree species diversity in the Bosque Protector Chongón Colonche,a lowland mountain range in coastal Ecuadorian

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Forest Ecosystems 2022年第6期9卷 725-733页

作者： Oswaldo Jadan David ADonoso Edwin Ponce-Ramírez franz Pucha-Cofrep Omar Cabrera Facultad de Ciencias Agropecuarias Universidad de Cuenca12 de Octubre y Diego de TapiaCuenca010107Ecuador Programa de Doctorado en Conservacion de Recursos Naturales Escuela Internacional de DoctoradoUniversidad Rey Juan CarlosMostolesMadridES-28933Spain Departamento de Biología Escuela Politecnica NacionalLadron de Guevara E11⋅253Quito170525Ecuador Geoforest S.A 12 de febrero y Av.Franklin VegaMacas140150Ecuador Grupo de Investigacion Hidrología y Climatología Universidad Tecnica Particular de LojaSan Cayetano Alto S/NLoja110101Ecuador Brandenburg University of Technology(BTU)Cottbus-Senftenberg 03044CottbusGermany Departamento de Ciencias Biologicas y Agropecuarias Universidad Tecnica Particular de LojaSan Cayetano Alto S/NLoja110101Ecuador

Tropical mountain ranges shape the structure of tree communities and promote highly diverse natural ***“Bosque Protector Chong on-Colonche”(BPCC),an 86,000-ha mountain formation situated on the coast of Ecuador,is biogeographically important for the region by connecting floristic elements of the wet Choco and the dry Tumbesian *** understanding of the factors that model tree and palm diversity and distribution in this mountain range are *** measured and identified all trees and palms(DBH≥10 cm)in 289 plots of0.2 ha,distributed throughout *** used generalized linear models to explain the relationship between forest diversity and structure and climatic variables(temperature,rain,aridity),and *** then used cluster and non-metric multidimensional scale(NMDS)analyses to search for distinct forest communities within the *** partition(varpart)was used to determine which predictor variables best explained these distinct forest communities.A species indicator analysis identified the species most likely to define these distinct forest ***,we carried out a niche modeling approach to identify the potential distribution of these forest communities within *** total,we identified 220 tree and palm species in our *** average number of species per plot was 17.8±5.8,ranging from 3 to 40 *** methods sorted the 289study plots into six different forest communities,three communities in the dry forest and three in the semi-humid Garúa *** and temperature,but not altitude or aridity,explained floristic *** results emphasize the high but little cataloged diversity in the lowland mountain rainforests of coastal Ecuador.

关键词： Chongón-Colonche Climatic variables Dry forest Forest communities Garúa forest

Envita’s Precision Cancer Care: 35-Fold Improvement in Response Rates

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Journal of Cancer Therapy 2024年第4期15卷 99-120页

作者： Sheba Goklany John C. Oertle III Ronald matthias Jr. Daniel Warren David Medina Rory Sears Robert Zieve Kendra Quart Christopher Aussems Jon Moma Shannon Miller Zach Poteet Conner Coffin Courtney Middleton Erika Ware Phylicia Zarnosky Julie Nowak Winlove Suasin Daniel Conway Chad Burk Ruth Tan-Lim Dino Prato Envita Medical Centers Scottsdale AZ USA

New clinical approaches are imperative beyond the widely adopted National Comprehensive Cancer Network (NCCN) guidelines, utilized by prominent cancer institutions. Cancer is the leading cause of death among individuals younger than 85 years within the United States. Despite significant technological advances, including the expenditure of hundreds of billions, treatment outcomes and overall survival have not notably improved for most types of advanced cancer over the last several decades. Over the past 24 years, Envita Medical Centers has pioneered a unique form of personalized treatment approach for late-stage and refractory cancer patients, introducing groundbreaking innovations in the field. Our integrated algorithm utilizes advanced genomics, transcriptomics, and highly tailored immunotherapy, resulting in remarkable outcome improvements. This study presents Envita’s innovative personalized treatment algorithms and examines the response outcomes of 199 late-stage cancer patients treated at Envita Medical Centers over a two-year period. Compared to standard of care and palliative chemotherapy, Envita’s treatment demonstrated a remarkable 35-fold improvement in overall response rates (Figure 1). Moreover, 88% of the patients, the majority presenting with Stage 3 or 4 cancer, experienced a 43-fold improvement in quality of life with minimal side effects, as compared to standard of care chemotherapy and palliative care. This revolutionary success is attributed to Envita’s personalized therapeutic algorithms, which incorporate customized immunotherapy. Envita’s precision care approach has also achieved a 100% better response rate compared to over 65 global chemotherapy clinical trials with more than 2700 patients. The results from this study suggest that a wider utilization of Envita’s personalized approach can significantly benefit patients with late-stage and refractory cancer.

关键词： Envita Medical Centers Late-stage Cancer Overall Response Rate Quality of Life Circulating Tumor Cells (CTCs) Mutant Allele Frequency (MAF) Precision Care

Stochastic Runge-Kutta–Munthe-Kaas Methods in the Modelling of Perturbed Rigid Bodies

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Advances in Applied Mathematics and Mechanics 2022年第2期14卷 528-538页

作者： Michelle Muniz matthias Ehrhardt Michael Günther Renate Winkler Institute of Mathematical Modelling Analysis and Computational Mathematics(IMACM)Applied Mathematics and Numerical AnalysisBergische Universität WuppertalGaußstraße 2042119 WuppertalGermany

In this paper we present how nonlinear stochastic Itˆo differential equations arising in the modelling of perturbed rigid bodies can be solved numerically in such a way that the solution evolves on the correct *** this end,we formulate an approach based on Runge-Kutta–Munthe-Kaas(RKMK)schemes for ordinary differ-ential equations on ***,we provide a proof of the mean-square convergence of this stochastic version of the RKMK schemes applied to the rigid body problem and illustrate the effectiveness of our proposed schemes by demonstrating the structure preservation of the stochastic RKMK schemes in contrast to the stochastic Runge-Kutta methods.

关键词： Stochastic Runge-Kutta method Runge-Kutta–Munthe-Kaas scheme nonlinear Itˆo SDEs rigid body problem

Simulating Temporally and Spatially Correlated Wind Speed Time Series by Spectral Representation Method

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Complex System Modeling and Simulation 2023年第2期3卷 157-168页

作者： Qing Xiao Lianghong Wu Xiaowen Wu matthias Rätsch School of Information and Electrical Engineering Hunan University of Science and TechnologyXiangtan 411201China Image Understanding and Interactive Robotics Group Reutlingen UniversityReutlingen D-72762Germany.

In this paper,it aims to model wind speed time series at multiple *** five-parameter Johnson mdistribution is deployed to relate the wind speed at each site to a Gaussian time series,and the resultant-Z(t)dimensional Gaussian stochastic vector process is employed to model the temporal-spatial correlation of mwind speeds at different *** general,it is computationally tedious to obtain the autocorrelation functions Z(t)(ACFs)and cross-correlation functions(CCFs)of Z(t),which are different to those of wind speed times *** order to circumvent this correlation distortion problem,the rank ACF and rank CCF are introduced to Z(t)characterize the temporal-spatial correlation of wind speeds,whereby the ACFs and CCFs of can be analytically ***,Fourier transformation is implemented to establish the cross-spectral density matrix Z(t)mof,and an analytical approach is proposed to generate samples of wind speeds at different ***,simulation experiments are performed to check the proposed methods,and the results verify that the five-parameter Johnson distribution can accurately match distribution functions of wind speeds,and the spectral representation method can well reproduce the temporal-spatial correlation of wind speeds.

关键词： multivariate wind speed time series rank autocorrelation function rank cross-correlation function cross-spectral density matrix five-parameter Johnson distribution

What are the contributions of maternal and paternal traits to fecundity and offspring development?A case study in an amphibian species,the spined toad Bufo spinosus

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Current Zoology 2023年第5期69卷 527-534页

作者： matthias Renoirt Frédéric Angelier Marion Cheron François Brischoux Centre d’Etudes Biologiques de Chizé CEBC UMR 7372 CNRS-La Rochelle Université79360 Villiers en BoisFrance

Assessing the determinants of reproductive success is critical but often complicated because of complex interactions between parental traits and environmental conditions occurring during several stages of a reproductive ***,we used a simplified ecological situation-an amphibian species lacking post-oviposition parental care-and a laboratory approach to investigate the relationships between parental(both maternal and paternal)phenotypes(body size and condition)and reproductive success(fecundity,egg size,embryonic and larval duration,larval and metamorphic morphology).We found significant effects of maternal phenotype on fecundity,hatching success,and tadpole size,as well as on the duration of larval ***,and more surprisingly,we also found a potential contribution of the paternal phenotype occurring during early(embryonic development duration)offspring *** our study focused on life-history traits such as body size and development duration,additional mechanisms involving physiological costs of development may well mediate the relationships between parental phenotypes and offspring *** studies are required to decipher the mechanisms underlying our findings in order to clarify the mechanistic basis of the links between parental phenotypes and offspring development.

关键词： clutch quality embryonic development larval development phenotype reproductive success