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Aorto-oesophageal fistula after corrosive ingestion:A case report

World Journal of Gastrointestinal Surgery 2022年第5期14卷 506-513页

作者： matthias frank Scriba Urda Kotze Nadraj Naidoo Eduard Jonas Galya Eileen Chinnery Surgical Gastroenterology Unit Department of SurgeryGroote Schuur HospitalUniversity of Cape TownCape Town 7925Western CapeSouth Africa Surgical Gastroenterology Unit Department of SurgeryUniversity of Cape TownFaculty of Health SciencesCape Town 7925Western CapeSouth Africa Vascular and Endovascular Surgery Unit Department of SurgeryGroote Schuur HospitalUniversity of Cape TownCape Town 7925Western CapeSouth Africa

BACKGROUND Aorto-oesophageal fistula(AOF)are uncommon and exceedingly rare after corrosive *** authors report a case of AOF after corrosive ingestion that survived.A comprehensive literature review was performed to identify all cases of AOF after corrosive ingestion to determine the incidence of this condition,how it is best managed and what the outcomes *** SUMMARY A previously healthy 30-year-old male,presented with a corrosive oesophageal injury after drain cleaner *** did not require acute surgical resection,but developed long-segment oesophageal stricturing,which was initially managed with cautious dilatation and later *** AOF was suspected at endoscopy performed two months after the ingestion,when the patient represented with massive upper gastrointestinal *** fistula was confirmed on computerised tomographic *** initial bleeding at endoscopy was temporised by oesophageal stenting;a second stent was placed when bleeding recurred later the same *** stenting successfully achieved temporary bleeding control,but resulted in sudden respiratory distress,which was found to be due to left main bronchus compression caused by the overlapping oesophageal *** bleeding control was achieved by endovascular aortic stent-grafting.A retrosternal gastroplasty was subsequently performed to achieve gastrointestinal diversion to reduce the risk of stent-graft *** was subsequently successfully discharged and remains well one year post *** AOF after corrosive ingestion is exceedingly rare,with a very high *** occur weeks to months after the initial corrosive *** management is ill-advised.

关键词： Aorto-oesophageal fistula Corrosive/caustic injury Corrosive ingestion Case report

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Predicting full-thickness necrosis in adult acute corrosive ingestion injuries in a sub-Saharan African setting

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World Journal of Gastrointestinal Pharmacology and Therapeutics 2024年第6期15卷 39-50页

作者： matthias frank Scriba Eduard Jonas Galya Eileen Chinnery Department of Surgical Gastroenterology Department of SurgeryGroote Schuur HospitalUniversity of Cape TownCape Town 7925Western CapeSouth Africa

BACKGROUND Corrosive ingestion remains an important global pathology with high morbidity and *** on the acute management of adult corrosive injuries from sub-Saharan Africa is scarce,with international investigative algorithms,relying heavily on computed tomography(CT),having limited availability in this *** To investigate the corrosive injury spectrum in a low-resource setting and the applicability of parameters for predicting full-thickness(FT)necrosis and *** A retrospective analysis of a prospective corrosive injury registry(March 1,2017–October 31,2023)was performed to include all adult patients with acute corrosive ingestion managed at a single,academic referral centre in Cape Town,South *** demographics,corrosive ingestion details,initial investigations,management,and short-term outcomes were described using descriptive statistics while multivariate analysis with receiver operator characteristic area under the curve graphs(ROC AUC)were used to identify factors predictive of FT necrosis and 30-day *** One-hundred patients were included,with a mean age of 32 years(SD:11.2 years)and a male predominance(65.0%).The majority(73.0%)were intentional suicide *** on admission was the most frequent initial investigation performed(95 patients),while only 17 were assessed with *** patients had full thickness necrosis at surgery,of which eleven underwent emergency resection and six were ***-day morbidity and mortality were 27.0%and 14.0%,*** with full thickness necrosis and those with an established perforation had a 30-day mortality of 58.8%and 91.0%,*** thickness necrosis was associated with a cumulative 2-year survival of only 17.6%.Multivariate analyses with ROC AUC showed admission endoscopy findings,CT findings,and blood gas findings(pH,base excess,lactate),to all have significant predictive value for full thickness necrosis,with endoscopy pr

关键词： Corrosive injuries Caustic injuries Adult Predicting necrosis Endoscopy predictive performance CT predictive performance Short-term survival

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Estimates of Genetic Variability of <i>Mycobacterium tuberculosis</i>Complex and Its Association with Drug Resistance in Cameroon

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Advances in Infectious Diseases 2013年第1期3卷 55-59页

作者： Larissa Kamgue Sidze Emmanuel Mouafo Tekwu Christopher Kuaban Jean-Paul Assam Assam Jean-Claude Tedom Stefan Niemann matthias frank Véronique N. Penlap Beng Institute for Tropical Medicine University of Tübingen Tübingen Germany Laboratory for Tuberculosis Research Biotechnology Centre of Nkolbisson (BTC) University of Yaoundé I Yaoundé Cameroon Pneumology Unit Jamot Hospital Yaoundé Cameroon Research Centre Borstel Molecular Mycobacteriology Borstel Germany

The present study investigates the genetic diversity among Mycobacterium tuberculosis complex circulating in the Centre region of Cameroon and analyzes the relationship between genotypes and drug resistance patterns. Spoligotyping was performed by PCR-amplification followed by the reverse hybridization of 298 cultured specimens. Spoligotypes patterns were identified by comparison to reference strains in SPolDB4 database via the MIRU VNTR plus web application. About 97.65% of all tuberculosis (TB) cases were attributed to M. tuberculosis. A total of 65 different profiles were identified. Of these, 40 were represented as Shared Types (ST) while the others were orphans. LAM10_CAM and Haarlem families were the most prevalent genetic families with 51.01% and 14.09% respectively. ST 61, a member of the LAM10_ CAM family formed the largest cluster with 128 (42.95%) isolates. No association was found between genotypes with regard to drug resistance and HIV sero-status. However, there was a significant association between genotypes and age groups. Patients belonging to 15 - 24 and 35 - 44 age groups were more likely infected by LAM10_CAM strains compared to others. The population structure of Mycobacterium tuberculosis complex strains from the Centre region was found to be diverse and the spoligotype 61 of the LAM10_CAM family was highly predominant. Isolates of the LAM10_CAM seem to be not associated with drug resistance.

关键词： M. tuberculosis Spoligotyping LAM10_CAM

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Decoding complexity: the need to enhance precision and streamline spatial understanding in neuroscience

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Neural Regeneration Research 2025年第3期20卷 801-802页

作者： Sameehan Mahajani Armita Salahi Brenda Gonzalez Charlotte Nelson frank Hsiung Biology&Applications Division NodexusSan JoseCAUSA

Neuroscience is the ultimate frontier in our quest for a comprehensive understanding of human behavior. Since its launch in 2009, the Human Connectome Project has emerged as a pioneering force, making heroic strides i... 详细信息

关键词： behavior frontier dating

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Acupuncture for the management of dry eye disease

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Frontiers of Medicine 2022年第6期16卷 975-983页

作者： Julia Prinz Nicola Maffulli matthias Fuest Peter Walter frank Hildebrand Filippo Migliorini Department of Ophthalmology RWTH Aachen UniversityPauwelsstr.3052074AachenGermany Department of Medicine Surgery and DentistryUniversity of SalernoVia S.Allende84081BaronissiSAItaly Queen Mary University of London Barts and the London School of Medicine and DentistryMile End Hospital275 Bancroft RoadLondonEI 4DGEngland School of Pharmacy and Bioengineering Keele University Faculty of MedicineThornburrow DriveStoke on TrentEngland Department of Orthopedics University Clinic AachenRWTH Aachen University Clinic52064AachenGermany

The effectiveness of using acupuncture for dry eye disease(DED)is ***,this systematic review investigated the effectiveness and feasibility of using acupuncture for DED in accordance with the 2020 PRISMA *** outcomes of interests were(1)to evaluate the efficacy of acupuncture in improving the ocular surface disease index(OSDI),Schirmer I test score,and tear breakup time from baseline to the last follow-up;(2)to determine possible complications of using acupuncture;and(3)to investigate the superiority of acupuncture over other commonly used treatments for *** from 394 patients were *** showed that acupuncture significantly prolonged the tear breakup time(P<0.0001),significantly increased the Schirmer I test score(P<0.0001),and significantly reduced the OSDI(P<0.0001)from baseline to the last *** with the control group,the acupuncture group had significantly greater Schirmer I test score(P<0.0001),significantly longer tear breakup time(P=0.0004),and significantly lower OSDI(P=0.002).These results suggest that acupuncture is effective and feasible in improving symptoms and signs of *** severe adverse effects of acupuncture were observed.

关键词： dry eye disease xerophthalmus acupuncture

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Model predictive control for autonomous ground vehicles:a review

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Autonomous Intelligent Systems 2021年第1期1卷 32-48页

作者： Shuyou Yu matthias Hirche Yanjun Huang Hong Chen frank Allgöwer State Key Laboratory of Automotive Simulation and Control Jilin UniversityChangchun 130022China Department of Control Science and Engineering Jilin UniversityChangchunChina Institute for Systems Theory and Automatic Control University of StuttgartPfaffenwaldring 9Stuttgart 70569Germany Institute of Intelligent Vehicles Tongji UniversityShanghaiChina College of Electronic and Information Engineering Tongji UniversityShanghaiChina

This paper reviews model predictive control(MPC)and its wide applications to both single and multiple autonomous ground vehicles(AGVs).On one hand,MPC is a well-established optimal control method,which uses the predicted future information to optimize the control actions while explicitly considering *** the other hand,AGVs are able to make forecasts and adapt their decisions in uncertain ***,because of the nature of MPC and the requirements of AGVs,it is intuitive to apply MPC algorithms to *** are interesting not only for considering them alone,which requires centralized control approaches,but also as groups of AGVs that interact and communicate with each other and have their own controller *** calls for distributed control ***,a short introduction into the basic theoretical background of centralized and distributed MPC is ***,it comprehensively reviews MPC applications for both single and multiple ***,the paper highlights existing issues and future research directions,which will promote the development of MPC schemes with high performance in AGVs.

关键词： Model predictive control Autonomous intelligent system Autonomous ground vehicle

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Gold-catalysed synthesis of phosphonatesubstituted oxetan-3-ones–an easy access to highly strained HWE reagents

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Organic Chemistry Frontiers 2022年第1期9卷 117-122页

作者： Shaista Tahir Jonas F.Wunsch matthias Rudolph frank Rominger A.Stephen K.Hashmi Organisch-Chemisches Institut Heidelberg UniversityIm Neuenheimer Feld 27069120 HeidelbergGermany Chemistry Department Faculty of ScienceKing Abdulaziz University21589 JeddahSaudi Arabia

A convenient approach for the attainment of strained phosphonate-substituted oxetan-3-ones,starting from easy to synthesise alkynyl phosphonates,is *** the aid of a pyridine-N-oxide,in a goldcatalysed step anα-oxo carbene species is generated as a key *** formal OH-insertion,synthetically useful HWE reagents can be *** synthetic utility of the obtained building blocks could be demonstrated,which yielded the 2-alkenyl oxetan-3-one scaffold in high yields after the HWE reaction.

关键词： reaction substituted synthesis

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Practical and modular construction of benzo[c]phenanthridine compounds

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Science China Chemistry 2022年第7期65卷 1338-1346页

作者： Cheng Zhang Qian Chen Lei Wang Qiaoying Sun Yangyang Yang matthias Rudolph frank Rominger A.Stephen K.Hashmi Organisch-Chemisches Institut Heidelberg UniversityHeidelberg 69120Germany Chemistry Department Faculty of ScienceKing Abdulaziz University(KAU)Jeddah 21589Saudi Arabia Cellular Immunotherapy Lab the Medical Faculty of Heidelberg UniversityHeidelberg University HospitalHeidelberg 69120Germany

Here,we describe a general and modular strategy for the rapid assembly of benzo[c]phenanthridine(BCP)derivatives using homogeneous gold ***,in contrast to traditional methods based on the specially preformed substrates that have an inherent preference for the formation of this class of compounds with limited flexibility,this protocol is achieved via a selectively intramolecular cascade of a diazo-tethered alkyne and subsequently an intermolecular cyclization with a nitrile to facilitate the successive C–N and C–C bonds *** methodology uses readily available nitriles as the nitrogen source to deliver the products in good yield with excellent functional group compatibility.A preliminary anti-tumor activity study of these generated products exhibits high anticancer potency against five tumor cell lines,including He La,Mel624,SW-480,8505C,***,we report a catalyst-controlled intermolecular cycloaddition/intramolecular insertion of the substrate with a fulvene to provide fused polycarbocycles containing a seven-membered ring.

关键词： selectivity homogeneous gold catalysis domino cyclization benzo[c]phenanthridine(BCP) anticancer activity

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First immunohistochemical evidence of human tendon repair following stem cell injection: A case report and review of literature

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World Journal of Stem Cells 2021年第7期13卷 944-970页

作者： Eckhard Alt Ralf Rothoerl matthias Hoppert Hans-Georg frank Tobias Wuerfel Christopher Alt Christoph Schmitz Chairman of the Board Isarklinikum MunichMunich 80331Germany Department of Spine Surgery Isarklinikum MunichMunich 80331Germany Department for Orthopedics and Trauma Surgery Isarklinikum MunichMunich 80331Germany Chair of Neuroanatomy Institute of AnatomyFaculty of MedicineLMU MunichMunich 80336Germany Director of Science and Research InGeneron GmbHMunich 80331Germany

BACKGROUND Current clinical treatment options for symptomatic,partial-thickness rotator cuff tear(sPTRCT)offer only limited potential for true tissue healing and improvement of clinical *** animal models,injections of adult stem cells isolated from adipose tissue into tendon injuries evidenced histological regeneration of tendon ***,it is unclear whether such beneficial effects could also be observed in a human tendon treated with fresh,uncultured,autologous,adipose derived regenerative cells(UA-ADRCs).A specific challenge in this regard is that UA-ADRCs cannot be labeled and,thus,not unequivocally identified in the host ***,histological regeneration of injured human tendons after injection of UA-ADRCs must be assessed using comprehensive,immunohistochemical and microscopic analysis of biopsies taken from the treated tendon a few weeks after injection of *** SUMMARY A 66-year-old patient suffered from sPTRCT affecting the right supraspinatus and infraspinatus tendon,caused by a bicycle *** day 18 post injury[day 16 post magnetic resonance imaging(MRI)examination]approximately 100 g of abdominal adipose tissue was harvested by liposuction,from which approximately 75×10^(6) UA-ADRCs were isolated within 2 ***,UA-ADRCs were injected(controlled by biplanar X-ray imaging)adjacent to the injured supraspinatus tendon immediately after *** fast clinical recovery,a follow-up MRI examination 2.5 mo post treatment indicated the need for open revision of the injured infraspinatus tendon,which had not been treated with *** this operation,a biopsy was taken from the supraspinatus tendon at the position of the injury.A comprehensive,immunohistochemical and microscopic analysis of the biopsy(comprising 13 antibodies)was indicative of newly formed tendon *** Injection of UA-ADRCs can result in regeneration of injured human tendons by formation of new tendon tissue.

关键词： Stem cells Partial-thickness rotator cuff tear Tendon regeneration Adipose derived regenerative cells Cell-based therapy at point of care Case report

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Australasian microtektites across the Antarctic continent: Evidence from the Sør Rondane Mountain range (East Antarctica)

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Geoscience Frontiers 2021年第4期12卷 202-214页

作者： Bastien Soens matthias van Ginneken Stepan Chernonozhkin Nicolas Slotte Vinciane Debaille frank Vanhaecke Herman Terryn Philippe Claeys Steven Goderis Analytical Environmentaland Geo-ChemistryVrije Universiteit BrusselPleinlaan 2BE-1050 BrusselsBelgium Laboratoire G-Time UniversitéLibre de Bruxelles 50Av.F.D.Roosevelt CP 160/02BE-1050 BrusselsBelgium Centre for Astrophysics and Planetary Science University of KentCT27NZCanterburyKentUnited Kingdom Atomic&Mass Spectrometry–A&MS Research Unit Department of ChemistryGhent UniversityCampus SterreKrijgslaan 281–S12BE-9000 GhentBelgium Electrochemical and Surface Engineering Vrije Universiteit BrusselPleinlaan 2BE-1050 BrusselsBelgium

The~790 ka Australasian(micro)tektite strewn field is one of the most recent and best-known examples of impact ejecta emplacement as the result of a large-scale cratering event across a considerable part of Earth's surface(>10%in area).The Australasian strewn field is characterized by a tri-lobe pattern consisting of a large central distribution lobe,and two smaller side lobes extending to the west and ***,we report on the discovery of microtektite-like particles in sedimentary traps,containing abundant micrometeorite material,in the Sør Rondane Mountain(SRM)range of East *** thirty-three glassy particles display a characteristic pale yellowcolor and are predominantly spherical in shape,except for a single dumbbell-shaped *** vitreous spherules range in size from220 to 570μm,with an average diameter of~370μ*** compares relatively well with the size distribution(75–778μm)of Australasian microtektites previously recovered from the TransantarcticMountains(TAM)and located ca.2500–3000 km fromthe *** addition,the chemical composition of the SRM particles exhibits limited variation and is nearly identical to the‘normal-type’(i.e.,<6%MgO)TAM *** Sr and Nd isotope systematics for a single batch of SRM particles(n=26)strongly support their affiliation with TAMmicrotektites and the Australasian tektite strewn field in ***,Sr isotope ratios and Nd model ages suggest that the target material of the SRM particles was composed of a plagioclase-or carbonate-rich lithology derived from a Paleo-or Mesoproterozoic crustal *** affiliation to the Australasian strewn field requires long-range transportation,with estimated great circle distances of ca.11,600 km from the hypothetical source crater,provided transportation occurred along the central distribution *** is in agreement with the observations made for the Australasian microtektites recovered from Victoria Land(ca.11,000 km)and Larkman Nunatak(ca.12,000 km),w

关键词： Impact cratering Impact ejecta Target stratigraphy Volatilization Antarctica Microtektites

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