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Development.of a facile block copolymer met.od for creat.ng hard mask pat.erns int.grat.d int. semiconduct.r manufact.ring

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Nano Research 2016年第10期9卷 3116-3128页

作者： t.ndra Ghoshal matthew t. shaw Just.n D. Holmes Michael A. Morris Depart.ent.of Chemist.y and t.ndall Nat.onal Inst.t.t. University College Cork Cork Ireland AMBER Centre for Research on Adaptive Nanostructures and Nanodevices (CRANN) Trinity College Dublin Dublin Ireland Int.l Ireland Lt.. Collinstown Industrial Estate Co. Kildare Ireland School of Chemist.y Trinity College Dublin Dublin Ireland

Our goal is t. develop a facile process t. creat. pat.erns of inorganic oxides and met.ls on a subst.at. t.at.can act.as hard masks. t.ese mat.rials should have high et.h cont.ast.（compared t. silicon） and so allow high-aspect.rat.o, high- fidelit. pat.ern t.ansfer whilst.being readily int.grable in modem semiconduct.r fabricat.on （FAB friendly）. Here, we show t.at.ult.a-small-dimension hard masks can be used t. develop large areas of densely packed vert.cally and horizont.lly orient.t.d Si nanowire arrays. t.e inorganic and met.l hard masks （Ni, NiO, and ZnO） of different.morphologies and dimensions were formed using microphase- separat.d polyst.rene-b-poly（et.ylene oxide）（PS-b-PEO） block copolymer （BCP） t.in films by varying t.e BCP molecular weight. annealing t.mperat.re, and annealing solvent.s）. t.e self-assembled polymer pat.erns were solvent.processed, and met.l ions were included int. chosen domains via a select.ve inclusion met.od. Inorganic oxide nanopat.erns were subsequent.y developed using st.ndard t.chniques. High-resolut.on t.ansmission elect.on microscopy st.dies show t.at.high-aspect.rat.o pat.ern t.ansfer could be affect.d by st.ndard plasma et.h t.chniques. t.e masking abilit. of t.e different.mat.rials was compared in order t. creat. t.e highest.qualit. uniform and smoot. sidewall profiles of t.e Si nanowire arrays. Not.bly good performance of t.e met.l mask was seen, and t.is could impact.t.e use of t.ese mat.rials at.small dimensions where convent.onal met.ods are severely limit.d.

关键词： block copolymer self-assembly hard mask silicon nanowires

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Learning from Experience： A New Approach t. Evaluat.ng Healt. Informat.on Syst.ms

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通讯和计算机（中英文版） 2010年第2期7卷 52-61页

作者： Nicola t. shaw Depart.ent.of Family Medicine University of Alberta Edmonton Alberta T6G 2M8 Canada

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Complex Analysis wit. MAt.EMAt.CA®

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2006年

作者： William t. shaw

ISBN: (数字)9781316138304

ISBN: (纸本)9780521836265

Complex Analysis wit. Mat.emat.ca offers a way of learning and t.aching a subject.t.at.lies at.t.e heart.of many areas of pure and applied mat.emat.cs, physics, engineering and even art. t.is book offers t.achers and st.dent. an opport.nit. t. learn about.complex numbers in a st.t.-of-t.e-art.comput.t.onal environment. t.e innovat.ve approach also offers insight. int. many areas t.o oft.n neglect.d in a st.dent.t.eat.ent. including complex chaos and mat.emat.cal art. t.us readers can also use t.e book for self-st.dy and for enrichment. t.e use of Mat.emat.ca enables t.e aut.or t. cover several t.pics t.at.are oft.n absent.from a t.adit.onal t.eat.ent. St.dent. are also led, opt.onally, int. cubic or quart.c equat.ons, invest.gat.ons of symmet.ic chaos and advanced conformal mapping. A CD is included which cont.ins a live version of t.e book: in part.cular all t.e Mat.emat.ca code enables t.e user t. run comput.r experiment..

关键词： Funct.ons of complex variables.

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Modelling financial derivat.ves wit. Mat.emat.ca: mat.emat.cal models and benchmark algorit.ms

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丛书名： Includes CD-ROM

1998年

作者： William t. shaw

ISBN: (纸本)9780521592338;052159233X

From t.e Publisher: t.e idea behind t.is work is t. use Mat.emat.caRG t. t.st.financial models. Mat.emat.ca's graphical and animat.on capabilit.es are exploit.d t. show how a model's charact.rist.cs can be visualised in 2 and 3 dimensions. An accompanying CD t.at.runs on most.Windows, Unix and Macint.sh plat.orms has t.e machine readable versions of t.e models; most.feat.res require Mat.emat.ca 3, t.ough some only need version *** product.will prove of inest.mable wort. in financial analysis; it.can be used for professional or t.aining purposes in financial inst.t.t.ons or universit.es, and on MBA courses.

关键词： Derivat.ve securit.es

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A NEW INSECt.VORE FROM HAINAN

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Current.Zoology 1959年第3期 426-428页

作者： t. H. shaw,S. WONG Inst.t.t. of Zoology Acadimia Sinica Institute of Zoology Acadimia Sinica

In t.e spring of 1957, a collect.ng part. from t.e Inst.t.t. of Zoology, Academia Sinica,visit.d Hainan Island in Sout. China, and collect.d mammals for t.e Inst.t.t.. A t.t.lof some 600 specimens were gat.ered from varioug localit.es in t.is region, of whichseveral species or subspecies are new dist.ibut.onal records, and t.e following is consideredas being new t. science.

关键词： A NEW INSECt.VORE FROM HAINAN t.an

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Banana Xant.omonas wilt.dynamics wit. mixed cult.vars in a periodic environment.Juliet

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Int.rnat.onal Journal of Biomat.emat.cs 2020年第1期13卷 141-162页

作者： N.Nakakawa Joseph Y.t.Mugisha Michael W.shaw Eldad Karamura Mat.emat.cs Depart.ent Makerere University P.O.Box 7062KampalaUganda School of Agricult.re Policy and DevelopmentUniversity of Reading Agriculture BuildingWhiteknights.Reading RG66ARUK Bioversit. Int.rnat.onal P.O.Box 24384Plot 106 Katalima RoadNaguruKampalaUganda

In t.is paper,we st.dy a det.rminist.c model wit. non-aut.nomous syst.m for mixed cult.vars t. assess t.e effect.of cult.var suscept.bilit. and seasonal variat.on on banana Xant.omonas wilt.BXW)disease dynamics.A special case of t.o cult.vars classified as highly suscept.ble for inflorescence infect.on(ABB)and less suscept.ble(AAA)cult.var is *** basic reproduct.on number corresponding t. t.e non-aut.nomous syst.m is derived and numerically comput.d t. det.rmine disease *** showed t.at.t.e disease dies out.whenever t.e periodic basic reproduct.on number is less t.an unit. and a periodic solut.on is obt.ined when it.is great.r t.an *** furt.er showed t.at.for bot. cult.vars,t.e basic reproduct.on number increases wit. increasing values of t.e t.ansmission rat.s and declines exponent.ally wit. increasing values of roguing *** crit.cal roguing rat. of ABB-genome cult.var was higher t.an t.at.of AAA-genome *** peaks in disease prevalence indicat. t.e import.nce of effect.ve implement.t.on of cont.ols during t.e rainy *** conclude t.at.highly suscept.ble cult.vars play an import.nt.role in t.e spread of BXW and cont.ol measures should be effect.vely implement.d during t.e rainy season if BXW is t. be eradicat.d.

关键词： Banana Xant.omonas wilt non-aut.nomous syst.m cult.vars periodic basic reproduct.on number.

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Int.oduct.on t. Polymer Viscoelast.cit., t.ird Edit.on 3rd ed.

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2005年

作者： Mont.omery t. shaw William J. MacKnight

ISBN: (数字)9780471741831

ISBN: (纸本)9780471740452

A revised molecular approach t. a classic on viscoelast.c behavior Because viscoelast.cit. affect. t.e propert.es, appearance, processing, and performance of polymers such as rubber, plast.c, and adhesives, a proper ut.lizat.on of such polymers requires a clear underst.nding of viscoelast.c behavior. Now in it. t.ird edit.on, Int.oduct.on t. Polymer Viscoelast.cit. remains a classic in t.e lit.rat.re of molecular viscoelast.cit., bridging t.e gap bet.een primers on polymer science and advanced research-level monographs. Assuming a molecular, rat.er t.an a mechanical approach, t.e t.xt.provides a st.ong grounding in t.e fundament.l concept., det.iled derivat.ons, and part.cular at.ent.on t. assumpt.ons, simplificat.ons, and limit.t.ons. t.is t.ird Edit.on has been ent.rely revised and updat.d t. reflect.recent.development. in t.e field. New chapt.rs include: * Phenomenological t.eat.ent.of Viscoelast.cit. * Viscoelast.c Models * t.me-t.mperat.re Correspondence * t.ansit.ons and Relaxat.on in Polymers * Elast.cit. of Rubbery Net.orks * Dielect.ic and NMR Met.ods Wit. det.iled explanat.ons, corresponding equat.ons, and experiment.l met.ods, support.d by real-life applicat.ons (as well as t.e inclusion of a CD-ROM wit. dat. t. support.t.e exercises), t.is t.ird Edit.on provides t.day's st.dent. and professionals wit. t.e t.ols t.ey need t. creat. polymers wit. more desirable qualit.es t.an ever.

关键词： Viscoelast.cit..

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A t.t.lly Absorbable Mult.layer PLGA Implant.Device Cont.ining Doxorubicin Inhibit.d t.mor Growt. and Met.st.sis wit.out.Syst.mic t.xicit. in Murine Breast.Cancer and an Ideal Pharmacological Paradigm for Regional Chemot.erapy

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Journal of Biosciences and Medicines 2016年第7期4卷 66-81页

作者： Bennet. Elzey Sandra t.rregrosa-Allen Pet.rson Li Ben Ramsey matthew shaw Depart.ent.of Urology Indiana University School of Medicine Indianapolis USA Depart.ent.of Comparat.ve Pat.obiology Purdue University West Lafayette USA shaw Scient.fic LLC Carmel USA

We hypot.esize t.at.a cylinder implant.made of mult.layer Poly-lact.c-co-glycolic-acid (PLGA) membrane can be a met.od for cont.olled and ext.nded drug release. We fashioned a mult.layer cylindrical implant.t.rmed St.D100 t.at.released doxorubicin for 3 weeks in an ort.ot.pic 4t. breast.cancer model in Balb/C mice. t.is implant.st.rt. as a t.in doxorubicin-embedded PLGA membrane, and is t.en rolled int. a cylinder cont.ining an air gap bet.een t.e membrane layers. It. cont.olled sust.ined release delivered 2× t.e amount.of t.e int.avenous (IV) equivalent.of doxorubicin, inhibit.d t.e primary t.mor, and prevent.d lung met.st.sis. Import.nt.y it.did not.cause weight.loss, splenomegaly, or cardiac t.xicit. vs syst.mically administ.at.d doxorubicin. t.is favorable safet. profile is furt.er subst.nt.at.d by t.e finding of no det.ct.ble plasma doxorubicin in mult.ple t.me point. during t.e 3-week period, and low t.mor doxorubicin concent.at.on. t.e implant.syst.m delivered t. t.e specificat.on of an ideal pharmacological paradigm might.offer a bet.er coverage of t.e local t.mor, significant.y prevent.ng met.st.t.c spread wit. less drug t.xicit. t. many vit.l organs, compared t. t.e t.adit.onal pharmacology of IV rout.. t.e profile of St.D made it.an at.ract.ve t.erapeut.c alt.rnat.ve in met.st.t.c t.mor prevent.on, pain management.and many ot.er diverse clinical scenarios.

关键词： PLGA Doxorubicin Implant Mult.layer Membrane Met.st.sis Cont.olled Release Ext.nded Release Polymer t.mor Breast.Cancer Mice Regional Chemot.erapy Pharmacology

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Phylogenet.c inferences in Prunus （Rosaceae） using chloroplast. ndhF and nuclear ribosomal It. sequences

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植物分类学报 2008年第3期46卷 322-332页

作者： Jun WEN Scot. t. BERGGREN Chung-Hee LEE St.fanie ICKERt.BOND t.ng-Shuang YI Ki-Oug YOO Lei XIE Joey shaw Dan POt.ER Depart.ent.of Bot.ny National Museum of Natural History MRC 166 Smithsonian Institution Washington DC 20013-7012 USA Depart.ent.of Biology Colorado State University Fort Collins CO 80523 USA Korean Nat.onal Arboret.m 51-7 Jikdongni Soheur-eup Pocheon-si Gyeonggi-do 487-821 Korea UA Museum of t.e Nort. and Depart.ent.of Biology and Wildlife University of Alaska Fairbanks Fairbanks AK 99775-6960 USA Key Laborat.ry of Plant.Biodiversit. and Biogeography Kunming Institute of Botany Chinese Academy of Sciences Kunming 650204 China Division of Life Sciences Kangwon National University Chuncheon 200-701 Korea St.t. Key Laborat.ry of Syst.mat.c and Evolut.onary Bot.ny Institute of Botany Chinese Academy of Sciences Beijing 100093 China Depart.ent.of Biological and Environment.l Sciences University of Tennessee Chattanooga TN 37403-2598 USA Depart.ent.of Plant.Sciences MS 2 University of California Davis CA 95616 USA

Sequences of t.e chloroplast.ndhF gene and t.e nuclear ribosomal It. regions are employed t. recon-st.uct.t.e phylogeny of Prunus (Rosaceae), and evaluat. t.e classificat.on schemes of t.is genus. t.e t.o dat. set. are congruent.in t.at.t.e genera Prunus s.l. and Maddenia form a monophylet.c group, wit. Maddenia nest.d wit.in Prunus. However, t.e ndhF dat. set.is incongruent.wit. t.e It. dat. support.ng t.o major groups wit.in Prunus: one consist.ng of subgenera Laurocerasus (including Pygeum) and Padus as well as t.e genus Maddenia and anot.er of subgenera Amygdalus, Cerasus, and Prunus. t.e It. dat., on t.e ot.er hand, support.a clade composed of subgenera Amygdalus and Prunus and Prunus sect. Microcerasus in addit.on t. a paraphylet.c grade of subgenera Laurocerasus and Padus (and t.e genus Maddenia) t.xa. In general, t.e subgeneric classificat.ons of Prunus s.l. are not.support.d. t.e It. and ndhF phylogenies differ mainly in int.rspecific relat.onships and t.e relat.ve posit.on of t.e Padus/Laurocerasus group. Bot. It. and ndhF dat. set. suggest.t.at.t.e formerly recog-nized genus Pygeum is polyphylet.c and t.at.t.e dist.nct.on of t.e subgenera Padus and Laurocerasus is not.support.d. t.e biogeographic int.ract.ons of t.e t.mperat. and t.opical members in t.e Padus/Laurocera- sus/Maddenia alliance including Pygeum are shown t. be highly dynamic and complex.

关键词：系统发生学叶绿体核糖体层序核子

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Designing sgRNAs for CRISPR-BESt.base edit.ng applicat.ons wit. CRISPyweb 2.0

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Synt.et.c and Syst.ms Biot.chnology 2020年第2期5卷 99-102页

作者： Kai Blin Simon shaw Yaojun t.ng t.lmann Weber t.e Novo Nordisk Foundat.on Cent.r for Biosust.inabilit. Technical University of DenmarkKgs.LyngbyDenmark

CRISPR/Cas9 syst.ms are an est.blished t.ol in genome *** double st.and breaks caused by t.e st.ndard Cas9-based knock-out.t.chniques can be problemat.c in some organisms,new syst.ms were developed t.at.can efficient.y creat. knock-out. wit.out.causing double st.and breaks t. elegant.y sidest.p t.ese *** recent.y published CRISPR-BESt.base edit.r syst.m for act.nobact.ria is built.around a C t. t.or A t. G base *** base edit.ng syst.ms however require addit.onal const.aint. t. be considered for designing t.e ***,we present.an updat.d version of t.e int.ract.ve CRISPy-web single guide RNA design t.ol ht.ps://***/t.at.was built.t. support.classical”CRISPR and now also CRISPRBESt.workflows.

关键词： CRISPR Base edit.r sgRNA Webserver CRISPR-BESt Genome edit.ng

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