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CALD1 facilitates epithelial-mesenchymal transition progression in gastric cancer cells by modulating the PI3K-Akt pathway

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 1029-1045页

作者： Wen-Qian Ma Ming-Chang Miao Ping-An Ding Bi-Bo Tan Wen-Bo Liu Shuo Guo Li-Mian er Zhi-Dong Zhang Qun Zhao Department of Endoscopy The Fourth Hospital of Hebei Medical UniversityShijiazhuang 050011Hebei ProvinceChina Hebei Key Laboratory of Precision Diagnosis and Comprehensive Treatment of Gastric Cancer Shijiazhuang 050011Hebei ProvinceChina Department of Radiotherapy The Fourth Hospital of Hebei Medical UniversityShijiazhuang 050011Hebei ProvinceChina The Third Department of Surgery The Fourth Hospital of Hebei Medical UniversityShijiazhuang 050011Hebei ProvinceChina

BACKGROUND CALD1 has been discovered to be abnormally expressed in a variety of malignant tumors,including gastric cancer(GC),and is associated with tumor progression and immune infiltration;however,the roles and mechanisms of CALD1 in epithe-lial-mesenchymal transition(EMT)in GC are *** To investigate the role and mechanism of CALD1 in GC progression,invasion,and *** In this study,the relationship between CALD1 and GC,as well as the possible network regulatory mechanisms of CALD1,was investigated by bioinformatics and validated by ***1-siRNA was synthesized and used to trans-fect GC *** activity was measured using the CCK-8 method,cell migration and invasive ability were measured using wound healing assay and Transwell assay,and the expression levels of relevant genes and proteins in each group of cells were measured using qRT-PCR and Western blot.A GC cell xenograft model RESULTS Bioinformatics results showed that CALD1 was highly expressed in GC tissues,and CALD1 was significantly higher in EMT-type GC tissues than in tissues of other types of *** prognosis of patients with high expression of CALD1 was worse than that of patients with low expression,and a prognostic model was constructed and *** experimental results were consistent with the results of the bioinformatics *** expression level of CALD1 in GC cell lines was all higher than that in gastric epithelial cell line GES-1,with the strongest expression found in AGS and MKN45 *** activity was significantly reduced after CALD1-siRNA trans-fection of AGS and MKN45 *** ability of AGS and MKN45 cells to migrate and invade was reduced after CALD1-siRNA transfection,and the related mRNA and protein expression was *** to bioinfor-matics findings in GC samples,the CALD1 gene was significantly associated with the expression of members of the PI3K-AKT-mTOR signaling pathway as well as the EMT signaling pathway,and was closely rel

关键词： Gastric tumor CALD1 Epithelial-mesenchymal transition Gene disruption Invasion Migration Bioinformatics

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Harm of Hail to Crops and Countermeasures of Artificial Hail Suppression in Ulanqab City

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Meteorological and Environmental Research 2024年第2期15卷 62-63,70页

作者： Pei WANG tengge'er WU Jinhua LIU Ulanqab Meteorological Bureau Ulanqab 012000China Huade Meteorological Bureau Huade 013350China

Hail is one of meteorological disasters affecting crop growth in Ulanqab *** happens frequently from May to September,and this period is also the main growing season of *** this period,hail will cause damage to crops,make farmland soil harden,and bring varying degrees of harm to agricultural *** hail suppression is an important scientific and technological means for disaster prevention and *** is necessary to strengthen the monitoring,analysis and forecast of severe convection weather,intensify the release of early warning information of hail weather,provide accurate and reliable real-time information for the implementation of artificial hail suppression operations,strengthen the implementation of artificial weather modification,effectively carry out artificial hail suppression operations,and avoid and reduce the impact of hail disaster.

关键词： Hail Crops Harm Artificial hail suppression Ulanqab City

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Integrated Stratigraphy and Mineralogy of the Doushantuo Formation in Weng’an,South China,and Implications for Ediacaran Phosphogenesis

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Journal of Earth Science 2024年第2期35卷 476-503页

作者： Liangxuan Jiao Zhenbing She Dominic Papineau Yaguan Zhang matthew S.Dodd Kenan Cao Qun Chen Guoyong Chen State Key Laboratory of Biogeology and Environmental Geology China University of GeosciencesWuhan430078China School of Earth Sciences China University of GeosciencesWuhan430047China London Centre for Nanotechnology University College London17-19 Gordon StreetLondonWC1E 6BTUK Department of Earth Sciences University College LondonLondonWC1E 6BTUK Centre for Planetary Science University College London and Birkbeck CollegeLondonWC1E 7HXUK Innovation Center of Ore Resources Exploration Technology in the Region of Bedrock Ministry of Natural Resources of People’s Republic of China’Guiyang550000China Guizhou Bureau of Geology and Mineral Exploration and Development Guiyang550000China

The Ediacaran–Cambrian Phosphogenic Episode is the Earth’s first true phosphogenic event and resulted in worldwide phosphate deposits,which occurred during the processes of the Neoproterozoic Oxygenation *** Ediacaran Doushantuo Formation(ca.635–551 Ma)of Weng’an area in central Guizhou,South China,contains two economic phosphorite beds(the Lower and Upper Phosphorite Beds).This paper presents a detailed stratigraphic,sedimentological and mineralogical study of multiple outcrop and drill core sections of the Doushantuo Formation across the Weng’an area,and identified 11 lithofacies and 4 types of phosphatic *** differences in lithofacies and grain types between the upper and lower phosphate deposits are observed,indicating that the two sets of phosphate deposits are the products of two distinct phosphogenic *** Lower Phosphorite Bed mainly consists of banded and laminated phosphorites,contains micro-oncoids formed by microbially-mediated precipitation and peloids formed by in-situ chemically oscillating reactions,indicating a biochemical and chemical enrichment of phosphorus to sediments during the Early Ediacaran *** Upper Phosphorite Bed is mainly composed of carbonaceous,massive,and stromatolitic phosphorites,contains bioclasts(phosphatized spheroidal fossils),and intraclasts formed by hydrodynamic agitation,suggesting that the major accesses of phosphorus to sediments were the remineralization of organic *** of the two economic phosphorite beds was controlled by two sea-level *** differences have also been documented in contemporaneous phosphate-bearing successions in Brazil and Mangolia,indicating a significant shift in global phosphogenic mechanism during the early and middle Ediacaran,which may be due to the changes in redox conditions in seawater,associated with the Neoproterozoic Oxygenation *** regional active P-cycle processes could produce more free oxygen,which may have contributed to the up

关键词： phosphorite lithofacies phosphatic grains phosphogenic paragenesis phosphorus cycle mineralogy

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Efficiency of a Modular Cleanroom for Space Applications

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Fluid Dynamics & Materials Processing 2024年第3期20卷 547-562页

作者： matthew R.Coburn Charlie Young Chris Smith Graham Schultz Miguel Robayo Zheng-Tong Xie Faculty of Engineering and Physical Sciences University of SouthamptonSouthamptonSO171BJUK Plastron UK Ltd. Westcott Venture ParkWestcottHP180XBUK Renewable Energy Group University of ExeterExeterTR109FEUK

A prototype cleanroom for hazardous testing and handling of satellites prior to launcher encapsulation,satisfying the ISO8 standard has been designed and analyzed in terms of *** Reynolds Averaged Navier-Stokes(URANS)models have been used to study the related flow field and particulate matter(PM)*** outcomes of the URANS models have been validated through comparison with equivalent large-eddy *** attention has been paid to the location and shape of the air intakes and their orientation in space,in order to balance the PM convection and diffusion inside the *** a cyclone-type flow pattern inside the cleanroom is a key to maintaining a high ventilation efficiency.

关键词： Diffuser LES PM RANS unsteady flow exponential decay

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Super P and MoO2/MoS2 co-doped gradient nanofiber membrane as multi-functional separator for lithium–sulfur batteries

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Rare Metals 2024年第9期43卷 4263-4273页

作者： Xin Liang Dong-Qing Zhao Qian-Qian Huang Sheng Liang Li-Li Wang Lei Hu Ling-Li Liu Kun-Hong Hu Chong-Hai Deng Sheng Cheng er-Tao Zhu Hua-Xia Deng School of Energy Materials and Chemical Engineering LIB Technology Center of Anhui ProvinceHefei University Instrumental Analysis Centre Hefei University of Technology Hefei Youngy Energy Materials Co. Ltd. Department of Modern Mechanics University of Science and Technology of China

Lithium-sulfur battery is one of the most promising battery systems for industrialization due to its high theoretical specific capacity and high energy ***,the??shuttle effect??has restrained the advancement of lithium-sulfur *** this work,a gradient-structured nanofiber membrane with pure gelatin on one side and Super P-MoO2/MoS2-gelatin on the other side was created using a multi-step electrostatic spinning technique,which was applied for multi-functional separator for lithium-sulfur *** pure gelatin layer facing the anode side primarily homogenizes the lithium flux,whereas the Super P-MoO2/MoS2-gelatin layer facing the cathode side primarily adsorbs polysulfides by physical and chemical adsorption and enhancing polysulfide conversion *** findings demonstrate that even after 150 cycles at 0.2C,the lithium-sulfur battery can still sustain a discharge-specific capacity of 572.3 mAh·*** used with Li||Li symmetric batteries,it has a cycle life of more than 1200 *** commercialization of lithium-sulfur batteries is given a fresh idea by this straightforward preparation technique.

关键词： Li–S battery Membrane MoO2/MoS2 Nanofiber

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Subpopulations of regulatory T cells are associated with subclinical atherosclerotic plaques,levels of LDL,and cardiorespiratory fitness in the elderly

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Journal of Sport and Health Science 2024年第3期13卷 288-296,I0002页

作者： Tim Böttrich Pascal Bauer Vincent Gröβer Magdalena Huber Hartmann Raifer Torsten Frech Svenja Nolte Theresa Dombrowski Franz Cemic Natascha Sommer Robert Ringseis Klaus Eder Karsten Krüger Christopher Weyh Department of Exercise Physiology and Sports Therapy Institute of Sports ScienceJustus-Liebig-UniversityGiessen 35394Germany Department of Cardiology and Angiology Justus-Liebig-University GiessenGiessen 35392Germany Institute for Systems Immunology Center for Tumor und ImmunologyMarburg 35032Germany TH Mittelhessen Department of Computer ScienceUniversity of Applied Sciences GiessenGiessen 35390Germany Department of Internal Medicine Universities of Giessen and Marburg Lung Center(UGMLC)Member of the German Center for Lung Research(DZL)Giessen 35394Germany Excellence Cluster Cardio-Pulmonary Institute(CPI) Justus-Liebig UniversityGiessen 35394Germany Institute of Animal Nutrition and Nutrition Physiology Justus-Liebig-University GiessenGiessen 35390Germany

Background:Atherosclerosis forms the pathological basis for the development of cardiovascular *** pathological processes initially develop without clinically relevant symptoms,the identification of early markers in the subclinical stage plays an important role for initiating early *** is evidence that regulatory T cells(Tregs)are involved in the development of ***,the present study aimed to identify and investigate associations with Tregs and their subsets in a cohort of healthy elderly individuals with and without subclinical atherosclerotic plaques(SAP).In addition,various lifestyle and risk factors,such as cardiorespiratory fitness,were investigated as associated ***:A cross-sectional study was performed in 79 participants(male:n=50;age=63.6±3.7 years;body mass index=24.9±3.1 kg/m2;mean±SD)who had no previous diagnosis of chronic disease and were not taking *** of the carotids to identify SAP,cardiovascular function measurement for vascular assessment and a cardiorespiratory fitness test to determine peak oxygen uptake were ***,tests were conducted to assess blood lipids and determine glucose *** of Tregs and their subtypes(resting(rTregs)and effector/memory(mTregs))was performed by 8-chanel flow *** were categorized according to atherosclerotic plaque *** and logistic regression models were used to analyze associations between ***:SAP was detected in a total of 29 *** participants with plaque were older(64.8±3.6 years vs.62.9±3.5 years)and had higher peripheral systolic blood pressure(133.8±14.7 mmHg vs.125.8±10.9 mmHg).The participants with SAP were characterized by a lower percentage of rTregs(28.8%±10.7%vs.34.6%±10.7%)and a higher percentage of mTregs(40.3%±14.7%vs.30.0%±11.9%).Multiple logistic regression identified age(odds ratio(OR)=1.20(95%confidence interval(95%CI):1.011.42))and

关键词： Cardiorespiratory fitness Elderly Regulatory T cells Subclinical atherosclerosis

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Endometrial carcinoma with cervical stromal invasion:Three case reports

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World Journal of Clinical Cases 2024年第24期12卷 5583-5588页

作者： Ming-Ming Liu Yu-Ting Liang er-Hu Jin Department of Radiology Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China Department of Radiology Beijing Obstetrics and Gynecology HospitalCapital Medical UniversityBeijing Maternal and Child Health Care HospitalBeijing 100006China

BACKGROUND Endometrial cancer is a kind of well-known tumors of female genitourinary *** stromal invasion is an adverse factor for poor prognosis of endometrial *** is still controversy regarding the use of magnetic resonance imaging(MRI)in the diagnosis of cervical stromal invasion of endometrial *** diagnosis of cervical stromal invasion varies significantly between different observers and *** present a limited case series of the particular pattern of endometrial cancer,which infiltrates the cervical stroma and is often *** SUMMARY We present three cases of endometrial carcinoma with cervical stromal invasion with cancer-free uterine *** patient,a reproductive-aged woman,exhibited irregular menstruation and was diagnosed with endometrial polyps by hysteroscopy and segmental curettage.A MRI scan revealed polypoid nodules within the internal cervical *** other two cases were postmenopausal women who presented with abnormal vaginal *** and segmental curettage suggested atypical hyperplasia of the *** scans did not detect any malignant signs in the *** one case,a nonthickened endometrium was observed,while in another,hyperplasia of the endometrium was ***,none of these patients had malignant tumors identified in the uterine cavity via MRI ***,postoperative pathological results following hysterectomy consistently indicated cervical stromal *** Cervical stromal invasion is easily missed if no cancer is found in the uterine body on *** of endoscopic curettage specimens should be conducted to avoid underestimation of the disease.

关键词： Endometrial carcinoma Cervical stromal invasion Atypical hyperplasia of the endometrium Magnetic resonance imaging Case report

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Identification of immune cell-related prognostic genes characterized by a distinct microenvironment in hepatocellular carcinoma

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World Journal of Clinical Oncology 2024年第2期15卷 243-270页

作者： Meng-Ting Li Kai-Feng Zheng Yi-er Qiu Department of Gastroenterology The Affiliated People's Hospital of Ningbo UniversityNingbo 315000Zhejiang ProvinceChina

BACKGROUND The development and progression of hepatocellular carcinoma(HCC)have been reported to be associated with immune-related genes and the tumor ***,there are not enough prognostic biomarkers and models available for clinical *** on seven prognostic genes,this study calculated overall survival in patients with HCC using a prognostic survival model and revealed the immune status of the tumor microenvironment(TME).AIM To develop a novel immune cell-related prognostic model of HCC and depict the basic profile of the immune response in *** We obtained clinical information and gene expression data of HCC from The Cancer Genome Atlas(TCGA)and International Cancer Genome Consortium(ICGC)*** and ICGC datasets were used for screening prognostic genes along with developing and validating a seven-gene prognostic survival model by weighted gene coexpression network analysis and least absolute shrinkage and selection operator regression with Cox *** relative analysis of tumor mutation burden(TMB),TME cell infiltration,immune check-points,immune therapy,and functional pathways was also performed based on prognostic *** Seven prognostic genes were identified for signature *** receiver operating characteristic curve analysis showed the good performance of survival *** could be regarded as an independent factor in HCC survival *** was a significant difference in stromal score,immune score,and estimate score between the high-risk and low-risk groups stratified based on the risk score derived from the seven-gene prognostic *** immune checkpoints,including VTCN1 and TNFSF9,were found to be associated with the seven prognostic genes and risk *** combinations of checkpoint blockade targeting inhibitory CTLA4 and PD1 receptors and potential chemotherapy drugs hold great promise for specific HCC *** pathways,such as cell cycle regulat

关键词： Hepatocellular carcinoma Prognostic model Weighted gene coexpression network analysis Microenvironment Chemotherapy

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高分辨率罗兰圆光学系统的色差校正方法研究

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光谱学与光谱分析 2024年第7期44卷 2011-2017页

作者：陈吉文陈作儿北方工业大学电气与控制工程学院北京100144

罗兰圆光学系统优点众多,但系统中因平凸透镜的使用,导致各特征波长色散后的成像点在罗兰圆附近产生了一定量的偏移量,使得各波长成像点依次排列在一条曲面上。由于目前新型采集器件线阵CMOS或CCD的使用,而这类传感器的感光面是一个平面... 详细信息

罗兰圆光学系统优点众多,但系统中因平凸透镜的使用,导致各特征波长色散后的成像点在罗兰圆附近产生了一定量的偏移量,使得各波长成像点依次排列在一条曲面上。由于目前新型采集器件线阵CMOS或CCD的使用,而这类传感器的感光面是一个平面,因此导致结果产生较严重的色差。提出了一种使用加权最小二乘法拟合像面的色差校正方法,并计算出系统像面的中心偏移距和偏移倾斜角这两个校正参数,将其引入原本罗兰圆光学系统进行色差校正,从而确定线阵光电传感器像面的最佳位置,实现高分辨率。此外在真空紫外光谱中C、P和S等元素非常重要,可使用本文提出的基于加权最小二乘法的色差校正方法,通过增加这类元素权值占比,实现最优分辨率。最后通过Zemax软件进行光学仿真,完成了罗兰圆光学系统的仿真以及优化。并给出170~410 nm波段点列图的成像宽度仿真以及各元素特征波长在CMOS传感器上所采集到的光谱图,推算出其实际应用中的分辨率,其照度光谱图显示其分辨率均可保持在0.02 nm,接近系统理论最佳分辨率。研究结果表明基于加权最小二乘法拟合像面的方法,可实现罗兰圆光学系统的色差校正,实现高分辨率。

关键词：罗兰圆光学系统平凸透镜色差校正高分辨率加权最小二乘法

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无电荷层InGaAs/Si雪崩光电探测器的优化设计

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光学学报 2024年第5期44卷 19-28页

作者：张娟姚儿柯少颖闽南师范大学物理与信息工程学院光场调控及其系统集成应用福建省高校重点实验室福建漳州363000

目前,在近红外波段中普遍采用InGaAs/InP雪崩光电二极管(APD),但这类APD存在增益带宽积小和等效噪声高等问题,而InGaAs/Si APD采用电子、空穴离化系数极低的Si材料作为倍增层,在一定程度解决了上述问题,但其制造过程涉及Si电荷层的离子... 详细信息

目前,在近红外波段中普遍采用InGaAs/InP雪崩光电二极管(APD),但这类APD存在增益带宽积小和等效噪声高等问题,而InGaAs/Si APD采用电子、空穴离化系数极低的Si材料作为倍增层,在一定程度解决了上述问题,但其制造过程涉及Si电荷层的离子注入和高温退火激活,该过程工艺复杂、杂质分布不均匀、成本高。因此,本研究采用刻蚀技术在Si倍增层内制备凹槽环,并在凹槽环内填充不同介质对InGaAs层及Si层内的电场进行调控,构建无电荷层InGaAs/Si APD器件模型。结果表明,在凹槽环内填充空气或SiO2可获得高性能的InGaAs/Si APD。该研究结果可为后续研制工艺简单、性能稳定、低噪声的InGaAs/Si APD提供理论指导。

关键词：探测器雪崩光电二极管增益带宽积电荷层凹槽环

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