检索结果-南通市图书馆

Root System Traits Contribute to Variability and Plasticity in Response to Phosphorus Fertilization in 2 Field-Grown Sorghum[Sorghum bicolor(L.)Moench]Cultivars

引用

Plant Phenomics 2023年第1期5卷 6-21页

作者： Michael O.Adu Paul A.Asare David O.Yawson kwadwo k.Amoah kofi Atiah matthew k.duah Alex Graham Department of Crop Science School of AgricultureCollege of Agriculture and Natural SciencesUniversity of Cape CoastCape CoastGhana Centre for Resource Management and Environmental Studies(CERMES) The University of the West IndiesCave Hill CampusP.O.Box 64Bridgetown BB11000Barbados Department of Soil Science School of AgricultureCollege of Agriculture and Natural SciencesUniversity of Cape CoastCape CoastGhana

Due to roots'physical and physiological roles in crop productivity,interest in root system architecture(RSA)and plasticity in responses to abiotic stresses is growing.Sorghum is significant for the food security of millions of people.Phosphorus deficiency is an important limitation of sorghum productivity.There is little information on the RSA-based responses of sorghum to variations in external P supply([P]_(ext)).This study evaluated the phenotypic plasticity and RSA responses to a range of[P]_(ext) in 2 sorghum genotypes.The results showed that both genotypes responded to[P]_(ext) but with significant variations in about 80%of the RSA traits analyzed.Aboveground biomass and most RSA traits increased with increasing[P]_(ext).Plasticity was both genotype-and trait-dependent.For most RSA traits,the white sorghum genotype showed significantly higher plasticity than the red genotype,with the former having about 28.4%higher total plasticity than the former.RSA traits,such as convex area,surface area,total root length,and length diameter ranges,showed sizeable genetic variability.Root biomass had a high degree of plasticity,but root number and angle traits were the leading contributors to variation.The results suggested 2 root trait spectra:root exploration and developmental spectrum,and there was an indication of potential trade-offs among groups of root traits.It is concluded that RSA traits in sorghum contribute to variability and plasticity in response to[P]_(ext).Given that there might be trade-offs among sorghum root traits,it would be instructive to determine the fundamental constraints underlying these trade-offs.

关键词： Root instru constraints

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Refining safety considerations for intradialytic blood flow restriction exercise. Commentary on “Concerns on the application of blood-flow restriction resistance exercise and thrombosis risk in hemodialysis patients”

引用

Journal of Sport and Health Science 2024年第4期13卷 455-456页

作者： matthew J.Clarkson Institute for Health and Sport Victoria UniversityMelbourneVIC 8001Australia

I read with great interest the article“Concerns on the application of blood flow restriction resistance exercise and thrombosis risk in hemodialysis patients”by Correa et al.1 The study presents complementary data from a previous randomized controlled trial,2 exploring the application of intradialytic blood flow restriction exercise for hemodialysis patients.

关键词： patients hemodialysis al.

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Alterations of SARS-CoV-2 Evolutionary Dynamics by Pharmaceutical Factors

引用

Infectious Diseases & Immunity 2024年第1期4卷 35-40页

作者： matthew Halma EbMCsquared CIC Bath BA24BLUnited Kingdom

The outbreak of SARS-CoV-2(severe acute respiratory syndrome coronavirus 2)has been influenced by the human response to the virus.These responses have undoubtedly impacted the evolutionary dynamics of the virus in ways distinct from a scenario lacking a widespread response.Two important pharmaceutical interventions,vaccination and the utilization of medications,particularly molnupiravir,known to have mutagenic properties,were the focus of this article.The impact of molnupiravir on human health was evaluated through 3 mechanisms:viral resistance,mutagenesis of SARS-CoV-2,and mutagenesis occurring in patients undergoing treatmentwithmolnupiravir.Thesemechanisms,as well as the impact of vaccination,have inadvertently given rise to unforeseen challenges in the management of the COVID-19 crisis.Taking a systems view in future pandemic responses,and taking into account the evolution of the pandemic virus,may be critical to ending the pandemic at an earlier date.

关键词： COVID-19 SARS-CoV-2 Evolution Spike protein Molnupiravir Mutagenesis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Evaluation of a software positioning tool to support SMEs in adoption of big data analytics

引用

Journal of Electronic Science and Technology 2024年第1期22卷 13-24页

作者： matthew Willetts Anthony S.Atkins Faculty of Digital TechnologyInnovationand BusinessStaffordshire UniversityStoke-on-TrentST42DEUnited Kingdom

Big data analytics has been widely adopted by large companies to achieve measurable benefits including increased profitability,customer demand forecasting,cheaper development of products,and improved stock control.Small and medium sized enterprises(SMEs)are the backbone of the global economy,comprising of 90%of businesses worldwide.However,only 10%SMEs have adopted big data analytics despite the competitive advantage they could achieve.Previous research has analysed the barriers to adoption and a strategic framework has been developed to help SMEs adopt big data analytics.The framework was converted into a scoring tool which has been applied to multiple case studies of SMEs in the Uk.This paper documents the process of evaluating the framework based on the structured feedback from a focus group composed of experienced practitioners.The results of the evaluation are presented with a discussion on the results,and the paper concludes with recommendations to improve the scoring tool based on the proposed framework.The research demonstrates that this positioning tool is beneficial for SMEs to achieve competitive advantages by increasing the application of business intelligence and big data analytics.

关键词： Big data analytics Evaluation Small and medium sized enterprises (SMEs) Strategic framework

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Runx2 regulates peripheral nerve regeneration to promote Schwann cell migration and re-myelination

引用

Neural Regeneration Research 2024年第7期19卷 1575-1583页

作者： Rong Hu Xinpeng Dun Lolita Singh matthew C.Banton School of Traditional Chinese Medicine Department of Traditional Chinese MedicineNanfang HospitalSouthern Medical UniversityGuangzhouGuangdong ProvinceChina The Co-innovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Faculty of Health University of PlymouthPlymouthUK

Runx2 is a major regulator of osteoblast differentiation and function;however,the role of Runx2 in peripheral nerve repair is unclea r.Here,we analyzed Runx2expression following injury and found that it was specifically up-regulated in Schwann cells.Furthermore,using Schwann cell-specific Runx2 knocko ut mice,we studied peripheral nerve development and regeneration and found that multiple steps in the regeneration process following sciatic nerve injury were Runx2-dependent.Changes observed in Runx2 knoc kout mice include increased prolife ration of Schwann cells,impaired Schwann cell migration and axonal regrowth,reduced re-myelination of axo ns,and a block in macrophage clearance in the late stage of regeneration.Taken together,our findings indicate that Runx2 is a key regulator of Schwann cell plasticity,and therefore peripheral nerve repair.Thus,our study shows that Runx2 plays a major role in Schwann cell migration,re-myelination,and peripheral nerve functional recovery following injury.

关键词： macrophage clearance migration peripheral nerve injury regeneration re-myelination Runx2 Schwann cells

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Designing a medical ethics curriculum in ophthalmology

引用

Annals of Eye Science 2024年第1期9卷 4-9页

作者： matthew D.Gearinger Flaum Eye Institute University of Rochester Medical CenterRochesterNYUSA

Ethical principles form a bedrock to medical practice in any specialty,guiding physicians to appropriate attitudes and behaviors.A formal ethics curriculum can be difficult to generate de novo in an ophthalmology training program.A number of barriers exist in most ophthalmology departments:trainees may think ethics is of secondary importance compared to core basic and clinical science topics;most ophthalmology faculty have no formal degree in medical ethics;there is limited didactic time with competing academic,clinical,and surgical priorities;work-hours regulations may limit the time available to deliver“para-professional”lectures;and there is a belief that the medical ethics lectures during medical school is a sufficient amount of coursework to last through a physician’s career with no need for continuing professional development.The four pillars of medical ethics are beneficence,non-maleficence,autonomy,and justice.In addition,morals,ethics,and professionalism are important aspects of sound medical practice.A curriculum specific to medical ethics in ophthalmology can be developed in any of our sub-specialties and include lectures,curated readings,case rounds,and clinic wrap-up sessions.Ethical considerations are part of everyday clinical practice,and a structured ethics curriculum can be incorporated into ophthalmology training programs.The concept of backward design can be used to structure the curriculum,starting with the expected outcome,then designing authentic assessments,and finally putting together a learning plan that has students actively involved in ethical discussions.This paper will provide a guide to developing an ethics curriculum for an ophthalmology training program utilizing the concept of backwards design and guide the reader through the process of developing expected learning outcomes,authentic assessments,and a unified learning plan.

关键词： Medical ethics curriculum design medical education

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Use of an immunocapture device to detect cytokine release in discrete brain regions

引用

Neural Regeneration Research 2024年第4期19卷 703-704页

作者： matthew G.Frank Michael V.Baratta Department of Integrative Physiology University of Colorado BoulderBoulderCOUSA(Frank MG)Department of Psychology and NeuroscienceUniversity of Colorado BoulderBoulderCOUSA(Baratta MV)

Production of proinflammatory cytokines in the central nervous system is a key process in the neuroinflammatory response to trauma,infection,and neurodegenerative diseases(kumar,2019).These intercellular signaling molecules play multiple roles in the immune response in the central nervous system including the orchestration of the sickness response to innate immune perturbations in the brain(Dantzer et al.,2008).

关键词： system release innate

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Will artificial intelligence widen the therapeutic gap between children and adults?

引用

儿科学研究(英文) 2024年第1期8卷 1-6页

作者： Nagy matthew Sisk Bryan Lai Albert kodish Eric Cleveland Clinic Lerner College of Medicine Case Western Reserve University Cleveland Ohio USA Department of Pediatrics Division of Hematology/Oncology Washington University School of Medicine St. Louis Missouri USA Department of Medicine Bioethics Research Center Washington University School of Medicine St. Louis Missouri USA Institute for Informatics Washington University School of Medicine St. Louis Missouri USA Department of Pediatric Hematology Oncology and Blood and Marrow Transplantation Cleveland Clinic Children’s Cleveland Ohio USA

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

A flexible,thin-film microchannel electrode array device for selective subdiaphragmatic vagus nerve recording

引用

Microsystems & Nanoengineering 2024年第1期10卷 115-128页

作者： Jongcheon Lim Peter A.Zoss Terry L.Powley Hyowon Lee matthew P.Ward Weldon School of Biomedical Engineering Purdue UniversityWest LafayetteINUSA Birck Nanotechnology Center Purdue UniversityWest LafayetteINUSA Center for Implantable Devices Purdue UniversityWest LafayetteINUSA Department of Psychological Sciences Purdue UniversityWest LafayetteINUSA Purdue Institute of Integrative Neuroscience Purdue UniversityWest LafayetteINUSA Indiana University School of Medicine IndianapolisINUSA

The vagus nerve(VN)plays an important role in regulating physiological conditions in the gastrointestinal(GI)tract by communicating via the parasympathetic pathway to the enteric nervous system(ENS).However,the lack of knowledge in the neurophysiology of the VN and GI tract limits the development of advanced treatments for autonomic dysfunctions related to the VN.To better understand the complicated underlying mechanisms of the VN-GI tract neurophysiology,it is necessary to use an advanced device enabled by microfabrication technologies.Among several candidates including intraneural probe array and extraneural cuff electrodes,microchannel electrode array devices can be used to interface with smaller numbers of nerve fibers by securing them in the separate channel structures.Previous microchannel electrode array devices to interface teased nerve structures are relatively bulky with thickness around 200µm.The thick design can potentially harm the delicate tissue structures,including the nerve itself.In this paper,we present a flexible thin film based microchannel electrode array device(thickness:11.5µm)that can interface with one of the subdiaphragmatic nerve branches of the VN in a rat.We demonstrated recording evoked compound action potentials(ECAP)from a transected nerve ending that has multiple nerve fibers.Moreover,our analysis confirmed that the signals are from C-fibers that are critical in regulating autonomic neurophysiology in the GI tract.

关键词： electrode recording film

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cannabinoids and endocannabinoids as therapeutics for nervous system disorders:preclinical models and clinical studies

引用

Neural Regeneration Research 2024年第4期19卷 788-799页

作者： R.Scott Duncan Sean M.Riordan matthew C.Gernon Peter koulen Department of Ophthalmology School of MedicineUniversity of Missouri Department of Biomedical Sciences School of MedicineUniversity of Missouri

Cannabinoids are lipophilic substances derived from Cannabis sativa that can exert a variety of effects in the human body.They have been studied in cellular and animal models as well as in human clinical trials for their therapeutic benefits in several human diseases.Some of these include central nervous system(CNS)diseases and dysfunctions such as forms of epilepsy,multiple sclerosis,Parkinson’s disease,pain and neuropsychiatric disorders.In addition,the endogenously produced cannabinoid lipids,endocannabinoids,are critical for normal CNS function,and if controlled or modified,may represent an additional therapeutic avenue for CNS diseases.This review discusses in vitro cellular,ex vivo tissue and in vivo animal model studies on cannabinoids and their utility as therapeutics in multiple CNS pathologies.In addition,the review provides an overview on the use of cannabinoids in human clinical trials for a variety of CNS diseases.Cannabinoids and endocannabinoids hold promise for use as disease modifiers and therapeutic agents for the prevention or treatment of neurodegenerative diseases and neurological disorders.

关键词： anandamide cannabidiol cannabinoid endocannabinoid epilepsy multiple sclerosis neurodegeneration neuroprotection tetrahydrocannabinol

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：