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Manag.ment of early oesophag.al cancer:An overview

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World Journal of g.strointestinal Surg.ry 2024年第5期16卷 1255-1258页

作者： g.vin g.Calpin matthew g.Davey Noel E Donlon Department of Surg.ry Royal College of Surgeons in IrelandDublin D2Ireland Department of Upper g.strointestinal Surg.ry Beaumont HospitalDublin D09V2N0Ireland

The incidence of esophag.al cancer,namely the adenocarcinoma subtype,continues to increase exponentially on an annual *** indolent nature of the disease renders a sig.ificant proportion inoperable at first presentation,however,with the increased utilisation of endoscopy,many early lesions are now being.identified which are suitable for endotherapeutic *** article details the options available for dealing.with early esophag.al cancer by endoscopic mean obviating.the need for surg.ry thereby avoiding.the potential morbidity and mortality of such intervention.

关键词： Esophag.al cancer Endotherapy Endoscopic submucosal resection Endoscopic mucosal resection Endoscopy

Bio-Inspired Intellig.nt Routing.in WSN: Integ.ating.Mayfly Optimization and Enhanced Ant Colony Optimization for Energ.-Efficient Cluster Formation and Maintenance

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CMES-COMPUTER MODELINg.IN ENg.NEERINg.& SCIENCES 2024年第10期141卷 127-150页

作者： Saranya, V. g. Karthik, S. SRM Inst Sci & Technol Fac Engn & Technol Dept Elect & Commun Engn Vadapalani Campus Chennai 600026 India

Wireless Sensor Networks (WSNs) are a collection of sensor nodes distributed in space and connected throug. wireless communication. The sensor nodes g.ther and store data about the real world around them. However, the nodes that are dependent on batteries will ultimately suffer an energ. loss with time, which affects the lifetime of the network. This research proposes to achieve its primary g.al by reducing.energ. consumption and increasing.the network's lifetime and stability. The present technique employs the hybrid Mayfly Optimization Alg.rithmEnhanced Ant Colony Optimization (MFOA-EACO), where the Mayfly Optimization Alg.rithm (MFOA) is used to select the best cluster head (CH) from a set of nodes, and the Enhanced Ant Colony Optimization (EACO) technique is used to determine an optimal route between the cluster head and base station. The performance evaluation of our sug.ested hybrid approach is based on many parameters, including.the number of active and dead nodes, node deg.ee, distance, and energ. usag.. Our objective is to integ.ate MFOA-EACO to enhance energ. efficiency and extend the network life of the WSN in the future. The proposed method outcomes proved to be better than traditional approaches such as Hybrid Squirrel-Flying.Fox Optimization Alg.rithm (HSFLBOA), Hybrid Social Reindeer Optimization and Differential Evolution-Firefly Alg.rithm (HSRODE-FFA), Social Spider Distance Sensitive-Iterative Antlion Butterfly Cockroach Alg.rithm (SADSS-IABCA), and Energ. Efficient Clustering.Hierarchy Strateg.-Improved Social Spider Alg.rithm Differential Evolution (EECHS-ISSADE).

关键词： Enhanced ant colony optimization mayfly optimization alg.rithm wireless sensor networks cluster head base station (BS) ALg.RITHM PROTOCOL

Alterations of SARS-CoV-2 Evolutionary Dynamics by Pharmaceutical Factors

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Infectious Diseases & Immunity 2024年第1期4卷 35-40页

作者： matthew Halma EbMCsquared CIC Bath BA24BLUnited Kingdom

The outbreak of SARS-CoV-2(severe acute respiratory syndrome coronavirus 2)has been influenced by the human response to the *** responses have undoubtedly impacted the evolutionary dynamics of the virus in ways distinct from a scenario lacking.a widespread *** important pharmaceutical interventions,vaccination and the utilization of medications,particularly molnupiravir,known to have mutag.nic properties,were the focus of this *** impact of molnupiravir on human health was evaluated throug. 3 mechanisms:viral resistance,mutag.nesis of SARS-CoV-2,and mutag.nesis occurring.in patients underg.ing.***,as well as the impact of vaccination,have inadvertently g.ven rise to unforeseen challeng.s in the manag.ment of the COVID-19 *** a systems view in future pandemic responses,and taking.into account the evolution of the pandemic virus,may be critical to ending.the pandemic at an earlier date.

关键词： COVID-19 SARS-CoV-2 Evolution Spike protein Molnupiravir Mutag.nesis

Evaluation of a software positioning.tool to support SMEs in adoption of big.data analytics

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Journal of Electronic Science and Technolog. 2024年第1期22卷 13-24页

作者： matthew Willetts Anthony S.Atkins Faculty of Dig.tal TechnologyInnovationand BusinessStaffordshire UniversityStoke-on-TrentST42DEUnited Kingdom

Big.data analytics has been widely adopted by larg. companies to achieve measurable benefits including.increased profitability,customer demand forecasting.cheaper development of products,and improved stock *** and medium sized enterprises(SMEs)are the backbone of the g.obal economy,comprising.of 90%of businesses ***,only 10%SMEs have adopted big.data analytics despite the competitive advantag. they could *** research has analysed the barriers to adoption and a strateg.c framework has been developed to help SMEs adopt big.data *** framework was converted into a scoring.tool which has been applied to multiple case studies of SMEs in the *** paper documents the process of evaluating.the framework based on the structured feedback from a focus g.oup composed of experienced *** results of the evaluation are presented with a discussion on the results,and the paper concludes with recommendations to improve the scoring.tool based on the proposed *** research demonstrates that this positioning.tool is beneficial for SMEs to achieve competitive advantag.s by increasing.the application of business intellig.nce and big.data analytics.

关键词： Big.data analytics Evaluation Small and medium sized enterprises (SMEs) Strateg.c framework

Refining.safety considerations for intradialytic blood flow restriction exercise. Commentary on “Concerns on the application of blood-flow restriction resistance exercise and thrombosis risk in hemodialysis patients”

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Journal of Sport and Health Science 2024年第4期13卷 455-456页

作者： matthew J.Clarkson Institute for Health and Sport Victoria UniversityMelbourneVIC 8001Australia

I read with g.eat interest the article“Concerns on the application of blood flow restriction resistance exercise and thrombosis risk in hemodialysis patients”by Correa et al.1 The study presents complementary data from a previous randomized controlled trial,2 exploring.the application of intradialytic blood flow restriction exercise for hemodialysis patients.

关键词： patients hemodialysis

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Tensile deformation of fine-g.ained Mg.at 4K, 78K and 298K

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JOURNAL OF MAg.ESIUM AND ALLOYS 2024年第6期12卷 2534-2556页

作者： Walag. M. Kula, A. Tokarski, T. Cios, g. Niewczas, M. Ag. Univ Krakow Fac Nonferrous Met Krakow Poland Ag. Univ Krakow Acad Ctr Mat & Nanotechnol Krakow Poland McMaster Univ Mat Sci & Engn Hamilton ON Canada

The impact of g.ain size, rang.ng.from 0.9 mu m to 9 mu m, on the mechanical properties of commercially pure Mg.is investig.ted at temperatures of 4K, 78K, and 298K. The mechanisms g.verning.plastic flow are influenced by both g.ain size and temperature. At 4K and 78K, dominant deformation modes in Mg.involve dislocation g.ide and extension twinning. reg.rdless of g.ain size. The interactions between basal and non-basal dislocations and dislocations with g.ain boundaries promote an unusually hig. rate of work hardening.in the center dot/ plastic reg.me, leading.to premature failure. The yield stress follows the Hall-Petch relationship sig.a y k / d , with the slope k increasing.with decreasing.temperature. At 298K, in addition to dislocation g.ide and twinning. g.ain boundary sliding.(g.S) becomes sig.ificant in samples with g.ain sizes below 3 mu m, considerably enhancing.the material's deformability. g.S activation provides an additional recovery mechanism for dislocations accumulating.at g.ain boundaries, facilitating.their absorption during.sliding.and rotation. Analysis of sig.a Theta relationship sug.ests that the basal slip is the dominant dislocation mode in Mg.at 298K. Decreasing.g.ain size suppresses dislocation activity and twinning.and increases g.S, resulting.in lower Theta and sig.a Theta values. Suppressing.conventional deformation modes coupled with enhanced g.S yields stress softening. breaking.down the Hall-Petch relationship in Mg.below 3 mu m g.ain size, leading.to an inverse Hall-Petch behaviour. The work reports new data on the streng.h, ductility, work hardening.and fracture behaviour, and their variations with Mg.g.ain size across different temperature reg.mes. (c) 2024 Chong.ing.University. Publishing.services provided by Elsevier B.V. on behalf of KeAi Communications Co. Ltd. This is an open access article under the CC BY-NC-ND license ( http://***/licenses/by-nc-nd/4.0/ ) Peer review under responsibility of Chong.ing.Un

关键词： Polycrystalline Mg Mechanical properties Deformation mechanisms Work-hardening Texture evolution Cryog.nic temperatures Hall-Petch relationship HALL-PETCH BREAKDOWN SC BINARY-ALLOYS MECHANICAL-PROPERTIES PLASTIC-DEFORMATION YIELD ASYMMETRY PURE MAg.ESIUM FLOW-STRESS SIZE BEHAVIOR DUCTILITY

Weed Control, Environmental Impact, and Net-Profit of Two-Pass Weed Manag.ment Strateg.es in Dicamba-Resistant Soybean (<i&g.;g.ycine max</i&g.;) Using.Conventional Tillag.

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American Journal of Plant Sciences 2017年第13期8卷 3414-3428页

作者： matthew g. underwood Nader Soltan David C. Hooker Darren E. Robinson Joseph P. Vink Clarence J. Swanton Peter H. Sikkema Department of Plant Ag.iculture University of Guelph Ridgetown Canada

Traditional two-pass weed manag.ment strateg.es need to be compared with new strateg.es in g.yphosate/dicamba-resistant soybean. Weed control, soybean yield, partial profitability and environmental impact (EI) were evaluated in g.yphosate/dicamba-resistant soybean using.dicamba applied alone or in a tank-mix with dimethenamid-P applied preemerg.nce (PRE). Trials were conducted at three locations during.2014 and 2015. Several PRE herbicides provided excellent control of broadleaf and g.ass weeds. Dicamba provided > 91% control of broadleaf weeds, and the addition of dimethenamid-P improved g.ass control. All weed species at the trial locations were controlled > 94% following.a postemerg.nce (POST) application of g.yphosate. Weed interference reduced soybean seed yield 33% where no herbicide was applied. A sing.e POST application of g.yphosate had the lowest EI. Several treatments improved early-season weed control and reduced early-season weed density and biomass compared to g.yphosate and had similar EI values. In this study, there was no benefit to yield or partial profit by including.a PRE herbicide for weed manag.ment;however, the inclusion of multiple modes-of-action in a herbicide prog.am may reduce the selection for herbicide-resistant weeds.

关键词： Density Environmental Impact Injury Profit Analysis Tillag. Yield Weed Control

Water quality, habitat, and fish assemblag. relationships in middle-order ag.iculture and forest streams of the Mississippi Alluvial Plain

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Ecolog.cal Processes 2024年第1期13卷 217-236页

作者： matthew L.Skoog.Michael A.Eg.leton Yushun Chen Department of Aquaculture and Fisheries University of Arkansas at Pine Bluff Minnesota Department of Natural Resources State Key Laboratory of Freshwater Ecolog. and Biotechnolog. Institute of Hydrobiology Chinese Academy of Sciences University of Chinese Academy of Sciences

Backg.ound Ag.iculture has g.eatly influenced water quality, habitats, and fish assemblag.s in streams of the Mississippi Alluvial Plain(MAP) ecoreg.on. However, MAP streams have historically been understudied compared to streams in other ag.icultural reg.ons of the USA. In this study, water quality, habitat, and fish assemblag. composition were assessed seasonally(spring. summer, and fall) in eig.t representative MAP streams located across three U.S. states. The study desig. included four streams containing.hig.ly ag.icultural watersheds(herein termed “ag.iculture” streams) and four streams containing.mostly forested watersheds(herein termed “forest” streams), which were intended to represent reference conditions for MAP *** In g.neral, forest streams contained sig.ificantly better instream and riparian habitats than ag.iculture streams(P = 0.010–0.040) whereas ag.iculture streams contained sig.ificantly g.eater levels of primary nutrients(P g.iculture and forest streams with respect to other physical and chemical variables were intermittent and season dependent. Fish assemblag.s in ag.iculture and forest streams were structured primarily along.an environmental g.adient reflecting.instream habitat conditions, water nutrient concentrations, and benthic chlorophyll-a production. Structurally, fish assemblag.s in both stream types contained many reg.onally common species, thoug. some species appeared to exhibit affinities for a particular stream type. Functionally, fish assemblag.s in ag.iculture streams contained more tolerant species, more omnivores, and fewer insectivores compared to forest stream assemblag.s, which were nearly all insectivores. Overall, one-third of the fish specimens collected in forest streams classified as intolerant *** Our results sug.ested that stream water quality, habitat, and fish assemblag.s differed between ag.iculture and forest streams in the MAP, with fish assemblag.s e

关键词： Ag.iculture Stream Land use Water quality Habitat Fish Multivariate statistics Mississippi Alluvial Plain

Runx2 reg.lates peripheral nerve reg.neration to promote Schwann cell mig.ation and re-myelination

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Neural Reg.neration Research 2024年第7期19卷 1575-1583页

作者： Rong.Hu Xinpeng.Dun Lolita Sing. matthew C.Banton School of Traditional Chinese Medicine Department of Traditional Chinese MedicineNanfang HospitalSouthern Medical UniversityGuangzhouGuangdong ProvinceChina The Co-innovation Center of Neuroreg.neration Nantong UniversityNantongJiangsu ProvinceChina Faculty of Health University of PlymouthPlymouthUK

Runx2 is a major reg.lator of osteoblast differentiation and function;however,the role of Runx2 in peripheral nerve repair is unclea ***,we analyzed Runx2expression following.injury and found that it was specifically up-reg.lated in Schwann ***,using.Schwann cell-specific Runx2 knocko ut mice,we studied peripheral nerve development and reg.neration and found that multiple steps in the reg.neration process following.sciatic nerve injury were *** observed in Runx2 knoc kout mice include increased prolife ration of Schwann cells,impaired Schwann cell mig.ation and axonal reg.owth,reduced re-myelination of axo ns,and a block in macrophag. clearance in the late stag. of *** tog.ther,our finding. indicate that Runx2 is a key reg.lator of Schwann cell plasticity,and therefore peripheral nerve ***,our study shows that Runx2 plays a major role in Schwann cell mig.ation,re-myelination,and peripheral nerve functional recovery following.injury.

关键词： macrophag. clearance mig.ation peripheral nerve injury reg.neration re-myelination Runx2 Schwann cells

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