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Migration and cognitive function:a conceptual framework for Global Health Research

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Global Health Research and Policy 2018年第1期3卷 35-46页

作者： Hanzhang Xu Allison A.Vorderstrasse eleanor S.McConnell matthew e.dupre TrulsØstbye Bei Wu School of Nursing Duke UniversityDurhamNCUSA Department of Community and Family Medicine Duke UniversityDurhamNCUSA New York University Rory Meyers College of Nursing New YorkNYUSA Geriatric Research Education and Clinical CenterDurham Department of Veterans Affairs Healthcare SystemDurhamNCUSA Department of Population Health Sciences Duke UniversityDurhamNCUSA Duke Clinical Research Institute Duke UniversityDurhamNCUSA Department of Sociology Duke UniversityDurhamNCUSA Duke Global Health Institute Duke UniversityDurhamNCUSA

Background:Migration is a fundamental demographic process that has been observed *** is suggested that migration is an issue of global health importance that can have an immediate and lasting impact on an individual’s health and *** is now an increasing body of evidence linking migration with cognitive function in older *** this paper,we synthesized the current evidence to develop a general conceptual framework to understand the factors contributing to the association between migration and cognitive ***:A comprehensive review of the literature was conducted on the associations between migration and cognition among middle-aged and older ***:Five potential mechanisms were identified from the literature:1)socioeconomic status-including education,occupation,and income;2)psychosocial factors-including social networks,social support,social stressors,and discrimination;3)behavioral factors-including smoking,drinking,and health service utilization;4)physical and psychological health status-including chronic conditions,physical function,and depression;and 5)environmental factors-including both physical and social *** underlying factors were also identified-including early-life conditions,gender,and genetic ***:The factors linking migration and cognitive function are multidimensional and *** conceptual framework highlights potential implications for global health policies and planning on healthy aging and migrant *** studies are needed to further examine these mechanisms to extend and refine our general conceptual framework.

关键词： linking occupation globally

Forecasting vulnerability of deep extraction level excavations to drawinduced cave loads

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Journal of Rock Mechanics and Geotechnical engineering 2019年第3期11卷 527-534页

作者： matthew e.Pierce Pierce engineering

Block and panel caving methods are increasingly used for mining of large and strong orebodies at large depths below the ground surface (>1 km). This paper focuses on the production phase of caving when the extraction level is fully developed and subjected to the weight of overlying caved material. A limit equilibrium solution for estimation of cave loads is critically reviewed and combined with existing empirical tools in order to forecast extraction level performance under cave loading. The analysis results, presented in nomogram form, suggest that the risk of severe squeezing of extraction level tunnels does not increase with cave depths below 500-1000 m due to the beneficial effects of arching. Under normal extraction ratios (eR = ~50%), severe squeezing experienced from cave loads in deep mines appears to be unlikely in all but the weakest rock masses (σcm ere σcm is the rock mass global strength), even with poor draw control or low drawpoint availability. The likelihood of severe squeezing is greater when large draw areas (HR = 50-75 m, where HR is the hydraulic radius) are combined with low drawpoint availability or poor draw control and locally higher extraction ratios (eR = ~75%), even in better quality rock (σcm = 5-10 MPa). The analysis results are back-analyzed with the extraction level performance before and after a doubling production of rate and draw area at the deep ore zone (DOZ) mine in Indonesia. The extraction level conditions predicted by the nomograms correlate well with the experience at the DOZ, in which extraction level damage increases significantly over the production rampup, accompanied by a significant drop in drawpoint availability.

关键词： Block caving Panel caving extraction level Draw control Squeezing

The importance of being connected:membrane contact sites and Parkinson’s disease

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Neural Regeneration Research 2023年第10期18卷 2202-2203页

作者： matthew e.Gegg Department of Clinical and Movement Neurosciences UCL Queen Square Institute of NeurologyLondonUK

Membrane contact sites (MCS) occur between closely apposed organelles and are a means to transport ions and macromolecules between themselves,co-ordinate cellular metabolism,and direct organelle fission and *** MCS be... 详细信息

关键词： connected transport ordinate

Teaching sustainable design in architecture education:Critical review of easy Approach for Sustainable and environmental Design(eASeD)

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Frontiers of Architectural Research 2019年第2期8卷 238-260页

作者： Camille de Gaulmyn Karine.dupre Griffith Architecture Griffith UniversitySouthportQld 4215Australia

In the current context of climate change and ecological awareness,designing sustainable environments is definitely understood as a shared *** the construction sector consuming half of the world's energy,the role of some key stakeholders such as architects becomes even more critical when providing responsible and relevant design for the built ***,improving the way our environments are being designed challenges some cultural systems that show evident limits,such as the training of future architects and *** this research,the focus is on architecture students and aims to demonstrate how the use of a new sustainable performance simulation tool,called easy Approach for Sustainable and environmental Design(eASeD)could contribute to educate them about innovatively sustainable *** was assessed through the evaluation of student engagement,their use of the tool and its *** show that individual work was not convincing,whereas success was met during group *** and improvement possibilities were found in the interface of eASeD as well as in the educational set up of the tool.

关键词： Architecture education energy Sustainable Design Teaching ecological

Comparative insights into mitochondrial adaptations to anoxia in brain

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Neural Regeneration Research 2016年第5期11卷 723-724页

作者： matthew e.Pamenter Department of Biology University of Ottawa

Numerous diseases and pathologies impair the delivery of oxygen to brain, with rapid and deleterious consequences. For example, diseases related to systemic hypoxemia （e.g., chronic pulmonary disorders, cystic fibrosis）, decreased oxygen carrying capacity of blood （e.g., anemia）, or decreased transport （e.g., heart attack, stroke） can all reduce or entirely prevent the delivery of oxygen to brain cells, resulting in the initiation of programmed cell death pathways, necrosis, or excitotoxic cell death in brain （Pamenter, 2014）. However, oxygen-limited environments are common on earth and many organisms naturally experience periods of intermit- tent or prolonged hypoxia or anoxia in their daily and/or annual life cycles （Bickler and Buck, 2007）.

关键词： Comparative insights into mitochondrial adaptations to anoxia in brain

THeRMAL eNVIRONMeNTS OF AN OFFICe BUILDING WITH DOUBLe SKIN FACADe

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Journal of Green Building 2017年第3期12卷 3-22页

作者： Maryam Khoshbakht Zhonghua Gou Karine.dupre Hasim Altan Cities Research Institute School of EnvironmentGriffith UniversityAustralia Faculty of engineering&IT The British University in DubaiDubaiUAE

As a symbol of green architecture,double skin facade(DSF)represents a design which possesses many energy saving features,but due to the complexity of the system,the real performances and benefits have been difficult to *** objective of this study was to inform the applicability of DSFs,and contribute to the positive impacts of DSF *** study compared and contrasted energy savings in a temperate climate,where heating was the dominant energy strategy,and in a subtropical climate,where cooling spaces was the dominant *** paper focused on a university office building with a west facing shaft box window *** research method was a paired analysis of simulation studies which compared the energy performance of a set of buildings in two different *** results showed a good agreement with measurements undertaken in the exiting building during a two-week *** results specified that DSFs are capable of almost 50%energy savings in temperate and 16%in subtropical *** these indicated DSFs are more suitable for temperate climates than warmer regions,the amount of energy savings in subtropical climates were also ***,due to the costs of DSFs and potential loss of leasable floor area,investigations into other feasible ventilation options are necessary before final building design decisions are made.

关键词： double skin facade shaft box window facade building envelope building simulation climate design energy savings

The role of DJ-1 complexes and catecholamine metabolism： relevance for familial and idiopathic Parkinson＇s disease

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Neural Regeneration Research 2018年第5期13卷 815-816页

作者： Dominik Piston matthew e.Gegg German Centre for Neurodegenerative Diseases (DZNe) Bonn Germany Department of Clinical Neuroscience UCL Institute of Neurology London UK

Autosomal recessive mutations in the PARK7 gene,which encodes for the protein DJ-1,result in a loss of function and are a cause of familial Parkinson’s disease（PD）,while increased wild-type DJ-1protein levels are associated with some forms of *** functions of DJ-1 have been described,with the greatest evidence indicating that DJ-1 is a redox-sensitive protein involved in the regulation of oxidative stress and cell survival.

关键词： The role of DJ-1 complexes and catecholamine metabolism relevance for familial and idiopathic Parkinson’s disease GBA DA

Stoichiometry of a semi-aquatic plethodontid salamander: Intraspecific variation due to location, size and diet

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Integrative Zoology 2014年第5期9卷 613-622页

作者： Joseph R.MILANOVICH matthew e.HOPTON United States environmental Protection Agency Office of Research and DevelopmentSustainable Technology DivisionNational Risk Management Research LaboratorySustainable Environments BranchCincinnatiOhioUSA Department of Biology Loyola University Chicago1032 West Sheridan Rd.ChicagoIL 60660USA.

ecological stoichiometry provides a framework to investigate an organism’s relationship to nutrient *** organism’s stoichiometry is thought to constrain its contribution to nutrient cycles(recycling or storage),and to limit its growth and *** that influence the stoichiometry of a consumer are largely unstudied,but what is known is that consumer stoichiometry is influenced by the elemental requirements of the consumer(*** growth,reproduction and cell maintenance)and the availability of *** examined whole-body stoichiometry of larval southern two-lined salamanders(eurycea cirrigera)and described the influence of location,body size,stoichiometry of diet items,and environmental nutrient supply on whole-body *** composition of phosphorous was 2.6%,nitrogen was 11.3%,and carbon was 39.6%,which are similar for other aquatic vertebrate *** most significant predictor of whole-body stoichiometry was the site where the samples were collected,which was significant for each nutrient and nutrient *** size and stoichiometry of diet items were also predictors of eurycea cirrigera *** study suggests that spatial differences in environmental nutrient supply have a stronger influence on consumer whole-body stoichiometry among similar-sized larvae compared to life history traits,such as body size or diet.

关键词： carbon eurycea cirrigera nitrogen phosphorus stream

Negative consequences of positive feedbacks in US wild-fire management

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Forest ecosystems 2015年第2期2卷 57-66页

作者： David e Calkin matthew P Thompson Mark A Finney Forestry Sciences Laboratory US Forest Service Rocky Mountain Research Station Fire Sciences Laboratory US Forest Service Rocky Mountain Research Station

Over the last two decades wildfire activity, damage, and management cost within the US have increased substantially. These increases have been associated with a number of factors including climate change and fuel accumulation due to a century of active fire suppression. The increased fire activity has occurred during a time of significant ex-urban development of the Wildland Urban Interface （WUI） along with increased demand on water resources originating on forested landscapes. These increased demands have put substantial pressure on federal agencies charged with wildfire management to continue and expand the century old policy of aggressive wildfire suppression. However, aggressive wildfire suppression is one of the major factors that drive the increased extent, intensity, and damage associated with the small number of large wildfires that are unable to be suppressed. In this paper we discuss the positive feedback loops that lead to demands for increasing suppression response while simultaneously increasing wildfire risk in the future. Despite a wealth of scientific research that demonstrates the limitations of the current management paradigm pressure to maintain the existing system are well entrenched and driven by the existing social systems that have evolved under our current management practice. Interestingly, US federal wildland fire policy provides considerable discretion for managers to pursue a range of management objectives however, societal expectations and existing management incentive structures result in policy implementation that is straining the resilience of fire adapted ecosystems and the communities that reside in and adjacent to them.

关键词： Wildfire suppression Wildfire paradox Wildland urban interface Resilience