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Machine learning in solid organ transplantation:Charting the evolving landscape

World Journal of Transplantation 2025年第1期15卷 165-177页

作者： Badi Rawashdeh Haneen Al-abdallat Emre Arpali Beje Thomas Ty B Dunn matthew cooper Division of Transplant Surgery Medical College of WisconsinMilwaukeeWI 53202United States Department of Medicine Jordan University HospitalAmman 11263Jordan Department of Nephrology Medical College of WisconsinMilwaukeeWI 53226United States

BACKGROUND Machine learning(ML),a major branch of artificial intelligence,has not only demonstrated the potential to significantly improve numerous sectors of healthcare but has also made significant contributions to the field of solid organ *** provides revolutionary opportunities in areas such as donorrecipient matching,post-transplant monitoring,and patient care by automatically analyzing large amounts of data,identifying patterns,and forecasting *** To conduct a comprehensive bibliometric analysis of publications on the use of ML in transplantation to understand current research trends and their *** On July 18,a thorough search strategy was used with the Web of Science *** and transplantation-related keywords were *** the aid of the VOS viewer application,the identified articles were subjected to bibliometric variable analysis in order to determine publication counts,citation counts,contributing countries,and institutions,among other *** Of the 529 articles that were first identified,427 were deemed relevant for bibliometric analysis.A surge in publications was observed over the last four years,especially after 2018,signifying growing interest in this *** 209 publications,the United States emerged as the top ***,the"Journal of Heart and Lung Transplantation"and the"American Journal of Transplantation"emerged as the leading journals,publishing the highest number of relevant *** keyword searches revealed that patient survival,mortality,outcomes,allocation,and risk assessment were significant themes of *** The growing body of pertinent publications highlights ML's growing presence in the field of solid organ *** bibliometric analysis highlights the growing importance of ML in transplant research and highlights its exciting potential to change medical practices and enhance patient *** collaboration between signific

关键词： Machine learning Artificial Intelligence Solid organ transplantation Bibliometric analysis

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Optical coherence tomography of the living human kidney

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Journal of Innovative Optical Health Sciences 2014年第2期7卷 88-97页

作者： Peter M.Andrews Hsing-Wen Wang Jeremiah Wierwlle Wei Gong Jennifer Verbesey matthew cooper Yu Chen Department of Biochemistry Molecular.and Celular Biology Georgetown University MedicalCenter WashingtonDC20007USA Fischell Department of Bioengineering Uriversity of Maryland College ParkMD 20742USA Colege of Photonic and Electric Engineering Fujian Normal University FuzhouChina Medstar Georgetown Transplant Inste Georgetown University Medical Center WashingtonD C 20007USA

Acute tubular necrosis(ATN)induced by ischemia is the most common insult to donor kidneysdestined for *** results from sweling and subsequent damage to cells lining thelkidney *** this study,we demonstrate the capability of optical coherence tomography(OcT)to image the renal microst ructures of living human donor kidneys and potentially providea measure to det ermine the extent of A *** also found that Doppler-based OCT(i.e.,DOCT)reveals renal blood flow dynamics that is another major factor which could relate to post-transplant renal *** OCT/DoCT oberva tions were performed in a noninvasive,sterileand timely manner on intact human kidneys both prior to(er vivo)and following(in vivo)*** results indicate that this imaging model provides transplant surgeons withan objective visualization of the transplant lidneys prior and immediately post transplantation.

关键词： Optical coherence tomography doppler optical coherence tomography acute tubularnecrosis kidney transplantation uriniferous tubules glomerulus renal blood flow

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Unveiling transplantation research productivity of United States: A bibliometric analysis

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World Journal of Transplantation 2023年第6期13卷 391-402页

作者： Badi Rawashdeh Saif Aldeen AlRyalat Mohammad Abuassi Raj Prasad matthew cooper Department of Transplant Surgery Medical College of WisconsinMilwaukeeWI 53202United States School of Mediine Jordan UniversityAmman 11100Jordan Department of Internal Medicine Jordan HospitalAmman 00962Jordan

BACKGROUND The United States has witnessed significant advancements in the field of organ transplantation over the course of the last five decades,as demonstrated by a notable increase in the quantity of academic *** presence of a highly dynamic research environment necessitates continuous evaluations to maintain the integrity and progress of the *** To evaluate the total output and thematic emphasis of transplant research conducted in the United *** On January 10,2023,we conducted a bibliometric search of United States research output in transplantation journals from the Web of Science database's Science Citation Index *** excluded editorials,meeting abstracts,and other non-article *** analyzed annual trends,authors,institutions,articles,keywords,and countries collaborating with the United States,using VOSviewer 1.6.18 to create figures and *** The United States published 25956 papers(3078 reviews and 22878 articles)representing 37.7%of the world's scientific *** emerged as the top collaborator with the United States,co-authoring 1263 *** institutions in United States transplantation research were the University of Pittsburgh(1749 articles),Mayo Clinic(1605 articles),Harvard Medical School(1549 articles),and Johns Hopkins University(1280 articles).The top three keywords with over 2000 occurrences were"recipients,""survival,"and"outcomes,"indicating a focus on graft and recipient outcome markers by United States *** Our findings demonstrate the United States leadership in organ transplantation research,contributing significantly to the global scientific output in this ***,opportunities exist for fostering expansive partnerships,particularly with developing *** study provides valuable insights into the transplantation research landscape in the United States,emphasizing the importance of ongoing evaluations to maintain and propel advancements in this critic

关键词： Scientometrics Bibliometrics Research output Organ transplantation United States

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Pancreas transplantation in type Ⅱ diabetes mellitus

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World Journal of Transplantation 2014年第4期4卷 216-221页

作者： Phillip Weems matthew cooper MedStar Georgetown Transplant Institute Washington DC 20007 United States

Although the diagnosis of type 2 diabetes mellitus was once considered a contraindication to simultaneous pancreas-kidney transplantation, a growing body of evidence has revealed that similar graft and patient survival can be achieved when compared to type 1 diabetes mellitus recipients. A cautious strategy regarding candidate selection may limit appropriate candidates from additional benefits in terms of quality of life and potential amelioration of secondary side effects of the disease process. Although our current understanding of the disease has changed, uniform listing characteristics to better define and study this population have limited available data and must be established.

关键词： Pancreas transplantation Type 2 diabetes mellitus Simultaneous pancreas-kidney transplantation

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Global fine-scale changes in ambient NO 2 during COVID-19 lockdowns

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四川生理科学杂志 2021年第11期43卷 1904-1904页

作者： matthew J cooper Department of Physics and Atmospheric Science Dalhousie University Halifax Nova Scotia Canada Department of Energy Environmental & Chemical Engineering Washington University in St. Louis St. Louis MO USA Harvard-Smithsonian Center for Astrophysics Cambridge MA USA Royal Netherlands Meteorological Institute (KNMI) De Bilt Netherlands University of Technology Delft Delft Netherlands National Center for Atmospheric Research Boulder CO USA Department of Geoscience and Remote Sensing Delft University of Technology Delft Netherlands NASA Goddard Space Flight Center Greenbelt MD USA Universities Space Research Association Columbia MD USA Dalla Lana School of Public Health University of Toronto Toronto Ontario Canada Department of Chemical Engineering and Applied Chemistry University of Toronto Toronto Ontario Canada Environment and Climate Change Canada Toronto Ontario Canada

Nitrogen dioxide(NO2)is an important contributor to air pollution and can adversely affect human health1-9.A decrease in NO2 concentrations has been reported as a result of lockdown measures to reduce the spread of *** remain,however,regarding the relationship of satellite-derived atmospheric column NO2 data with health-relevant ambient ground-level concentrations,and the representativeness of limited ground-based monitoring data for global *** we derive spatially resolved,global ground-level NO2 concentrations from NO2 column densities observed by the TROPOMI satellite instrument at sufficiently fine resolution(approximately one kilometre)to allow assessment of individual cities during COVID-19 lockdowns in 2020 compared to 2019.

关键词： pollution ambient column

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Reducing the risk of cerebrospinal fluid rhinorrhea following translabyrinthine surgery of the posterior fossa

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2021年第2期7卷 82-87页

作者： matthew W.cooper Bryan K.Ward Jeffery Sharon Howard W.Francis Department of Head and Neck Surgery Et Communication Sciences Duke University School of Aied/c/neDurhamNCL/SA Department of Otolarynsolosy-Head and Neck Surgery Johns Hopkins University School of MedicineBaltimoreMDUSA Department of Otolaryngology-Head and Neck Surgery University of California San FranciscoSan FranciscoCAUSA

Objective:To describe the procedure and results of an adapted closure and recon struction technique for translabyrinthine surgery that focuses on identifying and managing potential pathways for CSF egress to the middle ear and Eustachian ***:Retrospective review of a cohort of translabyrinthine acoustic neuroma cases that were reconstructed using this ***:In addition to meticulous packing of potential conduits using soft tissue,hydroxyapatite cement is used to seal opened air cell tracts prior to obliteration of the mastoid defect using adipose *** results of a small patient cohort using this technique are encouraging and there were no wound *** was a single case of CSF rhinorrhea associated with incomplete sealing of opened petrous apex cells,with no recurrence after appropriate implementation of the described protocol during revision ***:Proactive management of potential conduits of CSF egress including opened air cell tracts has a high likelihood of reducing rates of rhinorrhea and need for revision surgery after the translabyrinthine approach to the posterior fossa.

关键词： Translabyrinthine approach Cerebrospinal fluid leak Rhinorrhea Air cell tract Petrous apex Eustachian tube Hydroxyapatite cement

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BILATERAL RELATIONS BETWEEN CHINA AND THE UNITED STATES:POLICY PRIORITIZATION WITH THE ANP

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Journal of Systems Science and Systems Engineering 2013年第2期22卷 202-226页

作者： Orrin cooper Qingxing DONG Fogelman College of Business and Economics University of MemphisMemphis School of Business Administration Northeastern University

Improving relations between the People＇s Republic of China （PRC） and the United States of America （US） and ensuring that they work together as allies rather than as competitors can serve as a stabilizing force against armed conflict, particularly with surrounding nations. The economic, social, and political relationships between the PRC and US have progressed along a hilly journey. As the second largest economy in the world, the PRC has continued to develop its military and is determined to climb the technological ladder. This growth has led the US and the PRC to be referred to as a G-2 of superpowers. As the US hegemony continues to weaken this G-2 relationship is becoming more important. With significant economic, political, and security issues at stake it is crucial that efforts to strengthen these relations are prioritized and implemented. A rigorous prioritization process, the Analytic Network Process （ANP） is used herein to prioritize the efforts and initiatives in the G-2 relationship. The model is presented with results and the extensive sensitivity analysis present additional insight into the suggested solutions.

关键词： The analytic network process (ANP) policy making China United States

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The epididymis, cytoplasmic droplets and male fertility

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Asian Journal of Andrology 2011年第1期13卷 130-138页

作者： Trevor G cooper Centre of Reproductive Medicine and Andrology University of MOnster MOnster D-48149 Germany

The potential of spermatozoa to become motile during post-testicular maturation, and the relationship between the cytoplasmic droplet and fertilizing capacity are reviewed. Post-testicular maturation of spermatozoa involves the autonomous induction of motility, which can occur in vivo in testes with occluded excurrent ducts and in vitro in testicular explants, and artefactual changes in morphology that appear to occur in the testis in vitro. Both modifications may reflect time-dependent oxidation of disulphide bonds of head and tail proteins. Regulatory volume decrease （RVD）, which counters sperm swelling at ejaculation, is discussed in relation to loss of cytoplasmic droplets and consequences for fertility. It is postulated that：（i） fertile males possess spermatozoa with sufficient osmolytes to drive RVD at ejaculation, permitting the droplet to round up and pinch off without membrane rupture; and （ii） infertile males possess spermatozoa with insufficient osmolytes so that RVD is inadequate, the droplet swells and the resulting flagellar angulation prevents droplet loss. Droplet retention at ejaculation is a harbinger of infertility caused by failure of the spermatozoon to negotiate the uterotubal junction or mucous and reach the egg. In this hypothesis, the epididymis regulates fertility indirectly by the extent of osmolyte provision to spermatozoa, which influences RVD and therefore droplet loss. Man is an exception, because ejaculated human spermatozoa retain their droplets. This may reflect their short midpiece, approximating head length, permitting a swollen droplet to extend along the entire midpiece; this not only obviates droplet migration and flagellar angulation but also hampers droplet loss.

关键词： epididymis fertility infertility sperm maturation

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Semen quality： variations among fathers and effects of moderate alcohol drinking

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Asian Journal of Andrology 2015年第1期17卷 46-47页

作者： Trevor G cooper Tuen Mun New Territories Hong Kong SAR China

Semen analysis results from over 750 fathers in the USA demonstrated marked differences in the quality of semen from men at different locations and of different ethnic groups. Another paper failed to demonstrate any effects of moderate alcohol consumption during the week before provision of an ejaculate on semen quality and few on serum hormones, of over 8300 men in Europe and the USA. While these observations are interesting, the reasons for regional and ethnic differences in semen quality of fathers are unclear. Although, there was no attempt to confirm the participant-provided level of alcohol consumption, an increase in serum testosterone in the men at the higher end of alcohol intake is compatible with an alcohol effect on liver metabolism, although whether alcohol intake was the cause of higher testosterone, or men with higher androgen levels consume more alcohol, is not known.

关键词： Semen quality variations among fathers

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Remembering Mike Bedford （21.5.1932-24.2.2018）

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Asian Journal of Andrology 2018年第4期20卷 420-424页

作者： Trevor G cooper .

John Michael Bedford （Figure 1） studied at Sidney Sussex College, Cambridge University （1952-1958）, and gained his BA （1955） and MA （1958） in Natural Sciences, with postgraduate training in Veterinary Medicine and Surgery （Vet MB 1958）. He had academic appointments as a Fellow at Bristol University （1958-1959）, a scientist with MC Chang at the Worcester Foundation in Shrewsbury, MA, USA （1959-1961）,and studied for a PhD in Physiology with Professor Amoroso at the University of London （1961-1965）. During this time, he was also a lecturer at the Royal Veterinary College （1961-1966） and a teacher at the University of London （1965）.

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