检索结果-南通市图书馆

Combinatorial therapies for spinal cord injury repair

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第5期20卷 1293-1308页

作者： Carla s.sousa Andreia Monteiro António j.salgado Nuno A.silva Life and Health sciences Research Institute(ICVs) School of MedicineUniversity of MinhoCampus de Gualtar-gualtarBragaPortugal ICVs/3B’s Associate Lab PT Government Associated LabCampus de Gualtar-gualtarBragaPortugal

spinal cord injuries have profound detrimental effects on individuals, regardless of whether they are caused by trauma or non-traumatic events. The compromised regeneration of the spinal cord is primarily attributed to damaged neurons, inhibitory molecules, dysfunctional immune response, and glial scarring. Unfortunately, currently, there are no effective treatments available that can fully repair the spinal cord and improve functional outcomes. Nevertheless, numerous pre-clinical approaches have been studied for spinal cord injury recovery, including using biomaterials, cells, drugs, or technological-based strategies. Combinatorial treatments, which target various aspects of spinal cord injury pathophysiology, have been extensively tested in the last decade. These approaches aim to synergistically enhance repair processes by addressing various obstacles faced during spinal cord regeneration. Thus, this review intends to provide scientists and clinicians with an overview of pre-clinical combinatorial approaches that have been developed toward the solution of spinal cord regeneration as well as update the current knowledge about spinal cord injury pathophysiology with an emphasis on the current clinical management.

关键词： electric stimulation neural tissue regeneration neuroprotection polytherapy spinal cord injury

Emerging role of A-kinase anchoring protein 5 signaling in reward circuit function

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第10期20卷 2913-2914页

作者： William j.Flerlage Mark L.Dell’Acqua Brian M.Cox Fereshteh s.Nugent Uniformed services University of the Health sciences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA Department of Pharmacology University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is a strong evidence supporting the hypothesis of synaptic dysfunction as a major contributor to neural circuit and network disruption underlying emotional and mood dysregulation in psychiatric disorders(simmons et al.,2024).Diverse sets of distinct molecular signaling pathways converge on the synapse to regulate synaptogenesis,synaptic function,and synaptic plasticity in brain regions and circuits through complex interactions organized by numerous multivalent protein scaffolds,including the family of proteins known as A-kinase anchoring proteins(AKAPs).

关键词： function supporting

A systematic review of progenitor survival and maturation in Parkinsonian models

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第11期20卷 3172-3178页

作者： Giulia Comini Eilís Dowd Pharmacology&Therapeutics and Galway Neuroscience Center University of GalwayGalwayIreland

stem cell-based brain repair is a promising emergent therapy for Parkinson's disease based on years of foundational research using human fetal donors as a cell *** current therapeutic options for patients,this approach has the potential to provide longterm stem cell–derived reconstruction and restoration of the dopaminergic input to denervated regions of the brain allowing for restoration of certain functions to *** ultimate clinical success of stem cell–derived brain repair will depend on both the safety and efficacy of the approach and the latter is dependent on the ability of the transplanted cells to survive and differentiate into functional dopaminergic neurons in the Parkinsonian *** the pre-clinical literature suggests that there is considerable variability in survival and differentiation between studies,the aim of this systematic review was to assess these parameters in human stem cell-derived dopaminergic progenitor transplant studies in animal models of Parkinson's disease.A defined systematic search of the PubMed database was completed to identify relevant studies published up to March *** screening,76 articles were included in the analysis from which 178 separate transplant studies were *** these,graft survival could be assessed in 52 studies and differentiation in 129 ***,we found that graft survival ranged froms transplanted,with a median of 51%of transplanted cells surviving in the brain;while dopaminergic differentiation of the cells ranged from 0% to 46% of cells transplanted with a median of 3%.This systematic review suggests that there is considerable scope for improvement in the differentiation of stem cell-derived dopaminergic progenitors to maximize the therapeutic potential of this approach for patients.

关键词： cell replacement therapy differentiation embryonic stem cells graft induced pluripotent stem cells Parkinson's disease survival transplant

Deciphering the mechanobiology of microglia in traumatic brain injury with advanced microsystems

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第8期20卷 2304-2306页

作者： Anthony Procès sylvain Gabriele Univ.Grenoble Alpes InsermU1216Grenoble Institut des NeurosciencesGrenobleFrance Mechanobiology&Biomaterials Group CIRMAPResearch Institute for BiosciencesUniversity of MonsMonsBelgium

Advanced microsystems in traumatic brain injury research:Traumatic brain injury(TBI)results from a mechanical insult to the brain,leading to neuronal and axonal damage and subsequently causing a secondary *** minutes ... 详细信息

关键词： traumatic injury damage

A mild, configurable, flexible CoNi-LDH（v）/Zn battery based on H-vacancy-induced reversible Zn2+ intercalation

在线全文

学校读者我要写书评

暂无评论

journal of Energy Chemistry 2025年第1期100卷 498-508页

作者： Xinyue Cheng Dingsheng Wu Hao Gao Qingqing Wang Pengfei Lv sam s.Yoon Qufu Wei Key Laboratory of Eco-textiles Ministry of Education Jiangnan University school of Mechanical Engineering Korea University

Flexible Zn-based batteries have attracted increasing research interest as essential components of wearable energy storage ***,the advancement of flexible aqueous Zn-based batteries based on Co-Ni layered double hydroxide （CoNi-LDH） as the cathode material is hampered by their poor cycling stability and the corrosiveness of alkaline ***,CoNi-LDH nanosheets enriched with H vacancies (CoNi-LDH（v）) were constructed on a flexible carbon cloth （CC） substrate via electrochemical deposition and *** Zn-based battery comprising CoNi-LDH（v）@CC as the cathode exhibited highly reversible conversion reactions and stable operation in 3 M ZnsO4electrolyte （pH=4）.The battery delivered an excellent specific capacity (225 mA h g-1,0.26 mA h cm-2),acceptable cycling stability（53.9%,900 cycles）,and high discharging *** abundant H vacancies served as active sites for the reversible intercalation of Zn2+and the extravasation of NO3-generated channels and space for Zn2+transport and storage,together enabling an excellent Zn2+storage ***,a sandwich-structured solid-state CoNi-LDH（v）@CC//Zn@CC battery was fabricated and was found to exhibit a noteworthy electrochemical performance and mechanical *** a proof of concept,the unencapsulated battery powered a digital watch under various deformation conditions and operated stably for 80 ***,the flexible battery displayed outstanding customizability,maintaining an open-circuit voltage of 1.42 V even after being cut *** proposed engineering strategy contributes to the realization of textiles with truly wearable energy-storage devices.

关键词： CoNi/Zn battery H vacancies Mild aqueous electrolyte Tailorable battery Wearable energy storage device

Computational study on influence of RF shielding box on inductance of coil

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Plasma science and Technology 2019年第6期21卷 23-28页

作者： s j KIM j j LEE Y s LEE j H KIM s j YOU Applied Physics lab for PLasma Engineering(APPLE) Department of Physics Chungnam National University Daejeon 34134 Republic of Korea Korea Research Institute of standards and science(KRIss) Daejeon 34113 Republic of Korea

Despite the fact that a radio frequency (RF) shielding box affects a coil inductance used in matching network,RF engineers have used a coil inductance measured in open space on designing matching networks since it is difficult to precisely measure the coil inductance within the RF shielding *** this work,we investigate the influences of the RF shielding box on the coil inductance via a 3D full electromagnetic wave *** results shows that the coil inductance decreases from-6.0% to-11.9% compared with its ideal inductance depending on coil positions within the RF shielding *** inductive and capacitive coupling between the coil and surfaces of the RF shielding box contribute to the reduction of the coil *** expect that these results would be useful for those who design RF matching networks.

关键词： 3D full EM wave simulation RF matching component RF shield inductive and capacitive coupling

strip Casting of High Performance structural Alloys

在线全文

学校读者我要写书评

暂无评论

journal of Rare Earths 2004年第Z2期22卷 78-84页

作者： s s Park j G Lee Nack j Kim Center for Advanced Aerospace Materials Pohang University of Science and TechnologyPohang 790-784Korea Center for Advanced Aerospace MaterialsPohang University of Science and TechnologyPohang 790-784Korea Center for Advanced Aerospace MaterialsPohang University of Science and TechnologyPohang 790-784Korea

There exists a great need for the development of high performance alloys due to increasing demands for energy conservation and environmental protection. Application of strip casting shows a strong potential for the improvement of properties of existing alloys and also for the development of novel alloy systems with superior properties. The present paper reviews our Center's activities in the development of high performance alloys by strip casting. Examples include (1) Al alloys, (2) wrought Mg alloys, and (3) bulk metallic glass (BMG) alloys.

关键词： strip casting 6061 Al alloy AZ Mg alloy bulk metallic glass (BMG) alloy dispersion hardening

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

试色糊剂与树脂粘结剂间颜色差别的分析

中华口腔医学杂志 1999年第1期34卷 58-59页

作者：王新知 powe.,jM 北京医科大学口腔医学院美国德克萨斯大学休斯敦口腔医学院

目的测定分析试色糊剂与相应颜色的树脂粘结剂间颜色的一致性和差异。为全瓷修复时应用此种材料提供经验和依据。方法应用光电比色仪及ＣＩＥＬａｂ色度系统，对Ｖａｒｉｏｌｉｎｋ三种颜色的试色糊剂与相应颜色的树脂粘结剂进行... 详细信息

目的测定分析试色糊剂与相应颜色的树脂粘结剂间颜色的一致性和差异。为全瓷修复时应用此种材料提供经验和依据。方法应用光电比色仪及ＣＩＥＬａｂ色度系统，对Ｖａｒｉｏｌｉｎｋ三种颜色的试色糊剂与相应颜色的树脂粘结剂进行颜色测量和分析。结果２００号试色糊剂与相应的化学固化树脂的颜色相比，△Ｅ＜１．４。其余树脂粘结剂与相应的试色糊剂相比较，△Ｅ值均大于３３。结论２００号试色糊剂与化学固化树脂粘结剂的颜色一致性最好，但试色糊剂较光固化树脂粘结剂略亮、略黄。与试色糊剂相比，１００号树脂粘结剂略暗、略黄，３００号树脂粘结剂略亮、略黄，颜色均有明显差异。

关键词：颜色牙科材料树脂粘结剂试色粘剂

Does the molecular classification of breast cancer point the way for biomarker identification in prostate cancer?

在线全文

学校读者我要写书评

暂无评论

World journal of Clinical Urology 2016年第2期5卷 80-89页

作者： William jF Green Graham Ball Des powe Department of Urology Nottingham City Hospital Nottingham University Hospitals NHS Trust the john van Geest Cancer Research Centre Nottingham Trent University Department of Cellular Pathology Queen’s Medical Centre Nottingham University Hospitals NHS Trust

There is significant variation in clinical outcome between patients diagnosed with prostate cancer(Ca P). Although useful, statistical nomograms and risk stratification tools alone do not always accurately predict an individual's need for and response to treatment. The factors that determine this variation are not fully elucidated. In particular, cellular response to androgen ablation and subsequent paracrine/autocrine adaptation is poorly understood and despite best therapies, median survival in castrate resistant patients is only approximately 35 mo. We propose that one way of understanding this is to look for correlates in other comparable malignancies, such as breast cancer, where markers of at least 4 distinct gene clusters coding for 4 different phenotypic subtypes have been identified. These subtypes have been shown to demonstrate prognostic significance and successfully guide appropriate treatment regimens. In this paper we assess and review the evidence demonstrating parallels in the biology and treatment approach between breast and Ca P, and consider the feasibility of patients with Ca P being stratified into different molecular classes that could be used to complement prostate specific antigen and histological grading for clinical decision making. We show that there are significant correlations between the molecular classification of breast and Ca P and explain how techniques used successfully to predict response to treatment in breast cancer can be applied to the prostate. Molecular phenotyping is possible in Ca P and identification of distinct subtypes may allow personalised risk stratification way beyond that currently available.

关键词： Prostate cancer Molecular classification Biomarker Breast cancer Prognostic