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Phosphodiesterase 9 localization in cytoplasm and nucleus:the gateway to selective targeting in neuroprotection?

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Neural Regeneration Research 2025年第6期20卷 1701-1702页

作者： Giovanni Ribaudo matteo Giannangeli Margrate Anyanwu Alessandra Gianoncelli Department of Molecular and Translational Medicine University of BresciaBresciaItaly

The umbrella term"neurodege ne rative disorders"(NDDs) refers to several conditions characterized by a progressive loss of structure and function of cells belonging to the nervous *** diseases affect more than 50million people *** disorders are characterized by sundry factors and pathophysiological mechanisms that a re challenging to be fully *** of these rely on cell signaling pathways to preserve homeostasis,involving second messengers such as cyclic adenosine monophosphate (cAMP)and cyclic guanosine 3',5'-monophosphate(cGMP).Their ability to control the duration and amplitude of the signaling cascade is given by the presence of several common and uncommon *** kinases A and G (PKA and PKG),phosphodiesterases (PDEs),and scaffold proteins are among them.

关键词： gateway homeostasis preserve

Measurement of strong phases, D-D mixing, and CP violation using quantum correlation at charm threshold

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Frontiers of physics 2016年第1期11卷 1-15页

作者： matteo Rama Sezione di Pisa dell'Istituto Nazionale di Fisica Nucleate Pisa Italy

We review the measurements of the D decay strong-phase parameters based on quantum-correlated D^0D^-0 pairs produced in the e^＋e^→（3770） →D^0D^-0 process, and we discuss their role in the measurements of Cabibbo-Kobayashi-Maskawa angle 7 and D-/9 mixing. In addition, we present estimates of the size of quantum-correlated datasets necessary to support the 7 and charm mixing measurements conducted at the LHCb and Belle Ⅱ experiments. Finally, we review the methods for measuring the D-D^- mixing and cP violation parameters at a high-luminosity charm factory, giving sensitivity estimates.

关键词： quantum correlation charm mixing CP violation

A machine learning approach to map crystal orientation by optical microscopy

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npj Computational Materials 2022年第1期8卷 70-78页

作者： Mallory Wittwer matteo Seita School of Mechanical and Aerospace Engineering Nanyang Technological UniversitySingaporeSingapore School of Materials Science and Engineering Nanyang Technological UniversitySingaporeSingapore

Mapping grain orientation in crystalline solids is essential to investigate the relationships between local microstructure and crystallography and interpret materials *** of the main techniques used to perform these studies is electron backscatter diffraction(EBSD).Due to the limited measurement throughput,however,EBSD is not suitable for characterizing samples with long-range microstructure heterogeneity,nor for building large material libraries that include numerous *** present a machine learning approach for high-throughput crystal orientation mapping,which relies on the optical technique called directional reflectance *** successfully apply our method on Inconel 718 specimens produced by additive manufacturing,which exhibit complex,spatially-varying *** results demonstrate that optical orientation mapping on a metal alloy is *** our method is data-driven,it can be easily extended to different alloy systems produced using different manufacturing processes.

关键词： alloy microstructure crystal

Hepatic effector CD8＋ T-cell dynamics

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Cellular & Molecular Immunology 2015年第3期12卷 269-272页

作者： matteo Iannacone Division of Immunology Transplantation and Infectious Diseases I RCCS San Raffaele Scientific Institute and Vita-Saiute San Raffaele University Milan Italy

CD8＋ T cells play a critical role in hepatitis B virus （HBV） pathogenesis. During acute, self-limited infections, these cells are instrumental to viral clearance; in chronic settings, they sustain repetitive cycles of hepatocellular necrosis that promote hepatocellular carcinoma development. Both CD8＋ T-cell defensive and destructive functions are mediated by antigen-experienced effector cells and depend on the ability of these cells to migrate to the liver, recognize hepatocellular antigens and perform effector functions. Understanding the signals that modulate the spatiotemporal dynamics of CD8＋ T cells in the liver, particularly in the context of antigen recognition, is therefore critical to gaining insight into the pathogenesis of acute and chronic HBV infection. Here, we highlight recent data on how effector CD8＋ T cells traffic within the liver, and we discuss the potential for novel imaging techniques to shed light on this important aspect of HBV pathogenesis.

关键词： CD8+ T cells hepatitis B virus intravital microscopy liver immunopathology platelets

A comprehensive review of extrusion-based additive manufacturing processes for rapid production of metallic and ceramic parts

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Advances in Manufacturing 2019年第2期7卷 155-173页

作者： Kedarnath Rane matteo Strano Department of Mechanical Engineering Politecnico di Milano Via La Masa 1 Milan Italy

The extrusion-based additive manufacturing (EAM) technique is recently being employed for rapid production of metals and ceramic components. This technique involves extruding the metal or ceramic material in solid powder form mixed with a binder (i.e., an expendable viscous fluid), which is removed from the part after 3D printing. These technologies rely on the large design freedom allowed and the cost efficiency advantage over alternative metal additive manufacturing processes that are based on high energy beams, such as laser or electron beams. The EAM of metals and ceramics is not yet widespread, but published scientific and technical literature on it is rapidly growing. However, this literature is still less extensive than that on the fused deposition modeling (FDM) of plastics or the selective laser melting (SLM) of metals. This paper aims at filling this gap. FDM and powder injection molding are identified as preceding or enabling technologies for EAM. This paper systematically reviews all aspects of the feedstock EAM processes used for production of complex-shaped parts. The unique characteristics and advantages of these processes are also discussed with respect to materials and process steps. In addition, the key process parameters are explained to illustrate the suitability of the EAM process for diverse application domains.

关键词： Feedstock extrusion Rapid production Complex-shaped metallic Ceramic parts

Mechatronic Design of a Robot for Upper Limb Rehabilitation at Home

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Journal of Bionic Engineering 2021年第4期18卷 857-871页

作者： Elio matteo Curcio Giuseppe Carbone Department of Mechanical Energyand Management EngineeringUniversity of Calabria Via BucciCubo 46C87036 RendeItaly

This paper addresses the design of a novel bionic robotic device for upper limb rehabilitation tasks at *** main goal of the design process has been to obtain a rehabilitation device,which can be easily portable and can be managed remotely by a professional *** allows to treat people also in regions that are not easily reachable with a significant cost *** potential benefits can be envisaged,for instance,in the possibility to keep social distancing while allowing rehabilitation treatments even during a pandemic *** attention has been devoted to design the main mechatronic components by developing specific kinematics and dynamics *** design process includes the implementation of a specific control hardware and *** experimental tests are reported to show the effectiveness and feasibility of the proposed design solution.

关键词： bionic robot design simulations parallel robots upper limb rehabilitation

On the formation of Basu’s Type Ⅲ(peeled orange) gunshot residues

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Defence Technology（防务技术） 2019年第1期15卷 23-26页

作者： Felice Nunziata matteo Donghi the Chartered Society of Forensic Science Arma dei Carabinieri Reparto Investigazioni Scientifiche

In a famous paper published in 1982, a very special class of gunshot residue particles(GSR) was named by Samarendra Basu "peeled orange", due to their particular structure, consisting of a barium/antimony core covered by an outer lead leaflet. In this class of GSR particles the surface may show nodular structures of lead. Basu proposed an explanation in terms of a nucleus of antimony and barium that captures lead vapours produced after the explosion of a cartridge into a firearm: as solidification points of antimony and barium are close one another, both higher than solidification point of lead, he stated that lead occurs as a layer around the core in peeled orange GSR particles. In this paper we study the thermodynamic of the barium/antimony alloy and we hypothesize a formation process in terms of colloidal metal growth, charged particles and electrostatic attraction. We propose an updated model of formation for peeled orange GSR particles that explains the existence of outer lead leaflet and nodules in terms of electrostatic attraction of lead nanoparticles and instability of lead droplets.

关键词： Peeled orange particles GSR CDR Charged particles Electrostatic attraction Rayleigh droplet stability

Monoacylglycerol lipase reprograms lipid precursors signaling in liver disease

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World Journal of Gastroenterology 2020年第25期26卷 3577-3585页

作者： matteo Tardelli Division of Gastroenterology and Hepatology Joan and Sanford I Weill Cornell Department of MedicineWeill Cornell Medical CollegeNew YorkNY 10021United States Hans Popper Laboratory of Molecular Hepatology Division of Gastroenterology and HepatologyInternal Medicine IIIMedical University of ViennaVienna 1040Austria

Dietary oversupply of triglycerides represent the hallmark of obesity and connected complications in the liver such as non-alcoholic fatty liver disease and non-alcoholic steatohepatitis,which eventually progress to cirrhosis and hepatocellular *** lipase is the last enzymatic step in the hydrolysis of triglycerides,generating glycerol and fatty acids(FAs),which are signaling precursors in physiology and ***,monoacylglycerol lipase(MGL)also hydrolyzes 2-arachidonoylglycerol,which is a potent ligand within the endocannabinoid system,into arachidonic acid-a precursor for prostaglandin synthesis;thus representing a pivotal substrates provider in multiple organs for several intersecting biological pathways ranging from FA metabolism to inflammation,pain and *** inhibition has been shown protective in limiting several liver diseases as FAs may drive hepatocyte injury,fibrogenesis and de-activate immune cells,however the complexity of MGL network system still needs further and deeper *** present review will focus on MGL function and FA partitioning in the horizons of liver disease.

关键词： Lipid metabolism Monoacylglycerol lipase Non-alcoholic steatohepatitis Non-alcoholic fatty liver disease Cannabinoid Nuclear receptors

Ultrasonically sculpted virtual relay lens for in situ microimaging

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Light(Science & Applications) 2019年第1期8卷 596-610页

作者： matteo Giuseppe Scopelliti Maysamreza Chamanzar Department of Electrical and Computer Engineering Carnegie Mellon University5000 Forbes AvenuePittsburghPA 15213USA Carnegie Mellon Neuroscience Institute Carnegie Mellon University5000 Forbes AvenuePittsburghPA 15213USA Center for the Neural Basis of Cognition Carnegie Mellon University4400 Forbes AvenuePittsburghPA 15213USA

We demonstrate in situ non-invasive relay imaging through a medium without inserting physical optical *** show that a virtual optical graded-index(GRIN)lens can be sculpted in the medium using in situ reconfigurable ultrasonic interference patterns to relay images through the *** wave patterns change the local density of the medium to sculpt a graded refractive index pattern normal to the direction of light propagation,which modulates the phase front of light,causing it to focus within the medium and effectively creating a virtual relay *** demonstrate the in situ relay imaging and resolving of small features(22μm)through a turbid medium(optical thickness=5.7 times the scattering mean free path),which is normally *** focal distance and the numerical aperture of the sculpted optical GRIN lens can be tuned by changing the ultrasonic wave *** an example,we experimentally demonstrate that the axial focal distance can be continuously scanned over a depth of 5.4mm in the modulated medium and that the numerical aperture can be tuned up to 21.5%.The interaction of ultrasonic waves and light can be mediated through different physical media,including turbid media,such as biological tissue,in which the ultrasonically sculpted GRIN lens can be used for relaying images of the underlying structures through the turbid medium,thus providing a potential alternative to implanting invasive endoscopes.

关键词： scattering virtual graded