检索结果-南通市图书馆

Hepatobiliary Surgery and Nutrition 2020年第4期9卷 490-492页

作者： matteo Serenari matteo Ravaioli General Surgery and Transplant Unit Department of Medical and Surgical SciencesUniversity of BolognaBolognaItaly

Liver transplantation(LT)for hepatocellular carcinoma(HCC)was characterized in its early experience by high recurrence rates due to extensive tumor burden(1).Only after the adoption of Milan criteria(2),LT was recognized as a standard treatment for HCC(3).Besides HCC,other hepatic malignancies were proposed to be treated in the past with LT but due to the poor results observed(4),these indications were *** them,colorectal liver metastases(CRLM)were considered an absolute contraindication until recently.

关键词： colorectal metastases absolute

Impact of chronic kidney disease on mortality in older adults treated with pacemaker implantation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Geriatric Cardiology 2017年第10期14卷 597-603页

作者： Fabio Fabbian Alfredo De Giorgi matteo Guarino Michele Malagu matteo Bertini Department of Medical Sciences Clinical Medical Unit University Hospital St. Anna University of Ferrara Ferrara Italy Department of Medical Sciences Cardiology Unit University Hospital St. Anna University of Ferrara Ferrara Italy

Objective To investigate whether chronic kidney disease could negatively impact survival in older adults needing pacemaker implantation after admission for bradyarrhythmias. Methods This retrospective observational study considered 538 older adults consecutively admitted, who had been followed-up for 31 ± 20 months. Subjects with poor short-term prognosis were excluded. Charlson comorbidity index （CCI） and estimated glomerular filtration rate （eGFR） was calculated, along with the independent relationship between all-cause mortality and clinical data. Hazard Ratio （HR） was calculated by Cox regression analysis. Results Mean age of the population was 85 ± 3.7 years, and causes for implantation were atrioventricular block in 51.9% and other bradyarrhythmias in 48.1% of cases. Mean eGFR was 58.3 ± 24 mL/min per 1.73 m2, and mean CCI was 3.65 ± 2.28. Death for all-causes was recorded in 213 subjects. Deceased patients were older, had lower eGFR, higher comorbidity, higher prevalence of myocardial infarction, congestive heart failure, cerebrovascular disease, dementia and chronic pulmonary disease. Age （HR： 1.081, 95% CI： 1.044-1.119; P 〈 001）, CCI （HR： 1.651, 95% CI： 1.286-2.121, P 〈 001） and eGFR 〈 45 mL/min per 1.73 m2 （HR： 1.360, 95% CI： 1.024-1.806; P = 0.033） were predictors of death. Conclusions Renal dysftmction, as well as comorbidity, impacts negatively survival of older adults treated with pacemaker implantation because of bradyarrhythmias.

关键词： Bradyarrhythmias Charlson comorbidity index Chronic kidney disease Comorbidity Glomerular filtration rate Mortality Pacemaker

The interplay of drug therapeutics and immune responses to SARS-CoV-2

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2024年第2期21卷 197-200页

作者： Valeria Fumagalli matteo Iannacone Division of Immunology Transplantationand Infectious DiseasesIRCCS San Raffaele Scientific InstituteMilanItaly Vita-Salute San Raffaele University MilanItaly Experimental Imaging Centre IRCCS San Raffaele Scientific InstituteMilanItaly

The SARS-CoV-2 pandemic has necessitated rapid therapeutic and preventative *** vaccines form the frontline of defense,antiviral treatments such as nirmatrelvir have emerged as vital adjunctive measures,particularly for those unable or unwilling to be *** review delves into the potential influence of nirmatrelvir on enduring *** parallel,the potential of drug repurposing is explored,with bisphosphonates being examined for their possible effects against COVID-19 due to their immunomodulatory *** importance of rigorous clinical trials and careful interpretation of preliminary data is emphasized.

关键词： SARS-CoV-2 Nirmatrelvir Bisphosphonates Adaptive immunity Drug repurposing

CUBE, a Cable-driven Device for Limb Rehabilitation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Bionic Engineering 2019年第3期16卷 492-502页

作者： Daniele Cafolla matteo Russo Giuseppe Carbone IRCCS Neuromed Via delFelettronica 86077 Pozzilli IS Italy University of Nottingham Advanced Manufacturing Building C47 Nottingham NG8 IBB UK DIMEG University of Calabria Via Bucci Cubo 46C 87036 Rende Italy CESTER Technical University of Cluj-Napoca MunciiAve. 103-105 400641 Cluj-Napoca Romania

In this paper, a novel cable-driven parallel robot, CUBE, is introduced for the assistance of patients in rehabilitation exercising of both upper and lower limbs. The system is characterized by a lightweight structure that is easy to set-up and operate, for both clinical and home usage for both pre-determined and customized exercises, with control over the position of the end-effector while locking its rotation around the horizontal axes. Its cable-driven design makes it inherently safe in human/robot interactions also due to the extremely low inertia. While a novel end-effector design makes the device wearable both on the upper and lower limbs without having to disassemble any part of the structure. The design is presented with its kinematic analysis. Then, the manufacturing through 3D?printing and commercial components of a first prototype is reported. Finally, the system is validated through motion tests along simple trajectories and two different spatial exercises.

关键词： cable-driven robots medical robots parallel robots rehabilitation devices

Liver function impairment in liver transplantation and after extended hepatectomy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2013年第44期19卷 7922-7929页

作者： matteo Serenari matteo Cescon Alessandro Cucchetti Antonio Daniele Pinna General Surgery and Transplant Unit Department of Medical and Surgical Sciences Alma Mater Studiorum-University of Bologna 40138 Bologna Italy

Extended hepatectomy,or liver transplantation of reduced-size graft,can lead to a pattern of clinical manifestations,namely"post-hepatectomy liver failure"and"small-for-size syndrome"respectively,that can range from mild cholestasis to irreversible organ non-function and death of the *** mechanisms are involved in their occurrence but in the recent past,high portal blood flow through a relatively small liver vascular bed has taken a central ***,several techniques of inflow modulation have been attempted in cases of portal hyperperfusion first in liver transplantation,such as portocaval shunt,mesocaval shunt,splenorenal shunt,splenectomy or ligation of the splenic ***,high portal flow is not the only factor responsible,and before major liver resections,preoperative assessment of the residual liver function is *** such as portal vein embolization or portal vein ligation can be adopted to increase the future liver volume,preventing posthepatectomy liver *** recently,a new surgical procedure,that combines in situ splitting of the liver and portal vein ligation,has gradually come to light,inducing remarkable hypertrophy of the healthy liver in just a few *** studies are needed to confirm this hypothesis and overcome one of the biggest issues in the field of liver surgery.

关键词： Small-for-size syndrome Liver transplantation Extended hepatectomy Liver failure Cirrhosis

The impact of extent of pancreatic and venous resection on survival for patients with pancreatic cancer

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Hepatobiliary & Pancreatic Diseases International 2019年第4期18卷 389-394页

作者： matteo Serenari Giorgio Ercolani Alessandro Cucchetti matteo Zanello Enrico Prosperi Guido Fallani Michele Masetti Raffaele Lombardi matteo Cescon Elio Jovine Department of Medical and Surgical Sciences S.Orsola-Malpighi HospitalAlma Mater Studiorum-University of BolognaBolognaItaly Department of General Surgery Maggiore Hospital-Bologna Local Health DistrictBolognaItaly

Background:Borderline resectable pancreatic cancer may require extended resections in order to achieve tumor-free margins,especially in the case of up-front resections,but it is important to know the limits of surgical therapy in this *** study aimed to investigate the impact of extent of pancreatic and venous resection on short-and long-term outcomes in patients with pancreatic adenocarcinoma(PDAC).Methods:This was a retrospective study from a prospectively maintained database of pancreatic resections for ***-and long-term outcomes were analyzed in patients having borderline resectable PDAC submitted to up-front total pancreatectomy(TP)or pancreaticoduodenectomy(PD)with simultaneous portal vein(PV)and/or superior mesenteric vein(SMV)*** resections were carried out as tangential venous resection(TVR)or segmental venous resection(SVR).Patients were divided into 4 groups:(1)PD+TVR,(2)PD+SVR,(3)TP+TVR,(4)TP+***-and multivariate Cox regression analysis were performed to identify factors associated with ***:Ninety-nine patients were submitted to simultaneous pancreatic and venous resection for *** them,25 were submitted to PD+TVR(25.3%),12 to PD+SVR(12.1%),23 to TP+TVR(23.2%),and 39 to TP+SVR(39.4%).Overall,major morbidity(Clavien-Dindo grade≥IIIA)was 26.3%.Thirty-and 90-day mortality were 3%and 11.1%,*** were no significant differences among groups in terms of short-term *** overall survival of patients submitted to PD+TVR was significantly higher than those to TP+SVR(29.5 vs 7.9 months,P=0.001).Multivariate analysis identified TP(HR=2.11;95%CI:1.31–3.44;P=0.002)and SVR(HR=2.01;95%CI:1.27–3.15;P=0.003)as the only independent prognostic factors for overall ***:Up-front TP associated to SVR was predictive of worse survival in borderline resectable *** treatments in high-risk surgical groups may improve such poor outcomes.

关键词： Pancreatic resection Vascular resection Pancreatic cancer surgery

Recent Advances in the Synthesis and Polymerization of New CO_(2)-Based Cyclic

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Chemistry 2024年第4期42卷 430-443页

作者： matteo Lanzi Arjan W.Kleij Institute of Chemical Research of Catalonia(ICIQ) The Barcelona Institute of Science and Technology(BIST)Av.Països Catalans 1643007 TarragonaSpain Catalan Institute of Research and Advanced Studies(ICREA) Pg.Lluís Companys 2308010 BarcelonaSpain

Carbon dioxide can be converted into functional heterocycles known as cyclic carbonates,whose recent reactivity has been expanded towards the formation of tailor-made engineering *** minireview gives an overview of the most topical developments in this area with a special focus on the synthetic methods employed to prepare these CO_(2)based *** addition,their application potential in the area of polymer science using a variety of polymerization techniques is discussed that have in common the ring-opening of the carbonate *** perspectives are provided that provide impetus for the scientific communities aligning research to the use of sustainable processes for polymers from recyclable carbon sources such as CO_(2).

关键词： Carbon dioxide Cyclic carbonates Functional macromolecules Heterocycles Polycarbonates Recycling Ring opening polymerization

Liver Lesions at Risk of Transformation into Hepatocellular Carcinoma in Cirrhotic Patients:Hepatobiliary Phase Hypointense Nodules without Arterial Phase Hyperenhancement

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Clinical and Translational Hepatology 2024年第1期12卷 100-112页

作者： NicolòBrandi matteo Renzulli Department of Radiology IRCCS Azienda Ospedaliero-Universitaria di BolognaBolognaItaly

Recent technical advances in liver imaging and surveillance for patients at high risk for developing hepatocellular carcinoma(HCC)have led to an increase in the detection of borderline hepatic nodules in the gray area of multistep carcinogenesis,particularly in those that are hypointense at the hepatobiliary phase(HBP)and do not show arterial phase *** their potential to transform and advance into hypervascular HCC,these nodules have progressively attracted the interest of the scientific *** date,however,no shared guidelines have been established for the decision management of these borderline hepatic *** is therefore extremely important to identify features that indicate the malignant potential of these nodules and the likelihood of *** fact,a more complete knowledge of their history and evolution would allow outlining shared guidelines for their clinical-surgical management,to implement early treatment programs and decide between a preventive curative treatment or a watchful *** review aims to summarize the current knowledge on hepatic borderline nodules,particularly focusing on those imaging features which are hypothetically correlated with their malignant evolution,and to discuss current guidelines and ongoing management in clinical practice.

关键词： Nonhypervascular hypointense nodule Hepatocellular carcinoma Magnetic resonance imaging Gd-EOB Liver

Numerical Entropy andAdaptivity for FiniteVolume Schemes

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Communications in Computational Physics 2011年第10期10卷 1132-1160页

作者： Gabriella Puppo matteo Semplice Dipartimento di Matematica Politecnico di TorinoCorso Duca degli Abruzzi 2410129 TorinoItalia Dipartimento di Fisica e Matematica Universit`a dell’InsubriaVia Valleggio 1122100 ComoItalia

We propose an a-posteriori error/smoothness indicator for standard semidiscrete finite volume schemes for systems of conservation laws,based on the numerical production of *** idea extends previous work by the first author limited to central finite volume schemes on staggered *** prove that the indicator converges to zero with the same rate of the error of the underlying numerical scheme on smooth flows under grid *** construct and test an adaptive scheme for systems of equations in which the mesh is driven by the entropy *** adaptive scheme uses a single nonuniform grid with a variable *** show how to implement a second order scheme on such a space-time non uniform grid,preserving accuracy and conservation *** also give an example of a p-adaptive strategy.

关键词： Finite volume schemes hyperbolic systems local grid refinement entropy

Modeling cells spreading,motility,and receptors dynamics:a general framework

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Mechanica Sinica 2021年第6期37卷 1013-1030,I0003页

作者： Mattia Serpelloni matteo Arricca Claudia Bonanno Alberto Salvadori Universitàdegli Studi di Brescia DIMI-The Mechanobiology research center at UNIBS-Brescia25123BresciaItaly Universitàdegli Studi di Brescia DRIMI-The Mechanobiology research center at UNIBS-Brescia25123BresciaItaly Universitàdegli Studi di Brescia DICACIM-The Mechanobiology research center at UNIBS-Brescia25123BresciaItaly

The response of cells during spreading and motility is dictated by several multi-physics events,which are triggered by extracellular cues and occur at different *** this sake,it is not completely appropriate to provide a cell with classical notions of the mechanics of materials,as for“rheology”or“mechanical response”.Rather,a cell is an alive system with constituents that show a reproducible response,as for the contractility for single stress fibers or for the mechanical response of a biopolymer actin network,but that reorganize in response to external cues in a non-exactly-predictable and reproducible *** of such complexity,in this note we aim at formulating a multi-physics framework for modeling cells spreading and motility,accounting for the relocation of proteins on advecting lipid membranes.

关键词： Mechanobiology Receptor dynamics Cell motility