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Advances in Manufacturing 2019年第2期7卷 155-173页

作者： Kedarnath Rane matteo Strano Department of Mechanical Engineering Politecnico di Milano Via La Masa 1 Milan Italy

The extrusion-based additive manufacturing (EAM) technique is recently being employed for rapid production of metals and ceramic components. This technique involves extruding the metal or ceramic material in solid powder form mixed with a binder (i.e., an expendable viscous fluid), which is removed from the part after 3D printing. These technologies rely on the large design freedom allowed and the cost efficiency advantage over alternative metal additive manufacturing processes that are based on high energy beams, such as laser or electron beams. The EAM of metals and ceramics is not yet widespread, but published scientific and technical literature on it is rapidly growing. However, this literature is still less extensive than that on the fused deposition modeling (FDM) of plastics or the selective laser melting (SLM) of metals. This paper aims at filling this gap. FDM and powder injection molding are identified as preceding or enabling technologies for EAM. This paper systematically reviews all aspects of the feedstock EAM processes used for production of complex-shaped parts. The unique characteristics and advantages of these processes are also discussed with respect to materials and process steps. In addition, the key process parameters are explained to illustrate the suitability of the EAM process for diverse application domains.

关键词： Feedstock extrusion Rapid production Complex-shaped metallic Ceramic parts

Mechatronic Design of a Robot for Upper Limb Rehabilitation at Home

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Journal of Bionic Engineering 2021年第4期18卷 857-871页

作者： Elio matteo Curcio Giuseppe Carbone Department of Mechanical Energyand Management EngineeringUniversity of Calabria Via BucciCubo 46C87036 RendeItaly

This paper addresses the design of a novel bionic robotic device for upper limb rehabilitation tasks at *** main goal of the design process has been to obtain a rehabilitation device,which can be easily portable and can be managed remotely by a professional *** allows to treat people also in regions that are not easily reachable with a significant cost *** potential benefits can be envisaged,for instance,in the possibility to keep social distancing while allowing rehabilitation treatments even during a pandemic *** attention has been devoted to design the main mechatronic components by developing specific kinematics and dynamics *** design process includes the implementation of a specific control hardware and *** experimental tests are reported to show the effectiveness and feasibility of the proposed design solution.

关键词： bionic robot design simulations parallel robots upper limb rehabilitation

On the formation of Basu’s Type Ⅲ(peeled orange) gunshot residues

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Defence Technology（防务技术） 2019年第1期15卷 23-26页

作者： Felice Nunziata matteo Donghi the Chartered Society of Forensic Science Arma dei Carabinieri Reparto Investigazioni Scientifiche

In a famous paper published in 1982, a very special class of gunshot residue particles(GSR) was named by Samarendra Basu "peeled orange", due to their particular structure, consisting of a barium/antimony core covered by an outer lead leaflet. In this class of GSR particles the surface may show nodular structures of lead. Basu proposed an explanation in terms of a nucleus of antimony and barium that captures lead vapours produced after the explosion of a cartridge into a firearm: as solidification points of antimony and barium are close one another, both higher than solidification point of lead, he stated that lead occurs as a layer around the core in peeled orange GSR particles. In this paper we study the thermodynamic of the barium/antimony alloy and we hypothesize a formation process in terms of colloidal metal growth, charged particles and electrostatic attraction. We propose an updated model of formation for peeled orange GSR particles that explains the existence of outer lead leaflet and nodules in terms of electrostatic attraction of lead nanoparticles and instability of lead droplets.

关键词： Peeled orange particles GSR CDR Charged particles Electrostatic attraction Rayleigh droplet stability

Monoacylglycerol lipase reprograms lipid precursors signaling in liver disease

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World Journal of Gastroenterology 2020年第25期26卷 3577-3585页

作者： matteo Tardelli Division of Gastroenterology and Hepatology Joan and Sanford I Weill Cornell Department of MedicineWeill Cornell Medical CollegeNew YorkNY 10021United States Hans Popper Laboratory of Molecular Hepatology Division of Gastroenterology and HepatologyInternal Medicine IIIMedical University of ViennaVienna 1040Austria

Dietary oversupply of triglycerides represent the hallmark of obesity and connected complications in the liver such as non-alcoholic fatty liver disease and non-alcoholic steatohepatitis,which eventually progress to cirrhosis and hepatocellular *** lipase is the last enzymatic step in the hydrolysis of triglycerides,generating glycerol and fatty acids(FAs),which are signaling precursors in physiology and ***,monoacylglycerol lipase(MGL)also hydrolyzes 2-arachidonoylglycerol,which is a potent ligand within the endocannabinoid system,into arachidonic acid-a precursor for prostaglandin synthesis;thus representing a pivotal substrates provider in multiple organs for several intersecting biological pathways ranging from FA metabolism to inflammation,pain and *** inhibition has been shown protective in limiting several liver diseases as FAs may drive hepatocyte injury,fibrogenesis and de-activate immune cells,however the complexity of MGL network system still needs further and deeper *** present review will focus on MGL function and FA partitioning in the horizons of liver disease.

关键词： Lipid metabolism Monoacylglycerol lipase Non-alcoholic steatohepatitis Non-alcoholic fatty liver disease Cannabinoid Nuclear receptors

Ultrasonically sculpted virtual relay lens for in situ microimaging

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Light(Science & Applications) 2019年第1期8卷 596-610页

作者： matteo Giuseppe Scopelliti Maysamreza Chamanzar Department of Electrical and Computer Engineering Carnegie Mellon University5000 Forbes AvenuePittsburghPA 15213USA Carnegie Mellon Neuroscience Institute Carnegie Mellon University5000 Forbes AvenuePittsburghPA 15213USA Center for the Neural Basis of Cognition Carnegie Mellon University4400 Forbes AvenuePittsburghPA 15213USA

We demonstrate in situ non-invasive relay imaging through a medium without inserting physical optical *** show that a virtual optical graded-index(GRIN)lens can be sculpted in the medium using in situ reconfigurable ultrasonic interference patterns to relay images through the *** wave patterns change the local density of the medium to sculpt a graded refractive index pattern normal to the direction of light propagation,which modulates the phase front of light,causing it to focus within the medium and effectively creating a virtual relay *** demonstrate the in situ relay imaging and resolving of small features(22μm)through a turbid medium(optical thickness=5.7 times the scattering mean free path),which is normally *** focal distance and the numerical aperture of the sculpted optical GRIN lens can be tuned by changing the ultrasonic wave *** an example,we experimentally demonstrate that the axial focal distance can be continuously scanned over a depth of 5.4mm in the modulated medium and that the numerical aperture can be tuned up to 21.5%.The interaction of ultrasonic waves and light can be mediated through different physical media,including turbid media,such as biological tissue,in which the ultrasonically sculpted GRIN lens can be used for relaying images of the underlying structures through the turbid medium,thus providing a potential alternative to implanting invasive endoscopes.

关键词： scattering virtual graded

Refining selection criteria to further increase survival benefit in liver transplantation for unresectable colorectal liver metastases

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Hepatobiliary Surgery and Nutrition 2020年第4期9卷 490-492页

作者： matteo Serenari matteo Ravaioli General Surgery and Transplant Unit Department of Medical and Surgical SciencesUniversity of BolognaBolognaItaly

Liver transplantation(LT)for hepatocellular carcinoma(HCC)was characterized in its early experience by high recurrence rates due to extensive tumor burden(1).Only after the adoption of Milan criteria(2),LT was recognized as a standard treatment for HCC(3).Besides HCC,other hepatic malignancies were proposed to be treated in the past with LT but due to the poor results observed(4),these indications were *** them,colorectal liver metastases(CRLM)were considered an absolute contraindication until recently.

关键词： colorectal metastases absolute

Fruit ripeness classification:A survey

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Artificial Intelligence in Agriculture 2023年第1期7卷 44-57页

作者： matteo Rizzo matteo Marcuzzo Alessandro Zangari Andrea Gasparetto Andrea Albarelli Ca’Foscari Department of Environmental Sciences Informatics and StatisticsVia Torino 155Mestre(VE)30172Italy Ca’Foscari Department of Management Cannaregio 873Fondamenta San GiobbeVenice 30121Italy

Fruit is a key crop in worldwide agriculture feeding millions of *** standard supply chain of fruit products involves quality checks to guarantee freshness,taste,and,most of all,*** important factor that determines fruit quality is its stage of *** is usually manually classified by field experts,making it a labor-intensive and error-prone ***,there is an arising need for automation in fruit ripeness *** automatic methods have been proposed that employ a variety of feature descriptors for the food item to be *** learning and deep learning techniques dominate the top-performing ***,deep learning can operate on raw data and thus relieve the users from having to compute complex engineered features,which are often *** this survey,we review the latest methods proposed in the literature to automatize fruit ripeness classification,highlighting the most common feature descriptors they operate on.

关键词： Fruit ripeness classification Machine learning Deep learning

Impact of chronic kidney disease on mortality in older adults treated with pacemaker implantation

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Journal of Geriatric Cardiology 2017年第10期14卷 597-603页

作者： Fabio Fabbian Alfredo De Giorgi matteo Guarino Michele Malagu matteo Bertini Department of Medical Sciences Clinical Medical Unit University Hospital St. Anna University of Ferrara Ferrara Italy Department of Medical Sciences Cardiology Unit University Hospital St. Anna University of Ferrara Ferrara Italy

Objective To investigate whether chronic kidney disease could negatively impact survival in older adults needing pacemaker implantation after admission for bradyarrhythmias. Methods This retrospective observational study considered 538 older adults consecutively admitted, who had been followed-up for 31 ± 20 months. Subjects with poor short-term prognosis were excluded. Charlson comorbidity index （CCI） and estimated glomerular filtration rate （eGFR） was calculated, along with the independent relationship between all-cause mortality and clinical data. Hazard Ratio （HR） was calculated by Cox regression analysis. Results Mean age of the population was 85 ± 3.7 years, and causes for implantation were atrioventricular block in 51.9% and other bradyarrhythmias in 48.1% of cases. Mean eGFR was 58.3 ± 24 mL/min per 1.73 m2, and mean CCI was 3.65 ± 2.28. Death for all-causes was recorded in 213 subjects. Deceased patients were older, had lower eGFR, higher comorbidity, higher prevalence of myocardial infarction, congestive heart failure, cerebrovascular disease, dementia and chronic pulmonary disease. Age （HR： 1.081, 95% CI： 1.044-1.119; P 〈 001）, CCI （HR： 1.651, 95% CI： 1.286-2.121, P 〈 001） and eGFR 〈 45 mL/min per 1.73 m2 （HR： 1.360, 95% CI： 1.024-1.806; P = 0.033） were predictors of death. Conclusions Renal dysftmction, as well as comorbidity, impacts negatively survival of older adults treated with pacemaker implantation because of bradyarrhythmias.

关键词： Bradyarrhythmias Charlson comorbidity index Chronic kidney disease Comorbidity Glomerular filtration rate Mortality Pacemaker

The interplay of drug therapeutics and immune responses to SARS-CoV-2

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Cellular & Molecular Immunology 2024年第2期21卷 197-200页

作者： Valeria Fumagalli matteo Iannacone Division of Immunology Transplantationand Infectious DiseasesIRCCS San Raffaele Scientific InstituteMilanItaly Vita-Salute San Raffaele University MilanItaly Experimental Imaging Centre IRCCS San Raffaele Scientific InstituteMilanItaly

The SARS-CoV-2 pandemic has necessitated rapid therapeutic and preventative *** vaccines form the frontline of defense,antiviral treatments such as nirmatrelvir have emerged as vital adjunctive measures,particularly for those unable or unwilling to be *** review delves into the potential influence of nirmatrelvir on enduring *** parallel,the potential of drug repurposing is explored,with bisphosphonates being examined for their possible effects against COVID-19 due to their immunomodulatory *** importance of rigorous clinical trials and careful interpretation of preliminary data is emphasized.

关键词： SARS-CoV-2 Nirmatrelvir Bisphosphonates Adaptive immunity Drug repurposing

CUBE, a Cable-driven Device for Limb Rehabilitation

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Journal of Bionic Engineering 2019年第3期16卷 492-502页

作者： Daniele Cafolla matteo Russo Giuseppe Carbone IRCCS Neuromed Via delFelettronica 86077 Pozzilli IS Italy University of Nottingham Advanced Manufacturing Building C47 Nottingham NG8 IBB UK DIMEG University of Calabria Via Bucci Cubo 46C 87036 Rende Italy CESTER Technical University of Cluj-Napoca MunciiAve. 103-105 400641 Cluj-Napoca Romania

In this paper, a novel cable-driven parallel robot, CUBE, is introduced for the assistance of patients in rehabilitation exercising of both upper and lower limbs. The system is characterized by a lightweight structure that is easy to set-up and operate, for both clinical and home usage for both pre-determined and customized exercises, with control over the position of the end-effector while locking its rotation around the horizontal axes. Its cable-driven design makes it inherently safe in human/robot interactions also due to the extremely low inertia. While a novel end-effector design makes the device wearable both on the upper and lower limbs without having to disassemble any part of the structure. The design is presented with its kinematic analysis. Then, the manufacturing through 3D?printing and commercial components of a first prototype is reported. Finally, the system is validated through motion tests along simple trajectories and two different spatial exercises.

关键词： cable-driven robots medical robots parallel robots rehabilitation devices