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Role of gut microbiota-immunity axis in patients undergoing surgery for colorectal cancer:Focus on short and long-term outcomes

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World Journal of Gastroenterology 2020年第20期26卷 2498-2513页

作者： Ilenia Bartolini matteo risaliti Maria Novella Ringressi Filippo Melli Giulia Nannini Amedeo Amedei Paolo Muiesan Antonio Taddei Department of Experimental and Clinical Medicine University of FlorenceFlorence 50134Italy

Human body is colonized by a huge amount of microorganisms mostly located in the gastrointestinal *** dynamic communities,the environment and their metabolites constitute the *** data suggests a causal role of a dysbiotic microbiota in several pathologies,such as metabolic and neurological disorders,immunity dysregulations and cancer,especially the well-studied colorectal cancer ***,many were preclinical studies and a complete knowledge of the pathogenetic mechanisms in humans is still *** gut microbiota can exert direct or indirect effects in different phases of colorectal cancer *** example,Fusobacterium nucleatum promotes cancer through cellular proliferation and some strains of Escherichia coli and Bacteroides fragilis produce ***,dysbiosis may also cause a proinflammatory state and the stimulation of a Th17 response with IL-17 and IL-22 secretion that have a pro-oncogenic activity,as demonstrated for Fusobacterium *** has a crucial role in several stages of postoperative course;dysbiosis in fact seems related with surgical site infections and Enterococcus faecalis(and other collagenase-producers microbes)are suggested as a cause of anastomotic ***,unbalanced presence of some species,together with altered immune response may also have a prognostic *** has also a substantial role in effectiveness of chemotherapy,chemoresistance and in the related side *** other words,a complete knowledge of the fine pathological mechanisms of gut microbiota may provide a wide range of new diagnostic tools other than therapeutic targets in the light of tailored medicine.

关键词： Intestinal microbiota Colorectal cancer Chemo-resistance Therapeutic strategies

Impact of microbiota-immunity axis in pancreatic cancer management

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World Journal of Gastroenterology 2022年第32期28卷 4527-4539页

作者： Ilenia Bartolini Giulia Nannini matteo risaliti Francesco Matarazzo Luca Moraldi Maria Novella Ringressi Antonio Taddei Amedeo Amedei Department of Experimental and Clinical Medicine HPB Surgery UnitAzienda Ospedaliero-Universitaria CareggiFlorence 50134Italy Department of Experimental and Clinical Medicine SOD of Interdisciplinary Internal MedicineAzienda Ospedaliera-Universitaria CareggiFlorence 50134Italy Division of Oncologic Surgery Department of OncologyCareggi University HospitalFirenze 50134Italy

The microbiota impact on human diseases is well-known,and a growing body of literature is providing evidence about the complex interplay between microbiotaimmune system-human physiology/pathology,including *** with the defined risk factors(e.g.,smoke habits,diet,diabetes,and obesity),the oral,gut,biliary,and intrapancreatic microbiota contribute to pancreatic cancer development through different pathways including the interaction with the immune ***,a great majority of the pancreatic cancer patients received a diagnosis in advanced stages not amenable to be radically treated and potentially *** the poor pancreatic cancer prognosis,complete knowledge of these complicated relationships could help researchers better understand the disease pathogenesis and thus provide early potential noninvasive biomarkers,new therapeutic targets,and tools for risk stratification that might result in greater therapeutic possibilities and eventually in a better and longer patient survival.

关键词： Gastrointestinal tumors Hepatopancreatobiliary tumors Pancreatic cancer Gut microbiota Dysbiosis Cancer development Carcinogenesis

Evaluation of prognostic factors and clinicopathological patterns of recurrence after curative surgery for colorectal cancer

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World Journal of Gastrointestinal Surgery 2021年第1期13卷 50-75页

作者： Filippo Melli Ilenia Bartolini matteo risaliti Rosaria Tucci Maria Novella Ringressi Paolo Muiesan Antonio Taddei Amedeo Amedei Department of Clinical and Experimental Medicine University of FlorenceAzienda Ospedaliero-Universitaria CareggiFlorence 50134Italy

BACKGROUND Colorectal cancer is a common tumor with a quite high-related *** the used curative treatments,patients will develop cancer recurrence in up to 50%of the cases and/or other primary *** most of the recurrences are discovered within 3 years from the first treatment,a small percentage is found after 5 *** early detection of recurrence is crucial to allow further therapies improving patients’*** follow-up programs have been developed but the optimal one is far from being *** To evaluation of potential prognostic factors for timing and patterns of recurrence in order to plan tailored follow-up *** Perioperative and long-term data of all consecutive patients surgically treated with curative intent,from January 2006 to June 2009,for colorectal adenocarcinoma,were retrospectively reviewed to find potential prognostic factors associated with:(1)Recurrence incidence;(2)Incidence of an early(within 3 years from surgery)or late recurrence;and(3)Different sites of *** addition,the incidence of other primary neoplasms has been evaluated in a cohort of patients with a minimum potential follow-up of 10 *** Our study included 234 *** median follow-up period has been 119±46.2 *** recurrence rate has been 25.6%.Patients with a higher chance to develop recurrence had also the following characteristics:Higher levels of preoperative glycemia and carcinoembryonic antigen,highest anaesthesiologists Score score,occlusion,received a complex operation performed with an open technique,after a longer hospital stay,and showed advanced *** independent prognostic factors for recurrence were the hospital stay,N stage 2,and M stage 1(multivariate analysis).Younger ages were significantly associated with an early recurrence *** that received intermediate colectomies or segmental resections,having an N stage 2 or American Joint Committee on Cancer stage 3 tumors were al

关键词： Prognostic factors Recurrence Recurrence patterns Colorectal cancer Longterm follow-up Follow-up programs

Evaluating the best treatment for multifocal hepatocellular carcinoma:A propensity score-matched analysis

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World Journal of Gastroenterology 2022年第29期28卷 3981-3993页

作者： matteo risaliti Ilenia Bartolini Claudia Campani Umberto Arena Carlotta Xodo Valentina Adotti Martina Rosi Antonio Taddei Paolo Muiesan Amedeo Amedei Giacomo Batignani Fabio Marra Department of Experimental and Clinical Medicine AOU CareggiFlorence 50134Italy

BACKGROUND Hepatocellular carcinoma(HCC)is a common tumour often diagnosed with a multifocal *** with multifocal HCC represent a heterogeneous *** Trans-Arterial ChemoEmbolization(TACE)is the most frequently employed treatment for these patients,previous data suggested that liver resection(LR)could be a safe and effective *** To compare LR and TACE in patients with multifocal HCC in terms of procedurerelated morbidity and oncologic *** All patients with multifocal HCC who underwent LR or TACE as the first procedure between May 2011 and March 2021 were *** decision to perform surgery or TACE was made after a multidisciplinary team *** patients in Child-Pugh class A or B7 and stage B(according to the Barcelona Clinic Liver Cancer staging system,without severe portal hypertension,vascular invasion,or extrahepatic spread)were included in the final *** score matching was used to adjust the baseline differences between patients undergoing LR and the TACE group[number and diameter of lesions,presence of cirrhosis,alpha-fetoprotein(AFP)levels,and Model for End-Stage Liver Disease score].The Kaplan-Meier method was used to estimate overall survival(OS)and disease-free survival(DFS).The outcomes of LR and TACE were compared using the log-rank *** After matching,30 patients were eligible for the final analysis,15 in each *** rates were 42.9% and 40% for LR and TACE,respectively(P=0.876).Median OS was not different in the LR and TACE groups(53 mo vs 18 mo,P=0.312),while DFS was significantly longer with LR(19 mo vs 0 mo,P=0.0001).Subgroup analysis showed that patients in the Italian Liver Cancer(***)B2 stage,with AFP levels lower than 400 ng/mL,less than 3 lesions,and lesions bigger than 41 mm,benefited more from LR in terms of *** classified as *** B3,with AFP levels higher than 400 ng/mL and with more than 3 lesions,appeared to receive more benefi

关键词： Hepatocellular carcinoma Multifocal hepatocellular carcinoma Liver resection Trans-arterial chemoembolization Guidelines Liver tumour management

Phosphodiesterase 9 localization in cytoplasm and nucleus:the gateway to selective targeting in neuroprotection?

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Neural Regeneration Research 2025年第6期20卷 1701-1702页

作者： Giovanni Ribaudo matteo Giannangeli Margrate Anyanwu Alessandra Gianoncelli Department of Molecular and Translational Medicine University of BresciaBresciaItaly

The umbrella term"neurodege ne rative disorders"(NDDs) refers to several conditions characterized by a progressive loss of structure and function of cells belonging to the nervous *** diseases affect more than 50million people *** disorders are characterized by sundry factors and pathophysiological mechanisms that a re challenging to be fully *** of these rely on cell signaling pathways to preserve homeostasis,involving second messengers such as cyclic adenosine monophosphate (cAMP)and cyclic guanosine 3',5'-monophosphate(cGMP).Their ability to control the duration and amplitude of the signaling cascade is given by the presence of several common and uncommon *** kinases A and G (PKA and PKG),phosphodiesterases (PDEs),and scaffold proteins are among them.

关键词： gateway homeostasis preserve

Pros and cons of liver transplantation in human immunodeficiency virus infected recipients

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World Journal of Gastroenterology 2014年第18期20卷 5353-5362页

作者： Umberto Baccarani Elda Righi Gian Luigi Adani Dario Lorenzin Alberto Pasqualucci matteo Bassetti Andrea risaliti Liver Transplant Unit Department of Medical and Biological SciencesUniversity Hospital of Udine33100 UdineItaly Division of Infectious Disease University Hospital of Udine33100 UdineItaly Department of Anaesthesiology University of Perugia33100 UdineItaly

Before the introduction of combined highly active antiretroviral therapy, a positive human immunodeficiency virus (HIV) serological status represented an absolute contraindication for solid organ transplant (SOT). The advent of highly effective combined antiretroviral therapy in 1996 largely contributed to the increased demand for SOT in HIV-positive individuals due to increased patients’ life expectancy associated with the increasing prevalence of end-stage liver disease (ESLD). Nowadays, liver failure represents a frequent cause of mortality in the HIV-infected population mainly due to coinfection with hepatitis viruses sharing the same way of transmission. Thus, liver transplantation (LT) represents a reasonable approach in HIV patients with stable infection and ESLD. Available data presently supports with good evidence the practice of LT in the HIV-positive population. Thus, the issue is no longer “whether it is correct to transplant HIV-infected patients”, but “who are the patients who can be safely transplanted” and “when is the best time to perform LT”. Indeed, the benefits of LT in HIV-infected patients, especially in terms of mid- and long-term patient and graft survivals, are strictly related to the patients’ selection and to the correct timing for transplantation, especially when hepatitis C virus coinfection is present. Aim of this article is to review the pros and cons of LT in the cohort of HIV infected recipients.

关键词： Liver transplantation Human immunodeficiency virus/hepatitis C virus coinfection Hepatocellular carcinoma Immunosuppression

Measurement of strong phases, D-D mixing, and CP violation using quantum correlation at charm threshold

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Frontiers of physics 2016年第1期11卷 1-15页

作者： matteo Rama Sezione di Pisa dell'Istituto Nazionale di Fisica Nucleate Pisa Italy

We review the measurements of the D decay strong-phase parameters based on quantum-correlated D^0D^-0 pairs produced in the e^＋e^→（3770） →D^0D^-0 process, and we discuss their role in the measurements of Cabibbo-Kobayashi-Maskawa angle 7 and D-/9 mixing. In addition, we present estimates of the size of quantum-correlated datasets necessary to support the 7 and charm mixing measurements conducted at the LHCb and Belle Ⅱ experiments. Finally, we review the methods for measuring the D-D^- mixing and cP violation parameters at a high-luminosity charm factory, giving sensitivity estimates.

关键词： quantum correlation charm mixing CP violation

A machine learning approach to map crystal orientation by optical microscopy

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npj Computational Materials 2022年第1期8卷 70-78页

作者： Mallory Wittwer matteo Seita School of Mechanical and Aerospace Engineering Nanyang Technological UniversitySingaporeSingapore School of Materials Science and Engineering Nanyang Technological UniversitySingaporeSingapore

Mapping grain orientation in crystalline solids is essential to investigate the relationships between local microstructure and crystallography and interpret materials *** of the main techniques used to perform these studies is electron backscatter diffraction(EBSD).Due to the limited measurement throughput,however,EBSD is not suitable for characterizing samples with long-range microstructure heterogeneity,nor for building large material libraries that include numerous *** present a machine learning approach for high-throughput crystal orientation mapping,which relies on the optical technique called directional reflectance *** successfully apply our method on Inconel 718 specimens produced by additive manufacturing,which exhibit complex,spatially-varying *** results demonstrate that optical orientation mapping on a metal alloy is *** our method is data-driven,it can be easily extended to different alloy systems produced using different manufacturing processes.

关键词： alloy microstructure crystal

A comprehensive review of extrusion-based additive manufacturing processes for rapid production of metallic and ceramic parts

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Advances in Manufacturing 2019年第2期7卷 155-173页

作者： Kedarnath Rane matteo Strano Department of Mechanical Engineering Politecnico di Milano Via La Masa 1 Milan Italy

The extrusion-based additive manufacturing (EAM) technique is recently being employed for rapid production of metals and ceramic components. This technique involves extruding the metal or ceramic material in solid powder form mixed with a binder (i.e., an expendable viscous fluid), which is removed from the part after 3D printing. These technologies rely on the large design freedom allowed and the cost efficiency advantage over alternative metal additive manufacturing processes that are based on high energy beams, such as laser or electron beams. The EAM of metals and ceramics is not yet widespread, but published scientific and technical literature on it is rapidly growing. However, this literature is still less extensive than that on the fused deposition modeling (FDM) of plastics or the selective laser melting (SLM) of metals. This paper aims at filling this gap. FDM and powder injection molding are identified as preceding or enabling technologies for EAM. This paper systematically reviews all aspects of the feedstock EAM processes used for production of complex-shaped parts. The unique characteristics and advantages of these processes are also discussed with respect to materials and process steps. In addition, the key process parameters are explained to illustrate the suitability of the EAM process for diverse application domains.

关键词： Feedstock extrusion Rapid production Complex-shaped metallic Ceramic parts