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Data-driven drug repositioning using olfactory omics profiles:challenges and perspectives in neurodegeneration

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Neural Regeneration Research 2025年第7期20卷 1997-1998页

作者： paz Cartas-Cejudo Adriana Cortés Mercedes Lachén-Montes Elena Anaya-Cubero Joaquín Fernández-Irigoyen Enrique Santamaría Clinical Neuroproteomics Unit Proteomics PlatformNavarrabiomedHospitalario Universitario de Navarra(HUN)Universidad Pública de Navarra(UPNA)IdiSNANavarra Institute for Health ResearchPamplonaSpain

Data-driven drug repositioning using olfactory omics profiles-challenges and perspectives in neurodegeneration:Neurodegenerative diseases are characterized by progressive degeneration and loss of neuronal function in the central nervous *** diseases are often characterized as proteinopathies,which are disorders primarily driven by the aggregation or misfolding of specific amyloid proteins within cells,leading to their dysfunction and eventual *** the gain-of-function hypothesis related to the aggregation of these proteins,recently,an alternative hypothesis regarding the loss-of-function of the soluble monomeric proteins during the process of aggregation into amyloids is gaining *** last event is called proteinopenia and refers to conditions characterized by a deficiency or decrease in the levels of specific soluble proteins in the body(Ezzat et al.,2023).It has been demonstrated that levels of soluble proteins involved in neurodegenerative diseases are decreased.

关键词： diseases drug amyloid

Cattle change plant reproductive phenology,promoting community changes in a post-fire Nothofagus forest in northern Patagonia,Argentina

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Journal of Plant Ecology 2013年第6期6卷 459-467页

作者： Manuel de paz Estela Raffaele Laboratorio Ecotono INIBIOMACONICET-Universidad Nacional del ComahueQuintral 1250San Carlos de BarilocheRio Negro 8400Argentina

Aims Variations in rates and length of flowering and fruiting not only affect the reproduction of a given plant species but also the behavior and reproduction of associated *** and fruiting variations may be influenced by herbivory,especially by large *** aim of this study was to determine the effects of cattle browsing on the reproductive phenology of understory species in a subalpine post-fire Nothofagus forest in *** The effects of herbivory on plant reproductive phenology were studied in a set of experimental exclosures(fenced plots)installed since 2001 in a post-fire *** forest,located in Nahuel Huapi National Park(NHNP),*** monitored the beginning and duration of each reproductive phenological stage:floral bud,open flower,immature fruit and mature *** also counted the number of flowers,fruits,seeds and viable seeds of the dominant plants to assess whether browsing modifies temporal patterns of the flowering and fruiting *** Findings Cattle reduced the total number of species flowering and fruiting and changed the reproductive phenology of some *** found that palatable species seem to be negatively affected by browsing in terms of reduced fitness due to changes in flowering and fruiting *** contrast,cattle benefitted the reproduction of non-palatable species and could promote the invasion of shade-intolerant exotic forbs such as Cirsium *** effects of livestock reported in this study are important to understanding how browsing could alter native species establishment and possibly alter successional trajectories during recolonization after fire.

关键词： plant fitness livestock browsing flowering fruiting

Seismic Policy, Operations, and Research Uses for a Building Inventory in an Earthquake-Prone City

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International Journal of Disaster Risk Science 2020年第6期11卷 709-718页

作者： Ken Elwood Olga Filippova Ilan Noy Jacob Pastor paz School of Engineering The University of AucklandAuckland 1142New Zealand Business School The University of AucklandAuckland 1142New Zealand School of Economics Victoria University of WellingtonWellington 6140New Zealand

After the 2016 New Zealand Kaikoura Earthquake,the absence of information about the state of buildings in Wellington proved to be a source of significant policy *** did not know what damages to expect and therefore how to react,and policies needed to be formulated without a clear quantification of the ***,without detailed knowledge of the existing buildings,it was difficult to assess what the available legal and regulatory tools can achieve and choose among *** describe the creation of a building inventory database for Wellington initiated by the *** database aims to assist the generation of research on the risks,impacts,and viable solutions for reducing future seismic risk in Wellington’s central business district(CBD).The database includes structural,economic,and market information on virtually every significant building in the *** primary purposes are:to collate and provide the best available information about the expected seismic performance of the existing building stock;to assess the impact of possible multiple building failures due to a seismic event;to describe a viable cost-effective path for seismic retrofitting;and to inform the design of a regulatory structure that can facilitate this resilience-building agenda.

关键词： Building inventory Building standards Disaster risk assessment Earthquake-prone city Retrofit

Cell membrane and bioactive factors derived from mesenchymal stromal cells: Cell-free based therapy for inflammatory bowel diseases

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World Journal of Stem Cells 2019年第9期11卷 618-633页

作者： Fabiany da Costa Goncalves Ana Helena paz Nephrology and Transplantation Internal MedicineErasmus Medical CenterRotterdamGD 3015Netherlands Experimental Research Center Hospital de Clínicas de Porto AlegrePorto AlegreRS 90035-903Brazil

Inflammatory bowel diseases(IBD)are chronic inflammatory disorders of the gastrointestinal tract associated with multifactorial conditions such as ulcerative colitis and Crohn’s *** the underlying mechanisms of IBD remain unclear,growing evidence has shown that dysregulated immune system reactions in genetically susceptible individuals contribute to mucosal ***,conventional treatments have been effective in inducing remission of IBD but not in preventing the relapse of *** this way,mesenchymal stromal cells(MSC)therapy has been recognized as a promising treatment for IBD due to their immunomodulatory properties,ability to differentiate into several tissues,and homing to inflammatory *** so,literature is conflicted regarding the location and persistence of MSC in the body after *** this reason,recent studies have focused on the paracrine effect of the biofactors secreted by MSC,especially in relation to the immunomodulatory potential of soluble factors(cytokines,chemokines,and growth factors)and extracellular vehicles that are involved in cell communication and in the transfer of cellular material,such as proteins,lipids,and nucleic ***,treatment with interferon-γ,tumor necrosis factor-α,and interleukin-1βcauses MSC to express immunomodulatory molecules that mediate the suppression via cell-contact dependent *** together,we present an overview of the role of bioactive factors and cell membrane proteins derived from MSC as a cell-free therapy that can improve IBD treatment.

关键词： Bioactive factors Cell membrane Mesenchymal stem cells Cell-free therapy Inflammatory bowel diseases

Novel aspects of the apolipoprotein-E receptor family： regulation and functional role of their proteolytic processing

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Frontiers in Biology 2012年第2期7卷 113-143页

作者： Jorge A. LARIOS Maria-paz MARZOLO Laboratorio de Trafico lntracelular y Senalizacion Departamento de Biologla Celular y Molecular Pontifieia Universidad Catolica de Chile Alameda # 340 Santiago Chile Millenium Nucleus in Regenerative Biology （MINREB） Facultad de Ciencias Biol6gieas Pontificia Universidad Catolica de Chile Alameda # 340 Santiago Chile

Studies related to the functional and regulatory aspects of proteolytic processing are of interest to cell biologists, developmental biologists and investigators who work on human diseases. Much of what is known about this topic derives from the study of the proteolytic processing of the amyloid precursor protein （APP）, which is involved in the pathology of Alzheimer＇s disease, and of the Notch protein and its Delta ligand, which play roles during embryonic development and in biologic processes in the adult. The proteolytic processing of plasma membrane receptor proteins is under the control of different enzymes that are responsible for releasing the ectodomain into the extracellular environment, where it has the potential to function as a signaling molecule and/or regulate the availability of the receptor＇s ligand. Following shedding of the ectodomain, the y-secretase enzymatic complex cleaves the transmembrane domain and releases the cytoplasmic domain （ICD） of the receptor. The ICD can function in the cytoplasm and/or at the nucleus. Members of the low-density lipoprotein receptor （LDLR） family are cndocytic-signaling proteins that perform a wide variety of physiologic functions during development and in the adult life. In addition these receptors have been implicated in a variety of diseases in adults. The prototypic receptor for this family of proteins is the LDLR itself. Besides their binding to apolipoproteins, these receptors bind many ligands that are destined for internalization and degradation. Some ligands have signaling properties. The proteolytic processing of certain members of the LDLR family not only controls receptor availability at the cell surface but also has functional consequences that amplify the spectrum of roles that these receptors perform. In addition, many complex regulatory mechanisms control the proteolytie processing of these receptors.

关键词： ADAM APP LDLR LRP metalloproteinase secretase

Treatment of benign paroxysmal positional vertigo. A clinical review

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Journal of Otology 2017年第4期12卷 165-173页

作者： paz Perez-Vazquez Virginia Franco-Gutierrez ENT Department Hospital Universitario de Cabuenes Gijon Spain ENT Department Hospital Universitario Marques de Valdecilla Santander Spain

Benign paroxysmal positional vertigo(BPPV) is the most frequent episodic vestibular disorder. It is due to otolith rests that are free into the canals or attached to the cupulas. Well over 90% of patients can be successfully treated with manoeuvres that move the particles back to the utriculus. Among the great variety of procedures that have been described, the manoeuvres that are supported by evidenced-based studies or extensive series are commented in this review. Some topics regarding BPPV treatment, such as controlling the accuracy of the procedures or the utility of post-manoeuvre restrictions are also discussed.

关键词： Benign Paroxysmal Positional Vertigo Treatment Vestibular disorder

Stability of plane-parallel flow of magnetic fluids under external magnetic fields

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Applied Mathematics and Mechanics(English Edition) 2022年第2期43卷 295-310页

作者： P.Z.S.paz F.R.CUNHA Y.D.SOBRAL Department of Mathematics University of BrasíliaCampus Universitário Darcy RibeiroBrasília-DF70910-900Brazil Laboratory of Microhydrodynamics and Rheology-Vortex Group Department of Mechanical EngineeringUniversity of BrasíliaCampus Universitário Darcy RibeiroBrasília-DF70910-900Brazil

In this work,we present a theoretical study on the stability of a two-dimensional plane Poiseuille flow of magnetic fluids in the presence of externally applied magnetic *** fluids are assumed to be incompressible,and their magnetization is coupled to the flow through a simple phenomenological *** parameters are defined,and the equations are perturbed around the base *** eigenvalues of the linearized system are computed using a finite difference scheme and studied with respect to the dimensionless parameters of the *** examine the cases of both the horizontal and vertical magnetic *** obtained results indicate that the flow is destabilized in the horizontally applied magnetic field,but stabilized in the vertically applied *** characterize the stability of the flow by computing the stability diagrams in terms of the dimensionless parameters and determine the variation in the critical Reynolds number in terms of the magnetic ***,we show that the superparamagnetic limit,in which the magnetization of the fluids decouples from hydrodynamics,recovers the same purely hydrodynamic critical Reynolds number,regardless of the applied field direction and of the values of the other dimensionless magnetic parameters.

关键词： hydrodynamic stability magnetic fluid Orr-Sommerfeld equation magnetization evolution

Solving the inverse grating problem by white light interference Fourier scatterometry

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Light(Science & Applications) 2012年第1期1卷 17-23页

作者： Valeriano Ferreras paz Sandy Peterhansel Karsten Frenner Wolfgang Osten Institute of Applied Optics Stuttgart University70569 StuttgartGermany SCoPE—Stuttgart Research Center of Photonic Engineering Stuttgart UniversityStuttgartGermany

Scatterometry is a well-established,fast and precise optical metrology method used for the characterization of sub-lambda periodic *** Fourier scatterometry method,by analyzing the Fourier plane,makes it possible to collect the angle-resolved diffraction spectrum without any mechanical *** improve the depth sensitivity of this method,we combine it with white light *** show the exemplary application of the method on a silicon line *** characterize the sub-lambda features of the grating structures,we apply a model-based reconstruction approach by comparing simulated and measured *** simulations are based on the rigorous coupled-wave analysis method.

关键词： Fourier scatterometry inverse problem optical sub-lambda metrology RCWA white light interference

An analysis of key process parameters for hybrid manufacturing by material extrusion and CNC machining

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Bio-Design and Manufacturing 2018年第4期1卷 237-244页

作者： Ruben paz Javier Santamarta Mario D.Monzon Joshua Garcfa Eujin Pei Departamento de Ingenierfa Mecainica Universidad de Las Palmas de Gran CanariaLas Palmas de Gran Canaria 35017 Spain Institute of Materials and Manufacturing Brunel University LondonKingston LaneUxbridge UB83PHUK

Hybrid Manufacturing combines the advantages of Additive Manufacturing (AM)and Subtractive Manufacturing on a single *** previous research has provided a good background of the manufacturing parameters,the analysis is often carried out separately and there is a lack of combined *** purpose of this research is to examine the influence of the main manufacturing parameters involved in AM and subtracfive processes using different ***,the study is focused on the Material Extrusion process concerning the layer height,fill angle and fill density;as well as two factors related to machining,including stepover and pass *** parameters that were examined include the dimension,hardness, flatness,weight and roughness.A mulfifactofial Design of Experiments was proposed with a total of 64 ***,a statistical analysis was carried out to assess the influence of the different groups on the response ***,a decision table presented and facilitated the selection of parameters depending on the desired objectives,leading to a framework that was applied to a case study for *** decision guide could enable designers and engineers to select the best strategy for a specific application,leading to a more efficient approach for manufacturing.

关键词： Hybrid manufacturing Material extrusion Additive manufacturing Subtractive manufacturing ~Machining Statistical analysis