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Plant Communications 2024年第3期5卷 17-30页

作者： Noe´Perron matias Kirst Sixue Chen Plant Molecular and Cellular Biology Program University of FloridaGainesvilleFL 32608USA School of Forest Fisheries and Geomatics SciencesUniversity of FloridaGainesvilleFL 32603USA Department of Biology University of MississippiOxfordMS 38677-1848USA

Modern agricultural systems are directly threatened by global climate change and the resulting freshwater crisis.A considerable challenge in the coming years will be to develop crops that can cope with the conse-quences of declining freshwater resources and changing *** approach to meeting this chal-lenge may lie in our understanding of plant photosynthetic adaptations and water use *** from various taxa have evolved crassulacean acid metabolism(CAM),a water-conserving adaptation of photosynthetic carbon dioxidexation that enables plants to thrive under semi-arid or seasonally drought-prone *** past research on CAM has led to a better understanding of the inner workings of plant resilience and adaptation to stress,successful introduction of this pathway into C3 or C4 plants has not been *** recent revolution in molecular,systems,and synthetic biology,as well as innovations in high-throughput data generation and mining,creates new opportunities to uncover the minimum genetic tool kit required to introduce CAM traits into drought-sensitive ***,we pro-pose four complementary research avenues to uncover this tool ***,genomes and computational methods should be used to improve understanding of the nature of variations that drive CAM ***,single-cell’omics technologies offer the possibility for in-depth characterization of the mecha-nisms that trigger environmentally controlled CAM ***,the rapid increase in new’omics data enables a comprehensive,multimodal exploration of ***,the expansion of functional geno-mics methods is paving the way for integration of CAM into farming systems.

关键词： CAM photosynthesis single-cell genomics phylogenetics crop engineering synthetic biology stress resilience

Generation of lossy mode resonances(LMR)using perovskite nanofilms

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Opto-Electronic Advances 2024年第2期7卷 33-40页

作者： Dayron Armas Ignacio R.matias M.Carmen Lopez-Gonzalez Carlos Ruiz Zamarreño Pablo Zubiate Ignacio del Villar Beatriz Romero Electrical Electronic and Communications Engineering DepartmentPublic University of NavarraPamplona 31006Spain Institute of Smart Cities(ISC) Public University of NavarraPamplona 31006Spain Experimental Science and Technology School Rey Juan Carlos UniversityMostoles 28933Spain

The results presented here show for the first time the experimental demonstration of the fabrication of lossy mode resonance(LMR) devices based on perovskite coatings deposited on planar waveguides. Perovskite thin films have been obtained by means of the spin coating technique and their presence was confirmed by ellipsometry, scanning electron microscopy, and X-ray diffraction testing. The LMRs can be generated in a wide wavelength range and the experimental results agree with the theoretical simulations. Overall, this study highlights the potential of perovskite thin films for the development of novel LMR-based devices that can be used for environmental monitoring, industrial sensing, and gas detection, among other applications.

关键词： perovskite thin films slab waveguide lossy mode resonance

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无弹性物质参与的密封是未来的趋势

流程工业 2024年第4期 14-17页

作者： Harry Jost Anja Quattelbaum Matthias Dörr NEUMO GmbH+Co.KG

即将实施的PFAS(全氟和多氟烷基化合物)禁令以及更严格的TA Luft(空气清洁技术标准)排放限值,是当前困扰着化工和生命科学行业从业者的两大热门话题。这使得管道连接如何能够实现安全密封并符合法规要求成为焦点问题。本文描述了制药、... 详细信息

即将实施的PFAS(全氟和多氟烷基化合物)禁令以及更严格的TA Luft(空气清洁技术标准)排放限值,是当前困扰着化工和生命科学行业从业者的两大热门话题。这使得管道连接如何能够实现安全密封并符合法规要求成为焦点问题。本文描述了制药、生物科技、食品和化工及氢能领域在这样的政策环境下所面临的问题,并给出了解决方案。此外,本文还特别介绍了不含弹性密封材料的管道连接件,并强调了无弹性物质参与的密封是未来的趋势。

关键词：连接件密封交叉污染

Islands of misfit buildings: Detecting uncharacteristic electricity use behavior using load shape clustering

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Building Simulation 2021年第1期14卷 119-130页

作者： matias Quintana Pandarasamy Arjunan Clayton Miller National University of Singapore SingaporeSingapore Berkeley Education Alliance for Research in Singapore(BEARS) SingaporeSingapore

Many energy performance analysis methodologies assign buildings a descriptive label that represents their main activity,often known as the primary space usage(PSU).This attribute comes from the intent of the design team based on assumptions of how the majority of the spaces in the building will be *** reality,the way a building’s occupants use the spaces can be different than what was *** the recent growth of hourly electricity meter data from the built environment,there is the opportunity to create unsupervised methods to analyze electricity consumption behavior to understand whether the PSU assigned is *** or oversimplification of the use of the building is possible using these labels when applied to simulation inputs or benchmarking *** work towards accurate characterization of a building’s utilization,we propose a modular methodology for identifying potentially mislabeled buildings using distance-based clustering analysis based on hourly electricity consumption *** method seeks to segment buildings according to their daily behavior and predict which ones are misfits according to their assigned PSU *** process finds potentially uncharacteristic behavior that could be an indication of mixed-use or a misclassified *** results on two public data sets,from the Building Data Genome(BDG)Project and Washington DC(DGS),with 507 and 322 buildings respectively,show that 26%and 33%of these buildings are potentially mislabelled based on their load shape *** information provides a more realistic insight into their true consumption characteristics,enabling more accurate simulation *** of this process and a discussion of limitations and reproducibility are included.

关键词： uncharasteristic behaviour building energy use building energy benchmarking building performance rating primary-use-type analysis load profile clustering

Modulation of cell physiology under hypoxia in pancreatic cancer

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World Journal of Gastroenterology 2021年第28期27卷 4582-4602页

作者： matias Estaras Antonio Gonzalez Department of Physiology Institute of Molecular Pathology BiomarkersUniversity of ExtremaduraCaceres 10003Spain Department of Physiology Cell Biology and Communication Research GroupUniversity of ExtremaduraCaceres 10003Spain

In solid tumors,the development of vasculature is,to some extent,slower than the proliferation of the different types of cells that form the tissue,both cancer and stroma *** a consequence,the oxygen availability is compromised and the tissue evolves toward a condition of *** presence of hypoxia is variable depending on where the cells are localized,being less extreme at the periphery of the tumor and more severe in areas located deep within the tumor ***,the cells do not *** pathways that are critical for cell fate such as endoplasmic reticulum stress,apoptosis,autophagy,and others are all involved in cellular responses to the low oxygen availability and are orchestrated by hypoxia-inducible *** stress and inflammation are critical conditions that develop under *** with changes in cellular bioenergetics,all contribute to cell ***,cell-to-cell interaction is established within the tumor such that cancer cells and the microenvironment maintain a bidirectional ***,the release of extracellular vesicles,or exosomes,represents short and long loops that can convey important information regarding invasion and *** a result,the tumor grows and its malignancy ***,one of the most lethal tumors is pancreatic *** paper reviews the most recent advances in the knowledge of how cells grow in a pancreatic tumor by adapting to *** the physiological processes that help the tumor increase its size and their regulation will be of major relevance for the treatment of this deadly tumor.

关键词： Hypoxia Cancer Tumor Pancreas Proliferation Cell survival

Light Perception:A Matter of Time

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Molecular Plant 2020年第3期13卷 363-385页

作者： Sabrina E.Sanchez matias L.Rugnone Steve A.Kay Department of Neurology Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCAUSA

Optimizing the perception of external cues and regulating physiology accordingly help plants to cope with the constantly changing environmental conditions to which they are *** array of photoreceptors and intricate signaling pathways allow plants to convey the surrounding light information and synchronize an endogenous timekeeping system known as the circadian *** biological clock integrates multiple cues to modulate a myriad of downstream responses,timing them to occur at the best moment of the day and the ***,the mechanism underlying entrainment of the light-mediated clock is not *** review addresses known interactions between the light-signaling and circadian-clock networks,focusing on the role of light in clock entrainment and known molecular players in this process.

关键词： circadian clock light signaling Arabidopsis thaliana light entrainment photoreceptors signal integration

Coxiella burnetii:living inside the host cell

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BIOCELL 2019年第1期43卷 1-6页

作者： Jesus Sebastian DISTEL Walter BERON Rodolfo matias ORTIZ FLORES Instituto de Histologia y Embriologia de Mendoza(IHEM) ONICETUniversidad Nacional de CuyoMendozaArgentina Facultad de Odontologia Universidad Nacional de CuyoMendozaArgentina

Coxiella burnetii is an obligate intracellular pathogen and the causative agent of Q *** this brief review,we describe how recently described mechanisms help our understanding of *** invasion and its survival in the host cell by the formation of a replicative niche:the Coxiella-containing *** describe the actin-associated proteins involved in the internalization of ***,and we discuss the contribution of diverse degradation pathways of the cell during the formation and stabilization of the Coxiella-containing vacuole.

关键词： Actin Coxiellosis Phagocytic pathway Q fever

Evaluation of disinfection byproducts for their ability to affect mitochondrial function

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Journal of Environmental Sciences 2022年第7期34卷 295-304页

作者： George William Kajjumba Rachael E.Bokota matias Attene-Ramos Erica J.Marti Department of Civil and Environmental Engineering University of NevadaLas VegasNVUSA Department of Environmental and Occupational Health Milken Institute School of Public HealthGeorge Washington UniversityWashington DCUSA

In the race to deliver clean water to communities through potable water reuse, disinfection and water quality assessment are and will continue to be fundamental factors. There are over 700 disinfection byproducts(DBPs) in water;evaluating each compound is practically impossible and very time consuming. A bioanalytical approach could be an answer to this challenge. In this work, the response of four major classes of DBPs toward mitochondrial membrane potential( Δψm) and cytoplasmic adenosine triphosphate(C-ATP) was investigated with human carcinoma(Hep G2) cells. Within 90 min of cell exposure, only the haloacetic acid(HAA) mixture caused a cytotoxic response as measured by C-ATP. All four groups(haloacetonitriles(HANs), trihalomethanes(THMs), nitrosamines(NOAs), and HAAs) responded well to Δψm, R 2 > 0.70. Based on the half-maximum concentration that evoked a 50% response in Δψm, the response gradient was HANs >> HAAs ~ THM > NOAs. The inhibition of the Δψm by HANs is driven by dibromoacetonitrile(DBAN), while dichloroacetonitrile(DCAN) did not cause a significant change in the Δψm at less than 2000 μM. A mixture of HANs exhibited an antagonistic behavior on the Δψm compared to individual compounds. If water samples are concentrated to increase HAN concentrations, especially DBAN, then Δψm could be used as a biomonitoring tool for DBP toxicity.

关键词： Disinfection byproducts Toxicity Mitochondrial membrane potential Dose-response curve In vitro bioassay Emerging contaminants

EpiMap: Fine-tuning integrative epigenomics maps to understand complex human regulatory genomic circuitry

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Signal Transduction and Targeted Therapy 2021年第6期6卷 1627-1629页

作者： Dave S.B.Hoon Negin Rahimzadeh matias A.Bustos Department of Translational Molecular Medicine Division of Molecular OncologySaint John’s Cancer Institute at Providence Saint John’s Health CenterSanta MonicaCAUSA

In a recent paper published in Nature,Boix et al.1 developed an integrated platform on epigenomic maps that represents a significant updated resource in human regulatory circuitry as related to specific organ tissues and cells,as well as specific disease *** EpiMap(for epigenome integration across multiple annotation projects)is a highly valuable compendium comprising 10,000 epigenomic maps across 833 biospecimens and 33 tissue *** distinct biospecimens expanding coverage to life development(embryonic to adult)and different sample types including complex organ tissues as well as primary cells,and established normal and tumor cell *** biospecimen analysis provides a comprehensive view of human genome circuitry making EpiMap a remarkable platform for epigenomic landscapes assessment to the investigator.

关键词： maps tuning Map