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Strategy for reliable identification of ischaemic stroke, thrombolytics and thrombectomy in large administrative databases

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Stroke & Vascular Neurology 2021年第2期6卷 194-200页

作者： Kori S Zachrison Sijia Li mathew j reeves Opeolu Adeoye Carlos A Camargo Lee H Schwamm Renee Y Hsia Department of Emergency Medicine Massachusetts General HospitalBostonMassachusettsUSA Department of Emergency Medicine Harvard Medical SchoolBostonMassachusettsUSA Department of Epidemiology and Biostatistics Michigan State UniversityEast LansingMichiganUSA University of Cincinnati CincinnatiOhioUSA Massachusetts General Hospital BostonMassachusettsUSA Department of Emergency Medicine University of California San FranciscoSan FranciscoCaliforniaUSA

Background Administrative data are frequently used in stroke *** accurate identification of patients who had an ischaemic stroke,and those receiving thrombolysis and endovascular thrombectomy(EVT)is critical to ensure representativeness and *** examined differences in patient samples based on mode of identification,and propose a strategy for future patient and procedure identification in large administrative *** We used non-public administrative data from the state of California to identify all patients who had an ischaemic stroke discharged from an emergency department(ED)or inpatient hospitalisation from 2010 to 2017 based on International Classification of Disease(ICD-9)(2010-2015),ICD-10(2015-2017)and Medicare Severity-Diagnosis-related Group(MS-DRG)discharge *** identified patients with interhospital transfers,patients receiving thrombolytics and patients treated with EVT based on ICD,Current Procedural Terminology(CPT)and MS-DRG *** determined what proportion of these transfers and procedures would have been identified with ICD versus MS-DRG discharge *** Of 365099 ischaemic stroke encounters,most(87.70%)had both a stroke-related ICD-9 or ICD-10 code and stroke-related MS-DRG code;12.28% had only an ICD-9 or ICD-10 code and 0.02% had only an MS-DRG *** all transfers(99.99%)were identified using ICD *** identified 32433 thrombolytic-treated patients(8.9% of total)using ICD,CPT and MS-DRG codes;the combination of ICD and CPT codes identified nearly all(98%).We identified 7691 patients treated with EVT(2.1%of total)using ICD and MS-DRG codes;both MS-DRG and ICD-9/ICD-10 codes were necessary because ICD codes alone missed 13.2%of *** codes only pertain to outpatient/ED patients and are not useful for EVT *** ICD-9/ICD-10 diagnosis codes capture nearly all ischaemic stroke encounters and transfers,while the combination of ICD-9/ICD-10 and CPT codes are adequate

关键词： thrombolytic diagnosis administrative

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脑缺血与缺血耐受

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国际脑血管病杂志 2006年第3期14卷 190+195-196页

作者： Daniel Zemke jeremy L.Smith mathew j.reeves Arshad Majid 孙明徐超 Fromthe Department of Neurology and Ophthalmology Michigan State UniversityEastLansingMI48824USA Neuroscience Program Michigan State UniversityEastLan-singMI48824USA Department of Epidemiology Michigan State UniversityEast LansingMI48824USA 北京市神经外科研究所

在美国,卒中是死亡的第三大原因和成人致残的首要原因。本文概述了卒中后导致细胞死亡的通路,并对目前有关缺血耐受现象的文献加以总结。缺血耐受是一种内源性神经保护机制,通过这一机制保护神经元免受卒中期间和卒中后出现的脑缺血有... 详细信息

在美国,卒中是死亡的第三大原因和成人致残的首要原因。本文概述了卒中后导致细胞死亡的通路,并对目前有关缺血耐受现象的文献加以总结。缺血耐受是一种内源性神经保护机制,通过这一机制保护神经元免受卒中期间和卒中后出现的脑缺血有害效应。深入了解卒中后导致细胞死亡的过程和诸如缺血耐受之类的内源性神经保护机制,有助于为这种破坏性神经疾病找到新的治疗策略。

关键词：卒中缺血耐受预处理

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Heat and Mass Transfer for a Nanofluid Flow in Fluidized Bed Dryer in Presence of Induced Magnetic Field

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journal of Applied Mathematics and Physics 2024年第4期12卷 1401-1425页

作者： Kiptum j. Purity mathew N. Kinyanjui Edward R. Onyango Pan African University Institute for Basic Sciences Technology and Innovation Nairobi Kenya Department of Pure and Applied Mathematics Jomo Kenyatta University of Agriculture and Technology Nairobi Kenya

This research entails the study of heat and mass transfer of nanofluid flow in a fluidized bed dryer used in tea drying processes in presence of induced magnetic field. A mathematical model describing the fluid flow in a Fluidized bed dryer was developed using the nonlinear partial differential equations. Due to their non-linearity, the equations were solved numerically by use of the finite difference method. The effects of physical flow parameters on velocity, temperature, concentration and magnetic induction profiles were studied and results were presented graphically. From the mathematical analysis, it was deduced that addition of silver nanoparticles into the fluid flow enhanced velocity and temperature profiles. This led to improved heat transfer in the fluidized bed dryer, hence amplifying the tea drying process. Furthermore, it was noted that induced magnetic field tends to decrease the fluid velocity, which results in uniform distribution of heat leading to efficient heat transfer between the tea particles and the fluid, thus improving the drying process. The research findings provide information to industries on ways to optimize thermal performance of fluidized bed dryers.

关键词： Heat Transfer Induced Magnetic Field Nanofluid Fluidized Bed Dryer

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Integrated proteomic profiling identifies amino acids selectively cytotoxic to pancreatic cancer cells

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The Innovation 2024年第3期5卷 138-145页

作者： Alfred Akinlalu Zachariah Flaten Komila Rasuleva Md Saimon Mia Aaron Bauer Santhalingam Elamurugan Nega Ejjigu Sudipa Maity Amara Arshad Min Wu Wenjie Xia jia Fan Ang Guo Sijo mathew Dali Sun Department of Electrical and Computer Engineering University of Denver2155 E Wesley AvenueDenverCO 80210USA Biomedical Engineering Program North Dakota State University1401 Centennial BoulevardEngineering AdministrationRoom 203FargoND 58102USA Department of Pharmaceutical Sciences School of PharmacyNorth Dakota State University1001 S.1401 Albrecht Boulevard Sudro HallFargoND 58102USA Materials and Nanotechnology Program North Dakota State University1410 North 14th AvenueCIE 201FargoND 58102USA Wenzhou Institute University of Chinese Academy of SciencesWenzhouZhejiang 325000China Department of Aerospace Engineering Iowa State UniversityAmesIA 50011USA Center for Cellular and Molecular Diagnostics Tulane University School of Medicine1430 Tulane AvenueNew OrleansLA 70112USA Department of Biochemistry and Molecular Biology Tulane University School of Medicine1430 Tulane AvenueNew OrleansLA 70112USA Knoebel Institute for Healthy Aging University of Denver2155 E Wesley AvenueDenverCO 80210USA

Pancreatic adenocarcinoma(PDAC)is one of the most deadly cancers,characterized by extremely limited therapeutic options and a poor prognosis,as it is often diagnosed during late disease *** and selective treatments are urgently needed,since current therapies have limited efficacy and significant side *** proteomics analysis of extracellular vesicles,we discovered an imbalanced distribution of amino acids secreted by PDAC tumor *** findings revealed that PDAC cells preferentially excrete proteins with certain preferential amino acids,including isoleucine and histidine,via extracellular *** amino acids are associated with disease progression and can be targeted to elicit selective toxicity to PDAC tumor *** in vitro and in vivo experiments demonstrated that supplementation with these specific amino acids effectively eradicated PDAC ***,we also identified XRN1 as a potential target for these amino *** high selectivity of this treatment method allows for specific targeting of tumor metabolism with very low toxicity to normal ***,we found this treatment approach is easy-to-administer and with sustained tumor-killing ***,our findings reveal that exocytosed amino acids may serve as therapeutic targets for designing treatments of intractable PDAC and potentially offer alternative treatments for other types of cancers.

关键词： finding identif selectivity

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Reiner-Rivlin nanomaterial heat transfer over a rotating disk with distinct heat source and multiple slip effects

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Applied Mathematics and Mechanics(English Edition) 2021年第10期42卷 1495-1510页

作者： A.S.SABU j.MACKOLIL B.MAHANTHESH A.mathew Department of Mathematics St.Thomas College(Autonomous)Thrissur 680001KeralaIndia Center for Mathematical Needs Department of MathematicsCHRIST(Deemed to be University)Bengaluru 560029KarnatakaIndia

The thermodynamic features of the Reiner-Rivlin nanoliquid flow induced by a spinning disk are analyzed *** non-homogeneous two-phase nanofluid model is considered to analyze the effect of nanoparticles on the thermodynamics of the Reiner-Rivlin nanomaterial,which also includes a temperature-dependent heat source(THS)and an exponential space-dependent heat source(ESHS).Further,the transfer of heat and mass is analyzed with velocity slip,volume fraction jump,and temperature jump boundary *** finite difference method-based routine is used to solve the complicated differential equations formed after using the von-Karman similarity *** cases of the present problem are found to be in good agreement with benchmarking *** relationship of the pertinent parameters with the heat and mass transport is scrutinized using correlation,which is further evaluated based on the probable error *** models are fitted for the friction factor at the disk and heat transport,which accurately predict the dependent *** Reiner-Rivlin nanoliquid temperature is influenced comparatively more by the ESHS than by *** Nusselt number is decreased by the ESHS and THS,whereas the friction factor at the disk is predominantly decremented by the wall roughness *** increment in the non-Newtonian characteristic of the liquid leads more fluid to drain away in the radial direction far from the disk compared with the fluid nearby the disk in the presence of the centrifugal force during *** increased thermal and volume fraction slip lowers the nanoliquid temperature and nanoparticle volume fraction profiles.

关键词： rotating surface Reiner-Rivlin fluid nanomaterial exponential space-based heat source multiple slip effect regression analysis

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Generalized Baumslag-Solitar Graphs with Soluble Fundamental Groups

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Algebra Colloquium 2014年第1期21卷 53-58页

作者： Alberto L. Delgado Derek j.S. Robinson mathew Timm vDepartment of Mathematics illinois State University Normal IL 61790 USA Department of Mathematics University of Illinois at Urbana-Champaign Urbana IL 61801 USA Department of Mathematics Bradley University Peoria IL 61625 USA

It is shown that the generalized Baumslag-Solitar graphs which have soluble fundamental groups can be constructed from four simple types of graph by a process of decoration. The method of proof is elementary and emplo... 详细信息

关键词： generalized Baumslag-Solitar graph soluble fundamental group

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Atomic and Close-to-Atomic Scale Manufacturing:A Review on Atomic Layer Removal Methods Using Atomic Force Microscopy

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Nanomanufacturing and Metrology 2020年第3期3卷 167-186页

作者： Paven Thomas mathew Brian j.Rodriguez Fengzhou Fang Centre of Micro/Nano Manufacturing Technology(MNMT-Dublin) University College DublinDublin D04V1W8Ireland School of Physics University College DublinBelfieldDublin D04 V1W8Ireland Conway Institute of Biomolecular and Biomedical Research University College DublinBelfield.Dublin D04V1W8Ireland State Key Laboratory of Precision Measuring Technology and Instruments Centre of Micro/Nano Manufacturing TechnologyMNMT.Tianjin UniversityTianjin 300072China

Manufacturing at the atomic scale is the next generation of the industrial *** and close-to-atomic scalemanufacturing(ACSM)helps to achieve *** force microscopy(AFM)is a promising method for this purposesince an instrument to machine at this small scale has not yet been *** the need for increasing the number ofelectronic components inside an integrated circuit chip is emerging in the present-day scenario,methods should be adoptedto reduce the size of connections inside the *** can be achieved using ***,connecting moleculeswith the electrodes and then to the external world is *** must be laid to make this possible for *** layer removal,down to one atom,can be employed for this ***,theoretical works are beingperformed extensively to study the interactions happening at the molecule-electrode junction,and how electronic transportis affected by the functionality and robustness of the *** theoretical studies can be verified experimentally only if nano electrodes are *** is widely used in the semiconductor industry to fabricate electronic ***,carbon-based materials such as highly oriented pyrolytic graphite,gold,and silicon carbide find applications inthe electronic device manufacturing ***,ACSM of these materials should be developed *** paperpresents a review on the state-of-the-art research performed on material removal at the atomic scale by electrochemical andmechanical methods of the mentioned materials using AFM and provides a roadmap to achieve effective mass productionof these devices.

关键词： Atomic force microscopy Atomic-scale manufacturing Molecular scale devices Electrochemistry ACSM ManufacturingⅢ

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Nonlocal-Means Image Denoising Technique Using Robust M-Estimator

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journal of Computer Science & Technology 2010年第3期25卷 623-631页

作者： Dinesh j. Peter V. K. Govindan Abraham T. mathew Department of Computer Science National Institute of Technology Calicut Department of Electrical Engineering National Institute of Technology Calicut

Edge preserved smoothing techniques have gained importance for the purpose of image processing applications A good edge preserving filter is given by nonlocal-means filter rather than any other linear model based approaches. This paper explores a different approach of nonlocal-means filter by using robust M-estimator function rather than the exponential function for its weight calculation. Here the filter output at each pixel is the weighted average of pixels with surrounding neighborhoods using the chosen robust M-estimator function. The main direction of this paper is to identify the best robust M-estimator function for nonlocal-means denoising algorithm. In order to speed up the computation, a new patch classification method is followed to eliminate the uncorrelated patches from the weighted averaging process. This patch classification approach compares favorably to existing techniques in respect of quality versus computational time. Validations using standard test images and brain atlas images have been analyzed and the results were compared with the other known methods. It is seen that there is reason to believe that the proposed refined technique has some notable points.

关键词： image processing denoising technique nonlocal-means filter robust M-estimators

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AutoPhaseNN:unsupervised physics-aware deep learning of 3D nanoscale Bragg coherent diffraction imaging

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npj Computational Materials 2022年第1期8卷 1146-1153页

作者： Yudong Yao Henry Chan Subramanian Sankaranarayanan Prasanna Balaprakash Ross j.Harder mathew j.Cherukara Advanced Photon Source Argonne National LaboratoryLemontIL60439USA Center for Nanoscale Materials Argonne National LaboratoryLemontIL60439USA Mathematics and Computer Science Argonne National LaboratoryLemontIL60439USA

The problem of phase retrieval underlies various imaging methods from astronomy to nanoscale *** phase retrieval methods are iterative and are therefore computationally *** learning(DL)models have been developed to either provide learned priors or completely replace phase ***,such models require vast amounts of labeled data,which can only be obtained through simulation or performing computationally prohibitive phase retrieval on experimental *** 3D X-ray Bragg coherent diffraction imaging(BCDI)as a representative technique,we demonstrate AutoPhaseNN,a DL-based approach which learns to solve the phase problem without labeled *** incorporating the imaging physics into the DL model during training,AutoPhaseNN learns to invert 3D BCDI data in a single shot without ever being shown real space *** trained,AutoPhaseNN can be effectively used in the 3D BCDI data inversion about 100×faster than iterative phase retrieval methods while providing comparable image quality.

关键词： coherent iterative replace

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Cytokines from the pig conceptus:roles in conceptus development in pigs

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journal of Animal Science and Biotechnology 2015年第2期6卷 130-141页

作者： Rodney D Geisert Matthew C Lucy jeffrey j Whyte jason W Ross Daniel j mathew Animal Sciences Research Center University of Missouri Department of Animal Science Iowa State University

Establishment of pregnancy in pigs involves maintaining progesterone secretion from the corpora lutea in addition to regulating a sensitive interplay between the maternal immune system and attachment of the rapidly expanding trophoblast for nutrient absorption. The peri-implantation period of rapid trophoblastic elongation followed by attachment to the maternal uterine endometrium is critical for establishing a sufficient placental-uterine interface for subsequent nutrient transport for fetal survival to term, but is also marked by the required conceptus release of factors involved with stimulating uterine secretion of histotroph and modulation of the maternal immune system. Many endometrial genes activated by the conceptus secretory factors stimulate a tightly controlled proinflammatory response within the uterus. A number of the cytokines released by the elongating conceptuses stimulate inducible transcription factors such as nuclear factor kappa B （NFKB） potentially regulating the maternal uterine proinflammatory and immune response. This review will establish the current knowledge for the role of conceptus cytokine production and release in early development and establishment of pregnancy in the pig.

关键词： Cytokines Embryo development Porcine conceptus Pregnancy Prostaglandins uterus

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