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DEFORMATIONAL AND METAMORPHIC HISTORY OF THE CENTRAL LONGMEN MOUNTAINS, SICHUAN CHINA

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地学前缘 2000年第S1期7卷 273-274页

作者： Chris j.L. Wilson 1, Brenton A. Worley 1, Shefa Chen 1, mathew j. Harrowfield 1,Liu Shugen 2,Luo Zhili 2[WT5,5”BX](1 School of Earth Sciences, The University of Melbourne, Victoria,3010, Australia 2 Chengdu University of Technology, Chengdu 6

The Longmen Mountains and adj.cent regions on the eastern margin of the Tibetan plateau can be divided into three tectonic units: the eastern Songpan—Garzê fold belt, the Longmen Mountains (Longmen Shan) Thrust—Nappe belt and the Western Sichuan foreland basin that occupies the western part of the Sichuan basin. The Longmen Shan Thrust—Nappe belt is subdivided by six northwest\|dipping maj.r listric thrusts, with accompanying duplexes and imbricate fans, into five large\|scale nappes (Chen & Wilson, 1996). In the inner Longmen Shan, the nappe units have incorporated both Mesoproterozoic basement and Sinian (Neoproterozoic) to Triassic cover sequences as “thick\|skinned" horses. Whereas, in the frontal Longmen Shan, Sinian to Cretaceous cover sediments have been stripped from the basement as “thin\|skinned" fold and thrust sheets, including extensively distributed klippen structures. Pre\|thrusting extension during Devonian to middle Late Triassic times resulted in syndepositional normal faults. Structural inversion of these faults initiated the “Peng Xian—Guan Xian basement complex", j.uding Shan and Tangwangzhai nappes, during an early episode of the Indosinian Orogeny (Norian to Rhaetian). This was followed by episodic thrusting during latest Triassic to Early Cretaceous times to develop the Guan Xian—An Xian and Southeastern Marginal nappes that have incorporated sediments from the neighbouring foreland basin into the frontal part of the Thrust—Nappe belt. Differential thrusting occurred across the Thrust—Nappe belt during a Late Miocene reactivation of the pre\|existing faults.

关键词： Longmen Mountains Songpan—Garzê fold belt Wenchuan—Mouwen shear zone Wenchuan—Mouwen fault metamorphic belt transpressional shear Himalayan orogeny Indosinian orogeny

Integrated proteomic profiling identifies amino acids selectively cytotoxic to pancreatic cancer cells

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The Innovation 2024年第3期5卷 138-145页

作者： Alfred Akinlalu Zachariah Flaten Komila Rasuleva Md Saimon Mia Aaron Bauer Santhalingam Elamurugan Nega Ej.igu Sudipa Maity Amara Arshad Min Wu Wenj.e Xia j.a Fan Ang Guo Sij. mathew Dali Sun Department of Electrical and Computer Engineering University of Denver2155 E Wesley AvenueDenverCO 80210USA Biomedical Engineering Program North Dakota State University1401 Centennial BoulevardEngineering AdministrationRoom 203FargoND 58102USA Department of Pharmaceutical Sciences School of PharmacyNorth Dakota State University1001 S.1401 Albrecht Boulevard Sudro HallFargoND 58102USA Materials and Nanotechnology Program North Dakota State University1410 North 14th AvenueCIE 201FargoND 58102USA Wenzhou Institute University of Chinese Academy of SciencesWenzhouZhejiang 325000China Department of Aerospace Engineering Iowa State UniversityAmesIA 50011USA Center for Cellular and Molecular Diagnostics Tulane University School of Medicine1430 Tulane AvenueNew OrleansLA 70112USA Department of Biochemistry and Molecular Biology Tulane University School of Medicine1430 Tulane AvenueNew OrleansLA 70112USA Knoebel Institute for Healthy Aging University of Denver2155 E Wesley AvenueDenverCO 80210USA

Pancreatic adenocarcinoma(PDAC)is one of the most deadly cancers,characterized by extremely limited therapeutic options and a poor prognosis,as it is often diagnosed during late disease *** and selective treatments are urgently needed,since current therapies have limited efficacy and significant side *** proteomics analysis of extracellular vesicles,we discovered an imbalanced distribution of amino acids secreted by PDAC tumor *** findings revealed that PDAC cells preferentially excrete proteins with certain preferential amino acids,including isoleucine and histidine,via extracellular *** amino acids are associated with disease progression and can be targeted to elicit selective toxicity to PDAC tumor *** in vitro and in vivo experiments demonstrated that supplementation with these specific amino acids effectively eradicated PDAC ***,we also identified XRN1 as a potential target for these amino *** high selectivity of this treatment method allows for specific targeting of tumor metabolism with very low toxicity to normal ***,we found this treatment approach is easy-to-administer and with sustained tumor-killing ***,our findings reveal that exocytosed amino acids may serve as therapeutic targets for designing treatments of intractable PDAC and potentially offer alternative treatments for other types of cancers.

关键词： finding identif selectivity

TRIASSIC OROGENESIS IN SOUTHWEST CHINA: THE STRUCTURAL ORIGINS OF THE NORTHEAST TIBETAN PLATEAU

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地学前缘 2000年第S1期7卷 293-293页

作者： mathew j. Harrowfield,Christopher j.L. Wilson [WT5,5”BX](School of Earth Sciences, The University of Melbourne, Parkville, Victoria 3010, Australia, E\|mail: m.harrowfield@student.unimelb.edu au cj.w@myriad.its.unimelb.edu.au)

Whilst the topographic relief of the Tibetan Plateau’s northeast margin reflects recent Himalayan Orogenesis, its position and geometry reflect much older structures that developed during the Indosinian Orogeny c.200Ma. The Indosinian Orogeny was responsible for closure and shortening of the Songpan Garzê Basin, a Palaeo\|Tethyan relict, during accretion of the Cimmerian Continental Chain to the southern margin of Laurasia. Sandwiched between Laurasia and the Cimmerian fragments of the Qangtang (North Tibet) and Yangtze (South China) blocks, this basin evolved into the Songpan Garzê Fold Belt—a maj.r accretionary prism which now forms the northeast portion of the Tibetan Plateau.

关键词： Himalayan orogeny Indosinian orogeny Qingling orogeny Long men Mountains Songpan\|Garzê fold belt Palaeo\|Tethys Yangtze block

TECTONIC EVOLUTION OF THE YANGTZE PASSIVE MARGIN AND SONGPAN GARZ? FOLD BELT, CHINA

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地学前缘 2000年第S1期7卷 185-185页

作者： mathew j. Harrowfield,Christopher j.L. Wilson [WT5,5”BX](School of Earth Sciences, The University of Melbourne, Victoria 3010, Australia,E\|mail: m.harrowfield@student.unimelb.edu.au cj.w@myriad.its.unimelb.edu.au)

The Songpan Garzê Fold Belt records Triassic shortening of a relict Palaeo\|Tethyan basin during assembly and accretion of the Cimmerian continental chain to Laurasia’s southern margin. Enclosed by palaeo\|Laurasia and the Cimmerian fragments of Qiangtang (North Tibet) and Yangtze (South China), the Songpan Garzê Fold Belt was shortened by more than 50% during the Indosinian Orogeny c.200Ma. [BW(D(S,,)G2*7][BHDWG2*7,WK*2,WK5,WK15*2,WK17*2,WK*2W] 2000,7(增刊) 地学前缘 [FK(K+6mm。17*2] 4\ Maj.r Topic:Geology of the Inner Tibetan Plateau [BW(S(S,,)G2*7][BHDWG2*7,WK*2,WK17*2,WK15*2,WK5,WK*2W] [FK(K+6mm。17*2] 4\ Maj.r Topic:Geology of the Inner Tibetan Plateau 地学前缘 2000,7(增刊)South\|directed Indosinian compression decolléd onlapping basin sediments from the Yangtze Block’s passive margin—reactivating the margin’s tiered geometry and partitioning strain into margin\|normal and margin\|parallel structures on a large scale. Margin\|normal transport of the allochthonous sedimentary pile was accommodated by southeast\|directed nappe propagation in the Longmen Mountains Thrust—Nappe Belt, whilst conj.gate, margin\|parallel (southwest\|directed) transport was accommodated by a flat\|lying detachment at the base of the sedimentary *** later is characteristic of deformation of the greater Songpan Garzê Fold Belt.

关键词： Himalayan Orogeny Indosinian Orogeny Longmen Mountains Songpan—Garzê Fold Belt Yangtze Block Cimmerian Damba

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肺栓塞结节

世界核心医学期刊文摘（心脏病学分册） 2007年第7期3卷 54-54页

作者： mathew j. Powari M. 马超 Department of Histopathology Royal Cornwall Hospital Truro TR1 3LJ United Kingdom

目的：描述肺栓塞的一种罕见形态学表现。病例报道：1例成年男性因在家中虚脱后入院，不久便被宣布死亡。该患者除BMI为34、吸烟和近期胸部感染刚出院以外，无血栓栓塞的易感因素、危险因素或表现。尸检发现死亡系肺栓塞合并小腿深静脉... 详细信息

目的：描述肺栓塞的一种罕见形态学表现。病例报道：1例成年男性因在家中虚脱后入院，不久便被宣布死亡。该患者除BMI为34、吸烟和近期胸部感染刚出院以外，无血栓栓塞的易感因素、危险因素或表现。尸检发现死亡系肺栓塞合并小腿深静脉血栓形成所致。极其意外的是，在该肺血栓栓塞的上（头）端发现一结节。结论：本文是首次描述肺栓塞结节的病例报道，推测这种现象只可能在大静脉或穿经右心时出现。

关键词：肺栓塞结节深静脉血栓形成肺血栓栓塞病例报道形态学表现胸部感染易感因素

硬化性肠系膜炎伴隐性回肠穿孔:1例假性广泛性腹腔内恶性病变的病例报道

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世界核心医学期刊文摘（胃肠病学分册） 2005年第6期1卷 21-21页

作者： mathew j. McKenna F. Mason j. 陈云茹 8 Fern House M23 2RW Wythenshawe United Kingdom

Sclerosing mesenteritis is a rare condition that is characterized by fibrosis affecting mainly small-bowel mesentery, which in extensive cases may mimic advanced intraabdominal malignancy. Establishing the diagnosis in such cases is a clinical and histopathologic challenge. We report the successful management of a case of extensive sclerosing mesenteritis with occult ileal perforation, which was possibly the triggering cause. Severe complications occurred as a result of both the disease itself and its surgical treatment. Despite the complex course and life-threatening complications, a good prognosis can be expected. Although occasional recovery has been attributed to spontaneous regression and response to immunosuppressive therapy, a search for, and full eradication of, possible triggering focus is of paramount importance.

关键词：硬化性肠系膜炎免疫抑制治疗组织病理学上均检查和

Nonlocal-Means Image Denoising Technique Using Robust M-Estimator

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j.urnal of Computer Science & Technology 2010年第3期25卷 623-631页

作者： Dinesh j. Peter V. K. Govindan Abraham T. mathew Department of Computer Science National Institute of Technology Calicut Department of Electrical Engineering National Institute of Technology Calicut

Edge preserved smoothing techniques have gained importance for the purpose of image processing applications A good edge preserving filter is given by nonlocal-means filter rather than any other linear model based approaches. This paper explores a different approach of nonlocal-means filter by using robust M-estimator function rather than the exponential function for its weight calculation. Here the filter output at each pixel is the weighted average of pixels with surrounding neighborhoods using the chosen robust M-estimator function. The main direction of this paper is to identify the best robust M-estimator function for nonlocal-means denoising algorithm. In order to speed up the computation, a new patch classification method is followed to eliminate the uncorrelated patches from the weighted averaging process. This patch classification approach compares favorably to existing techniques in respect of quality versus computational time. Validations using standard test images and brain atlas images have been analyzed and the results were compared with the other known methods. It is seen that there is reason to believe that the proposed refined technique has some notable points.

关键词： image processing denoising technique nonlocal-means filter robust M-estimators

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脓胸患儿胸膜腔内注入链激酶的随机对照试验

世界核心医学期刊文摘（儿科学分册） 2005年第4期1卷 10-10页

作者： Singh M. mathew j. L Chandra S. 李开 Department of Paediatrics Advanced Paediatrics-Centre Postgrad. Inst. of Med. Educ. /Res. Chandigarh India

目的:对于严重的脓胸患儿,可从肋间导管将药物注入到胸膜腔内,本文对比胸膜腔内注入链激酶与注入安慰剂的疗效差异。方法:收集病情大于5期的脓胸患儿病例,利用肋间引流法进行胸膜腔内药物注入,根据注入成分不同,分为链激酶组(n=19)

关键词：链激酶胸膜腔肋间引流随机对照试验药物注入安慰剂胸膜增厚超声影像学可从 reserved

长期甲氨蝶呤治疗银屑病和杂合α1-抗胰蛋白酶缺乏诱导肝纤维化?

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世界核心医学期刊文摘（皮肤病学分册） 2006年第11期2卷 56-56页

作者： mathew j. Igbokwe U.O. Morley N. Burt A.D. 周少娜 Department of Histopathology Royal Cornwall Hospital Truro Cornwall TR1 3LJ United KingdomDr.

Background: Dermatologists, or pathologists, occasionally need to decide whether or not to continue methotrexate therapy in a patient with an identifiable risk factor for liver fibrosis, in this instance heterozygous α1-antitrypsin deficiency. Case Presentation: We relate our experience with an elderly male patient, diagnosed as having α1-antitrypsin deficiency on a liver biopsy, genotypically confirmed as PiMZ. He had been receiving methotrexate for psoriasis for 17 years with a cumulative dose of 7,200 mg. He was monitored by biochemical profiling and interval (10) liver biopsies. Non-specific changes were seen on liver histology although grade 1 liver fibrosis was seen in his last 2 biopsies. Conclusion: We suggest that methotrexate therapy is relatively safe in patients with heterozygous α1-antitrypsin deficiency, with no other risk factor. We however advise that the risk of fibrosis should be monitored and that the patient receives appropriate counselling.

关键词：银屑病抗胰蛋白酶缺乏甲氨蝶呤肝纤维化杂合皮肤科医生肝组织学生化检测肝活检累积剂量