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Substances of abuse consumption among patients seeking medical help for uro-andrological purposes:a sociobehavioral survey in the real-life scenario

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Asian Journal of Andrology 2021年第5期23卷 456-461页

作者： Federico Belladelli Luca Boeri Paolo Capogrosso Walter Cazzaniga Eugenio Ventimiglia Luigi Candela Edoardo Pozzi Andrea Baudo massimo alfano Costantino Abbate Francesco Montorsi Andrea Salonia Division of Experimental Oncology/Unit of Urology URIIRCCS Ospedale San Raffaelevia Olgettina 60Milan 20131Italy University Vita-Salute San Raffaele via Olgettina 60Milan 20131Italy Department of Urology Foundation IRCCS Ca'Granda-Ospedale Maggiore PoliclinicoUniversity of Milanvia Della Commenda 15Milan 20122Italy

Substances of abuse(SoA),as well as smoking and alcohol consumption,are well known for their impact on male fertility status,erectile function,and ejaculation.We assessed SoA consumption habits in a cohort of men seeking medical attention for uro-andrological purposes.Data from 7447 men seeking medical attention for the first time for uro-andrological purposes were analyzed.A complete medical and sexual history was collected for each patient.Smoking,alcohol,and SoA consumption were investigated.Descriptive statistics was used to describe the whole cohort.The primary motivations for their evaluation were lower urinary tract symptoms(LUTS),erectile dysfunction(ED),and infertility in 1912(25.7%),2944(39.5%),and 2591(34.8%)men,respectively.Previous use of SoA was reported by 378(5.1%)men,and 190(2.6%)individuals were current users.Patients seeking medical attention for infertility were more frequently current SoA users(107;4.1%)than men with ED(66;2.2%)and LUTS(17;0.9%)(both P<0.001).Current users of SoA were younger than those with past or no SoA history(P<0.001).Current SoA users were more frequently smokers(P<0.001)and alcohol consumers(P<0.001)than those with a previous history or those who had never tried SoA.In conclusion,approximately 3%of men seeking medical attention for uro-andrological purposes were current SoA consumers.Infertile men reported a higher use of SoA than those with ED or LUTS.Current SoA users were younger and more frequently concomitant smokers and alcohol consumers compared to those who did or had never used SoA.

关键词： cannabis cocaine erectile dysfunction male infertility risk factors substances of abuse

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Testicular volume in infertile versus fertile white-European men: a case-control investigation in the real-life setting

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Asian Journal of Andrology 2021年第5期23卷 501-509页

作者： Luca Boeri Paolo Capogrosso Eugenio Ventimiglia Walter Cazzaniga Edoardo Pozzi Federico Belladelli Filippo Pederzoli massimo alfano Costantino Abbate Emanuele Montanari Luca Valsecchi Enrico Papaleo Paola Vigano Patrizia Rovere-Querini Suks Minhas Francesco Montorsi Andrea Salonia Division of Experimental Oncology/Unit of Urology URIIRCCS Ospedale San RaffaeleVia Olgettina 60Milan 20131Italy Department of Urology Foundation IRCCS Ca'Granda-Ospedale Maggiore PoliclinicoUniversity of MilanVia Della Commenda 15Milan 20122Italy University Vita-Salute San Raffaele Via Olgettina 60Milan 20131Italy Department of Obstetrics and Gynaecology IRCCS Ospedale San RaffaeleVia Olgettina 60Milan 20131Italy Division of Genetics and Cell Biology Reproductive Sciences LaboratoryIRCCS Ospedale San RaffaeleVia Olgettina 60Milan 20131Italy Division of Immunology Transplantation and Infectious Diseases Department of MedicineIRCCS Ospedale San RaffaeleVia Olgettina 60Milan 20131Italy Department of Urology Imperial Healthcare NHS TrustCharing Cross HospitalFulham Palace RoadHammersmithLondon W68RFUK

Testicular volume(TV)is considered a good clinical marker of hormonal and spermatogenic function.Accurate reference values for TV measures in infertile and fertile men are lacking.We aimed to assess references values for TV in white-European infertile men and fertile controls.We analyzed clinical and laboratory data from 1940(95.0%)infertile men and 102(5.0%)fertile controls.Groups were matched by age using propensity score weighting.TV was assessed using a Prader orchidometer(PO).Circulating hormones and semen parameters were investigated in every male.Descriptive statistics,Spearman's correlation,and logistic regression models tested potential associations between PO-estimated TV values and clinical variables.Receiver operating characteristic(ROC)curves were used to find TV value cutoffs for oligoasthenoteratozoospermia(OAT)and nonobstructive azoospermia(NOA)status in infertile men.The median testicular volume was smaller in infertile than that of fertile men(15.0 ml vs 22.5 ml;P<0.001).TV positively correlated with total testosterone,sperm concentration,and progressive sperm motility(all P≤0.001)in infertile men.At multivariable logistic regression analysis,infertile status(P<0.001)and the presence of left varicocele(P<0.001)were associated with TV<15 ml.Testicular volume thresholds of 15 ml and 12 ml had a good predictive ability for detecting OAT and NOA status,respectively.In conclusion,infertile men have smaller testicular volume than fertile controls.TV positively correlated with total testosterone,sperm concentration,and progressive motility in infertile men,which was not the case in the age-matched fertile counterparts.

关键词： hypogonadism male infertility orchidometer Prader semen analysis testicular volume

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