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Impact of COVID-19 pandemic on the neuropsychiatric status of Wilson’s disease

World Journal of Gastroenterology 2021年第39期27卷 6733-6736页

作者： Giuseppe Lanza massimiliano godani Raffaele Ferri Alberto Raggi Department of Surgery and Medical-Surgical Specialties University of CataniaCatania 95123Italy Clinical Neurophysiology Research Unit Oasi Research Institute-IRCCSTroina 94018Italy Neurology Unit Sant’Andrea Civic HospitalLa Spezia 19121Italy Department of Neurology IC Sleep Research CenterOasi Research Institute-IRCCSTroina 94018Italy Unit of Neurology G.B.Morgagni-L.Pierantoni HospitalForlì47121Italy

We have read with interest the Letter to the Editor by *** and Zhong,who presented the clinical data of 68 patients with Wilson’s disease(WD)who were admitted to the hospital before and during the coronavirus disease 2019(COVID-19)pandemic,and appreciated their findings on hepatic and some extrahepatic ***,given the strong impact of the pandemic on patients with neurological and psychiatric disorders,we would have expected a worsening of the psychiatric and/or neurological impairments in these *** contrast,according to the authors,these manifestations remained,somewhat unexpectedly,*** finding is in contrast with most of the current literature that highlights not only an increased incidence of mental health disorders in the general population but also an exacerbation of neurological and psychiatric symptoms in patients with chronic diseases,especially in those with pre-existing neuropsychiatric disorders,such as *** the study was mainly focused on the hepatic features of WD patients taking anti-copper treatment,a generic and cumulative definition of neurological and psychiatric manifestations,as in this study,does not allow for further *** studies during and after the pandemic are necessary to clarify the real impact,either direct or indirect,of the COVID-19 pandemic on the neurological and psychiatric symptoms of WD patients.

关键词： Wilson’s disease Extra-hepatic manifestations Neuropsychiatric symptoms COVID-19 Therapy Resilience

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Zoonotic Pathogens Detected in Ticks in Kenyan Game Reserves

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Advances in Entomology 2023年第1期11卷 1-9页

作者： Salim Kobo godani Menza Nelson Chengo Margaret W. Muturi Department of Medical Laboratory Sciences Kenyatta University Nairobi Kenya

Little is known on tick-borne pathogens and their role in disease in game reserves in Kenya. Ticks were collected by sterile forceps from restrained cattle hide and placed into labeled falcon tubes. Ticks were screened for pathogens by High Resolution Melting (HRM) analysis and sequencing of specific RT-PCR products of Anaplasma, Ehrlichia, and Rickettsia species. A total of 317 ticks (281 adult ticks and 36 nymphs) comprising seven species were collected around the Tsavo National Reserve (TNR) in Taita Taveta County with Amblyomma gemma being the most commonly collected species (n = 135, 42.6%). From near Shimba Hill game reserve (SHNR), a total of 240 adult’s ticks were sampled, representing eight species, with again Amblyomma gemma being the most sampled species (n = 156, 65%). From Tsavo, a total of three pools of Rhipicephalus appendiculatus were positive for Theileria parva, two pools of Rhipicephaline evertsi for Anaplasma platys and one pool of Amblyomma variegatum nymphs for Rickettsia africae. Rickettsia africae, which causes African tick-bite fever, was detected in two pools of Am. variegatum and one pool of Amblyomma gemma collected near Shimba Hill game reserve. Rickettsia sp. and Anaplasma sp. were detected in Am. gemma and Rh. evertsi respectively. Rickettsia aeschlimannii was detected in a pool of Am. gemma. These findings highlight the risk of transmission of zoonotic pathogens to humans in regions with high human-wildlife interfaces. Of specific importance, we provide evidence of R. aeschlimannii in A. gemma for the first time, representing a potential new R. aeschlimannii vectors.

关键词： High Resolution Melting Amblyomma gemma Rickettsia africae Rickettsia aeschlimannii

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