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白介素-6基因的多态性(-174G/C)与心肌梗死和传统的心血管危险因子之间无相关性

世界核心医学期刊文摘（心脏病学分册） 2005年第3期1卷 43-43页

作者： Lieb W. Pavlik R. Erdmann J. h. Schunkert 孟欣 Clin. Policlinic for Int. med. II University of Luebeck Ratzeburger Allee 160 23538 Lübeck Germany

Background: Recently, a polymorphism at position-174 (G >C) of the interleukin-6(IL-6) promoter was found to be associated with an increased prevalence of myocardial infarction(MI). The aim of the present study was to further investigate the association of the IL-6-174 G/C allele status with specific end organ damage, i.e. myocardial infarction in large population-based samples. Methods: Individuals from two Bavarian samples of MI patients (total n=1322) and the population-based Augsburg MONICA survey(1023 unselected controls) were studied by questionnaire, physical examination, echocardiographical assessment and biochemical analyses. The-174 G/C polymorphism was genotyped using a newly established PCR-RFLP. IL-6 levels were measured in a subset of 574 MI patients. Results: In the population-based sample, the IL-6 genotype was neither associated with traditional cardiovascular risk factors(systolic and diastolic blood pressure, total cholesterol, hDL and LDL cholesterol, body mass index, diabetes mellitus) nor with cardiac structural or functional parameters(left ventricular mass index, ejection fraction, diastolic inflow pattern). Moreover, the genotype distribution of the-174 G/C polymorphism was not different in MI patients(GG: 34.1%; GC: 47.4%; CC: 18.5%) and population-based controls (GG: 32.4%; GC: 48.8%; CC: 18.9%) (p=0.67). IL-6 levels were neither related to the-174 G/C polymorphism (p=0.29) nor to ACE-inhibitor treatment (2.16 with vs. 2.09 pg/ml without ACE-inhibitor, p=0.27). however, patients receiving statins displayed significantly lower IL-6 levels(1.83 vs. 2.32 pg/ml in the group without statins, phis extensive investigation failed to obtain evidence that the IL-6-174G/C promoter polymorphism affects traditional cardiovascular risk factors or the prevalence of myocardial infarction in a Caucasian sample.

关键词：多态性器官损伤左室重量指数他汀类药物高密度脂蛋白心肌收缩心肌结构亚组启动子射血分数

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后端皮层萎缩是否是阿尔茨海默病的变异形式:一系列具有PET发现的病例

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世界核心医学期刊文摘（神经病学分册） 2005年第6期1卷 34-34页

作者： Schmidtke K. hü ll M. Talazko J. 胡慧敏 Ctr. Geriatric med. Gerontology F. Lehener Str. 88 79106 Freiburg Germany Dr.

Nine patients with posterior cortical atrophy (PCA), a rare degenerative brain disease of unclear etiology and nosology, were followed over a mean time of 7.4 years. The mean age at onset was low (56.2 years). At onset, eight patients had visuo- spatial and eight had memory impairment. A minority showed early signs of occipital lobe involvement with visual agnosia or hemianopia. Eight patients developed dementia after a mean course of five years. 18F- FDG- PET data of six patients were analysed with statistical parametric mapping. They showed hypometabolism centred on the lateral and medial parietal associative cortex, with variable involvement of the adjacent temporal and occipital associative cortex. A minority showed involvement of the frontal lobes, possibly related to deafferenting of areas related to the control of eye movements. Atrophy and hypometabolism were markedly asymmetric in a subset of cases. Autopsy was performed in one patient. Presenile onset, location, and asymmetry of atrophy suggest that PCA represents a biologically separable variant of Alzheimer’ s disease.

关键词：阿尔茨海默病 PET 变异形式视觉失认症后端退行性疾病去传入病因学疾病分类学视觉空间

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听觉正常人群和听神经病变患者的听觉时间进程

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世界核心医学期刊文摘（神经病学分册） 2005年第8期1卷 28-28页

作者： Michalewski h.J. Starr A. Nguyen T.T. 高中宝 Department of Neurology University of California150 Med. Surge I Irvine CA 92697-4290 United States

Objective: To study objectively auditory temporal processing in a group of nor mal hearing subjects and in a group of hearing-impaired individuals with audito ry neuropathy (AN) using electrophysiological and psychoacoustic methods. Method s:Scalp recorded evoked potentials were measured to brief silent intervals (gaps ) varying between 2 and 50 ms embedded in continuous noise. Latencies and amplit udes of N100 and P200 were measured and analyzed in two conditions:(1) active, w hen using a button in response to gaps;(2) passive, listening, but not respondin g. Results: In normal subjects evoked potentials(N100/P200 components) were reco rded in response to gaps as short as 5 ms in both active and passive conditions. Gap evoked potentials in AN subjects appeared only with prolonged gap durations (10-50 ms). There was a close association between gap detection thresholds mea sured psychoacoustically and electrophysiologically in both normals and in AN su ***: Auditory cortical potentials can provide objective measures of auditory temporal processes. Significance:The combination of electrophysiolog ical and psychoacoustic methods converged to provide useful objective measures f or studying auditory cortical temporal processing in normals and hearing-impair ed individuals. The procedure used may also provide objective measures of tempor al processing for evaluating special populations such as children who may not be able to provide subjective responses.

关键词：听神经病电生理诱发电位皮层电位检测阈主观反应延长期正常受试者

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垂直肌完全移位术联合内直肌后部固定缝线术治疗内收功能不足

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世界核心医学期刊文摘（眼科学分册） 2005年第10期1卷 61-61页

作者： Snir M. Friling R. Kalish-Stiebel h. 王永强 Pediatric Ophthalmology Unit Schneider Children's Med. Ctr. I. Petah Tiqva 49202 Israel Dr.

Purpose: To compare the surgical and functional results of full tendon rectus muscle transposition to the medial rectus muscle augmented with posterior medial fixation sutures in patients with adduction deficiency (ADD) and Duane's syndr ome type 2. Design: Retrospective nonconcurrent interventional comparative case series. Participants: Twelve consecutive patients with ADD and Duane's syn drome type 2. Interventions: Six patients treated by the full tendon rectus mu scle transposition procedure alone were compared with 6 patients treated by the full tendon rectus muscle transposition combined with posterior medial fixation sutures. Main Outcome Measures: Postoperative ocular alignment, duction improvem ent, binocular functions, and reoperation. Results: In the augmented surgery gro up, mean distance and near deviation decreased by 74.5%and 74%, respectively, versus 56%and 59%, respectively, in the control group (P=0.007 and 0.02, betwe en-group comparison for distance and near deviation, respectively). Mean ductio n improved in 73%of the study group compared with 52%of controls (P=0.025). No postoperative complications or duction anomalies were observed during follow-u p in the entire cohort; reoperation was needed in 1 patient in the study group a nd in all 6 patients in the control group. Conclusions: The augmented full verti cal rectus muscle procedure is a beneficial surgical approach for patients with ADD and Duane's retraction syndrome type 2, reducing the need for multiple extr aocular muscle surgery.

关键词：后固定缝线术双上肌麻痹直肌移位术眼位偏斜视功能眼球转动眼外肌干预性

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低密度脂蛋白甘油三酯与低度系统炎症、黏附分子和血管造影证实的冠心病的相关性:Ludwigshafen危险度和心血管健康研究

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世界核心医学期刊文摘（心脏病学分册） 2005年第4期1卷 45-45页

作者： Risk and Cardiovascular health Study arz W. Scharnagl h. Winkler K. 陶磊 Clin. Inst. med. Chem. Lab. D. Medical University of Graz Auenbruggerplatz 15 8036 Graz Austria Dr .

Background -Markers of systemic inflammation and LDL cholesterol(LDL-C) have been considered independent risk factors of coronary artery disease(CAD). We ex amined whether alterations of LDL metabolism not reflected by LDL-C were associ ated with low-grade inflammation, vascular injury, and CAD. Methods and Results -We studied 739 subjects with stable angiographic CAD and 570 matched control subjects in which CAD had been ruled out by angiography. The association of LDL triglycerides(LDL-TGs)(odds ratio[OR], 1.30; 95%CI, 1.19 to 1.43; Ph CAD was stronger than that of LDL-C (OR, 1.10; 95%CI, 1.00 to 1.21; P=0.047 ). The predictive value of LDL-TG for CAD was independent of LDL-C. "Sensitiv e"C-reactive protein(CRP), serum amyloid A, fibrinogen, interleukin 6, interce llular adhesion molecule-1(ICAM-1), and vascular adhesion molecule-1(VCAM-1) increased in parallel to LDL-TG. CRP, ICAM-1, and VCAM-1 were inversely rela ted to LDL-C. To examine whether LDL-TGs were associated with the distribution of LDL subfractions, we studied 114 individuals with impaired fasting glucose, impaired glucose tolerance, or type 2 diabetes mellitus. In subjects with high L DL-TG, LDLs were depleted of cholesteryl esters(CEs), and VLDLs, IDLs, and dens e LDLs were significantly elevated. Conclusions -Alterations of LDL metabolism characterized by high LDL-TG are related to CAD, systemic low-grade inflammati on, and vascular damage. high LDL-TGs are indicative of CE-depleted LDL, eleva ted IDL, and dense LDL. LDL-TG may better reflect the atherogenic potential of LDL than LDL-C.

关键词：心血管健康 Ludwigshafen 低密度脂蛋白系统炎症黏附分子血管造影险度炎症标记物胆固醇酯粥样硬化性

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肥胖儿童的胰岛素分泌过多与胰岛素抵抗的种族及疾病发生学上的差异

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世界核心医学期刊文摘（儿科学分册） 2005年第8期1卷 31-31页

作者： Preeyasombat C. Bacchetti P. Lazar A.A. Lustig R.h. 郭战宏 Division of Pediatric Endocrinology Box 0434 Univ. of California San Francisco 513 Parnassus Ave San Francisco CA 94143- 0434 United States Dr.

Objectives: To assess insulin dynamics to oral glucose tolerance testing in o bese children, denoting individual contributions of insulin hypersecretion versu s resistance to racial and etiopathogenetic specificity. Study design: We perfor med 3- hour oral glucose tolerance testing in 113 nondiabetic obese children (a ge 13.6 ± 3.1 years; 41 male, 78 female; 37 black, 41 white; 35 with central n ervous system [CNS] insult). The corrected insulin response (CIRgp; measuring β - cell secretion) and the composite insulin sensitivity index (CISI) were comp uted and log- transformed, and each was modeled in terms of the other, plus rac e/etiology, age, sex, body mass index z score, glucose tolerance, pubertal statu s, and geographic location. Results: A scatterplot of logCIRgp versus logCISI sh owed that racial and etiopathogenetic groups plotted in different areas. CISI (c ontrolled for CIRgp and other variables) was only 13% lower in blacks than in whites (P = .32). Conversely, CIRgp (controlled for CISI and other variables) wa s 49% higher in blacks (P = .028). CNS insult exhibited a 40% higher CIRgp ( P = .054) and 11% higher CISI (P = .42) than intact white subjects. Conclusion s: Insulin hypersecretion and resistance are distinct phenomena in childhood obe sity. Insulin hypersecretion ap- pears to be the more relevant insulin abnormal ity both in obese blacks and in CNS insult.

关键词：疾病发生学分泌过多肥胖儿童胰岛素抵抗儿童期肥胖 β细胞口服糖耐量试验发病机制胰岛素敏感指数黑色人种

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Interactions of IL-12A and IL-12B Polymorphisms on the Risk of Cervical Cancer in Chinese Women

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南京医科大学学报（自然科学版） 2009年第3期29卷 360-360页

作者： Chen, X. J. han, S. P. Wang, S. N. Zhou, X. Y. Zhang, M. F. Dong, J. Shi, X. Y. Qian, N. F. Wang, X. R. Wei, Q. Y. Shen, h. B. hu, Z.B. Nanjing med Univ Ctr Canc Dept Epidemiol & Biostat Nanjing Peoples R China Naniing med Univ Lab Reprod MedNanjingPeoples R China Nanjing med Univ Affiliated Hosp 1 Dept GynecolNanjing Peoples R China Nanjing med Univ Nanjing Matern & Child Hlth Hosp Nanjing Peoples R China Tumor hosp Nantong City NantongPeoples R China Univ Texas MD Anderson Canc Ctr Dept Epidemiol Houston TX 77030 USA

Purpose: Accumulative evidence suggests that interleukin-12 (IL-12) plays a central role in the Thl responses and thus participates in the carcinogenesis of human papillomavirus-related cervical *** hypothesized that potentially functional polymorphisms in IL12A and IL12B may individually and jointly contribute to cervical cancer risk. Experimental Design: We geno- typed IL12A rs568408[3′untranslated region(UTR)G > A] and rs2243115(5′UTR T > G) and IL12B rs3212227(3′UTR A > C) in a hospital-based study of 404 cervical cancer cases and 404 cancer-free controls. Resuhs:The IL12A rs568408 GA/AA and IL12B rs3212227 AC/CC variant genotypes were associated with a significantly increased risk of cervical cancer [adjusted odds ratio, 1.43; 95% confidence interval(CI), 1.06-1.93; and adjusted odds ratio, 1.30; 95% CI,0.97-1.75, respectively], compared with their corresponding wild-type homozygotes. Moreover, a significant gene-gene interaction of these 2 loci were evident in the risk of cervical cancer, and subjects carrying variant genotypes of both loci had a 1.82-fold(95% CI, 1.28-2.57) increased risk of cervical cancer. In the stratified analyses, the combined genetic effect was more pronounced in patients who had early-stage tumors or more parities. Subjects carrying rs568408 AG/AA and rs3212227 AC/CC genotypes and having>2 parities showed a 6.00-fold (95% CI,2.86- 12.56) elevated cervical cancer risk(P for muhiplicative interaction=0.046). Conclusion:These findings suggest that IL12A rs568408 and IL12B rs3212227 may individually and jointly contribute to the risk of cervical cancer and may modify cervical cancer risk associated with parity, but these data need further validation.

关键词：子宫癌妇科中国女性病例分析

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Nat Genet:科学家发现相同肿瘤中存在不同遗传复杂性的癌细胞

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现代生物医学进展 2017年第3期17卷 I0004-I0004页

作者： hao, Jia-Jie Lin, De-Chen Dinh, huy Q. Mayakonda, Anand Jiang, Yan-Yi Chang, Chen Jiang, Ye Lu, Chen-Chen Shi, Zhi-Zhou Xu, Xin Zhang, Yu Cai, Yan Wang, Jin-Wu Zhan, Qi-Min Wei, Wen-Qiang Berrnan, Benjamin P. Wang, Ming-Rong Koeffler, h. Phillip Chinese Acad med Sci Natl Canc Ctr Canc Hosp State Key Lab Mol Oncol Beijing Peoples R China Peking Union med Coll Beijing Peoples R China Univ Calif Los Angeles Cedars Sinai Med Ctr Sch Med Div Hematol Oncol Los Angeles CA 90048 USA Sun Yat Sen Univ Sun Yat Sen Mem Hosp Med Res Ctr Guangdong Prov Key Lab Malignant Tumor Epigenet & Guangzhou Guangdong Peoples R China Cedars Sinai med Ctr Biomed Sci Ctr Bioinformat & Funct Genom Los Angeles CA 90048 USA Natl Univ Singapore Canc Sci Inst Singapore Singapore Singapore Kunming Univ Sci & Technol Fac Med Kunming Peoples R China Linzhou Canc hosp Dept Pathol Linzhou Henan Peoples R China Chinese Acad med Sci Natl Canc Ctr Canc Hosp Dept Canc Epidemiol Beijing Peoples R China Natl Univ Singapore Inst Canc Natl Univ Singapore Hosp Singapore Singapore

近日，一项刊登于国际杂志Namre Genetics上的研究报告中。来自美国洛杉矶希达-西奈（Cedars-Sinai）医学院的研究人员通过研究在食管肿瘤的组织样本中鉴别出了2000多个基因突变，从而详细阐述了癌症的复杂性。本文研究表明。单一肿瘤... 详细信息

近日，一项刊登于国际杂志Namre Genetics上的研究报告中。来自美国洛杉矶希达-西奈（Cedars-Sinai）医学院的研究人员通过研究在食管肿瘤的组织样本中鉴别出了2000多个基因突变，从而详细阐述了癌症的复杂性。本文研究表明。单一肿瘤的不同区域或许具有多种遗传模式。

关键词：食管肿瘤遗传模式复杂性 Nat 癌细胞科学家基因突变研究人员

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Comprehensive treatment for the peritoneal metastasis from gastric cancer

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World Journal of Surgical Procedures 2015年第2期5卷 187-197页

作者： Yutaka Yonemura Emel Canbay Yoshio Endou haruaki Ishibashi Akiyosi Mizumoto Yan Li Yang Liu Kazuyoshi Takeshita Masumi Ichinose Nobuyuki Takao Takuya Saitou Kousuke Noguchi Masamitu hirano Oliver Glehen Bjorn Br?cher Paul h Sugarbaker NPO to Support Peritoneal Surface Malignancy Treatment Department of Regional Cancer Therapies Peritoneal Surface Malignancy Center Kishiwada Tokusyukai Houspital Kusatsu General Hospital Department of Experimental Therapeutics Cancer Research Institute Kanazawa University Department of Surgery Wuhan University Dēpartement de Chirurgie Gēnerale Centre Hospitalier Lyon-Sud Hospices Civils de Lyon Surgical Oncology Department of Surgery T?bingen Comprehensive Cancer center University of T?bingen Center of Gastrointestinal Malignancies Program in Peritoneal Surface Malignancies Med Star Washington Hospital Center

Recently, a novel comprehensive treatment consisting of cytoreductive surgery(CRS) and perioperative chemotherapy(POC) was developed for the treatment of peritoneal metastasis(PM) with a curative intent. In the treatment, the macroscopic disease is completely removed by the peritonectomy techniques in combination with POC. This article reviews the results of the comprehensive treatment for PM from gastric cancer, and verifies the effects of CRS and POC, including neoadjuvant chemotherapy(NAC) and hyperthermic intraoperative intraperitoneal chemotherapy(hIPEC). Completeness of cytoreduction, peritoneal carcinomatosis index(PCI) less than the threshold levels after NAC,absence of ascites, cytologic status, pathologic response after NAC are the independent prognostic factors. Among these prognostic factors, PCI threshold level is the most valuable independent prognostic factor. After staging laparoscopy, patients with PM from gastric cancer are recommended to treat with NAC before CRS. After NAC, indication for CRS is determined by laparoscopy. The indications of the comprehensive treatment are patients with PCI less than the threshold levels, negative cytology, and responders after NAC. Patients satisfy these factors are the candidates for the CRS and hIPEC.

关键词： Gastric cancer hyperthermic intraoperative intraperitoneal chemotherapy Peritoneal metastasis Peritonectomy

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通过初级医疗提供哮喘治疗指导以减少贫困的未成年城市儿童住院治疗及急症就医率

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世界核心医学期刊文摘（儿科学分册） 2005年第10期1卷 53-53页

作者： Cloutier M.M. hall C.B. Wakefield D.B. Bailit h. 虎小毅李丹 Asthma Center Connecticut Children's Med. Center 282 Washington Street Hartford CT 0 6106 United States Dr.

Objectives: To determine whether an organized, citywide asthma management prog ram delivered by primary care providers (PCPs) increases adherence to the Nation al Asthma Education and Prevention Program (NAEPP) Asthma Guidelines and whether adherence to the guidelines by PCPs decreases medical services utilization in l ow-income, minority children. Study design: Analysis of the utilization of medi cal services for a cohort of 3748 children with asthma who presented for care at one of six primary care urban clinics in hartford, Connecticut, and whowere enr olled in a disease management program (Easy BreathingTM) between June 1, 1998 an d August 31, 2002. Results: Of the 3748 children with physician confirmed asthma , 48%had persistent disease. Paid claims for inhaled corticosteroids increased 25%(P hing. Provider adherence to the NAE PP guidelines for anti-inflammatory therapy increased from 38%to 96%. Easy Br eathing children with asthma experienced a 35%decrease in overall hospitalizati on rates (P hma emergency department (ED) visits (P herence to the NAEPP guidelines for anti-inflammatory use by PCPs in urban clinics. Adherence to this element of t he guidelines by PCPs reduced hospitalizations, ED visits, and outpatient visits for children with asthma.

关键词：哮喘治疗城市儿童哮喘儿童住院治疗哮喘管理依从性急诊就医疾病管理持续症状医疗诊所

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