听觉正常人群和听神经病变患者的听觉时间进程

作     者：Michalewski H.J. Starr A. Nguyen T.T. 高中宝 

作者机构：Department of Neurology University of California150 Med. Surge I Irvine CA 92697-4290 United States 

出 版 物：《世界核心医学期刊文摘（神经病学分册）》 (Digest of the World Core Medical Journals:Clinical Neurology)

年 卷 期：2005年第1卷第8期

页      面：28-28页

学科分类：1002[医学-临床医学] 100213[医学-耳鼻咽喉科学] 10[医学] 

主　　题：听神经病 电生理 诱发电位 皮层电位 检测阈 主观反应 延长期 正常受试者 

摘      要：Objective: To study objectively auditory temporal processing in a group of nor mal hearing subjects and in a group of hearing-impaired individuals with audito ry neuropathy (AN) using electrophysiological and psychoacoustic methods. Method s:Scalp recorded evoked potentials were measured to brief silent intervals (gaps ) varying between 2 and 50 ms embedded in continuous noise. Latencies and amplit udes of N100 and P200 were measured and analyzed in two conditions:(1) active, w hen using a button in response to gaps;(2) passive, listening, but not respondin g. Results: In normal subjects evoked potentials(N100/P200 components) were reco rded in response to gaps as short as 5 ms in both active and passive conditions. Gap evoked potentials in AN subjects appeared only with prolonged gap durations (10-50 ms). There was a close association between gap detection thresholds mea sured psychoacoustically and electrophysiologically in both normals and in AN su ***: Auditory cortical potentials can provide objective measures of auditory temporal processes. Significance:The combination of electrophysiolog ical and psychoacoustic methods converged to provide useful objective measures f or studying auditory cortical temporal processing in normals and hearing-impair ed individuals. The procedure used may also provide objective measures of tempor al processing for evaluating special populations such as children who may not be able to provide subjective responses.