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Effects of low level laser treatment on the survival of axotomized retinal ganglion cells in adult Hamsters

Neural Regeneration Research 2014年第21期9卷 1863-1869页

作者： Kwok-Fai So mason chin pang leung Qi Cui GHM Institute of CNS Regeneration and Guangdong Key Laboratory of Brain Function and DiseasesJinan University Department of Anatomy LKS Faculty of MedicineThe University of Hong Kong Department of Ophthalmology LKS Faculty of MedicineThe University of Hong Kong Department of Rehabilitation Sciences The Hong Kong Polytechnic University

Injury to axons close to the neuronal bodies in the mammalian central nervous system causes a large proportion of parenting neurons to degenerate. It is known that optic nerve transection close to the eye in rodents leads to a loss of about half of retinal ganglion cells in 1 week and about 90% in 2 weeks. Using low level laser treatment in the present study, we demonstrated that treatment with helium-neon （660 nm） laser with 15 mW power could delay retinal ganglion cell death after optic nerve axotomy in adult hamsters. The effect was most apparent in the ifrst week with a short period of treatment time （5 minutes） in which 65–66% of retinal ganglion cells survived the optic nerve axotomy whereas 45–47% of retinal ganglion cells did so in optic nerve axotomy controls. We also found that single dose and early commencement of laser irradiation were important in protecting retinal ganglion cells following optic nerve axotomy. These ifndings thus convincingly show that appropriate laser treatment may be neuroprotective to retinal gan-glion cells.

关键词： low level laser treatment retinal ganglion cells optic nerve injury neuroprotection mi-croglial proliferation optic nerve axotomy

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Acupuncture improves cognitive function A systematic review

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Neural Regeneration Research 2013年第18期8卷 1673-1684页

作者： mason chin pang leung Ka Keung Yip Chung Tsung Lam Ka Shun Lam Wai Lau Wing Lam Yu Amethyst King Man leung Kwok-fai So Department of Rehabilitation Sciences the Hong Kong Polytechnic University Cambridge Regional College Department of Anatomy and the State Key Laboratory of Brain and Cognitive Science the University of Hong Kong Pokfulam Hong Kong Special Administrative Region China GHM Institute of CNS Regeneration Jinan University

BACKGROUND： Acupuncture has been used as a treatment for cognitive impairment. OBJECTIVE： This review assesses clinical evidence for or against acupuncture as a treatment for cognitive impairment. This review also discusses the proposed mechanism（s） that could link acupuncture to improved cognitive function. METHODS： We searched the literature using PolyUone search from its inception to January 2013, with full text available and language limited to English. Levels of evidence were examined using Oxford Centre for Evidence-based Medicine-Levels of Evidence （March, 2009）. RESULTS： Twelve studies met the inclusion criteria： 3 human studies and 9 animal studies. Levels of evidence ranged from level lb to level 5. CONCLUSION： Most animal studies demonstrated a positive effect of acupuncture on cognitive impairment. However, the results of human studies were inconsistent. Further high-quality human studies with greater statistical power are needed to determine the effectiveness of acupuncture and an optimal protocol.

关键词： neural regeneration dementia acupuncture electroacupuncture learning cognitive cognition memory neuroregeneration

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Effect of transcutaneous electrical nerve stimulation at acupoints on patients with type 2 diabetes mellitus:a randomized controlled trial

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Journal of Traditional chinese Medicine 2015年第2期35卷 134-140页

作者： Wu Zhiyuan Yang Ming Jia Jie Wu Yi Huang Tiansheng Li Mingfen He Zhijie Guo Zhenzhen leung mason chin pang Department of Rehabilitation Huashan Hospital Affiliated to Fudan University Department of Gastroenterology Shanghai Jiading Traditional Chinese Medicine Hospital Department of Rehabilitation Sciences The Hong Kong Polytechnic University

OBJECTIVE:To examine whether transcutaneous electric nerve stimulation at acupoints(Acu-TENS)improved the biochemical and physical indices of patients with type 2 diabetes mellitus(T2DM).METHODS:Ninety subjects with T2DM were divided randomly into a control group(n = 30),aerobic exercise group(n- 30),or Acu-TENS group(n = 30).In addition to conventional diabetes drug treatment,patients in the Acu-TENS group received acupoint stimulation,the aerobic exercise group engaged in walking exercises,and the control group was given sham electrical *** groups were treated for 30 min for each session and five times a week for 2 *** indices of glycosylated hemoglobin,2 h postprandial glucose,fasting serum insulin,triglyceride,total cholesterol,and body mass index were assessed at pre-treatment,post-treatment,and follow-up,which was 2 months after ***:The indices of the control group were not changed(P > 0.05) at the three time *** the pre-treatment measurement,there were significant differences(P > 0.05) in indices among the three *** post-treatment,each index of the two groups was lower than that of the control group(P < 0.05),and improved in comparison with the pre-treatment measurement(P < 0.05).In follow-up,each index of the aerobic exercise group and Acu-TENS group increased,but was still decreased compared with the pre-treatment value(P < 0.05),excluding body mass ***:Acu-TENS could improve the state of patients with T2 DM and be used as a therapy in clinical application.

关键词： Diabetes mellitus type 2 Transcutaneous electric nerve stimulation Acupuncture points Exercise

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