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Journal of Chemistry and Chemical Engineering 2017年第4期11卷 135-151页

作者： Shun yamane Yuuki Hiyoshi Shinnosuke Tanaka Shun Ikenomoto Takashi Numata Kazuya Takakura Tomoyuki Haraguchi Mauricio A. Palafox Michikazu Hara Mutsumi Sugiyama Takashiro Akitsu Department of Chemistry Faculty of Science Tokyo University of Science 1-3 Kagurazaka Shinjuku-ku Tokyo 1628601 Japan Departamento de Quimica-Fisica 1 Facultad de Ciencias Quimicas Universidad Complutense de Madrid Madrid 28040 Spain Materials and Structures Laboratory Tokyo Institute of Technology Nagatsuta-cho 4259 Midori-ku Yokohama-city Kanagawa226 8503 Japan Department of Electrical Engineering Faculty of Science and Technology Tokyo University of Science 2641 YamazakL NodaChiba 278 8510 Japan

The authors have designed and synthesized new chiral salen-type metal （M = Fe, Co, Ni, Cu, Zn） complexes （1-5） for new conceptual dyes （co-sensitizer or colorful multi-dyes） of DSSCs （dye-sensitized solar cells）. The authors measured substituent effects on their absorption spectra and redox properties, and compared them with TD-DFT （time-dependent density functional theory） calculations. Electron withdrawing groups resulted in red-shift of ultraviolet-visible （UV-Vis） spectra. For the first time, the authors also proposed and confirmed the importance of substituent effects on their electric transition dipole moments, calculated by TD-DFT for designing dyes. Chemisorption for TiO2 of the complex by carboxyl groups was confirmed by XPS measurement. In view of electronic properties, all compounds have the possibility to be dyes of DSSCs.

关键词： DSSCs (Dye-sensitized solar cells) salen complexes chirality DFT.

Delayed perforation after endoscopic submucosal dissection for early gastric cancer: Clinical features and treatment

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World Journal of Gastrointestinal Endoscopy 2016年第8期8卷 368-373页

作者： Takafumi Yano Satoshi Tanabe Kenji Ishido Mizutomo Azuma Takuya Wada Mizuto Suzuki Natsuko Kawanishi Sakiko yamane Tohru Sasaki Chikatoshi Katada Tetsuo Mikami Natsuya Katada Wasaburo Koizumi Department of Gastroenterology Kitasato University School of Medicine Research and Development Center for New Frontiers Kitasato University School of Medicine Department of Pathology Toho University School of Medicine Department of Surgery Kitasato University School of Medicine

Perforation is an important procedural complication of endoscopic submucosal dissection(ESD) for early gastric cancer. Although the incidence of delayed perforation after ESD is low, extreme caution is necessary because many cases require surgical intervention. Among 1984 lesions of early gastric cancer treated in our hospital by ESD in 1588 patients from September 2002 through March 2015, delayed perforation developed in 4 patients(4 lesions, 0.25%). A diagnosis of delayed perforation requires prompt action, including surgical intervention when required.

关键词： Endoscopic submucosal dissection Early gastric cancer Delayed perforation

A Phase II Study of Erlotinib in Patients with Previously Treated Non-Small Cell Lung Cancer

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Advances in Lung Cancer 2014年第1期3卷 10-20页

作者： Tetsuya Kubota Yoshio Okano Mizu Sakai Takashi yamane Naoki Shiota Hiroshi Ohnishi Hisanori Machida Nobuo Hatakeyama Eiji Takeuchi Tomoyuki Urata Fumitaka Ogushi Akihito Yokoyama Department of Hematology and Respiratory Medicine School of Medicine Kochi University Kochi Japan Division of Pulmonary Medicine Kochi Medical Center Kochi Japan Division of Pulmonary Medicine Kochi Red Cross Hospital Kochi Japan Division of Pulmonary Medicine NHO Kochi Hospital Kochi Japan

Background: Erlotinib has been reported to be effective for the treatment of non-small cell lung cancer (NSCLC). To evaluate the efficacy and safety of erlotinib under conditions similar to daily clinical practice, a phase II trial was conducted in Japanese patients with previously treated NSCLC. Methods: The eligibility criteria were stage IIIB/IV NSCLC, a performance status (PS) of 0 - 2, and previous treatment with 1 - 2 non-EGFR-TKI regimens. Patients received erlotinib (150 mg/day) orally until disease progression or intolerable toxicity occurred. The primary endpoint was the objective response rate (ORR). In addition, the disease control rate (DCR), progression-free survival (PFS), overall survival (OS), safety, and EGFR gene mutation status were evaluated. Results: Thirty-eight patients were enrolled, and 37 patients were evaluated. The median age was 69 years (range, 50 - 80 years). Patient characteristics were as follows: 26 were male and 11 were female;12 had a PS of 0, 20 had a PS of 1, and 5 had a PS of 2;and 26 had adenocarcinoma, and 11 had non-adenocarcinoma histology. The ORR and DCR were 21.6% (95% confidence interval [CI], 11.4% - 37.2%) and 54.1% (95% CI, 35.9% - 66.6%), respectively. Twenty-seven patients could be evaluated for EGFR gene status (12, mutated;15, wild-type). The ORR for EGFR-mutated patients was 41.7%, while that for patients with wild-type EGFR was 13.3%. The median PFS was evaluated as 4.4 months (95% CI, 2.2 - 10.7 months). The median OS was 14.9 months (95% CI, 9.2 months - not reached). Common adverse events were tolerable skin toxicities, diarrhea, and stomatitis. In addition, interstitial lung disease occurred in 8.1% of patients. Conclusion: As efficacy and safety were similar to previous studies, erlotinib was found to be effective for Japanese patients with previously treated NSCLC in clinical practice.

关键词： Non-Small Cell Lung Cancer Phase II Study Erlotinib Previously Treated

嗜酸性筋膜炎患者血清金属蛋白酶-1和2组织抑制剂水平的测定

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世界核心医学期刊文摘（皮肤病学分册） 2005年第2期1卷 20-21页

作者： Jinnin M. Ihn H. yamane K. 刘超 Department of Dermatology Faculty of Medicine University of Tokyo 7-3-1 Hongo Bunkyo-ku Tokyo 113-8655 Japan

Background: Serum levels of tissue inhibitor ofmetalloproteinases (TIMPs) have been reported to be elevated in patients with various connective tissue diseases. However, there has been no report that evaluates TIMPs in patients with eosinophilic fasciitis (EF). Objectives: To determine serum TIMP-1 and TIMP-2 levels in patients with EF and to investigate their clinical significance. Methods: Immunohistochemical stainings were performed in normal and EF skin samples. Serum TIMP-1 and TIMP-2 levels of 11 patients with EF and 12 healthy individuals were also measured with specific enzyme-linked immunosorbent assays. Results: The fascia of EF patients was stained only by TIMP-1. Serum TIMP-1 levels (mean ±SD) were significantly higher in EF patients than in healthy individuals (206.3 ±65.4 vs. 145.2 ±36.2 ng mL-1, P < 0.01). Serum TIMP-1 levels in EF patients were significantly correlated with serum γ-globulin and IgG levels (r = 0.86, P < 0.05; r = 0.83, P < 0.005, respectively). Conclusions: These results suggest that TIMP-1 is involved in the pathogenesis of EF, and that TIMP-1 may be a useful marker for the disease activity as well as serum γ-globulin or IgG levels.

关键词：嗜酸性筋膜炎组织抑制剂金属蛋白酶 TIMP 病情活动性结缔组织疾病 γ-球蛋白免疫组化染色 IgG 皮肤标本

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新型除草剂——dithiopyr

农药译丛 1991年第2期13卷 62-64页

作者： M.Fujiyama M.KasaiM.Itoh S.yamane 石蓉孟山都公司日本子公司

ditbiopyr系美国孟山都公司开发的芽前除草剂,它具有很高的单位活性,以低剂量即可防除杂草。1985年以来,日本已将其作为水稻和草皮除草剂进行开发。本文根据1985～88年田间试验结果,扼要介绍该药剂的除草活性以及在水稻和草皮中的选择性... 详细信息

ditbiopyr系美国孟山都公司开发的芽前除草剂,它具有很高的单位活性,以低剂量即可防除杂草。1985年以来,日本已将其作为水稻和草皮除草剂进行开发。本文根据1985～88年田间试验结果,扼要介绍该药剂的除草活性以及在水稻和草皮中的选择性。 dithiopyr的化学名称为:S,S-二甲基-2-(二氟甲基)-4-(2-甲基丙基)-6-(三氟甲基)-3,5-吡啶硫代二羧酸酯,其结构式如下:

关键词：新型除草剂除草活性选择性

Apple whole genome sequences:recent advances and new prospects

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Horticulture Research 2019年第1期6卷 1247-1270页

作者： Cameron P.Peace Luca Bianco Michela Troggio Eric van de Weg Nicholas P.Howard Amandine Cornille Charles-Eric Durel Sean Myles ZoëMigicovsky Robert J.Schaffer Evelyne Costes Gennaro Fazio Hisayo yamane Steve van Nocker Chris Gottschalk Fabrizio Costa David Chagné Xinzhong Zhang Andrea Patocchi Susan E.Gardiner Craig Hardner Satish Kumar Francois Laurens Etienne Bucher Dorrie Main Sook Jung Stijn Vanderzande Department of Horticulture Washington State UniversityPullmanWA 99164USA Computational Biology Fondazione Edmund MachSan Michele all’AdigeTN 38010Italy Department of Genomics and Biology of Fruit Crops Fondazione Edmund MachSan Michele all’AdigeTN 38010Italy Plant Breeding Wageningen University and ResearchWageningen 6708PBThe Netherlands Department of Horticultural Science University of MinnesotaSt.PaulMN 55108USA Institut für Biologie und Umweltwissenschaften Carl von Ossietzky Universität26129 OldenburgGermany GQE-Le Moulon Institut National de la Recherche AgronomiqueUniversity of Paris-SudCNRSAgroParisTechUniversitéParis-Saclay91190 Gif-sur-YvetteFrance Institut National de la Recherche Agronomique Institut de Recherche en Horticulture et SemencesUMR 134549071 BeaucouzéFrance Department of Plant Food and Environmental SciencesFaculty of AgricultureDalhousie UniversityTruroNS B2N 5E3Canada The New Zealand Institute for Plant and Food Research Ltd Motueka 7198New Zealand School of Biological Sciences University of AucklandAuckland 1142New Zealand AGAP INRACIRADMontpellier SupAgroUniversity of MontpellierMontpellierFrance Plant Genetic Resources Unit USDA ARSGenevaNY 14456USA Laboratory of Pomology Graduate School of AgricultureKyoto UniversityKyoto 606-8502Japan Department of Horticulture Michigan State UniversityEast LansingMI 48824USA The New Zealand Institute for Plant and Food Research Ltd(Plant&Food Research) Palmerston North Research CentrePalmerston North 4474New Zealand College of Horticulture China Agricultural University100193 BeijingChina Agroscope 8820 WädenswilSwitzerland Queensland Alliance of Agriculture and Food Innovation University of QueenslandSt Lucia 4072Australia New Cultivar Innovation Plant and Food ResearchHavelock North 4130New Zealand Agroscope 1260 ChanginsSwitzerland

In 2010,a major scientific milestone was achieved for tree fruit crops:publication of the first draft whole genome sequence(WGS)for apple(Malus domestica).This WGS,v1.0,was valuable as the initial reference for sequence information,fine mapping,gene discovery,variant discovery,and tool development.A new,high quality apple WGS,GDDH13 v1.1,was released in 2017 and now serves as the reference genome for *** the past decade,these apple WGSs have had an enormous impact on our understanding of apple biological functioning,trait physiology and inheritance,leading to practical applications for improving this highly valued *** gene identities for phenotypes of fundamental and practical interest can today be discovered much more ***-wide polymorphisms at high genetic resolution are screened efficiently over hundreds to thousands of individuals with new insights into genetic relationships and ***-density genetic maps are constructed efficiently and quantitative trait loci for valuable traits are readily associated with positional candidate genes and/or converted into diagnostic tests for *** understand the species,geographical,and genomic origins of domesticated apple more precisely,as well as its relationship to wild *** WGS has turbo-charged application of these classical research steps to crop improvement and drives innovative methods to achieve more durable,environmentally sound,productive,and consumer-desirable apple *** review includes examples of basic and practical breakthroughs and challenges in using the apple *** for“what’s next”focus on necessary upgrades to the genome sequence data pool,as well as for use of the data,to reach new frontiers in genomics-based scientific understanding of apple.

关键词： breakthrough hundreds frontier

常规激光原位角膜磨镶术后眼睛高阶像差和对比敏感度

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世界核心医学期刊文摘（眼科学分册） 2005年第4期1卷 39-40页

作者： yamane N. Miyata K. Samejima T. T. Oshika 王媛 Department of Ophthalmology Institute of Clinical Medicine University of Tsukuba 1- 1- 1 Tennoudai Tsukuba Ibaraki 305- 8575 Japan

PURPOSE. To investigate prospectively the relation between induced changes in higher- order aberrations of the eye and changes in contrast sensitivity by conventional laser in situ keratomileusis (LASIK) for myopia. METHODS. In 200 eyes of 110 consecutive patients (mean age, 32.7 ± .8.4 years) undergoing LASIK, ocular aberrations and contrast sensitivity function were determined before and 1 month after surgery. The amount of myopic correction was 5.2 ± .2.8 D (range, 1.0- 13.0). Ocular higher- order aberrations were measured for a 4- mm pupil using the Hartmann- Shack wavefront analyzer (KR- 9000PW; Topcon, Tokyo, Japan). The root mean square (RMS) of the third- and fourth- order Zernike coefficients was used to represent coma- and spherical- like aberrations, respectively. Total higher- order aberrations were calculated as the RMS of the third- and fourth- order coefficients. Contrast sensitivity and low- cont- rast visual acuity were measured. From the contrast sensitivity data, the area under the log contrast sensitivity function (AULCSF) was calculated. RESULTS. LASIK significantly improved logMAR best corrected visual acuity (Wilcoxon signed- rank test, P < .0.001), but significantly reduced AULCSF (P < 0.001) and low- contrast visual acuity (P=0.007). Total higher- order (P < 0.001), coma- like (P < 0.001), and spherical- like (P < .0.001) aberrations were significantly increased after LASIK. The greater the amount of achieved myopia correction was, the more the changes in contrast sensitivity function and ocular higher- order aberrations were. The induced changes in AULCSF by LASIK showed significant correlations with changes in total higher- order (Pearson r=- 0.221, P=0.003), coma- like (r=- 0.205, P=0.006), and spherical- like (r=- 0.171, P=0.022) aberrations. The changes in logMAR low- contrast visual acuity by surgery significantly correlated with changes in total higher- order (r=0.222 , P=0.003), comalike (r=0.201 , P=0.007), and spherical- like (r=0.

关键词：高阶像差对比敏感度近视矫正波前视敏度彗形像差矫正视力 Zernike 均方根秩检验

64层螺旋CT评估胃肠道穿孔位置:上、下胃肠道直接征象的检出率

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国际医学放射学杂志 2010年第4期 404-405页

作者： S.Oguro T.Funabiki K.Hosoda Y.Inoue T.yamane M.Sato 高飞 Department of Emergency and Critical Care Medicine Saiseikai Yokohamashi Tobu Hospital3-6-1ShimosueyoshiTsurumiYokohama230-0012Japan

目的通过64层螺旋CT(64-MDCT)评估肠壁的不连续性作为发现胃肠道穿孔位置的直接征象。方法回顾性研究41例急腹症病人,64-MDCT上有腔外气体(EA)显示。同评估直接征象

关键词：胃肠道敏感度直接征象 CT 螺旋

Nature:单核细胞SatM导致组织纤维化

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现代生物医学进展 2017年第3期17卷 I0001-I0001页

作者： Takashi Satoh, Katsuhiro Nakagawa, Fumihiro yamane, Kiyoharu Fukushima, Isao Ebina Shizuo Akira Takashi Satoh, Katsuhiro Nakagawa, Fumihiro yamane, Kiyoharu Fukushima, Isao Ebina Shizuo Akira Fuminori Sugihara Yoshichika Yoshioka Ryusuke Kuwahara Motooki Ashihara, Yosuke Minowa Isao Ebina Atsushi Kumanogoh Atsushi Kumanogoh Laboratory of Host Defense World Premier Institute Immunology Frontier Research Center Osaka University Osaka 565-0871 Japan Department of Host Defense Research Institute for Microbial Diseases (RIMD) Osaka University Osaka 565-0871 Japan Laboratory of Biofunctional Imaging World Premier Institute Immunology Frontier Research Center Osaka University Osaka 565-0871 Japan Research Center for Ultra-high Voltage Electron Microscopy Osaka University Osaka 567-0047 Japan Discovery Research Department Research Division Chugai Pharmaceutical Co. Ltd. Kanagawa 247-8530 Japan Core Research for Evolutional Science and Technology Japan Agency for Medical Research and Development Tokyo 100-0004 Japan Department of Respiratory Medicine Allergy and Rheumatic Diseases Graduate School of Medicine Osaka University Osaka 565-0871 Japan

在一项新的研究中，来自日本大阪大学免疫学前沿研究中心（IFReC）的研究人员报道了一类新的他们称之为SatM的单核细胞。针对小鼠的研究表明SatNI可能是导致组织纤维化的原因，而且成为一种治疗很少有有效疗法的疾病的新药物靶标。

关键词：单核细胞纤维化组织日本大阪大学研究人员药物靶标免疫学

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东京晴海岛海神广场的结构制振设计

建筑钢结构进展 2008年第3期10卷 17-20页

作者：浅野美次山野佑司吉江庆佑株式会社日建设计东京结构设计部

东京晴海岛海神广场建于2001年,是由3栋超高层智能型办公大楼及周边商业设施构成的综合建筑群。基于抗震性能设计理念,结构设计师在这3栋超高层办公大楼里合理地布置了阻尼器,以用来有效地吸收大地震时的地震能量。本文介绍了大楼的结... 详细信息

东京晴海岛海神广场建于2001年,是由3栋超高层智能型办公大楼及周边商业设施构成的综合建筑群。基于抗震性能设计理念,结构设计师在这3栋超高层办公大楼里合理地布置了阻尼器,以用来有效地吸收大地震时的地震能量。本文介绍了大楼的结构体系和设计方针,同时也介绍了制振构件的布置及其制振效果的验证。

关键词：超高层建筑群抗震性能设计耗能装置弹塑性动力时程分析