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World Journal of Transplantation 2023年第6期13卷 379-390页

作者： masayuki Nagasawa Department of Pediatrics Musashino Red Cross HospitalMusashino City 180-8610TokyoJapan Department of Pediatrics and Developmental Biology Tokyo Medical and Dental UniversityTokyo 113-8519TokyoJapan

BACKGROUND Numerous reports have demonstrated that the pathophysiology of graft-versushost disease(GVHD)during hematopoietic stem cell transplantation(HSCT)is closely related to vascular endothelial disorders and coagulation *** previously presented the discovery of a principle and the development of a novel instrument for measuring whole blood *** was achieved by assessing the variations in the dielectric properties of whole *** To investigate how GVHD affects the changes of dielectric properties of whole blood in patients with *** We examined the changes of dielectric properties of whole blood and erythrocyte proteins by sodium dodecyl sulfate-polyacrylamide gel electrophoresis sequentially in patients with HSCT and compared it with clinical symptoms and inflammatory parameters of *** During severe GVHD,the dielectric relaxation strength markedly increased and expression of band3 *** dielectric relaxation strength normalized with the improvement of *** vitro analysis confirmed that the increase of relaxation strength was associated with severe erythrocyte aggregates,but not with decreased expression of *** Severe erythrocyte aggregates observed in GVHD may cause coagulation abnormalities and circulatory failure,which,together with the irreversible erythrocyte dysfunction we recently reported,could lead to organ failure.

关键词： Graft-versus-host disease Dielectric relaxation Erythrocyte Stem cell transplantation Coagulation

Synthetic Study on Polyhydroxyestrogens Modeled for Inagami-Tamura Endogenous Digitalis-like Factor and Their Activity

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复旦学报（自然科学版） 2007年第5期46卷 603-604页

作者： masayuki Sakakibara Lab of Pharmaceutical Resource Discovery Dalian Institute of Chemistry and Physics

1 Results Mammalian possess receptors for digitalis,cardiac glycosides,derived from *** one of the results from studies on a real endogenous ligand for the receptors,so called an endogenous digitalis-like factor (EDF) or substance (EDS),Inagami and Tamura isolated a promising candidate possessing a molecular weight,*** elucidated several possible structures (Fig.1) for the factor and synthesized several modeled compounds,some of which exhibited remarkable constriction at higher concentrations t...

关键词： inagami-tamura endogenous digitalis-like factor (EDF) activity

Application of Rainbow Schlieren Deflectometry for Axisymmetric Supersonic Jets (Comparison of Experiments with Numerical Analysis)

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Journal of Thermal Science 2010年第3期19卷 218-221页

作者： Hideki Yamamoto masayuki Irie Yoshiaki Miyazato Kazuyasu Matsuo Department of Mechanical Systems Engineering Faculty of Environmental EngineeringThe University of Kitakyushu1-1 HibikinoWakamatsu-kuKitakyushuFukuoka 808-0135Japan

This paper analyzes the correctly-expanded supersonic jet from a convergent-divergent axisymmetric nozzle by using numerical simulation of turbulent *** the calculated density distributions in this flow are compared with the present experimental data using rainbow schlieren *** value of the density from the experimental data agrees well with the results calculated by this ***,the present method of the measurement using rainbow schlieren deflectometry is useful for the measurement of the density of the correctly-expanded supersonic jet.

关键词： Rainbow Schlieren Technique Numerical Analysis Axisymmetric Nozzle Correctly-Expanded Supersonic Jet

Relative importance of tidal flats and artificial habitats for two spoonbill species and related interspecific differences

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Avian Research 2023年第3期14卷 317-325页

作者： Takehiko Shimizu masayuki Senzaki Yuichiro Fujioka Satoquo Seino School of Interdisciplinary Science and Innovation Kyushu UniversityMotooka 744Nishi-kuFukuoka819-0395Japan Graduate School of Environmental Science Hokkaido UniversityKita 10-jo Nishi 5-chome Kita-kuSapporoHokkaido060-0810Japan Faculty of Environmental Earth Science Hokkaido UniversityKita 10-jo Nishi 5-chome Kita-kuSapporoHokkaido060-0810Japan Faculty of Social and Cultural Studies Kyushu UniversityMotooka 744Nishi-kuFukuoka819-0395Japan Faculty of Engineering Kyushu UniversityMotooka 744Nishi-kuFukuoka819-0395Japan

Artificial/seminatural environments,such as aquacultural ponds,saltpans,and croplands,have recently been acknowledged as important habitats for coastal *** coastal waterbirds tend to use artificial habitats around tidal flats as roosting sites during high-tide,it remains unclear whether the importance of surrounding habitats relative to tidal flats varies among landscape types,seasons,species,or tidal *** Black-faced Spoonbill(Platalea minor)and Eurasian Spoonbill(***)are two closely related sympatric species in East Asia with narrow and wide distribution ranges and habitat requirements,*** therefore expect that both species will use surrounding artificial habitats across seasons at high tides,but Blackfaced Spoonbills will use them less frequently than Eurasian ***,we address these hypotheses in the Imazu tidal flat and its surrounding environments in southern *** investigated the habitat use and behavioral patterns of both species through route and behavioral surveys during the fall migration and wintering seasons in *** found that both species used surrounding habitats including artificial ones more frequently than the tidal flat regardless of the tidal condition or season,but spoonbills used these habitats more frequently in winter than in *** also found that Eurasian Spoonbills foraged in surrounding artificial habitats more frequently than Black-faced *** results not only demonstrate how coastal waterbirds exploit surrounding habitats relative to tidal flats but also suggest that the importance of surrounding habitats varies among species and *** study thus emphasizes that valuing and managing surrounding habitats in addition to tidal flats are key to conserving globally declining waterbirds.

关键词： Artificial habitat Behavior Black-faced Spoonbill Eurasian Spoonbill Habitat use Surrounding environment Species distribution model Tidal flat

A combination of tides and nontidal variations in ocean bottom pressure may generate interannual slip fluctuations in the transition zone along a subduction plate interface

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Geodesy and Geodynamics 2023年第1期14卷 43-51页

作者： Yoshiyuki Tanaka Hiromu Sakaue masayuki Kano Suguru Yabe Department of Earth and Planetary Science The University of Tokyo7-3-1 HongoBunkyo-kuTokyo 113-0033Japan Graduate School of Science Tohoku University6-3Aramaki-aza-aobaAoba-kuSendai980-8578Japan Geological Survey of Japan National Institute of Advanced Industrial Science and Technology(AIST)Tsukuba Central 71-1-1 HigashiTsukubaIbaraki 305-8567Japan

The tidal triggering of earthquakes has been studied for many *** discovery of slow earthquakes in the early 2000s,including slow slip,has urged scientists to investigate the tidal responses of these earthquakes due to their sensitivity to weak stress *** studies have shown that slow earthquakes correlate with diurnal and semidiurnal tides and seasonal variations in surface loads more clearly than ordinary ***,little is known about long-term responses to external *** this paper,based on a widely accepted frictional law for faults,a mechanism is proposed by which nontidal variations in ocean bottom pressure,when combined with tides,pro mote the occurrence of slow *** slow earthquakes accompany a slip on the plate interface,this mechanism allows one to estimate slip modulations.A one-degree-of-freedom slip model is constructed and applied to Ise Bay in the Tonankai region of southwestern Japan,where large-scale ocean mass redistributions have *** model calculated with parameters determined from the observation of tectonic tremors is quantitatively consistent with the slip during 1997-2013 inferred from GNSS data,suggesting that the decrease in the sea-level change in approximately 2006 could cause the accele ration of a slip observed after *** result implies that the decreases in sea level in approximately 1996 and 2014 could also cause subsequent slip *** three slip acceleration periods temporally coincide with the increases in background seismicity in a shallower portion of the plate *** changes in seismicity are common to shallow earthquakes in the Tokai area,and a similar model can reproduce *** studies are expected to reveal causality between shallow earthquakes and long-term slip fluctuations based on modeling that considers changes in the frictional property along the plate interface.

关键词： Tides Ocean bottom pressure Slow earthquake Seismicity Kuroshio current

Pyloric-gland metaplasia may be an origin of cancer and intestinal metaplasia with possible CDX2 expression

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Gastroenterology Report 2021年第4期9卷 370-373,I0003页

作者： Kazuyoshi Yagi Atsunori Tsuchiya Satoru Hashimoto Taisuke Kato Osamu onodera Shuji Terai Department of Gastroenterology and Hepatology Uonuma Institute of Community MedicineNiigata University Medical and Dental HospitalNiigataJapan Division of Gastroenterology and Hepatology Graduate School of Medical and Dental SciencesNiigata UniversityNiigataJapan Department of System Pathology for Neurological Disorders Brain Science BranchBrain Research InstituteNiigata UniversityNiigataJapan Department of Neurology Brain Research InstituteNiigata UniversityNiigataJapan

Introduction The majority of cases of gastric cancer are thought to develop due to chronic inflammation from Helicobacter pylori(***)infection leading to intestinal metaplasia,termed the intestinal metaplasia–dysplasia–cancer sequence[1].Chronic inflammation from *** infection causes mucin core protein 6-positive(MUC6t)pyloric-gland metaplasia;however,its origin is *** MUC6t pyloric-gland metaplasia is similar to spasmolytic polypeptide-expressing metaplasia in mouse studies[2–4].

关键词：肠上皮化生幽门腺 Helicobacter CDX2

Novel approaches for posterior segment ocular drug delivery with folate-modified liposomal formulation

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Asian Journal of Pharmaceutical Sciences 2016年第1期11卷 201-202页

作者： Toshiki Hayashi Risako onodera Kohei Tahara Hirofumi Takeuchi Gifu Pharmaceutical University

The leading causes of vision impairment and blindness are posterior segment-related diseases including age-related macular degeneration,diabetic macular edema and ***,pharmaceutical approaches to these diseases have used steroids and *** drugs are usually administered via invasive injection because noninvasive delivery method such as eye drop administration of drugs is not ***,repeated injections are associated with potential risks of ***,patients may not comply with such regimens.

关键词： Liposome Retina Eyedrop Active targeting

Synchronization of Fourier-Synthesized Optical Pulses to a Mode-Locked Optical Clock

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光学学报 2003年第S1期23卷 475-476页

作者： Masaharu Hyodo Kazi Sarwal Abedin Noriaki onodera Masayoshi Watanabe Kansai Advanced Research Center Communications Research Laboratory 588-2 Iwaoka Nishi-ku Kobe 651-2492 JapanCommunications Research Laboratory 4-2-1 Nukui-kitamachi Koganei Tokyo 184-8795 JapanNational Defense Academy 1-10-20 Hashirimizu Yokosuka 239-8686 JapanKansai Advanced Research Center Communications Research Laboratory 588-2 Iwaoka Nishi-ku Kobe 651-2492 Japan

A Fourier-synthesized 40-GHz optical pulse train was successfully synchronized to an 8-GHz optical clock generated from a mode-locked fiber ring laser. The measured timing jitter of the synchronization was 0.43 ps.

关键词： of as be GHz FWM Synchronization of Fourier-Synthesized Optical Pulses to a Mode-Locked Optical Clock Figure were SSB from

Evaluation of precipitation behavior of zirconium molybdate hydrate

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Frontiers of Chemical Science and Engineering 2013年第1期7卷 65-71页

作者： Liang ZHANG masayuki TAKEUCHI Tsutomu KOIZUMI Izumi HIRASAWA Graduate School of Applied Chemistry Faculty of Science and Engineering Waseda University Tokyo 169-8555 Japan Japan Atomic Energy Agency Ibaraki 319-1194 Japan

In the dissolution step of spent nuclear fuel, there is a world-concern problem that zirconium molybdate hydrate precipitates as a byproduct, and accumulates in some reprocessing equipments. In order to prevent this accumulation, we have developed a new method based on the controlled reaction crystallization of zirconium molybdate hydrate （ZMH） in the reprocessing solution, followed by solid liquid separation. In order to measure the particle size of ZMH, batch crystallization experiments were conducted by varying nitric acid concentration and operating temperature. In result, almost all particle sizes scatter around 1μm on average, despite the higher concentration of nitric aid and operating temperature, and then small particles grow up as an aggregate sticking to the crystallizer. Moreover, polymorph and color changing were observed by varying the concentration of nitric acid and reaction time. These results suggest that crystal color and adhesiveness are closely related to the particle size of ZMH. And the control of nitric acid concentration and small particle growth would be the useful technique to prevent the ZMH sticking.

关键词： spent nuclear fuel zirconium molybdate hydrate cleaning method accumulation

The simplest route to generating a train of attosecond pulses

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Light(Science & Applications) 2013年第1期2卷 204-208页

作者： Kazumichi Yoshii John Kiran Anthony masayuki Katsuragawa Department of Engineering Science University of Electro-CommunicationsTokyoJapan

We report on two novel routes to generating a train of attosecond pulses from a broad discrete spectrum in the near-infrared–visible–ultraviolet *** extends an integer-temporal-Talbot(ITT)concept to include high-order spectral dispersions and generates a pulse train that completely satisfies the transform-limited *** other numerically explores the optimum conditions under which we can obtain an attosecond pulse train that approximately satisfies the transform-limited *** second method is more practical than the *** of these methods is extremely simple and robust;we need only to place a few thin dispersive materials in the optical path and to adjust their thicknesses without spatially dispersing the frequency *** numerically demonstrate the generation of a train of attosecond pulses with a transform-limited pulse duration of 728 as and a repetition period of 8.03 fs in gaseous parahydrogen.

关键词： adiabatic excitation of Raman transition attosecond pulse generation integer-temporal-Talbot(ITT)method molecular modulation