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Ceramide induces apoptosis in human lung adenocarcinoma A549 cells through mitogen-activated protein kinases

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Acta Pharmacologica Sinica 2007年第3期28卷 439-445页

作者： Nobuo murata Tatsuo YAMAKAWA Department of Surgery Mini-invasive surgery CenterTeikyo University Mizonokuchi HospitalKawasaki 213-8507Japan

Aim:To provide experimental data for further research on the signal transductionof apoptosis in lung adenocarcinoma cells,we examined the effects of exogenousC2-ceramide administration on several members of the mitogen-activated proteinkinase(MAPK)superfamily and caspase-3 in A549 ***:Cell viabilityand apoptosis were analyzed by cell counting kit-8 assay and flow *** MAPK and caspase-3 proteins were detected by Western ***:C2-ceramide selectively altered the phosphorylation state &members ofthe MAPK superfamily,causing hyperphosphorylation ofmitogen-activated pro-tein kinase kinase(MEK)1/2 and the p38 MAPK,but not affecting the phosphory-lation ofextracellular signal-regulated kinase 1/2 and the c-Jun N-terminal ***-203580(a p38 MAPK inhibitor)and p38 siRNA,but not U0126(a MEKinhibitor),partially rescued cell death induced by C2-ceramide.C2-ceramide promoted theactivation of ***:Exogenous C2-ceramide induced apoptosisin human lung adenocarcinoma A549 *** activation of MAPK and caspase-3were involved in the mechanisms ofC2-ceramide-induced apoptosis in A549 cells.

关键词： ceramide apoptosis mitogen-activated protein kinases A549 cells

Insensitivity to Unethical Behavior in Dictator Game When Indirectly Intermediated-Implications of Indirect Blindness for Safety Management

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Journal of Behavioral and Brain Science 2016年第5期6卷 199-208页

作者： Atsuo murata Department of Intelligent Mechanical Systems Graduate School of Natural Science and Technology Okayama University Okayama Japan

The aim of this study was to demonstrate that indirect mediation in behaviors leads to insensitivity to unethical behavior through a dictator game and to give some implications for safety management. The indirect involvement in the unethical behavior such as the violation of regulation is believed to lessen the responsibility and the criticism from others for the unethical behavior as compared to the direct involvement in it. The instruction condition for the evaluator of behavior in a dictator game was taken up as an experimental variable. Instruction condition 1 was to pay attention to the behavior of only a dictator. In instruction condition 2, the participant (evaluator) was required to review all players’ behavior and evaluate a dictator. It has been investigated whether allowing indirect actions (mediations) leads to reduced punishment as a function of the instruction condition. While the punishment to the indirectness did not get smaller for instruction condition 2, the punishment to the indirectness tended to get smaller only for instruction condition 1.

关键词： Unethical Behavior Punishment and Fairness Intermediation Dictator Game Decision Making Safety Management

Proximity-induced magnetic order in topological insulator on ferromagnetic semiconductor

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Science China(Information Sciences) 2023年第12期66卷 267-274页

作者： Hangtian WANG Koichi murata Weiran XIE Jing LI Jie ZHANG Kang L.WANG Weisheng ZHAO Tianxiao NIE School of Integrated Circuit Science and Engineering and Advanced Innovation Center for Big Data and Brain Computing Beihang University Beihang-Goertek Joint Microelectronics Institute Qingdao Research InstituteBeihang University Department of Electrical Engineering University of California

Introducing magnetic order into topological insulator(TI) to break the time-reversal symmetry can yield numerous fascinating physical phenomena,which brings new hope for the emerging spintronic *** proximity effect is regarded as a promising strategy that could advance the step for realistic application by choosing a suitable ferromagnetic layer with the merits of high Curie temperature and high compatibility with mainstream semiconductor ***,we prepare a Bi2Se3thin film on Sicompatible ferromagnetic semiconductor(FMS) of MnxGe1-xby molecular beam *** integration,the nonmagnetic Bi2Se3exhibits an anomalous Hall signal and a clear weak localization cusp in magnetoresistance until 150 K,confirming that a high-temperature magnetism can be induced by the proximity *** investigation of the magnetoconductance quantitatively indicates that the Bi2Se3conductance suffers a transition from weak antilocalization to weak localization behavior after integrating with MnxGe1-x,and an 80 meV bandgap is predicted to be opened in the surface states in Bi2Se3layer due to the proximityinduced *** results prove that the proximity effect could be an important method to achieve topological magnetism at high temperatures,and reveals its potential for the manipulation of the topological surface states.

关键词： topological insulator ferromagnetic semiconductor proximity effect quantum interference

Physiological significance of Rag1 in retinal ganglion cell death

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Neural Regeneration Research 2015年第2期10卷 192-194页

作者： Takuma Hayashi Toshinori murata Department of Immunology and Infectious Disease Shinshu University Graduate School of Medicine Department of Ophthalmology Shinshu University Graduate School of Medicine

Although the transcription factor, nudear factor-κB （NF-κB） is known to regulate cell death and survival, its precise role in cell death within the central nervous system （CNS） remains unknown. We previously reported that mice with a homozygous deficiency for NF-κBp50 spon- taneously developed optic neuropathy. We examined the expression and activation of pro-apoptotic factor（s） that mediate optic neuropathy in p50-/- mice. Recombination activating gene 1 （Ragl） is known to regulate the recombination of immunoglobulin V（D）J.

关键词： RGCs Physiological significance of Rag1 in retinal ganglion cell death cell

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Improvement of a Real Gas-Sensor for the Origin of Methane Selectivity Degradation by l-XAFS Investigation

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Nano-Micro Letters 2015年第3期7卷 255-260页

作者： Takahiro Wada Naoyoshi murata Takuya Suzuki Hiromitsu Uehara Hiroaki Nitani Yasuhiro Niwa Motohiro Uo Kiyotaka Asakura Graduate School of Medical and Dental Sciences Tokyo Medical and Dental University Corporate R&D Headquarters Fuji Electric Co. Ltd Catalysis Research Center Hokkaido University Photon Factory Institute of Materials Structure Science

We have directly investigated the chemical state of the Pd species in a real l-gas sensor device by examining the l-fluorescence X-ray absorption fine structure. The l-gas sensor device was heavily damaged by a heating process in which the temperature was ill-controlled, resulting in decrease of methane selectivity. We found that the Pd O in the fresh l-gas sensor was reduced to Pd metal particles as the methane selectivity decreased. Based on the investigation results, we modified the device structure so as to heat up homogeneously. The lifetime of the sensor was then successfully increased by more than 5 years.

关键词： Micro gas sensor Micro-XAFS Pd/Al2O3 Deactivation

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Non-regular Employment of Women,Fertility Rate,and Economic Growth

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