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Food Bioscience 2022年第3期47卷 1294-1300页

作者： Mari Enokida Ken-ichiro Minato Susumu Yoshino Nobuaki Ohto Hiroshige Kuwahara masashi mizuno Department of Agrobioscience Graduate School of Agricultural ScienceKobe UniversityKobe657-8501Japan Department of Applied Biological Chemistry Graduate School of AgricultureMeijo UniversityNagoya468-8502Japan Research Center Maruzen Pharmaceuticals Co.Ltd.Fukuyama729-3102Japan

In recent years,researches on food components with anti-allergic effects have been gathering attention,because of the expectation for the establishment of a safe and effective treatment for food *** studies have reported that Lactiplantibacillus plantarum 22A-3 (LP22A3) inhibited degranulation of mast cells and reduced IgE *** have developed a gastrointestinal allergy system in which mice are sensitized by intraperitoneal and oral administration of OVA and then challenged by oral administration of high doses of *** a result,an increase in the amount of IgE in the blood and a decrease in the temperature of the colon were confirmed,and it was clarified that food allergy was induced by oral administration of high dose of OVA as the *** administration of LP22A3 ameliorated allergic responses significantly by reducing the amount of IgE in the blood and to recovered the decrease of rectal ***,LP22A3 did not affect the intestinal barrier *** LP22A3 significantly suppressed mRNA expression of OX40L and *** results suggested that LP22A3 suppressed Th2 differentiation and IL-4 production via downregulation of OX40L,and consequently suppressed IgE ***22A3 might provide a safe and effective treatment for allergic diseases due to ability modulating intestinal immune system.

关键词： Anti-allergic activity Food allergy Lactiplantibacillus plantarum 22A-3 Ovalbumin OX40L

Regeneration mechanisms and therapeutic strategies for neuromuscular junctions in aging and diseases

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Neural Regeneration Research 2025年第1期20卷 193-194页

作者： masashi Fujitani Abu Md Mamun Tarif Yoshinori Otani Department of Anatomy and Neuroscience Faculty of MedicineShimane UniversityShimaneJapan

The neuromuscular junction(NMJ)is an essential synaptic structure composed of motor neurons,skeletal muscles,and glial cells that orchestrate the critical process of muscle contraction(Li et al.,2018).The typical NMJ structure is classically described as having a“pretzel-like”shape in mice(Figure 1),whereas human NMJs have a smaller,fragmented structure throughout *** NMJs exhibit smaller or fragmented endplates,partial denervation,reduced numbers of synaptic vesicles,abnormal presynaptic mitochondria,and dysfunctional perisynaptic Schwann cells(Alhindi et al.,2022).

关键词： aging structure Figure

不同品种苹果采后后熟软化过程中细胞壁多糖的降解

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植物生理与分子生物学学报 2006年第6期32卷 617-626页

作者：金昌海水野雅史阚娟索标汪志君土田广信扬州大学食品科学与工程学院中国扬州225001 神戸大学农学部园艺资源学大讲座

以2种苹果为试材,提取了不同贮藏时期果实的细胞壁物质和8种细胞壁多糖组分,并采用气相色谱法分析了细胞壁多糖组分的单糖组成。结果表明,在贮藏过程中,‘金星’苹果果肉的硬度下降明显,在贮藏第10天前后出现明显的乙烯释放量高峰,而耐... 详细信息

以2种苹果为试材,提取了不同贮藏时期果实的细胞壁物质和8种细胞壁多糖组分,并采用气相色谱法分析了细胞壁多糖组分的单糖组成。结果表明,在贮藏过程中,‘金星’苹果果肉的硬度下降明显,在贮藏第10天前后出现明显的乙烯释放量高峰,而耐贮藏性‘富士’苹果在贮藏期间只释放极少量的乙烯。‘金星’苹果的Na2CO3-1溶性果胶多糖组分的减少尤为显著。这些结果表明,苹果果实Na2CO3-1溶性果胶多糖组分侧链成分的酶降解,是引起苹果细胞壁多糖网络结构的变化,进而导致果实软化的重要原因之一。

关键词：苹果贮藏乙烯后熟软化细胞壁多糖

Potential of non-Western medicines in chemoradiotherapy for cervical cancer

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World Journal of Clinical Cases 2025年第2期13卷 21-23页

作者： Takashi Ono masashi Koto Department of Radiation Oncology Faculty of MedicineYamagata UniversityYamagata 990-9585Japan

This editorial explores the potential integration of non-Western medicine into radiotherapy for cervical *** radiotherapy remains a radical treatment for cervical cancer,its associated toxicity and decline in quality of life can significantly impact patients’***,most treatments are supportive,with no specific treatment options available in Western ***-Western medicine,often less toxic and easier to administer,has shown promising results when used alongside radiotherapy for cervical *** these potential benefits,challenges such as limited evidence and restricted application areas *** non-Western medicines may offer potential improvements in chemoradiotherapy outcomes for cervical cancer,further research is necessary to substantiate these benefits.

关键词： Cervical cancer Radiotherapy Non-Western medicine Kampo Herbal medicine

Long-term efficacy of endoscopic coagulation for different types of gastric vascular ectasia

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World Journal of Gastroenterology 2013年第18期19卷 2799-2805页

作者： Yukinori Imai Yoshie mizuno Kiyoko Yoshino Kazuhiro Watanabe Kayoko Sugawara Daisuke Motoya masashi Oka Satoshi Mochida Department of Gastroenterology and Hepatology Faculty of Medicine Saitama Medical University Saitama 350-0495 Japan

AIM: To examine the long-term therapeutic efficacies of endoscopic cauterization for gastric vascular ectasia, according to the type of lesion. METHODS: Thirty-eight patients with hemorrhagic gastric vascular ectasia (VE) were treated by endoscopic cauterization: 13 by heater probe coagulationand 25 by argon plasma coagulation. Depending on the number of lesions, 14 and 24 patients were classified into localized VE (≤ 10; LVE) and extensive VE (> 10; EVE), respectively. The patients were followedup by repeated endoscopic examinations after the therapy, and the incidences of VE recurrence and rebleeding from the lesions were evaluated. RESULTS: Although the VE lesions disappeared initially in all the patients after the therapy, the recurrence of VE developed in 25 patients (66%) over a mid-term observation period of 32 mo, and re-bleeding occurred in 15 patients (39%). The recurrence of VE was found in all patients with EVE, with re-bleeding occurring in 14 patients (58%). In contrast, only 1 patient (7%) with LVE showed recurrence of the lesions and complicating hemorrhage. Both the cumulative recurrence-free rates and cumulative re-bleeding-free rates were significantly lower in the EVE group than in the LVE group (P < 0.001 and P < 0.001, respectively). Moreover, the cumulative re-bleeding-free rate in the EVE group was 47.6% at 1 year and 25.4% at 2 years in patients with chronic renal failure, which were significantly lower than the rates in the patients without chronic renal failure (83.3% and 74.1%, respectively) (P < 0.05). CONCLUSION: The recurrence of VE and re-bleeding from the lesions was more frequent in the patients with EVE, especially in those with complicating renal failure.

关键词： Gastric vascular ectasia Heater probe coagulation Argon plasma coagulation Renal failure Recurrence

Studies on multiferroic materials in high magnetic fields

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Frontiers of physics 2012年第4期7卷 386-398页

作者： masashi Tokunaga The International MegaGauss Science Laboratory The Institute for Solid State Physics (IMGSL-ISSP) The University of Tokyo Kashiwa 277-8581 Japan

In this article, studies on the magnetoelectric effects of multiferroic materials in high magnetic fields, particularly pulsed magnetic fields, are discussed and results for some representative ma- terials are presented. In the discussions on representative materials, the relationship between the crystallographic symmetry and the linear magnetoelectric effect in Cr203 is introduced. Then dras- tic changes in polarization caused by magnetic transitions are discussed through a case study of manganites with a perovskite4ype structure. In addition, high field studies on the magnetoelectric effects in BiFeO3, which is an exceptional multiferroic material, are presented and discussed in the framework of the Landau-Ginzburg theory.

关键词： high magnetic field multiferroic materials magnetoelectric effect

Application of the generalized body-fixed coordinate system for the wave-body interaction problem of a small-depth elastic structure in head seas

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Journal of Hydrodynamics 2021年第6期33卷 1255-1270页

作者： Kyeonguk Heo masashi Kashiwagi School of Naval Architecture and Ocean Engineering University of UlsanUlsanKorea Department of Naval Architecture and Ocean Engineering Osaka UniversitySuitaJapan

The body-fixed coordinate system is applied to the wave-body interaction problem of a small-depth elastic structure which has both rigid and elastic body motions in head *** the weakly non-linear assumption,the perturbation scheme is used and the expansion is conducted up to second-order to consider several non-linear *** solve the boundary value problem,linearization is carried out based not on inertial coordinate but on body-fixed coordinate which could be accelerated by a motion of a *** first,the main feature of the application of body-fixed coordinate system for a seakeeping problem is briefly *** that the transformation of a coordinate system is extended to consider an elastic body motion and several physical variables are re-described in the generalized *** has been found that the deformation gradient could be used for the transformation of a coordinate system if several conditions are *** there are only vertical bending in elastic modes and the structure has relatively small depth,these conditions are generally *** calculate an elastic motion of a body,the generalized mode method is adopted and the mode shape is obtained by solving eigen-value problem of dynamic beam *** the boundary condition of the body-fixed coordinate system,the motion effect reflected to free-surface boundary is considered by extrapolating each mode shape to the horizontal direction from a *** last,simple numerical tests are implemented as a validation *** second-order hydrodynamic force of a freely floating hemisphere is first calculated in zero forward speed ***,motion and added resistance of a ship with forward speed are considered at different flexibility to confirm the effect of an elastic body motion in body-fixed coordinate system.

关键词： Hydroelasticity Higher-order boundary element method(HOBEM) generalized mode method perturbation scheme body-fixed coordinate system wave-body interaction

Two-dimensional self-assembly of melem and melemium cations at pH-controlled aqueous solution-Au（111） interfaces under electrochemical control

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Frontiers of Chemical Science and Engineering 2016年第2期10卷 294-300页

作者： Shinobu Uemura Kenki Sakata masashi Aono Yusuke Nakamura masashi Kunitake Department of Advanced Materials Sciences Faculty of Engineering Kagawa University Kagawa 761-0396 Japan Graduate School of Science and Technology Kumamoto University Kumamoto 860-8555 Japan

Two-dimensional self-assembly of melem at pH-controlled aqueous solution-Au（111） interfaces has been investigated by electrochemical scanning tunneling microscopy. In the solutions with pH 〉 pKbl of melem, two ordered self-assembled structures （honeycomb and close-packed structures） and one disordered fibrillar structure were observed as a function of the surface coverage ofmelem controlled by the electrode potential. In contrast, in the acidic solution with pH 〈 pKbl of melem, only the self-assembled honeycomb network was observed in a relatively wide potential range probably due to the presence of monoprotonated melem cations. Dots attrib- uted to counteranions were frequently observed in the pores of the honeycomb network. The lack of close-packed and fibrillar structures at low pH （〈 pKbl） is attributed to ionic repulsion of melemium cations.

关键词： self-assembly scanning tunneling micro-scopy electrochemistry structural phase transition melem

Flow Visualization around a Double Wedge Airfoil Model with Focusing Schlieren System

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Journal of Thermal Science 2006年第1期15卷 31-36页

作者： masashi KASHITANI Yutaka YAMAGUCHI Department of Aerospace Engineering National Defense Academy 1-10-20 Hashirimizu Yokosuka Kanagawa 239-8686Japan

In the present study, aerodynamic characteristics of the double wedge airfoil model were investigated in a transonic flow by using the shock tube as an intermittent wind tunnel. The driver and driven gases of the shock tube are dry air. The airfoil model of double wedge has the span of 58 mm, chord length c = 75 mm and its maximum thickness is 7.5 mm. The apex of the double wedge airfoil model is located on the 35% chord length from the leading edge. The range of hot gas Mach numbers are from 0.80 to 0.88, and the Reynolds numbers based on chord length are 3.11× 10^5- 3.49× 10^5, respectively. The flow visualizations were performed by the sharp focusing schlieren method which can visualize the three dimensional flow fields. The results show that the present system can visualize the transonic flowfield clearer than the previous system, and the shock wave profiles of the center of span in the test section are visualized

关键词： shock wave schlieren method transonic flow double wedge airfoil model

Regulation of hepatic function by brain neuropeptides

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World Journal of Gastroenterology 1998年第3期4卷 12-16页

作者： masashi Yoneda School of Medicine Hirosaki University Japan Postgraduate School Hirosaki University Japan University of California Los Angeles CA United States Second Department of Medicine Asahikawa Medical College Japan Department of Medicine Intl. Univ. of Health and Welfare Japan Japan. Society of Gastroenterology Japan Second Department of Medicine Asahikawa Medical College Asahikawa 078 Nishikagura 4-5-3 Japan

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关键词： liver/physiology thyrotropin releasing hormone corticotropin releasing factor neuropeptide Y central nervous system bombesin βendorphin DAlaMet enkepalinamide