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Y chromosome microdeletion screening using a new molecular diagnostic method in 1030 Japanese males with infertility

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Asian Journal of Andrology 2020年第4期22卷 368-371页

作者： masashi Iijima Kazuyoshi Shigehara Hideki Igarashi Koichi Kyono Yasuo Suzuki Yuji Tsuji Yoshitomo Kobori Hideyuki Kobayashi Atsushi Mizokami Department of Integrative Cancer Therapy and Urology Kanazawa University Graduate School of Medical ScienceKanazawa 920-8641Japan Kyono ART Clinic Sendai 980-0014Japan Kyono ART Clinic TakanawaTokyo 108-0074Japan Suzuki Lady's Hospital Kanazawa 921-8033Japan Ebisu Tsuji Clinic Tokyo 150-0021Japan Tenjin Tsuji Clinic Fukuoka 810-0001Japan Dokkyo Medical University Koshigaya Hospital Saitama 343-8555Japan Department of Urology Faculty of MedicineToho UniversityTokyo 143-8541Japan

The azoospermia factor(AZF)region is important for spermatogenesis,and deletions within these regions are a common cause of oligozoospermia and *** several studies have reported this cause,the present research,to the best of our knowledge,is the first large-scale study assessing this factor in *** this study,1030 male patients with infertility who were examined for Y chromosome microdeletion using the polymerase chain reaction-reverse sequence-specific oligonucleotide(PCR-rSSO)method,a newly developed method for Y chromosome microdeletion screening,were *** study enrolled 250 patients with severe oligospermia and 717 patients with *** the 1030 patients,4,4,10,and 52 had AZFa,AZFb,AZFb+c,and AZFc deletions,*** sperm recovery rate(SRR)of microdissection testicular sperm extraction in patients with AZFc deletions was significantly higher than that in those without AZF deletions(60.0%vs 28.7%,P=0.04).In patients with gr/gr deletion,SRR was 18.7%,which was lower than that in those without gr/gr deletion,but was not statistically *** conclusion,our study showed that the frequency of Y chromosome microdeletion in male patients in Japan was similar to that reported in patients from other countries,and SRR was higher in patients with AZFc deletion.

关键词： azoospermia factor Japanese infertile men sperm recovery rate Y chromosome microdeletion

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Photosafety testing of dermally-applied chemicals based on photochemical and cassette-dosing pharmacokinetic data

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Asian Journal of Pharmaceutical Sciences 2016年第1期11卷 237-238页

作者： Hiroto Ohtake Yukiko Suzuki masashi Kato Yoshiki Seto Satomi Onoue Department of Pharmacokinetics and Pharmacodynamics School of Pharmaceutical Sciences University of Shizuoka

Drug-induced phototoxicity is elicited by exposure of skin and/or eyes to topical or systemic administration of chemicals,followed by exposure to *** photosafety testing,a new screening strategy,employing in vitro photochemical/photobiological and in vivo cassette-dosing pharmacokinetic(PK)studies,was proposed[1,2].The screening system provided reliable phototoxic predictions of tested chemicals at least within the same chemical series;however,the applicability of the proposed strategy is not fully understood.

关键词： Photosafety assessment Phototoxicity Photoreactivity Pharmacokinetics

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Recent advances in the surgical treatment of hepatocellular carcinoma

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World Journal of Gastroenterology 2014年第39期20卷 14381-14392页

作者： Zenichi Morise Norihiko Kawabe Hirokazu Tomishige Hidetoshi Nagata Jin Kawase Satoshi Arakawa Rie Yoshida masashi Isetani Department of Surgery Fujita Health University School of Medicine Banbuntane Houtokukai Hospital Nagoya 454-8509 Japan

Hepatocellular carcinoma(HCC) is the most common primary liver malignancy. The treatment of HCC is complex and complicated by the severity of associated chronic liver disease, the stage of HCC, and the clinical condition of the patient. Liver resection(LR) is one of the most efficient treatments for patients with HCC, with an expected 5-year survival of 38%-61% depending on the stage of the disease. Improved liver function assessment, increased understanding of segmental liver anatomy from advanced imaging studies, and surgical technical progress are important factors that have led to reduced mortality in patients with HCC. The indication for LR may be expanded due to emerging evidences from laparoscopic hepatectomies and combined treatments with newly developed chemotherapies. Liver transplantation(LT) is considered as an ideal treatment for removal of existing tumors and the injured/preneoplastic underlying liver tissue with impaired liver function and the risk of multicentric carcinogenesis that results from chronically injured liver. However, LT is restricted to patients with minimal risk of tumor recurrence under immunosuppression. The expansion of criteria for LT in HCC patients is still under trial and discussion. Limited availability of grafts, as well as the risk and the cost of transplantation have led to considerable interest in expansion of the donor pool, living donor-related transplantation, and combined treatment involving LR and LT. This highlight presents evidence concerning recent studies evaluating LR and LT in HCC patients. In addition, alternative therapies for the treatment of early stage tumors and the management of patients on transplant waiting lists are discussed.

关键词： Hepatocellular carcinoma Surgical treatment Hepatectomy Liver transplantation Laparoscopic hepatectomy Tumor thrombi Chemotherapy

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Visceral Ischemia Caused by Extra-Anatomical Bypass for Coral Reef Aorta

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World Journal of Cardiovascular Surgery 2015年第7期5卷 70-73页

作者： masashi Kawabori Division of Cardiac Surgery Brigham and Women’s Hospital Harvard Medical School Boston MA USA

A 72-year-old woman was presented with intermittent claudication of bilateral lower extremities, refractory hypertension, and mild renal impairment. Computed tomographic angiography showed severe aortic stenosis caused by calcifications protruding into the aortic lumen proximal and distal to the visceral and renal branches, so-called coral reef aorta. An axillo-iliac bypass was performed. Postoperatively, the patient developed ileus and acute renal failure, presumably caused by a steal phenomenon to the lower extremities. Endovascular stenting of the aorta increased forward blood flow and dramatically improved the patient’s condition. This case study illustrates potential hemodynamic complications after extra-anatomical axillo-iliac bypass for coral reef aorta.

关键词： Coral Reef Aorta Extra-Anatomical Bypass Aortic Stenosis Ischemia

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Impairment of extra-high frequency auditory thresholds in subjects with elevated levels of fasting blood glucose

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Journal of Otology 2018年第1期13卷 29-35页

作者： Anindya Das Ahmed Faisal Sumit Nazmul Ahsan masashi Kato Nobutaka Ohgami Anwarul Azim Akhand Department of Genetic Engineering and Biotechnology University of Dhaka Dhaka Bangladesh BRAC James P Grant School of Public Health BRAC University Dhaka Bangladesh Department of Occupational and Environmental Health Nagoya University Graduate School of Medicine Nagoya Japan

This study was performed to assess whether there is an association between elevated Fasting Blood Glucose(FBG) and hearing impairment in Bangladeshi population. A total of 142 subjects(72 with elevated FBG; 70 control) were included in the study. The mean auditory thresholds of the control subjects at 1,4,8 and 12 kHz frequencies were 6.35 ± 0.35,10.07 ± 0.91,27.57 ± 1.82, 51.28 ± 3.01 dB SPL(decibel sound pressure level), respectively and that of the subjects with elevated FBG were 8.33 ± 0.66,14.37 ± 1.14, 38.96 土 2.23, and 71.11 ± 2.96 ***. The auditory thresholds of the subjects with elevated FBG were significantly(p 10 years) showed significantly(p 40 years) and younger(<40 years) age groups compared to the respective controls. The binary logistic regression analysis showed a 5.79-fold increase in the odds of extra-high frequency hearing impairment in diabetic subjects after adjustment for age, gender and BMI. This study provides conclusive evidence that auditory threshold at an extra-high frequency could be a sensitive marker for hearing impairment in diabetic subjects.

关键词： Fasting blood glucose Hearing impairment Auditory thresholds Extra-high frequency

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Aortic Valve Replacement in Bicuspid Aortic Valve with a Single Coronary Artery

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World Journal of Cardiovascular Surgery 2015年第12期5卷 131-134页

作者： masashi Kawabori Division of Cardiac Surgery Brigham and Women’s Hospital Harvard Medical School Boston MA USA

Coronary artery anomalies combined with bicuspid aortic valve are rare but cause perioperative complications if not detected on time. Because anomalous coronary arteries vary with respect to the ostium’s origin and transverse route, the precise anatomy should be identified preoperatively and the procedure modified. We describe a severely stenotic bicuspid aortic valve and anomalous coronary artery corrected successfully with a modified valve replacement procedure, illustrating the importance of analyzing coronary anatomy preoperatively, regardless of age, to avoid occluding an anomalous artery’s ostium and to address the anomalies. We describe our modified procedure based on the artery’s location for a safe operation.

关键词： Aortic Valve Stenosis Bicuspid Aortic Valve Coronary Angiography Coronary Vessels Heart Defects Congenital

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Isolated ileal perforation due to cytomegalovirus reactivation during management of terbinafine hypersensitivity

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World Journal of Gastroenterology 2010年第26期16卷 3339-3342页

作者： Soichi Sano Hiroki Ueno Keiko Yamagami Yosuke Yakushiji Yoshihiro Isaka Isao Kawasaki masashi Takemura Takeshi Inoue Masayuki Hosoi Department of Internal Medicine Osaka City General Hospital Osaka 534-0021 Japan Department of Metabolism and Endocrinology Osaka City General Hospital Osaka 534-0021 Japan Department of Gastrointestinal Surgery Osaka City General Hospital Osaka 534-0021 Japan Department of Pathology Osaka City General Hospital Osaka 534-0021 Japan

We report a case of 71-year-old man who developed a hypersensitivity syndrome associated with terbinafine. He was placed on terbinafine (250 mg/d) for the treatment of tinea pedis due to diabetes mellitus. Following the treatment with terbinafine, he developed druginduced hypersensitivity syndrome (DIHS). Systemic corticosteroid led to transient improvement of his clinical manifestations. Three months after disease onset, he presented with panperitonitis due to ileal perforation, and underwent an emergency operation. The affected ileum was resected and ileostomy was performed in the terminal ileum. Cytomegalovirus (CMV)-specific IgG antibodies were significantly increased, high-titer CMV antigenemia was detected, and pathological examination of the resected ileum confirmed CMV infection. Based onthese observations, we strongly recommend that physicians monitor reactivation of the family of herpesvirus other than herpesvirus 6, to manage DIHS properly.

关键词： Terbinafi ne Drug hypersensitivity Human herpesvirus 6 Cytomegalovirus Intestinal perforation Ileum

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Autoimmune pancreatitis with IgG4-positive plasma cell infiltration in salivary glands and biliary tract

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World Journal of Gastroenterology 2005年第35期11卷 5577-5581页

作者： masashi Taguchi Gentaro Aridome Shintaro Abe Keiichiro Kume Mitsuo Tashiro Mitsuyoshi Yamamoto Yasuyuki Kihara Hayato Nakamura Makoto Otsuki Third Department of Internal Medicine University of Occupational and Environmental Health Japan School of Medicine Kitakyushu Japan

A 62-year-old male was referred to our hospital because of liver dysfunction, diffuse pancreatic swelling, and trachelophyma. At admission, the patient was free of pain. Physical examination showed enlarged and palpable bilateral submandibular masses, but no palpable mass or organomegaly in the abdomen. Laboratory findings were as follows： total protein 90 g/L with γ-globulin of 37.3% （33 g/L）, total bilirubin 4 mg/L, aspartate aminotransferase 39 IU/L, alanine aminotransferase 67 IU/L,γ-glutamyl transpeptidase 1 647 IU/L, and amylase 135 IU/L. Autoantibodies were negative, and tumor markers were within the normal range. Serum IgG4 level was markedly elevated （18 900 rag/L）. Computed tomography （CT） showed diffuse swelling of the pancreas and dilatation of both common and intra-hepatic bile ducts. Endoscopic retrograde pancreatography （ERP） revealed diffuse irregular and narrow main pancreatic duct and stenosis of the lower common bile duct. Biopsy specimens from the pancreas, salivary gland and liver showed marked periductal IgG4-positive plasma cell infiltration with fibrosis. We considered this patient to be autoimmune pancreatitis （AIP） with fibrosclerosis of the salivary gland and biliary tract, prescribed prednisolone at an initial dose of 40 mg/d. Three months later, the laboratory data improved almost to normal. Abdominal CT reflected prominent improvement in the pancreatic lesion. Swelling of the salivary gland also improved. At present, the patient is on 10 mg/d of prednisolone without recurrence of the pancreatitis. We present here a case of AIP with fibrosclerosis of salivary gland and biliary tract.

关键词： Autoimmune pancreatitis Fibrosclerosis IgG4-positive plasma cell Salivary gland

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An association study of the single-nucleotide polymorphism c190C〉T （Arg64Cys） in the human testis-specific histone variant, H3t, of Japanese patients with Sertoli cell-only syndrome

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Asian Journal of Andrology 2018年第5期20卷 527-528页

作者： Toshinobu Miyamoto masashi Iijima Takeshi Shin Gaku Minase Hiroto Ueda Yasuaki Saijo Hiroshi Okada Kazuo Sengoku Department of Obstetrics and Gynecology Asahikawa Medical University Asahikawa 078-8510 Japan Department of Urology Kanazawa University Graduate School of Medical Science Kanazawa 920-8641 Japan Department of Urology Dokkyo Medical University Koshigaya Hospital Koshigaya 343-8555 Japan Division of Public Health and Epidemiology Department of Social Medicine Asahikawa Medical University Asahikawa 078-8510 Japan

Dear Editor,Approximately 20% of men with nonobstructive azoospermia （NOA） are diagnosed with infertility caused by genetic defects.1 These include chromosomal abnormalities, Y-chromosome microdeletions, and several specific gene mutations/deletions, such as in DAZ, RBMY, USP9Y, SYCP3, HSF2, PLK4, and TEX11.1,2 Several histones have been detected in mammalian testes, and testis-specific variants are specifically and highly expressed during spermatogenesis^3.

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Pseudolymphoma of the liver associated with primary biliary cirrhosis:A case report and review of literature

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World Journal of Gastroenterology 2009年第36期15卷 4587-4592页

作者： Toshihide Okada Hiroshi Mibayashi Kenkei Hasatani Yoshiaki Hayashi Shigetsugu Tsuji Yoshibumi Kaneko masashi Yoshimitsu Takashi Tani Yoh Zen Masakazu Yamagishi Department of Internal Medicine Kanazawa University Graduate School of Medical Science13-1TakaramachiKanazawa 920-8641Japan Department of Gastroenterologic Surgery Kanazawa University Hospital13-1TakaramachiKanazawa 920-8641Japan Department of Human Pathology Kanazawa University HospitalKanazawa 920-8641Japan

We report a case of two pseudolymphomas of the liver in a 63-year-old Japanese woman with primary biliary *** of the lesions was found incidentally during a medical examination,presenting as a 10 mm hypodense nodule that revealed hyperdensity in the early phase and hypodensity in the late phase in computed tomography(CT)after injection of contrast ***,the 10 mm nodule had first been discovered as a 4 mm nodule during CT 4 years *** iron oxide-enhanced MRI revealed another 4 mm hyperintense nodule in segment 6 in addition to the 10 mm hyperintense nodule in segment *** during arterial portography revealed two hypointense *** with other imaging modalities such as ultrasonography,magnetic resonance imaging,and hepatic angiography were consistent with hepatocellular carcinoma.A right posterior segmentectomy was performed,and the lesions were microscopically diagnosed as *** the best of our knowledge,only 31 other cases of this disease have ever been reported,with a highly asymmetrical male:female ratio of 1:*** we could find only one case of transformation of hepaticpseudolymphoma into lymphoma in the liver,the exact nature of development from benign pseudolymphoma to malignant lymphoma is still not fully understood and cases of hepatic lymphoma need to be followed carefully.

关键词： Liver diseases PseudoIymphoma Primarybiliary cirrhosis

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