An association study of the single-nucleotide polymorphism c190C〉T （Arg64Cys） in the human testis-specific histone variant, H3t, of Japanese patients with Sertoli cell-only syndrome

作     者：Toshinobu Miyamoto Masashi Iijima Takeshi Shin Gaku Minase Hiroto Ueda Yasuaki Saijo Hiroshi Okada Kazuo Sengoku 

作者机构：Department of Obstetrics and Gynecology Asahikawa Medical University Asahikawa 078-8510 Japan Department of Urology Kanazawa University Graduate School of Medical Science Kanazawa 920-8641 Japan Department of Urology Dokkyo Medical University Koshigaya Hospital Koshigaya 343-8555 Japan Division of Public Health and Epidemiology Department of Social Medicine Asahikawa Medical University Asahikawa 078-8510 Japan 

出 版 物：《Asian Journal of Andrology》 (亚洲男性学杂志（英文版）)

年 卷 期：2018年第20卷第5期

页      面：527-528页

核心收录：

学科分类：081703[工学-生物化工] 0905[农学-畜牧学] 08[工学] 0817[工学-化学工程与技术] 09[农学] 090501[农学-动物遗传育种与繁殖] 0836[工学-生物工程] 082203[工学-发酵工程] 0822[工学-轻工技术与工程] 

基　　金：supported by Grants-in-Aid for Scientific Research from the Japan Society for the Promotion of Science 

摘      要：Dear Editor,Approximately 20% of men with nonobstructive azoospermia （NOA） are diagnosed with infertility caused by genetic defects.1 These include chromosomal abnormalities, Y-chromosome microdeletions, and several specific gene mutations/deletions, such as in DAZ, RBMY, USP9Y, SYCP3, HSF2, PLK4, and TEX11.1,2 Several histones have been detected in mammalian testes, and testis-specific variants are specifically and highly expressed during spermatogenesis^3.