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Molecular anatomy and pathogenic actions of Helicobacter pylori CagA that underpin gastric carcinogenesis

Cellular & Molecular Immunology 2020年第1期17卷 50-63页

作者： Atsushi Takahashi-Kanemitsu Christopher T.Knight masanori Hatakeyama Department of Microbiology Graduate School of MedicineThe University of TokyoTokyoJapan

Chronic infection with Helicobacter pylori cagA-positive strains is the strongest risk factor for gastric *** cagA gene product,CagA,is delivered into gastric epithelial cells via the bacterial type IV secretion *** CagA then undergoes tyrosine phosphorylation at the Glu-Pro-Ile-Tyr-Ala(EPIYA)motifs in its C-terminal region and acts as an oncogenic scaffold protein that physically interacts with multiple host signaling proteins in both tyrosine phosphorylation-dependent and-independent *** of CagA using in vitro cultured gastric epithelial cells has indicated that the nonphysiological scaffolding actions of CagA cell-autonomously promote the malignant transformation of the cells by endowing the cells with multiple phenotypic cancer hallmarks:sustained proliferation,evasion of growth suppressors,invasiveness,resistance to cell death,and genomic *** expression of CagA in mice leads to in vivo oncogenic action of CagA without any overt *** in vivo oncogenic activity of CagA is further potentiated in the presence of chronic *** Helicobacter pylori infection triggers a proinflammatory response in host cells,a feedforward stimulation loop that augments the oncogenic actions of CagA and inflammation is created in CagA-injected gastric *** that Helicobacter pylori is no longer colonized in established gastric cancer lesions,the multistep nature of gastric cancer development should include a“hit-and-run”process of CagA ***,acquisition of genetic and epigenetic alterations that compensate for CagA-directed cancer hallmarks may be required for completion of the“hit-and-run”process of gastric carcinogenesis.

关键词： cagA/CagA Helicobacter pylori SHP2 PAR1 inflammation “hit-and-run”carcinogenesis

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Relationship between Job Stress and Hypo-high-density Lipoproteinemia of Chinese Workers in Shanghai： The Rosai Karoshi Study

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Chinese Medical Journal 2016年第20期129卷 2409-2415页

作者： Tomohiko Muratsubaki Tomomi Hattori Jue Li Shin Fukudo masanori Munakata Department of Behavioural Medicine Tohoku University Graduate School of MedicineSendai 980-8575Japan Research Centre for Lifestyle-Related Disease Tohoku Rosai HospitalSendai 981-8563Japan Heart Lung and Blood Vessel Research CentreTongji University School of MedicineShanghai 200092China Division of Hypertension Tohoku Rosai HospitalSendai 981-8563Japan

Background：Karoshi,or death due to overwork,has now become a serious social problem in *** of cardiovascular risks by stress might initiate *** studies have examined the relationship between job stress and obesity,hypertension,and type 2 diabetes mellitus,but less evidence exists for dyslipidemia like hypo-high-density lipoproteinemia （hypo-HDL）.The aim of this study was to investigate the relationship between job stress and hypo-HDL of Chinese workers in ***：We studied 2219 Chinese workers in Shanghai,who participated in the Japan-China cooperative study for the prevention of karoshi.A questionnaire was administered to examine the lifestyle characteristics,job category,weekly working hours,and job *** demand and job control were quantified using the National Institute for Occupational Safety and Health *** job strain measure was defined by the combination of low job control and high ***-HDL was defined as plasma high-density lipoprotein cholesterol concentration of〈1.04 mmol/L （40 mg/dl）.Multivariate logistic regression analysis was performed for hypo-HDL as a dependent ***：Modified job strain was not related to hypo-HDL either in men or *** men,multivariate adjusted odds ratio （OR） for having hypo-HDL was significantly higher in the lowest job control tertile compared with the highest job control tertile （OR =1.39,95% confidence interval [CI] 1.03-1.87,P =0.034）.In the same model,a similar trend was observed for women,but it did not reach a statistically significant level （OR =1.51,95% CI,0.88-2.56,P =0.132）.Conclusion：A low level of job control but not modified job strain was significantly related to higher prevalence ofhypo-HDL of Chinese workers in Shanghai.

关键词： Chinese Workers Hypo-high-density Lipoproteinemia Job Stress

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Generation of Overpressure due to Condensation in Moist Air Jet

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Journal of Thermal Science 2007年第2期16卷 145-148页

作者： Yumiko OTOBE Hideo KASHIMURA Shigeru MATSUO masanori TANAKA Toshiaki SETOGUCHI Kitakyushu National College of Technology 5-20-1 ShiiKokuraminamiKitakyushuJapan Saga University 1HonjoSagaJapan

In the present study, a computational fluid dynamics method has been applied to investigate the effects of initial degree of supersaturation at reservoir condition on under-expanded sonic jet structures, such as Mach disk location and diameter, barrel shock wave and jet boundary. The axisymmetric nozzle geometry investigated was a converging nozzle with straight part. As a result, it was found that the overpressures due to condensation generate and the characteristics of flow with generation of overpressure due to condensation in the jet were different from those without condensation.

关键词： compressible flow axisymmetric flow sonic jet Mach disk condensation humidity overpressure

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Comparative evaluation of processes for heavy metal removal from municipal solid waste incineration fly ash

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Journal of Environmental Sciences 1998年第4期10卷 75-82页

作者： Masafumi Tateda Michihiko Ike masanori Fujita Department of Environmental Engineering Osaka UniversityJapan

Hydrochloric acid leaching, chloride evaporation, acetic acid leaching, and biological leaching were evaluated and compared as processes of heavy metal removal for municipal solid waste incineration fly ash(MSWFA). Six factors, namely, energy consumption, process efficiency, process handling, process cost estimation, cost reduction potential, and study progress, were used in order to find out their advantages and disadvantages and to help develop a better recovery process of heavy metals from MSWFA in terms of treatment of the waste material. Hydrochloric acid leaching process was found to be most balanced among the evaluated processes. It showed superiority on energy consumption, process cost estimation, and study progress. On the other hand, despite of its excellency in process efficiency, chloride evaporation process was most unfavorable mainly due to heavy energy dependence. Biological process, with huge potential of cost reduction, was concluded to be the second best process.

关键词： municipal solid waste incineration fly ash heavy metal removal process process evaluation.

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Inverse correlation between CD8^+ inflammatory cells and E-cadherin expression in gallbladder cancer:Tissue microarray and imaging analysis

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World Journal of Clinical Cases 2017年第1期5卷 1-8页

作者： Keita Kai masanori Masuda Shinichi Aishima Department of Pathology Saga University Hospital Department of Pathology and Microbiology Saga University Faculty of Medicine

AIM To investigated the association between the tumor cells' expression of E-cadherin and the numbers of several types of inflammatory cells infiltrating into the invasive portion of gallbladder cancer(GBC).METHODS We analyzed 50 GBC cases for which a sufficient amount of tumor tissues for tissue microarray(TMA) had been saved. Three tissue cores(3.0 mm) of invasive lesion from each case were used for the TMA. The 4-μm cut sections on slides were immunostained using primary antibodies including E-cadherin for cancer cells, leukocyte common antigen for leukocyte, myeloperoxidase for neutrophils, CD3 for T cells, CD4 for helper T cells, CD8 for killer T cells, CD20 for B cells and CD68 for macrophages. The immunostained slides were digitally analyzed by imaging analysis *** A significant inverse correlation between the number of infiltrating CD8^+ cells at invasive areas and the expression of E-cadherin by cancer cells was observed(P = 0.0001), although the degree of this correlation was relatively weak(R = 0.32). The number of CD8^+ cells and the cancer cells' E-cadherin expression were also significantly correlated with tumor differentiation(welldifferentiated vs poorly differentiated)(P = 0.0467 and P = 0.0294, respectively). Inverse correlation of T-stageand the number of CD8^+ cell infiltration was observed with statistical significance in comparison of T2 and T3 cases(P = 0.0324).CONCLUSION Our findings indicate an inverse correlation of CD8^+ T cell infiltration and cancer cells' E-cadherin expression at invasive areas of GBC. Further analyses are essential to test these findings.

关键词： E-cadherin Inflammation CD8 Gallbladder cancer Tissue microarray

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Prolonged survival in patients with hand-foot skin reaction secondary to cooperative sorafenib treatment

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World Journal of Gastroenterology 2021年第32期27卷 5424-5437页

作者： masanori Ochi Toshiro Kamoshida Masahiro Araki Tadashi Ikegami Department of Gastroenterology Hitachi General HospitalIbaraki 317–0077Japan Department of Gastroenterology and Hepatology Ibaraki Prefectural Central HospitalIbaraki Cancer CenterIbaraki 309-1793Japan Division of Gastroenterology and Hepatology Tokyo Medical University Ibaraki Medical CenterIbaraki 309-1793Japan

BACKGROUND Sorafenib is an oral drug that prolongs overall survival(OS)in patients with hepatocellular *** events,including hand-foot skin reaction(HFSR),lead to permanent sorafenib *** To clarify the association between interventions for adverse events and patient *** We performed a retrospective,multicenter study of patients treated with sorafenib monotherapy between May 2009 and March *** developed a mutual cooperation system that was initiated at the start of sorafenib treatment to effectively manage adverse *** mutual cooperation system entailed patients receiving consultations during which pharmacists provided accurate information about sorafenib to alleviate the fear and anxiety related to adverse *** stratified the patients into three groups:Group A,patients without HFSR but with pharmacist intervention;Group B,patients with HFSR and pharmacist interventions unreported to oncologists(nonmutual cooperation system);and Group C,patients with HFSR and pharmacist interventions known to oncologists(mutual cooperation system).OS and time to treatment failure(TTF)were evaluated using the Kaplan-Meier *** We enrolled 134 patients(Group A,n=41;Group B,n=30;Group C,n=63).The median OS was significantly different between Groups A and C(6.2 vs 13.9 mo,p<0.01)but not between Groups A and B(6.2 vs 7.7 mo,P=0.62).Group A vs Group C was an independent OS predictor(HR,0.41;95%CI:0.25-0.66;P<0.01).In Group B alone,TTF was significantly lower and the nonadherence rate was higher(P<0.01).In addition,the Spearman’s rank correlation coefficients between OS and TTF in each group were 0.41(Group A;P<0.01),0.13(Group B;P=0.51),and 0.58(Group C;P<0.01).There was a highly significant correlation between OS and TTF in Group ***,there was no correlation between OS and TTF in Group *** The mutual cooperation system increased treatment duration and improved prognosis in patients with *** prospect

关键词： Hepatocellular carcinoma Sorafenib Pharmacists Oncologists Prognosis Duration of therapy

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Biodegradability of four phthalic acid esters under anaerobic condition assessed using natural sediment

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Journal of Environmental Sciences 2006年第4期18卷 793-796页

作者： Ruttapol Lertsirisopon Satoshi Soda Kazunari Sei Michihiko Ike masanori Fuj ita Graduate School of Engineering Osaka University 2-1 Yamada-oka Suita Osaka Japan.

Biodegradability of di-n-butyl phthalate （DBP）, butylbenzyl phthalate （BBP）, di-ethylhexyl phthalate （DEHP）, and di-isononyl phthalate （DINP） under an anaerobic condition was evaluated using three natural sediment microcosms obtained from ponds in Osaka, which had not been significantly polluted by the chemicals. The degradabilities of the four phthalic acid esters（PAEs） were analyzed by a first-order kinetic model with a lag phase and ranked as DBP〉BBP〉〉DEHP〉DINP. The PAEs with shorter alkyl-chains, DBP and BBP, were degraded with quite short lag phases near to zero and short half-lives of a few days. The PAEs with longer alkyl-chains, DEHP and DINP, were degraded with lag phases of 5-30 d and the quite long half-lives of a couple of hundred days. Although no data was available on the anaerobic biodegradability of D1NP before this study, it was clarified that DINP can be degraded with slow degradation rates. The fact that all the three intact sediments were capable of biodegradation of the PAEs suggests that potential of anaerobic biodegradation of PAEs is widespread in the aquatic environment.

关键词： phthalic acid esters anaerobic biodegradation sediment first-order kinetics

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Two-dimensional optical tomography of hemodynamic changes in a preterm infant brain

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Chinese Optics Letters 2007年第8期5卷 472-474页

作者：高峰薛媛赵会娟 Takashi Kusaka masanori Ueno Yukio Yamada College of Precision Instrument and Optoelectronics Engineering Tianjin University Faculty of Medicine Kagawa University Kagawa 761-0793Japan Department of Mechanical Engineering and Intelligent Systems University of Electro-Communications Tokyo 182-8585Japan

Our preliminary results on two-dimensional （2D） optical tomographic imaging of hemodynamic changes in a preterm infant brain are reported. We use the established 16-channel time-correlated single photon counting system for the detection and generalized pulse spectrum technique based algorithm for the image reconstruction. The experiments demonstrate that diffuse optical tomography may be a potent means for investigating brain functions and neural development of infant brains in the perinatal period.

关键词： In Two-dimensional optical tomography of hemodynamic changes in a preterm infant brain

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Prediction of Acoustic Absorption Performance of a Perforated Plate with Air Jets

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Journal of Thermal Science 2017年第4期26卷 378-384页

作者： Hiromitsu Hamakawa masanori Miyazaki Yuta Asai Eru Kurihara Eiichi Nishida Hidechito Hayashi Department of Mechanical Engineering Oita University700 DannoharuOita 870-1192Japan Graduate Student Oita University700 DannoharuOita 870-1192Japan Department of Mechanical Systems Engineering Shonan Institute of Technology1-1-25 Tsujido-NishikaiganFuji-sawaKanagawa 251-8511Japan Department of Mechanical Engineering Nagasaki University1-14 Bunkyo machiNagasaki852-8521Japan

The present study focuses on the prediction of acoustic absorption performance of a perforated plate with air jets by theoretical calculations. In addition, we experimentally measured the flow rate, internal pressure, acoustic pressure, and transfer function using an acoustic impedance tube. The normal incidence absorption coefficient was calculated from the measured transfer function using transfer function methods. We investigated the influences of background air space, flow velocity, thickness, aperture rate, and aperture diameter of a perforated plate on the acoustic absorption characteristics. The frequency characteristics of the acoustic absorption coefficient showed a maximum value at a local frequency. As the background air space increased, the peak frequency of acoustic absorption characteristics decreased. As the flow velocity passing through the apertures increased, the peak level of the acoustic absorption coefficient also increased. The theoretical results agreed well with the experimental ones qualitatively.

关键词： acoustic absorption perforated plate theoretical prediction acoustic impedance tube air jets

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Effect of Axisymmetric Sonic Nozzle Geometry on Characteristics of Supersonic Air Jet

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Journal of Thermal Science 2004年第2期13卷 121-126页

作者： Shigeru MATSUO masanori TANAKA Yumiko OTOBE Hideo KASHIMURA Heuy-Dong KIM Toshiaki SETOGUCHI Department of Mechanical Engineering Saga University 1 Honjo-machi Saga-shi Saga 840-8502 Japan Department of Control and Information Systems Engineering Kitakyushu National College of Technology 5-20-1 Shii Kokuraminami-ku Kitakyushu-shi Fukuoka 802-0985 Japan School of Mechanical Engineering College of Natural Science Andong National University 388 Song-Cheon Dong Andong Kyung-Pook Korea

The effect of nozzle geometry on sonic line and characteristics of supersonic air jet was studied. Computational fluid dynamics was applied in this study. The axisymmetric nozzle geometries investigated were two different contour converging nozzles, two different conically converging sharp-edged nozzles and a sharp-edged orifice. The results show that the supersonic jet structure, sonic line and streamlines in supersonic jet are strongly influenced by the nozzle geometry, and the total pressure loss increases with the increase of Mach disk diameter. The present numerical simulation is an effective tool to evaluate compressible flows in supersonic air jet.

关键词： compressible flow supersonic jet non-equilibrium condensation simulation.

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