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Thermal physiological response to local heating and cooling during sleep

Frontiers of Architectural Research 2012年第1期1卷 51-57页

作者： Yu Hibino Shuichi Hokoi Katsuaki Yoshida Satoru Takada masanori Nakajima Miho Yamate KVOtO University Japan Kobe University Japan The Kansai Electric Power Co. Inc. Japan

For a healthy and productive life, good steep is essential, which has prompted studies on how comfortable sleep can be achieved. Understanding the relationship between thermal environment and physiological responses such as skin and core temperatures, and psychological responses such as thermal and sleep sensations is necessary to identify the most suitable thermal environment for steep. As an energy-saving and practical method of creating the most appropriate thermal environment for sleep, local heating or cooling is sometimes used, which takes into consideration the differences in local thermal responses. We performed this study to identify the most effective thermal environment for inducing comfortable sleep by identifying the physiological responses during sleep on the basis of sleep experiments conducted under local body heating or cooling conditions. We also used a human thermal model, which can be applied for predicting physiological responses. In the experiments, the feet of the subject were the primary area to be heated or cooled, which was achieved by installing a flexible duct with an outlet placed close to the subject＇s feet and inlet connected to an air conditioner. Differences in the fluctuation of body temperature and sleep stage depended on the airflow direction from the duct to the feet. When air was blown downward towards the feet, body temperature decreased and the subject was able to sleep well. Measured skin and core temperatures were calculated using an improved 27-node human thermal model that was originally developed for use in subjects who are not in steep. Although skin

关键词： Sleep Thermal environ-ment Local air conditioning Physiologicalresponse Human thermal mode[

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Ⅳ期胃癌转化治疗

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Science Bulletin 2023年第7期68卷 653-656页

作者：胡灿 masanori Terashima 程向东 Department of Gastric Surgery Zhejiang Cancer HospitalInstitutes of Basic Medicine and Cancer(IBMC)Chinese Academy of SciencesHangzhou 310022China Key Laboratory of Prevention Diagnosis and Therapy of Upper Gastrointestinal Cancer of Zhejiang ProvinceHangzhou 310022China Zhejiang Provincial Research Center for Upper Gastrointestinal Tract Cancer Zhejiang Cancer HospitalHangzhou 310022China Division of Gastric Surgery Shizuoka Cancer CenterShizuoka 411-8777Japan

Gastric cancer(GC)is one of the most common malignant tumors and represents the fourth most common cause of cancer death *** is the optimal treatment for patients with ***,70%–80%of GC patients are diagnosed at locally advanced stages.A large number of clinical studies have shown that no existing treatment has ideal efficacy against advanced unresectable GC with No.16 lymph nodes or distant organ metastasis,and the median survival time of patients is only approximately 10 *** recent years,conversion therapy has shown great *** approach consists mainly of developing reasonable comprehensive treatment programs,including chemotherapy,radiotherapy,and targeted therapy delivered by a multidisciplinary team(MDT),to convert initially unresectable GC to resectable cancer,thus prolonging patients’survival and improving their quality of ***,we aim to discuss the treatment strategies,challenges and opportunities of conversion therapy for GC,along with our experience in conversion therapy for patients with advanced GC(Fig.1).

关键词： Surgery Gastric treatment

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Ratio of mean platelet volume to platelet count is a potential surrogate marker predicting liver cirrhosis

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World Journal of Hepatology 2018年第1期10卷 82-87页

作者： Hiroya Iida Masaki Kaibori Kosuke Matsui Morihiko Ishizaki masanori Kon Department of Surgery Kansai Medical University

AIM To provide a simple surrogate marker predictive of liver cirrhosis(LC).METHODS Specimens from 302 patients who underwent resection for hepatocellular carcinoma between January 2006 and December 2012 were retrospectively analyzed. Based on pathologic findings, patients were divided into groups based on whether or not they had LC. Parameters associated with hepatic functional reserve were compared in these two groups using MannWhitney U-test for univariate analysis. Factors differing significantly in univariate analyses were entered into multivariate logistic regression *** There were significant differences between the LC group(n = 100) and non-LC group(n = 202) in prothrombin activity, concentrations of alanine aminotransferase, aspartate aminotransferase, total bilirubin, albumin, cholinesterase, type Ⅳ collagen, hyaluronic acid, indocyanine green retention rate at 15 min, maximal removal rate of technitium-99 m diethylene triamine pentaacetic acid-galactosyl human serum albumin and ratio of mean platelet volume to platelet count(MPV/PLT). Multivariate analysis showed that prothrombin activity, concentrations of alanine aminotransferase, aspartate aminotransferase, total bilirubin and hyaluronic acid, and MPV/PLT ratio were factors independently predictive of LC. The area under the curve value for MPV/PLT was 0.78,with a 0.8 cutoff value having a sensitivity of 65% and a specificity of 78%.CONCLUSION The MPV/PLT ratio, which can be determined simply from the complete blood count, may be a simple surrogate marker predicting LC.

关键词： Mean platelet volume Platelet count Liver cirrhosis Hepatic functional reserve Liver fibrosis

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流动加速腐蚀引起的管壁减薄分析及验证

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金属学报 2011年第7期47卷 784-789页

作者： masanori Naitoh 陈耀东 Shunsuke Uchida Hidetoshi Okada The Institute of Applied Energy Tokyo 105-0003Japan 中国核电工程有限公司北京100840

针对危害电站安全运行的流动加速腐蚀(FAC)现象,结合专用分析程序包DRAWTHREE的模型和结构.阐明了FAC的发生机理及其决定性因素,提出了用于评估FAC和管壁减薄速率的方法和步骤,并将上述程序分析结果与实验及电厂实际测量数据进行了比较... 详细信息

针对危害电站安全运行的流动加速腐蚀(FAC)现象,结合专用分析程序包DRAWTHREE的模型和结构.阐明了FAC的发生机理及其决定性因素,提出了用于评估FAC和管壁减薄速率的方法和步骤,并将上述程序分析结果与实验及电厂实际测量数据进行了比较,结果吻合较好.最后给出了用于缓解FAC的一些措施.

关键词：流动加速腐蚀管壁减薄电化学双氧化层评价程序DRAWTHREE

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新型排列组合高压缩多载波调制系统

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通信学报 2007年第1期28卷 69-74页

作者：侯亚飞 HAMAMURA masanori 张世永复旦大学计算机与信息技术系上海200433 高知工科大学情报信息系

提出一种基于高压缩多载波调制(HC-MCM,high compaction multi-carrier modulation)技术和排列组合正交频分复用(PC-OFDM,parallel combinatory OFDM)技术的新型调制系统,即排列组合高压缩多载波调制(PC/HC-MCM)系统。同PC-OFDM系统相比,PC/HC-MCM能够大幅度提高系统的带宽效率。同时给出了2种PC/HC-MCM系统的仿真性能。PC/HC-MCM系统稍加改造可以应用于不同的多载波系统。

关键词：正交频分复用排列组合正交频分复用带宽效率高压缩多载波调制

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Overexpression of β3/γ2 chains of laminin-5 and MMP7 in biliary cancer

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World Journal of Gastroenterology 2009年第31期15卷 3865-3873页

作者： Toshikuni Oka Hiroyuki Yamamoto Shigeru Sasaki masanori Ii Keiichi Hizaki Hiroaki Taniguchi Yasushi Adachi Kohzoh Imai Yasuhisa Shinomura First Department of Internal Medicine Sapporo Medical University School of Medicine Sapporo Medical University

AIM： To clarify the clinicopathological significance of laminin-5 y2 （LNγ2） and 133 （LNI33） chains and MMP7 expression in biliary tract cancer. METHODS： We analyzed the association between immunohistochemically detected LNγ2, LNβ3, and MMP7 expression in biliary tract cancer and clinicopathological characteristics. Activity of MMP7 was analyzed by casein zymography. An in vitro invasion assay after treatment with MMP7-specific siRNA was performed. RESULTS： LNγ2 expression was predominantly observed in carcinoma cells at the invasive front. LNγ2 expression was seen in 57% of patients with biliary tract cancer, and was associated with depth of invasion, histologic type, and advanced stage. The expression pattern of LNβ3 was classified Into two types： invasive front dominant type （38%） and diffuse type （28%）.The invasive front dominant type was associated with histologic type and advanced stage. MMP7 positivity was correlated with LNγ2 or LNβ3 expression but not with clinicopathological characteristics. Active MMP7 detected by casein zymography was correlated with depth of invasion and advanced stage. Downregulation of MMP7 expression by siRNA resulted in a significant decrease in biliary tract cancer cell invasion in ***： Our results suggest that LNγ2 and LNβ3, in conjunction with MMP7, play a key role in the progression of biliary tract cancer.

关键词： Biliary tract cancer Laminin-5 Laminin γ2 Laminin β3 MMP7

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Atheroprotective effects of antioxidants through inhibition of mitogen-activated protein kinases

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Acta Pharmacologica Sinica 2004年第8期 3-11页

作者： Moe KYAW,masanori YOSHIZUMI,Koichiro TSUCHIYA,Yuki IZAWA,Yasuhisa KANEMATSU,Toshiaki TAMAKI Department of Pharmacology Department of Pharmacology Department of Clinical Pharmacology Department of Pharmacology Department of Pharmacology Department of Pharmacology The University of Tokushima Graduate School of Medicine The University of Tokushima Graduate School of Medicine The University of Tokushima Graduate School of Pharmaceutical Sciences 3-18-15 Kuramoto Tokushima 770-8503 Japan The University of Tokushima Graduate School of Medicine The University of Tokushima Graduate School of Medicine The University of Tokushima Graduate School of Medicine

Reactive oxygen species (ROS) have been known to play an important role in the pathogenesis of atherosclerosis and several other cardiovascular diseases. It is now apparent that ROS induce endothelial cell damage and vascular smooth muscle cell (VSMC) growth and cardiac remodeling, which are associated with hypertension, atherosclerosis, heart failure, and restenosis. Several lines of evidence have indicated that ROS and mitogen activated protein (MAP) kinases were involved in vascular remodeling under various pathological conditions. Recently, it was also reported that MAP kinases were sensitive to oxidative stress. MAP kinases play an important role in cell differentiation, growth, apoptosis, and the regulation of a variety of transcription factors and gene expressions. Bioflavonoids and polyphenolic compounds are believed to be beneficial for the prevention and treatment of atherosclerosis and cardiovascular diseases. One of the most widely distributed bioflavonoids, 3,3',4',5,7-penta hydroxyflavone (

关键词： reactive oxygen species mitogen-activated protein kinase antioxidant vascular smooth muscle cell atherosclerosis

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A Note on Approximation of Likelihood Ratio Statistic in Exploratory Factor Analysis

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Open Journal of Statistics 2015年第6期5卷 600-603页

作者： masanori Ichikawa Graduate School of Global Studies Tokyo University of Foreign Studies Tokyo Japan

In normal theory exploratory factor analysis, likelihood ratio (LR) statistic plays an important role in evaluating the goodness-of-fit of the model. In this paper, we derive an approximation of the LR statistic. The approximation is then used to show explicitly that the expectation of the LR statistic agrees with the degrees of freedom of the asymptotic chi-square distribution.

关键词： Factor Analysis Likelihood Ratio Statistic Maximum Likelihood Estimation

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Mouse models for investigating the underlying mechanisms of nonalcoholic steatohepatitis-derived hepatocellular carcinoma

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World Journal of Gastroenterology 2018年第18期24卷 1989-1994页

作者： Kazuki Takakura Tsunekazu Oikawa Yoichi Tomita Yusuke Mizuno masanori Nakano Chisato Saeki Yuichi Torisu Masayuki Saruta Division of Gastroenterology and Hepatology Department of Internal Medicine The Jikei University School of Medicine

As the incidence of hepatocellular carcinoma(HCC) caused by infection with the hepatotropic viruses hepatitis B and hepatitis C decreases, greater attention has become focused on HCC caused by nonalcoholic steatohepatitis(NASH), an advanced form of nonalcoholic fatty liver disease which has shown increasing prevalence in correspondence with the overall increase in metabolic syndrome over the recent decades. Several clinical population studies have shown a positive relationship between NASH and HCC, while also providing initial insights into the underlying mechanisms of HCC development from NASH. Research into the pathological progression of NASH to HCC has advanced by use of several beneficial rodent models. In this review, we summarize the established mouse models for preclinical research of NASH-associated HCC and discuss the underlying hepatic mechanisms of NASH-related tumorigenesis identified to date that could lead to new targets for treatment and prevention.

关键词： Hepatocellular carcinoma Nonalcoholic steatohepatitis Nonalcoholic fatty liver disease

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Effects of age on survival and morbidity in gastric cancer patients undergoing gastrectomy

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World Journal of Gastrointestinal Oncology 2017年第6期9卷 257-262页

作者： Yoshinori Fujiwara Shuichi Fukuda masanori Tsujie Hajime Ishikawa Kotaro Kitani Keisuke Inoue Masao Yukawa Masatoshi Inoue Department of Digestive Surgery Nara HospitalKindai University School of Medicine Department of Digestive Surgery Kawasaki Medical School

To evaluate clinicopathological features and surgical outcomes of gastric cancer in elderly and non-elderly patients after inverse probability of treatment weighting (IPTW) method using propensity score. METHODSWe enrolled a total of 448 patients with histologically confirmed primary gastric carcinoma who received gastrectomies. Of these, 115 patients were aged > 80 years old (Group A), and 333 patients were aged < 79 years old (Group B). We compared the surgical outcomes and survival of the two groups after IPTW. RESULTSPostoperative complications, especially respiratory complications and hospital deaths, were significantly more common in Group A than in Group B (P < 0.05). Overall survival (OS) was significantly lower in Group A patients than in Group B patients. Among the subset of patients who had pathological Stage I disease, OS was significantly lower in Group A (P < 0.05) than Group B, whereas cause-specific survival was almost equal in the two groups. In multivariate analysis, pathological stage, histology, and extent of lymph node dissection were independent prognostic values for OS. CONCLUSIONWhen the gastrectomy was performed in gastric cancer patients, we should recognized high mortality and comorbidities in that of elderly. More extensive lymph node dissection might improve prognoses of elderly gastric cancer patients.

关键词： Gastric cancer Mortality Morbidity Elderly Lymphadenectomy Propensity score matching Prognosis Survival

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