Ⅳ期胃癌转化治疗

作     者：胡灿 Masanori Terashima 程向东 Can Hu;Masanori Terashima;Xiangdong Cheng

作者机构：Department of Gastric SurgeryZhejiang Cancer HospitalInstitutes of Basic Medicine and Cancer(IBMC)Chinese Academy of SciencesHangzhou 310022China Key Laboratory of PreventionDiagnosis and Therapy of Upper Gastrointestinal Cancer of Zhejiang ProvinceHangzhou 310022China Zhejiang Provincial Research Center for Upper Gastrointestinal Tract CancerZhejiang Cancer HospitalHangzhou 310022China Division of Gastric SurgeryShizuoka Cancer CenterShizuoka 411-8777Japan 

出 版 物：《Science Bulletin》 (科学通报（英文版）)

年 卷 期：2023年第68卷第7期

页      面：653-656页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：This work was supported by the National Key Research and Development Program of China(2021YFA0910100) the Zhejiang Provincial Research Center for Upper Gastrointestinal Tract Cancer(JBZX-202006) the Medical Science and Technology Project of Zhejiang Province(WKJ-ZJ-2202 and WKJ-ZJ-2104) the National Natural Science Foundation of China(82074245,81973634 and 81903842) the Natural Science Foundation of Zhejiang Province(LR21H280001) the Science and Technology Projects of Zhejiang Province(2019C03049) the Program of Zhejiang Provincial TCM Sci-tech Plan(2018ZY006 and 2020ZZ005) 

主　　题：Surgery Gastric treatment 

摘      要：Gastric cancer(GC)is one of the most common malignant tumors and represents the fourth most common cause of cancer death *** is the optimal treatment for patients with ***,70%–80%of GC patients are diagnosed at locally advanced stages.A large number of clinical studies have shown that no existing treatment has ideal efficacy against advanced unresectable GC with No.16 lymph nodes or distant organ metastasis,and the median survival time of patients is only approximately 10 *** recent years,conversion therapy has shown great *** approach consists mainly of developing reasonable comprehensive treatment programs,including chemotherapy,radiotherapy,and targeted therapy delivered by a multidisciplinary team(MDT),to convert initially unresectable GC to resectable cancer,thus prolonging patients’survival and improving their quality of ***,we aim to discuss the treatment strategies,challenges and opportunities of conversion therapy for GC,along with our experience in conversion therapy for patients with advanced GC(Fig.1).