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Transformed gastric mucosa-associated lymphoid tissue lymphoma originating in the colon and developing metachronously after Helicobacter pylori eradication:A case report

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World Journal of Gastrointestinal Oncology 2024年第10期16卷 4281-4288页

作者： Makoto Saito Zen-Ichi Tanei Masumi Tsuda Toma Suzuki Emi Yokoyama Minoru Kanaya Koh Izumiyama Akio Mori masanobu morioka Takeshi Kondo Blood Disorders Center Aiiku HospitalSapporo 064-0804HokkaidoJapan Department of Cancer Pathology Faculty of MedicineHokkaido UniversitySapporo 060-8638HokkaidoJapan

BACKGROUND Helicobacter pylori(***)eradication treatment for primary gastric mucosaassociated lymphoid tissue(MALT)lymphoma has already been ***,t(11;18)(q21;q21)/API2-MALT1 translocation-positive lesions are a type of primary gastric MALT lymphoma in which a response to eradication treatment is difficult to *** addition,trisomy 18 may be associated with diffuse large B-cell lymphoma(DLBCL)transformation of gastric MALT *** SUMMARY A 66-year-old man was diagnosed with MALT lymphoma in the ascending colon by colonoscopy and *** years later,esophagogastroduodenoscopy revealed chronic atrophic gastritis that was positive for ***,and eradication treatment was *** years and nine months later(at the age of 70),a new ulcerative lesion suggestive of MALT lymphoma appeared in the gastric body,and six months later,a similar lesion was also found in the *** year later(4 years and 3 months after *** eradication),at the age of 72,the lesion in the gastric body had become deeper and had propagated.A biopsy revealed a pathological diagnosis of *** MALT lymphoma lesions in the ascending colon and DLBCL lesions in the stomach were positive for the t(11;18)(q21;q21)/API2-MALT1 translocation,and trisomy 18q21 was also *** 6 courses of R-CHOP(rituximab,cyclophosphamide,doxorubicin,vincristine and prednisone)chemotherapy,all of the above lesions disappeared[complete remission(CR)],and CR has been maintained for more than 3 *** addition,both the colonic and gastric lesions were proven to have the same *** Because the patient had a MALT1 translocation with trisomy 18q21,it was thought that this gastric MALT lymphoma developed independently of *** infection and progressed.

关键词： Gastric mucosa-associated lymphoid tissue lymphoma Transform Diffuse large B-cell lymphoma Colonic mucosa-associated lymphoid tissue lymphoma Helicobacter pylori eradication MALT1 translocation Case report

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Acquired hemophilia A in solid cancer: Two case reports and review of the literature

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World Journal of Clinical Cases 2018年第14期6卷 781-785页

作者： Makoto Saito Reiki Ogasawara Koh Izumiyama Akio Mori Takeshi Kondo Masanori Tanaka masanobu morioka Masahiro Ieko Department of Internal Medicine and Hematology Aiiku Hospital Department of Internal Medicine Health Sciences University of Hokkaido

Acquired hemophilia A （AHA） is a rare, hemorrhagic autoimmune disease, whose pathogenesis involves reduced coagulation factor Ⅷ （FⅧ） activity related to the appearance of inhibitors against FⅧ. Common etiological factors include autoimmune diseases, ma-lignancy, and pregnancy. We report two cases of AHA in solid cancer. The first case is a 63-year-old man who developed peritoneal and intestinal bleeding after gastrectomy for gastric cancer. He was diagnosed with AHA, and was treated with prednisone, followed by cyclophosphamide. In the second case, a 68-year-old man developed a subcutaneous hemorrhage. He was diagnosed with AHA in hepatocellular carcinoma on CT imaging, and treated with rituximab alone. Hemostasis was achieved for both patients without bypassing agents as the amount of inhibitors was reduced and eradicated. However, both patients died within 1 yeardue to cancer progression. Successful treatment for AHA in solid cancer can be diffcult because treatment of the underlying malignancy is also required.

关键词： Acquired hemophilia A Coagulation factor Ⅷ Solid cancer Gastric cancer Hepatocellular carcinoma Case report

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Duodenal-type follicular lymphoma more than 10 years after treatment intervention:A retrospective single-center analysis

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World Journal of Gastrointestinal Oncology 2022年第8期14卷 1552-1561页

作者： Makoto Saito Akio Mori Shihori Tsukamoto Takashi Ishio Emi Yokoyama Koh Izumiyama masanobu morioka Takeshi Kondo Hirokazu Sugino Blood Disorders Center Aiiku HospitalSapporo 064-0804Japan Department of Cancer Pathology Hokkaido UniversityFaculty of MedicineSapporo 060-8638Japan

BACKGROUND Duodenal-type follicular lymphoma(D-FL)has been recognized as a rare entity that accounts for approximately 4%of primary gastrointestinal lymphomas.D-FL follows an indolent clinical course compared with common nodal FL and is generally considered to have a better ***,the“watch and wait”approach is frequently adopted as the treatment ***,there is an option to actively intervene in ***,the long-term outcomes of such cases are poorly *** To clarify the clinical outcomes after long-term follow-up in cases of D-FL with treatment *** We retrospectively analyzed patients who met the following criteria:the lesion was confirmed by endoscopy,the diagnosis of D-FL was confirmed histopathologically,and the patient was followed-up for more than 10 years after the intervention at our *** We identified 5 cases of *** patients showed a small amount of bone marrow involvement(Stage IV).Rituximab was used as a treatment for remission in all 5 *** was also used in combination with chemotherapy in 2 Stage IV patients as well as for maintenance *** therapy was performed in 2 cases,which was followed by complete remission(CR).Eventually,all 5 patients achieved CR and survived for more than 10 ***,3 patients experienced *** patient achieved a second CR by retreatment,and in another case,the lesion showed spontaneous *** remaining patient had systemic widespread recurrence 13 years after the first *** results suggested that the FL lesions were transformed into diffuse large B-cell *** patient died 4 years later despite receiving various *** In this study,the treatment for patients of D-FL in Stage IV was *** the future,criteria for how to treat“advanced”D-FL should be established based on additional *** study of patients with D-FL indicates that whole-body follow-up examinations shou

关键词： Duodenal-type follicular lymphoma Treatment Long-term follow-up Radiation Rituximab Chemotherapy

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Phlegmonous gastritis developed during chemotherapy for acute lymphocytic leukemia:A case report

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World Journal of Clinical Cases 2021年第22期9卷 6493-6500页

作者： Makoto Saito masanobu morioka Koh Izumiyama Akio Mori Reiki Ogasawara Takeshi Kondo Toru Miyajima Emi Yokoyama Satoshi Tanikawa Department of Internal Medicine and Hematology Aiiku HospitalSapporo 0640804HokkaidoJapan Department of Cancer Pathology Hokkaido UniversityFaculty of MedicineSapporo 0608638HokkaidoJapan Institute for Chemical Reaction Design and Discovery(WPI-ICReDD) Hokkaido UniversitySapporo 001-0021HokkaidoJapan

BACKGROUND Phlegmonous gastritis(PG)is a rare bacterial infectious disease characterized by neutrophil-based purulent inflammation of the gastric *** most representative causative bacterium is Streptococcus pyogenes,followed by Staphylococcus,Pneumococcus and *** portal venous gas(HPVG)is considered a potentially fatal condition and is rarely associated with *** SUMMARY The white blood cell count of a 70-year-old woman with acute lymphocytic leukemia in complete remission dropped to 100/μL after consolidation *** vital signs were consistent with septic *** blood culture revealed the presence of Bacillus *** computed tomography(CT)and esophagogastroduodenoscopy(EGD)showed marked thickening of the gastric *** with the other findings,CT was suggestive of HPVG,and EGD showed pseudomembrane-like tissue covering the superficial *** examination of gastric biopsy specimens showed mostly necrotic tissue with lymphocytes rather than *** of gastric specimens revealed the presence of Bacillus *** finally diagnosed this case as PG with Bacillus cereus-induced sepsis and *** patient recovered successfully with conservative treatment,chiefly by using carbapenem *** The histopathological finding of this gastric biopsy specimen should be called"neutropenic necrotizing gastritis".

关键词： Phlegmonous gastritis Chemotherapy neutropenia Bacillus cereus Histopathology Case report

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ALK-positive anaplastic large cell lymphoma presenting multiple lymphomatous polyposis: A case report and literature review

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World Journal of Clinical Cases 2019年第15期7卷 2049-2057页

作者： Makoto Saito Koh Izumiyama Reiki Ogasawara Akio Mori Takeshi Kondo Masanori Tanaka masanobu morioka Kencho Miyashita Mishie Tanino Department of Internal Medicine and Hematology Aiiku HospitalSapporo 0640804Japan Department of Gastroenterology Aiiku HospitalSapporo 0640804Japan Department of Surgical Pathology Asahikawa Medical University Hospital(formerly Department of Cancer PathologyHokkaido UniversityFaculty of Medicine)Asahikawa 0788510Japan

BACKGROUND Anaplastic large cell lymphoma(ALCL)is a type of T-cell lymphoma that can be divided into two categories:anaplastic lymphoma kinase-positive(ALK+)and *** ALK+ALCL is *** lymphomatous polyposis(MLP)is thought to be a representative form of gastrointestinal lesion in mantle cell lymphoma,and T-cell lymphomas seldom show this ***,we report the first known case of ALK+ALCL with gastroduodenal involvement to present with *** SUMMARY The patient was a 43-year-old man who was complained of a mass in the left inguinal area and was performed open ***+ALCL was diagnosed *** tomography scan demonstrated multiple lymph node lesions in the abdomen-pelvis/inguinal region,and scattered nodular lesions in both lung *** did not complain of gastrointestinal ***,esophagogastroduodenoscopy identified MLP lesions from the antrum of the stomach to the descending portion of the duodenum and mild thickened folds on the corpus of the stomach,and biopsy showed invasion of ALK+*** treated this patient with six cycles of CHOEP(Cyclophosphamide,Doxorubicin,Vincristine,Etoposide,and Prednisone)*** the conclusion of treatment,there was complete *** white scars were found on the stomach,endoscopically consistent with a remission image of *** endoscopic features of this case were thought to be similar to those of *** The macroscopic/endoscopic features of gastrointestinal ALK+ALCL may be more similar to those of B-cell lymphomas rather than T-cell lymphomas.

关键词： Anaplastic large-cell lymphoma Anaplastic lymphoma kinase Multiple lymphomatous polyposis T-cell lymphoma Gastrointestinal involvement

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^(18)F-FDG PET/CT imaging for a gastrointestinal mantle cell lymphoma with multiple lymphomatous polyposis

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World Journal of Gastroenterology 2014年第17期20卷 5141-5146页

作者： Makoto Saito Masaya Miyazaki Mishie Tanino Shinya Tanaka Kencho Miyashita Koh Izumiyama Akio Mori Tatsuro Irie Masanori Tanaka masanobu morioka Eriko Tsukamoto Department of Internal Medicine and Hematology Aiiku HospitalSapporo 064-0804Japan Department of Cancer Pathology Hokkaido University Graduate School of MedicineSapporo 060-8638Japan Department of Gastroenterology Aiiku HospitalSapporo 064-0804Japan Department of Nuclear Medicine Central CI ClinicSapporo 060-0042Japan

Multiple lymphomatous polyposis(MLP)is an uncommon type of gastrointestinal lymphoma characterized by the presence of multiple polyps along the gastrointestinal *** of this entity is in fact considered the counterpart of gastrointestinal tract involvement for mantle cell lymphoma(MCL).To our knowledge,there have been no reports on[fluorine-18]-fluorodeoxy-glucose(18F-FDG)-positron emission tomography(PET)/computed tomography(CT)imaging for gastrointestinal MCL with *** present the results of 18F-FDG PET/CT imaging in a patient with gastrointestinal tract involvement of MCL showing continuous MLP from the stomach to the rectum and intestinal ***-PET/CT findings were false negative in typical MLP spreading widely over the gastrointestinal tract,but uptake was noted in large lesions with deep infiltration considered atypical as *** FDG-PET/CT imaging,the Ki-67proliferative index,which is a cell proliferation marker,showed neither correlation with the presence of uptake nor the maximum standardized uptake value.

关键词： 18F-fluorodeoxy-glucose-positron emission tomography/computed tomography imaging Mantle cell lymphoma Multiple lymphomatous polyposis Gastrointestinal tract Ki-67 proliferative index

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Helicobacter pylori eradication treatment for primary gastric diffuse large B-cell lymphoma:A single-center analysis

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世界临床病例杂志 2023年第27期11卷 6424-6430页

作者： Makoto Saito Akio Mori Sayaka Kajikawa Emi Yokoyama Minoru Kanaya Koh Izumiyama masanobu morioka Takeshi Kondo Zen-Ichi Tanei Ai Shimizu Blood Disorders Center Aiiku HospitalSapporo 064-0804HokkaidoJapan Department of Cancer Pathology Faculty of MedicineHokkaido UniversitySapporo 060-8638HokkaidoJapan Department of Surgical Pathology Hokkaido University HospitalSapporo 060-8648HokkaidoJapan

BACKGROUND Unlike the already established effect of Helicobacter pylori(***)eradication on gastric mucosa-associated lymphoid tissue(MALT)lymphoma,its therapeutic effect on primary gastric diffuse large B-cell lymphoma(DLBCL)is still *** To clarify the efficacy of *** eradication treatment for primary gastric *** We reported on 3 new cases,and added them to 3 previously reported *** analyzed the usefulness of *** eradication treatment for gastric DLBCL for a total of 6 cases at our *** Of the 6 patients(27-90 years old,3 males and 3 females),all 3 patients with single lesions(one transformed from MALT lymphoma)achieved complete remission(CR)after *** *** the 2 newly reported cases,CR was maintained for more than 6 years with eradication treatment *** contrast,none of the 3 patients with 2 lesions achieved *** 1 newly reported case,endoscopic CR was achieved in one lesion,while stable disease was obtained in the other *** patients with progressive disease responded to standard chemo therapy±radiation and remained in CR for more than 6 *** We believe it is worthwhile to attempt *** eradication for elderly patients with primary gastric DLBCL in a single lesion with a small tumor burden.

关键词： Primary gastric diffuse large B-cell lymphoma Treatment Helicobacter pylori Eradication

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Flow Rate Measurement of Gravity Infusion Set and Functional Evaluation of Drop Counter: A Pilot Study

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Journal of Biomedical Science and Engineering 2024年第7期17卷 129-135页

作者： Rina Sakai Shuichi Tanaka Kaya Murakami Tomomi Mizuhashi Kazuhiro Yoshida masanobu Ujihira Department of Medical Engineering and Technology Kitasato University School of Allied Health Sciences Sagamihara Japan Faculty of Medical Engineering Gunma University of Health and Welfare Maebashi Japan Kitasato University Graduate School of Medical Sciences Sagamihara Japan

Developing a novel drop counter by introducing the Internet of Things concept has been vigorously conducted in recent years. Understanding the newly introduced drop counter’s flow rate control accuracy and flow rate count feature is essential for improving safety in infusion management. This study aimed to verify if the new drop counters could secure accurate flow rate and drip count by conducting actual flow rate measurements using gravimetry and functional evaluation. A drop counter was attached to each drip chamber of the infusion set, and an IV drip was conducted at the 100 ml/h flow rate. The weight of discharged physiological saline was measured to plot trumpet curves. Next, three different types of drop counters were evaluated to determine if they maintained drip count accuracy according to the changes in their position angles. The flow rate errors in all conditions indicated trumpet-like curves, exhibiting an overall error range within ±10% in all observation windows. Although every drop counter successfully detected and measured dripping, it was challenging in some counters to detect dripping when the drip chamber was tilted. In comparing adult and pediatric IV sets, the adult IV set was found to be less likely to detect dripping in the angled position. No significant differences in results were confirmed between high and low flow rates, suggesting that the drop count function would not be affected by the flow rate in the ranges of typical infusion practices. Doppler sensors have a wide range of measurements and high sensitivity;the dripping was detected successfully even when the drip chamber was tilted, probably due to the advantages of these sensors. In contrast, miscounts occurred in those equipped with infrared sensors, which could not detect light intensity changes in tilted positions. Understanding the tendencies in flow rate errors in infusion can be valuable information for infusion management.

关键词： Gravity Infusion Set Drop Counter IV Fluids Flow Rate Trumpet Curves

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Stresses in the Scapular Fossa Do Not Exceed the Yield Stress When Elevated up to 135 Degrees of Abduction after Reverse Shoulder Arthroplasty

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Journal of Biomedical Science and Engineering 2024年第2期17卷 35-40页

作者： Rina Sakai Tomonori Kenmoku Ryo Tazawa Kazuhiro Yoshida Tomomi Mizuhashi masanobu Ujihira Department of Medical Engineering and Technology Kitasato University School of Allied Health Sciences Sagamihara Japan Department of Orthopedic Surgery Kitasato University School of Medicine Sagamihara Japan Kitasato University Graduate School of Medical Sciences Sagamihara Japan

Reverse shoulder arthroplasty (RSA) is an effective treatment for rotator cuff tears. Despite its advantages, complications occur at a high rate. Complications requiring revision include a high rate of base plate failure, 38% of which are due to instability. The primary stability the base plate ensures is a crucial factor and, thus, is the subject of much debate in clinical studies and biomechanical research. This study is aimed to provide data that will contribute to the base plate’s pri-mary stability and glenoid longevity by clarifying the stresses at the scapular fossa and base plate interface associated with elevation after RSA. A 3D finite element model was created from the DICOM data for the scapulohumeral joint and SMR shoulder system. For loading conditions, 30 N was applied for each posi-tion with abduction angles of 0, 45, 90, and 135 degrees. A three-dimensional fi-nite element analysis was performed using the static implicit method with LS-DYNA. The von Mises stresses in the scapular fossa were found not to exceed the yield stress on the bone even after elevation to an abduction angle of 135 de-grees after RSA. It is rough to uniformly compare the yield stress and the von Mises stress, but it was inferred that the possibility of fracture is low unless a large external force is applied. A maximum von Mises stress showed 0 degrees of abduction, suggesting that the lowered position is in a more severe condition than the elevated position. If better improvement is desired, it may be necessary to devise ways to reduce the stress on the upper screw. .

关键词： Reverse Shoulder Arthroplasty Finite Element Analysis Yield Stress Glenoid

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利用探针跳跃式扫描离子电导显微镜技术揭示结直肠癌单细胞层面对H_(2)O_(2)良性应激的动态响应

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Science Bulletin 2024年第12期69卷 1909-1919页

作者：王东 Emily Woodcock 杨羲 Hiromi Nishikawa Elena V.Sviderskaya masanobu Oshima Christopher Edwards 张彦军 Yuri Korchev WPI Nano Life Science Institute(WPI-Nano LSI) Kanazawa UniversityKanazawa 920-1192Japan Department of Medicine Imperial College LondonLondon W120NNUnited Kingdom Cell Biology Research Centre Molecular and Clinical Sciences Research InstituteSt George’sUniversity of LondonLondon SW170REUnited Kingdom

Colorectal cancer(CRC),a widespread malignancy,is closely associated with tumor microenvironmental hydrogen peroxide(H_(2)O_(2))*** clinical trials targeting H_(2)O_(2)for cancer treatment have revealed its paradoxical role as a promoter of cancer *** the dynamics of cancer cell H_(2)O_(2)eustress at the single–cell level is *** this study,non–contact hopping probe mode scanning ion conductance microscopy(HPICM)with high-sensitive Pt–functionalized nanoelectrodes was employed to measure dynamic extracellular to intracellular H_(2)O_(2)gradients in individual colorectal cancer Caco–*** explored the relationship between cellular mechanical properties and H_(2)O_(2)*** to 0.1 or 1 mmol/L H_(2)O_(2)eustress increased the extracellular to intracellular H_(2)O_(2)gradient from 0.3 to 1.91 or 3.04,***,cellular F–actin–dependent stiffness increased at 0.1 mmol/L but decreased at 1 mmol/L H_(2)O_(2)*** H_(2)O_(2)–induced stiffness modulated AKT activation positively and glutathione peroxidase 2(GPX2)expression *** findings unveil the failure of some H_(2)O_(2)-targeted therapies due to their ineffectiveness in generating H_(2)O_(2),which instead acts eustress to promote cancer cell *** research also reveals the complex interplay between physical properties and biochemical signaling in cancer cells'antioxidant defense,illuminating the exploitation of H_(2)O_(2)eustress for survival at the single–cell *** GPX and/or catalase(CAT)enhances the cytotoxic activity of H_(2)O_(2)eustress against CRC cells,which holds significant promise for developing innovative therapies targeting cancer and other H_(2)O_(2)-related inflammatory diseases.

关键词： SPM Nanoprobe Nanobiology SECM ROS Stiffness

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