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Novel biomarkers for early detection of gastric cancer

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World Journal of Gastroenterology 2023年第17期29卷 2515-2533页

作者： Tasuku Matsuoka masakazu Yashiro Molecular Oncology and Therapeutics Osaka Metropolitan University Graduate School of MedicineOsaka 5458585Japan

Gastric cancer(GC)remains a leading cause of cancer-related death *** than half of GC cases are diagnosed at an advanced stage due to its lack of early *** is a heterogeneous disease associated with a number of genetic and somatic *** detection and effective monitoring of tumor progression are essential for reducing GC disease burden and *** current widespread use of semi-invasive endoscopic methods and radiologic approaches has increased the number of treatable cancers:However,these approaches are invasive,costly,and ***,novel molecular noninvasive tests that detect GC alterations seem to be more sensitive and specific compared to the current *** technological advances have enabled the detection of blood-based biomarkers that could be used as diagnostic indicators and for monitoring postsurgical minimal residual *** biomarkers include circulating DNA,RNA,extracellular vesicles,and proteins,and their clinical applications are currently being *** identification of ideal diagnostic markers for GC that have high sensitivity and specificity would improve survival rates and contribute to the advancement of precision *** review provides an overview of current topics regarding the novel,recently developed diagnostic markers for GC.

关键词： Gastric cancer Diagnostic biomarkers Early detection Liquid biopsy

Biomarkers of gastric cancer:Current topics and future perspective

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World Journal of Gastroenterology 2018年第26期24卷 2818-2832页

作者： Tasuku Matsuoaka masakazu Yashiro Department of Surgical Oncology Osaka City University Graduate School of MedicineOsaka 545-8585Japan Oncology Institute of Geriatrics and Medical Science Osaka City University Graduate School of MedicineOsaka 545-8585Japan

Gastric cancer(GC) is one of the most prevalent malignant types in the world and an aggressive disease with a poor 5-year survival. This cancer is biologically and genetically heterogeneous with a poorly understood carcinogenesis at the molecular level. Although the incidence is declining, the outcome of patients with GC remains dismal. Thus, the detection at an early stage utilizing useful screening approaches, selection of an appropriate treatment plan, and effective monitoring is pivotal to reduce GC mortalities. Identification of biomarkers in a basis of clinical information and comprehensive genome analysis could improve diagnosis, prognosis, prediction of recurrence and treatment response. This review summarized the current status and approaches in GC biomarker, which could be potentially used for early diagnosis, accurate prediction of therapeutic approaches and discussed the future perspective based on the molecular classification and profiling.

关键词： Biomarkers Ccancer diagnosis Prognostic marker Predictive marker Gastric cancer

Molecular targets for the treatment of pancreatic cancer:Clinical and experimental studies

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World Journal of Gastroenterology 2016年第2期22卷 776-789页

作者： Tasuku Matsuoka masakazu Yashiro Department of Surgical Oncology Osaka City University Graduate School of MedicineOsaka 545-8585Japan Oncology Institute of Geriatrics and Medical Science Osaka City University Graduate School of MedicineOsaka 545-8585Japan

Pancreatic cancer is the fourth most common cause of cancer deaths worldwide. Although recent therapeutic developments for patients with pancreatic cancer have provided survival benefits, the outcomes for patients with pancreatic cancer remain unsatisfactory. Molecularly targeted cancer therapy has advanced in the past decade with the use of a number of pathways as candidates of therapeutic targets. This review summarizes the molecular features of this refractory disease while focusing on the recent clinical and experimental findings on pancreatic cancer. It also discusses the data supporting current standard clinical outcomes, and offers conclusions that may improve the management of pancreatic cancer in the future.

关键词： Pancreatic cancer Targeted therapy Tyrosinekinase inhibitors Microenvironment Cancer stem cell

Synthesis of Nitrogen-doped Titania by Solvothermal Reactions in Alcohols

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过程工程学报 2006年第3期6卷 472-476页

作者： Tsugio Sato Yohei Aida masakazu Komatsu 殷澍 Institute of Multidisciplinary Research for Advanced Materials Tohoku UniversitySendai 980-8577Japan

Nitrogen-doped titania nanoparticles were obtained by the homogeneous precipitation in hexamethylenetetraminetitanium trichloride-alcohol aqueous solutions at 90 ℃ followed by heating at 190 ℃. Anatase, rutile and brookite were obtained, where the crystallite size, specific surface area and color greatly changed as 5～50 nm, 20～200 m2/g and light gray to yellow, depending on the solvent and pH. The products after calcination were yellow, indicating doping with nitrogen ion. All colored titania showed photocatalytic activity under visible light irradiation for the oxidative decomposition of nitrogen monoxide in air. Especially, the nanoparticles of anatase type nitrogen-doped titania obtained using methanol aqueous solution showed excellent photocatalytic activity.

关键词： nitrogen-doped titania solvothermal synthesis alcohol photocatalysis nitrogen monoxide decomposition

Precision medicine for gastrointestinal cancer:Recent progress and future perspective

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World Journal of Gastrointestinal Oncology 2020年第1期12卷 1-20页

作者： Tasuku Matsuoka masakazu Yashiro Department of Gastroenterological Surgery Osaka City University Graduate School of MedicineOsaka 5458585Japan Oncology Institute of Geriatrics and Medical Science Osaka City University Graduate School of MedicineOsaka 5458585Japan

Gastrointestinal(GI)cancer has a high tumor incidence and mortality rate *** significant improvements in radiotherapy,chemotherapy,and targeted therapy for GI cancer over the last decade,GI cancer is characterized by high recurrence rates and a dismal *** is an urgent need for new diagnostic and therapeutic *** technological advances and the accumulation of clinical data are moving toward the use of precision medicine in GI *** we review the application and status of precision medicine in GI *** of liquid biopsy specimens provide comprehensive real-time data of the tumor-associated changes in an individual GI cancer patient with *** the introduction of gene panels including next-generation sequencing,it has become possible to identify a variety of mutations and genetic biomarkers in GI *** the genomic aberration of GI cancer is apparently less actionable compared to other solid tumors,novel informative analyses derived from comprehensive gene profiling may lead to the discovery of precise molecular targeted *** progressions will make it feasible to incorporate clinical,genome-based,and phenotype-based diagnostic and therapeutic approaches and apply them to individual GI cancer patients for precision medicine.

关键词： Gastrointestinal cancer Esophageal cancer Gastric cancer Colorectal cancer Precision medicine Liquid biopsy Gene panel Precision surgery Biomarkers

A New Method of Portfolio Optimization Under Cumulative Prospect Theory

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Tsinghua Science and Technology 2018年第1期23卷 75-86页

作者： Chao Gong Chunhui Xu masakazu Ando Xiangming Xi Department of Risk Science in Finance and Management Chiba Institute of Technology Chiba 275-0016 Japan Department of Automation Tsinghua University Beijing 100084 China

In this paper, the portfolio selection problem under Cumulative Prospect Theory （CPT） is investigated and a model of portfolio optimization is presented. This model is solved by coupling scenario generation techniques with a genetic algorithm. Moreover, an Adaptive Real-Coded Genetic Algorithm （ARCGA） is developed to find the optimal solution for the proposed model. Computational results show that the proposed method solves the portfolio selection model and that ARCGA is an effective and stable algorithm. We compare the portfolio choices of CPT investors based on various bootstrap techniques for scenario generation and empirically examine the effect of reference points on investment behavior.

关键词： portfolio choice cumulative prospect theory bootstrap method adaptive real-coded genetic algorithm

HYERS-ULAM STABILITY OF SECOND-ORDER LINEAR DYNAMIC EQUATIONS ON TIME SCALES

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Acta Mathematica Scientia 2021年第5期41卷 1809-1826页

作者： Douglas R.ANDERSON masakazu ONITSUKA Department of Mathematics Concordia CollegeMoorheadMN 56562 USA Department of Applied Mathematics kayama University of ScienceOkayama700-0005Japan

We investigate the Hyers-Ulam stability(HUS)of certain second-order linear constant coefficient dynamic equations on time scales,building on recent results for first-order constant coefficient time-scale *** particular,for the case where the roots of the characteristic equation are non-zero real numbers that are positively regressive on the time scale,we establish that the best HUS constant in this case is the reciprocal of the absolute product of these two *** for instability are also given.

关键词： stability second order Hyers-Ulam time scales

Recent advances in the HER2 targeted therapy of gastric cancer

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World Journal of Clinical Cases 2015年第1期3卷 42-51页

作者： Tasuku Matsuoka masakazu Yashiro Department of Surgical Oncology Osaka City University Graduate School of Medicine Osaka 545-8585 Japan Oncology Institute of Geriatrics and Medical Science Osaka City University Graduate School of Medicine Osaka 545-8585 Japan

Recent advances in molecular targeted therapies, including targeting human epidermal growth factor receptor 2(HER2), had a major forward step in the therapy for gastric cancer patients. Application of HER2-targeted therapies, in particular trastuzumab in combination with chemotherapy in metastatic HER2-positive gastric cancers, resulted in improvements in response rates, time to progression and overall survival. Nevertheless, as with breast cancer, many patients with gastric cancer develop resistance to trastuzumab. Several promising therapies are currently being developed in combination with chemotherapy to increase the efficacy and overcome the cancerresistance. Here we review the current overview of clinical application of agents targeting HER2 in gastric cancer. We also discuss the ongoing trials supporting the use of HER2-targeted agents combined with cytotoxic agents or other monoclonal antibodies.

关键词： Human epidermal growth factor receptor 2 Gastric cancer Targeting therapy Trastuzumab

Effect of ambient polycyclic aromatic hydrocarbons and nicotine on the structure of Aβ_(42) protein

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Frontiers of Environmental Science & Engineering 2023年第2期17卷 9-18页

作者： Samal Kaumbekova Mehdi Amouei Torkmahalleh Naoya Sakaguchi masakazu Umezawa Dhawal Shah Department of Chemical and Materials Engineering School of Engineering and Digital SciencesNazarbayev UniversityKabanbay Batyr 53Nur-Sultan010000Kazakhstan Department of Materials Science and Technology Faculty of Advanced EngineeringTokyo University of Science6-3-1 NiijukuKatsushikaTokyo 125-8585Japan

Recent studies have correlated the chronic impact of ambient environmental pollutants like polycyclic aromatic hydrocarbons(PAHs)with the progression of neurodegenerative disorders,either by using statistical data from various cities,or via tracking biomarkers during in-vivo *** different neurodegenerative disorders,PAHs are known to cause increased risk for Alzheimer’s disease,related to the development of amyloid beta(Aβ)peptide ***,the complex molecular interactions between peptide monomers and organic pollutants remains *** this work,we performed an atomistic molecular dynamics study via GROMACS to investigate the structure of Aβ_(42) peptide monomer in the presence of benzo[a]pyrene,nicotine,and *** the results revealed strong hydrophobic,and hydrogen-bond based interactions between Aβpeptides and these environmental pollutants that resulted in the formation of stable intermolecular *** strong interactions affected the secondary structure of the Aβ_(42) peptide in the presence of the organic pollutants,with almost 50%decrease in theα-helix and 2%–10%increase in theβ-sheets of the ***,the undergoing changes in the secondary structure of the peptide monomer in the presence of the pollutants under the study indicates an enhanced formation of Aβpeptide oligomers,and consequent progression of Alzheimer’s disease.

关键词： Polycyclic aromatic hydrocarbons Nicotine toxicology Aβ_(42)peptide Alzheimer’s disease Molecular dynamics simulations Environmental pollution