Precision medicine for gastrointestinal cancer:Recent progress and future perspective

作     者：Tasuku Matsuoka Masakazu Yashiro 

作者机构：Department of Gastroenterological SurgeryOsaka City University Graduate School of MedicineOsaka 5458585Japan Oncology Institute of Geriatrics and Medical ScienceOsaka City University Graduate School of MedicineOsaka 5458585Japan 

出 版 物：《World Journal of Gastrointestinal Oncology》 (世界胃肠肿瘤学杂志（英文版）（电子版）)

年 卷 期：2020年第12卷第1期

页      面：1-20页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：Supported by KAKENHI(Grant-in-Aid for Scientific Research) No.18H02883 

主　　题：Gastrointestinal cancer Esophageal cancer Gastric cancer Colorectal cancer Precision medicine Liquid biopsy Gene panel Precision surgery Biomarkers 

摘      要：Gastrointestinal(GI)cancer has a high tumor incidence and mortality rate *** significant improvements in radiotherapy,chemotherapy,and targeted therapy for GI cancer over the last decade,GI cancer is characterized by high recurrence rates and a dismal *** is an urgent need for new diagnostic and therapeutic *** technological advances and the accumulation of clinical data are moving toward the use of precision medicine in GI *** we review the application and status of precision medicine in GI *** of liquid biopsy specimens provide comprehensive real-time data of the tumor-associated changes in an individual GI cancer patient with *** the introduction of gene panels including next-generation sequencing,it has become possible to identify a variety of mutations and genetic biomarkers in GI *** the genomic aberration of GI cancer is apparently less actionable compared to other solid tumors,novel informative analyses derived from comprehensive gene profiling may lead to the discovery of precise molecular targeted *** progressions will make it feasible to incorporate clinical,genome-based,and phenotype-based diagnostic and therapeutic approaches and apply them to individual GI cancer patients for precision medicine.