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A New Method of Portfolio Optimization Under Cumulative Prospect Theory

Tsinghua Science and Technology 2018年第1期23卷 75-86页

作者： Chao Gong Chunhui Xu masakazu ando Xiangming Xi Department of Risk Science in Finance and Management Chiba Institute of Technology Chiba 275-0016 Japan Department of Automation Tsinghua University Beijing 100084 China

In this paper, the portfolio selection problem under Cumulative Prospect Theory （CPT） is investigated and a model of portfolio optimization is presented. This model is solved by coupling scenario generation techniques with a genetic algorithm. Moreover, an Adaptive Real-Coded Genetic Algorithm （ARCGA） is developed to find the optimal solution for the proposed model. Computational results show that the proposed method solves the portfolio selection model and that ARCGA is an effective and stable algorithm. We compare the portfolio choices of CPT investors based on various bootstrap techniques for scenario generation and empirically examine the effect of reference points on investment behavior.

关键词： portfolio choice cumulative prospect theory bootstrap method adaptive real-coded genetic algorithm

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Pediatric bowel preparation: Sodium picosulfate, magnesium oxide, citric acid vs polyethylene glycol, a randomized trial

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World Journal of Gastroenterology 2020年第40期26卷 6260-6269页

作者： Carmen Cuffari Steven L Ciciora masakazu ando Mena Boules Joseph M Croffie Department of Pediatrics The Johns Hopkins School of MedicineBaltimoreMD 21287United States Department of Pediatrics The Ohio State University College of MedicineColombusOH 43205United States Department of Statistics Ferring Pharmaceuticals IncParsippanyNJ 07054United States Department of Medical Affairs Ferring Pharmaceuticals IncParsippanyNJ 07054United States Department of Pediatrics Indiana University School of MedicineIndianapolisIN 46202United States

BACKGROUND Bowel preparation in children can be *** To describe the efficacy, safety, and tolerability of sodium picosulfate, magnesium oxide, and citric acid(SPMC) bowel preparation in *** Phase 3, randomized, assessor-blinded, multicenter study of low-volume, divided dose SPMC enrolled children 9-16 years undergoing elective colonoscopy. Participants 9-12 years were randomized 1:1:1 to SPMC ? dose × 2, SPMC 1 dose × 2, or polyethylene glycol(PEG). Participants 13-16 years were randomized 1:1 to SPMC 1 dose × 2 or PEG. PEG-based bowel preparations were administered per local protocol. Primary efficacy endpoint for quality of bowel preparation was responders(rating of ‘excellent' or ‘good') by modified Aronchick Scale. Secondary efficacy endpoint was participant's tolerability and satisfaction from a 7-item questionnaire. Safety assessments included adverse events(AEs) and laboratory *** 78 participants were randomized, 48 were 9-12 years, 30 were 13-16 years. For the primary efficacy endpoint in 9-12 years, 50.0%, 87.5%, and 81.3% were responders for SPMC ? dose × 2, SPMC 1 dose × 2, and PEG groups, respectively. Responder rates for 13-16 years were 81.3% for SPMC 1 dose × 2 and 85.7% for PEG. Overall, 43.8% of participants receiving SPMC 1 dose × 2 reported it was ‘very easy' or ‘easy' to drink, compared with 20.0% receiving PEG. Treatment-emergent AEs were reported by 45.5% of participants receiving SPMC 1 dose × 2 and 63.0% receiving *** SPMC was an efficacious and safe for bowel preparation in children 9-16 years, with comparable efficacy to PEG. Tolerability for SPMC was higher compared to PEG.

关键词： Children Colonoscopy Colon cleansing Sodium picosulfate magnesium oxide and citric acid Polyethylene glycol

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Solid-State NMR Analysis of Irradiated Fluoropolymers

Solid-State NMR Analysis of Irradiated Fluoropolymers

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RadTech Asia 2005

作者： Yukari Numata Akihiro Oshima Keitaro Aimi Shinji ando Katsuyoshi Murata Hiroyuki Kono masakazu Washio Etsuko Katoh Department of Biochemistry National Institute of Agrobiological Science （NIAS） 2-1-2 Kannondai Tsukuba Ibaraki 305-8602Japan Advanced Research Institute for Science and Engineering Waseda University 3-4-1 Okubo Shinjuku-ku Tokyo 169-8555Japan Department of Organic and polymeric Materials Tokyo Institute of Technology 2-12-1 Ookayama Meguro-ku Tokyo152-8552 Japan Department of Organic and polymeric Materials Tokyo Institute of Technology 2-12-1 Ookayama Meguro-ku Tokyo152-8552 Japan Department of Biochemistry National Institute of Agrobiological Science （NIAS） 2-1-2 Kannondai Tsukuba Ibaraki 305-8602 Japan Bruker BioSpin Company Ltd. Ninomiya 3-21-5 Tsukuba Ibaraki 305-0051 Japan Advanced Research Institute for Science and Engineering Waseda University 3-4-1 Okubo Shinjuku-ku Tokyo 169-8555Japan Department of Biochemistry National Institute of Agrobiological Science （NIAS） 2-1-2 Kannondai Tsukuba Ibaraki 305-8602Japan

＜正＞ We have investigated changes in chemical structures and molecular dynamics for electron beam（EB）-irradiated MPE/PTFE polymer-blend using solid-state NMR spectroscopy. Although 13the 13C MAS NMR spectra did not yield useful information regarding changes in the chemical structure of MPE/PTFE by the EB- irradiation, it was possible to obtain detailed structural information from the 19F MAS NMR spectra. The results indicate that 19F signals at -215 （-CFH- and/or -CFH2） and -140 ppm （-CF2H） for EB-irradiated MPE/PTFE are characteristic signals, which are not observed in independently irradiated PTFE. Furthermore, relaxation times for these samples were measured, and the results indicate that the molecular motion of the crystalline components of PTFE and MPE is altered by EB-irradiation. These NMR experimental results indicate that a chemical reaction occurred between MPE and PTFE, and that their molecular motion was significantly changed by irradiation.

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