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Journal of Diabetes Mellitus 2012年第2期2卷 170-178页

作者： Takahiro Hata Takeshi Ohta Yukihito Ishii Tomohiko Sasase Takayuki Yamaguchi Yasuko Mera Katsuhiro miyajima Gimpei Tanoue Eimei Sato Mutsuyoshi Matsushita Japan Tobacco Inc. Central Pharmaceutical Research Institute Osaka Japan Japan Tobacco Inc. Central Pharmaceutical Research Institute Toxicology Research Laboratories Hadano Japan Laboratory of Animal Reproduction Graduate School of Agricultural Science Tohoku University Sendai Japan

Nutritional regulation plays a critical role to reduce the incidence or progression of diabetes mellitus. In this study, we investigated the effects of a high-fat diet on Spontaneously Diabetic Torii Leprfa (SDT fatty) rats, a novel model for obese type 2 diabetes. The SDT fatty rats were divided into two dietary groups, which were fed a high-fat diet or a standard diet for 18 weeks, from 6 to 24 weeks of age. The calorie intake in the high-fat diet (HF) group was reduced after 10 weeks of age and the group inhibited an incidence of diabetes. Interestingly, the HF induced an increase of serum glucagon-like peptide-1 (GLP-1) levels in SDT fatty rats with refeeding. Fat tissue weights in the HF group increased, but the visceral fat/subcutaneous fat (V/S) ratio decreased. Moreover, histopathological observations revealed an improvement of the pancreatic abnormalities and fatty liver in the HF group. In conclusion, a preventive effect on diabetes in rats fed a high-fat diet has a relation with an increase in incretin hormone, and it might be advantageous for prevention of incidence or progression of diabetes to develop functional foods inducing an increase in incretin hormone.

关键词： Glucagon-Like Peptide-1 High Fat Diets SDT Fatty Rats

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LE-5发动机比冲分析

上海航天(中英文) 1987年第3期 16-23页

作者： H.miyajima ,K.Makahashi ,汪钺

LE-5液氧/液氢燃气发生器循环发动机实测真空比冲被用来评定一种新的喷管性能分析计算方法.涡轮排气引入到主流的超音速段,涡轮排气的有效比冲用一种简单方法计算,然后乘上一个由缩比热试模型试验确定的系数.主流比冲用一种类似于JANNA... 详细信息

LE-5液氧/液氢燃气发生器循环发动机实测真空比冲被用来评定一种新的喷管性能分析计算方法.涡轮排气引入到主流的超音速段,涡轮排气的有效比冲用一种简单方法计算,然后乘上一个由缩比热试模型试验确定的系数.主流比冲用一种类似于JANNAF的喷管分析方法进行计算,计算时假设能量释放效率等于测定的C*（特征速度）效率.测得的发动机比冲与分析计算值相当一致.在有些情况下,发现C*-效率和能量释放效率之间存在偏差.

关键词： 1.液体推进剂火箭发动机,运载火箭 2.氢氧发动机——发动机试验

Female spontaneously diabetic Torii fatty rats develop nonalcoholic steatohepatitis-like hepatic lesions

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World Journal of Gastroenterology 2015年第30期21卷 9067-9078页

作者： Yukihito Ishii Yu Motohashi Makoto Muramatsu Yoshiaki Katsuda Katsuhiro miyajima Tomohiko Sasase Takahisa Yamada Tohru Matsui Shinichi Kume Takeshi Ohta Japan Tobacco Inc. Central Pharmaceutical Research Institute Japan Tobacco Inc. Central Pharmaceutical Research InstituteToxicology Research Laboratories Niigata University Graduate School of Science and Technology Kyoto University Graduate School of Agriculture

AIM:To investigate the histological features of the liver in spontaneously diabetic Torii(SDT) fatty rats compared with age-matched Sprague-Dawley(SD) ***:Female SDT Leprfa(SDT fatty) rats and age-matched SD rats were fed ad libitum. Body weight and biochemical parameters,such as serum glucose,triglyceride(TG),total cholesterol(TC),alanine aminotransferase(ALT) and aspartate aminotransferase(AST) levels as well as fatty acid and TG accumulation in the liver were evaluated at 8 wk of age in the nonfasting state and at 8-wk intervals from 8 to 40 wk of age. Histopathological examinations of the liver were performed using hematoxylin and eosin and Sirius Red staining as well as double staining for ED-1 and toluidine blue. The expression of genes involved in TG synthesis,inflammation,and fibrosis was examined in the ***:SDT fatty rats showed significantly increased body weight compared with SD rats. Serum glucose,TG,and TC levels were significantly higher in SDT fatty rats compared with SD rats. The serum AST and ALT levels in SDT fatty rats were significantly elevated at 8 wk of age compared with the levels in SD rats. Hepatic TG content was marked in SDT fatty rats from 8 to 32 wk of age. Histopathologically,severe hepatosteatosis accompanied by inflammation was observed at 8 wk of age,and fibrosis started to occur at 32 wk of age. Furthermore,Sirius Red and ED-1 staining were increased in the liver at 32 wk of age. Hepatic gene expression related to TG synthesis,inflammation and fibrosis tended to increase in SDT fatty rats compared with SD rats,and the gene expression related to TG secretion was decreased in SDT fatty rats compared with SD rats. CONCLUSION:Female SDT fatty rats have the potential to become an important animal model of nonalcoholic steatohepatitis with type 2 diabetes and obesity.

关键词： Nonalcoholic steatohepatitis Spontaneouslydiabetic Torii fatty rat Fibrosis Fatty liver Metabolicsyndrome

Piezoelectric Power Harvesting Process via Phase Changes of Low-Boiling-Point Medium Together with Water for Recovering Low-Temperature Heats

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Journal of Power and Energy Engineering 2018年第11期6卷 65-77页

作者： Seiichi Deguchi Akinori miyajima Hajime Arimura Haruna Banno Noriyuki Kobayashi Norifumi Isu Kentaro Takagi Tsuyoshi Inoue Takashi Nozoe Seigo Saito Takahiko Sano Department of Chemical Process Engineering Nagoya University Nagoya Japan Analysis & Assessment Center LIXIL Corporation Noda Japan Department of Mechanical Systems Engineering Nagoya University Nagoya Japan Fuji Ceramics Corporation Fujinomiya Japan

Low-temperature thermal energy conversions down to exergy zero to electric power must contribute energy sustainability. That is to say, reinforcements of power harvesting technologies from extremely low temperatures less than 373 K might be at least one of minimum roles for the current generations. Then, piezoelectric power harvesting process for recovering low-temperature heats was invented by using a unique biphasic operating medium of an underlying water-insoluble/low-boiling-point medium (i.e. NOVEC manufactured by 3M Japan Ltd.) in small quantity and upper-layered water in large quantity. The higher piezoelectric power harvesting densities were naturally revealed with an increase in heating temperatures. Excessive cooling of the operating medium deteriorated the power harvesting efficiency. The denser operating medium was surpassingly helpful to the higher piezoelectric power harvesting density. Concretely, only about 5% density increase of main operating medium (i.e. water with dissolving alum at 0.10 mol/dm3) came to the champion piezoelectric power harvesting density of 92.6 pW/dm2 in this study, which was about 1.4 times compared to that with the original biphasic medium of pure water together with a small quantity of NOVEC.

关键词： Piezoelectric Power Generation Low-Temperature Heat Recovery Biphasic Medium Phase Change Multiphase Flow Power Harvesting

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混凝土裂缝深度的测量

无损检测 1992年第10期14卷 297-300页

作者： Y.ogura T.miyajima T.Takishita K.ohtake Y.Akutsu 夏启清

本文研究采用低频超声法测量混凝土构件表面开口裂缝的深度。通过改变超声波模式、频率和探头间距等基本试验,获得了裂缝深度与超声波传播时间/接收频率之间的对应关系。表明选择适当的超声波模式,裂缝深度与声传播时间/接收频率之间存... 详细信息

本文研究采用低频超声法测量混凝土构件表面开口裂缝的深度。通过改变超声波模式、频率和探头间距等基本试验,获得了裂缝深度与超声波传播时间/接收频率之间的对应关系。表明选择适当的超声波模式,裂缝深度与声传播时间/接收频率之间存在着相关性。该方法测量结果的标准偏差在9mm 以内。

关键词：混凝土裂缝超声波测深

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北京和东京居民的时间分配比较研究

中国人民大学学报 2000年第3期14卷 48-57页

作者：袁卫村上征胜王琪延中国人民大学统计系北京100872 日本文部省数理研究所中国人民大学成人教育学院北京100872

本文以时间作为测量人类生活的计量单位，运用北京和东京两市居民的生活时间分配调查资料，对北京和东京两市居民的生活时间分配以及变动趋势进行了比较研究，反映了两市居民的生活方式的差异及其变化，探讨了形成这些差异和变化的主要... 详细信息

本文以时间作为测量人类生活的计量单位，运用北京和东京两市居民的生活时间分配调查资料，对北京和东京两市居民的生活时间分配以及变动趋势进行了比较研究，反映了两市居民的生活方式的差异及其变化，探讨了形成这些差异和变化的主要原因。

关键词：北京东京居民生活活动时间分配比较研究

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Clinical impact of endoscopy position detecting unit(UPD-3) for a non-sedated colonoscopy

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世界胃肠病学杂志：英文版 2015年第16期21卷 4903-4910页

作者： masakatsu Fukuzawa Junichi Uematsu Shin Kono Sho Suzuki Takemasa Sato Naoko Yagi Yuichiro Tsuji Kenji Yagi Chika Kusano Takuji Gotoda Takashi Kawai Fuminori Moriyasu Department of Gastroenterology and Hepatology Tokyo Medical University Endoscopy Center Tokyo Medical University Hospital

AIM:To evaluate whether an endoscopy position detecting unit(UPD-3) can improve cecal intubation rates, cecal intubation times and visual analog scale(VAS) pain scores, regardless of the colonoscopist's level of ***:A total of 260 patients(170 men and 90women)who underwent a colonoscopy were divided into the UPD-3-guided group or the conventional group(no UPD-3 guidance).Colonoscopies were performed by experts(experience of more than 1000colonoscopies)or trainees(experience of less than 100colonoscopies).Cecal intubation rates,cecal intubation times,insertion methods(straight insertion:shortening the colonic fold through the bending technique;roping insertion:right turn shortening technique)and patient discomfort were *** discomfort during the endoscope insertion was scored by the VAS that was divided into 6 degrees of ***:The cecum intubation rates,cecal intubation times,number of cecal intubations that were performed in<15 min and insertion methods were not significantly different between the conventional group and the UPD-3-guided *** number of patients who experienced pain during the insertion was markedly less in the UPD-3-guided group than in the conventional *** and multivariate analysis showed that the following factors were associated with lower VAS pain scores during endoscope insertion:insertion method(straight insertion)and UPD-3guidance in the trainee *** the experts group,univariate analysis showed that only the insertion method(straight insertion)was associated with lower VAS pain ***:Although UPD-3 guidance did not shorten intubation times,it resulted in less patient painduring endoscope insertion compared with conventional endoscopy for the procedures performed by trainees.

关键词： Colonoscopy Training Endoscopy positiondetecting unit

CYP3A5 and MDR1 Polymorphisms are Associated with Calcineurin Inhibitor-related Neurotoxicity after Allogenic Stem Cell Transplantation in Children

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CYP3A5 and MDR1 Polymorphisms are Associated with Calcineuri...

第五届亚洲儿科研究大会

作者： masakatsu Yanagimachi Takuya Naruto Reo Tanoshima Hiromi Kato Tomoko Yokosuka Hisaki Fujii Hiroaki Goto Tatsuhiko Yagihashi Kenjiro Kosaki Shumpei Yokota Department of Pediatrics Yokohama City University School of Medicine

＜正＞Calcineurin inhibitors such as cyclosporine（CsA） and tacrolimus（FK506） are widely used as prophylactics and for treatment of graft-versus-host disease（GVHD） after hematopoietic stem cell transplantation（HSCT）.One severe side effect of these calcineurin inhibitors is *** substances are substrates for CYP3A5 and P-glycoprotein,the product of multidrug resistance gene （MDR1）.The effect of the polymorphisms,such as CYP3A5 6986G＞A,MDR1 1236C＞T,2677G＞A/T and

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日本热喷涂防腐应用现状

热喷涂技术 2009年第1期1卷 8-13页

作者：馬込正勝大阪产业大学工学部

介绍了近期日本热喷涂防腐应用相关标准和现状、应用实例,提出了相关待研究解决的问题。

关键词：热喷涂腐蚀防腐应用

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Clinical significance of monocyte-derived dendritic cell activation in patients with acute coronary syndrome

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World Journal of Cardiovascular Diseases 2012年第2期2卷 74-81页

作者： Yasue Takahashi Kazunori Shimada Katsuhiko Sumiyoshi Takashi Kiyanagi Makoto Hiki Kosuke Fukao Kuniaki Hirose Rie Matsumori Hiromichi Ohsaka Atsumi Kume Tetsuro Miyazaki Hiroaki miyajima Isao Nagaoka Hiroyuki Daida Department of Cardiovascular Medicine Juntendo University School of Medicine Tokyo Japan Department of Host Defense and Biochemical Research Juntendo University Graduate School of Medicine Tokyo Japan Division of Cell Biology Juntendo University Graduate School of Medicine Tokyo Japan

Background: Acute coronary syndrome (ACS) is an amplified state of inflammation and immune reaction. Dendritic cells (DCs) expressing various Toll-like receptors (TLRs) have been observed in atherosclerotic lesions, however, the clinical significance of DCs in pathogenesis of ACS has not been completely investigated. Methods: Ten patients with ACS and 10 patients with stable angina pectoris (SAP) were enrolled in this study. Monocyte-derived DCs were generated from CD14+ cells by culturing with granulocyte macrophage colony-stimulating factor and interleukin (IL)-4 for 6 days. Expression of cell surface CD86 and CD83 were measured by flowcytometry. Expression of genes, including CD86, CD83, CCL19, CCR7, TLR2, TLR4, TLR5, TLR8, and TLR9, were measured by real-time PCR. Plasma IL-6 and tumor necrosis factor (TNF)-α levels were also measured. Results: The number of CD86+CD83+DCs in the ACS group was significantly higher than that in the SAP group (P P P +CD83+ cells and plasma levels of IL-6 (P = 0.88, P +CD83+ cells TNF-α levels (r = 0.78, P < 0.0001). Conclusions: These results demonstrated that mono-cyte-derived DCs are activated in patients with ACS, suggesting that activated DCs may play an important role in the pathogenesis of ACS.

关键词： Acute Coronary Syndrome (ACS) Dendritic Cells (DCs) Toll-Like Receptors (TLRs)