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The Expression of Surfactant Proteins A and D in the Intestines and Pancreas of Murine Fetuses

Open Journal of Pediatrics 2014年第1期4卷 12-20页

作者： Ryuta Saka Hiroomi Okuyama Kaoru Uchida Kumiko Nakahira Takashi Sasaki Satoko Nose masahiro nakayama masahiro Fukuzawa Itaru Yanagihara Department of Developmental Medicine Osaka Medical Center and Research Institute for Maternal and Child Health Izumi Japan Department of Pediatric Surgery Hyogo College of Medicine Nishinomiya Japan Department of Pediatric Surgery Osaka University Graduate School of Medicine Suita Japan Pathology and Laboratory Medicine Osaka Medical Center and Research Institute for Maternal and Child Health Izumi Japan

Purpose: Surfactant proteins exist in the digestive tract and may play an important role in the host defense. However, the expression of surfactant proteins in the premature digestive system remains unclear. The aim of this study was to investigate the expression of surfactant proteins in the intes-tines and pancreas of murine fetuses. Methods: Immunostaining for SP-A and SP-D was assessed in the small intestine and pancreas of ICR murine fetuses on days 15, 16, 17 and 18 of gestation (normal duration of pregnancy: 19 - 21 days). RT-PCR was performed to detect the expression of spa and spd mRNA in the small intestine and pancreas on day 16, 17 and 18 of gestation. Results: Immunoreactivity for SP-A and SP-D in the acinar cells of pancreas and intestinal mucosal surface were positive on day 16 of gestation onward. RT-PCR revealed that the expression of spa and spd mRNA was significant in the pancreas but weak in the small intestine. Conclusions: Our data revealed that surfactant proteins are present in the fetal intestines and pancreas and that a significant expression of spa and spd mRNA is detected in the fetal pancreas. Pancreas may be a possible organ involved in the synthesis and secretion of surfactant proteins into the intestinal lumen.

关键词： Surfactant Protein Fetus Intestine Pancreas

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Identification of telomere maintenance gene variations related to lung adenocarcinoma risk by genome-wide association and whole genome sequencing analyses

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Cancer Communications 2024年第2期44卷 287-293页

作者： Kouya Shiraishi Atsushi Takahashi Yukihide Momozawa Yataro Daigo Syuzo Kaneko Takahisa Kawaguchi Hideo Kunitoh Shingo Matsumoto Hidehito Horinouchi Akiteru Goto Takayuki Honda Kimihiro Shimizu masahiro Torasawa Daisuke Takayanagi Motonobu Saito Akira Saito Yuichiro Ohe Shun-ichi Watanabe Koichi Goto masahiro Tsuboi Katsuya Tsuchihara Sadaaki Takata Tomomi Aoi Atsushi Takano Masashi Kobayashi Yohei Miyagi Kazumi Tanaka Hiroyuki Suzuki Daichi Maeda Takumi Yamaura Maiko Matsuda Yoko Shimada Takaaki Mizuno Hiromi Sakamoto Teruhiko Yoshida Yasushi Goto Tatsuya Yoshida Taiki Yamaji Makoto Sonobe Shinichi Toyooka Kazue Yoneda Katsuhiro Masago Fumihiro Tanaka Megumi Hara Nobuo Fuse Satoshi S.Nishizuka Noriko Motoi Norie Sawada Yuichiro Nishida Kazuki Kumada Kenji Takeuchi Kozo Tanno Yasushi Yatabe Kuniko Sunami Tomoyuki Hishida Yasunari Miyazaki Hidemi Ito Mitsuhiro Amemiya Hirohiko Totsuka Haruhiko nakayama Tomoyuki Yokose Kazuyoshi Ishigaki Toshiteru Nagashima Yoichi Ohtaki Kazuhiro Imai Ken Takasawa Yoshihiro Minamiya Kazuma Kobayashi Kenichi Okubo Kenji Wakai Atsushi Shimizu Masayuki Yamamoto Motoki Iwasaki Koichi Matsuda Johji Inazawa Yuichi Shiraishi Hiroyoshi Nishikawa Yoshinori Murakami Michiaki Kubo Fumihiko Matsuda Yoichiro Kamatani Ryuji Hamamoto Keitaro Matsuo Takashi Kohno Division of Genome Biology National Cancer Center Research InstituteTokyoJapan Department of Clinical Genomics National Cancer Center Research InstituteTokyoJapan Laboratory for Statistical Analysis Center for Integrative Medical SciencesRIKENYokohamaJapan Department of Genomic Medicine Research InstituteNational Cerebral and Cardiovascular CenterOsakaJapan Laboratory for Genotyping Development Center for Integrative Medical SciencesRIKENYokohamaJapan Center for Antibody and Vaccine Therapy Research HospitalInstitute of Medical ScienceThe University of TokyoTokyoJapan Department of Medical Oncology and Cancer Center and Center for Advanced Medicine against CancerShiga University of Medical ScienceOtsuJapan Division of Medical AI Research and Development National Cancer Center Research InstituteTokyoJapan Center for Genomic Medicine Graduate School of MedicineKyoto UniversityKyotoJapan Department of Medical Oncology Japanese Red Cross Medical CenterTokyoJapan Department of Thoracic Oncology National Cancer Center Hospital EastJapan Department of Thoracic Oncology National Cancer Center HospitalTokyoJapan Department of Cellular and Organ Pathology Graduate School of MedicineAkita UniversityAkitaJapan Department of Respiratory Medicine Tokyo Medical and Dental UniversityBunkyo-kuTokyoJapan Division of General Thoracic Surgery Department of SurgeryShinshu University School of MedicineMatsumotoNaganoJapan Department of General Surgical Science Division of General Thoracic SurgeryGunma University Graduate School of MedicineIntegrative Center of General SurgeryGunma University HospitalGunmaJapan Department of Gastrointestinal Tract Surgery Fukushima Medical University School of MedicineFukushimaJapan StaGen Co. LtdTokyoJapan Division of Thoracic Surgery National Cancer Center HospitalTokyoJapan Department of Thoracic Surgery National Cancer Center Hospital EastChibaJapan Division of Translational Informatics Exploratory Oncology Research and Clinical Trial Center(EPOC

Dear editor,Lung carcinoma is responsible for the highest fatal-ity rate among cancer-related deaths globally,with lung adenocarcinoma(LADC)emerging as the prevailing sub-type.

关键词： adenocarcinoma lung Lung

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Antibody to eosinophil cationic protein suppresses dextran sulfate sodium-induced colitis in rats

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World Journal of Gastroenterology 2005年第29期11卷 4505-4510页

作者： Kazuko Shichijo Kazuya Makiyama Chun-Yang Wen Mutsumi Matsuu Toshiyuki nakayama masahiro Nakashima Makoto Ihara Ichiro Sekine Department of Molecular Pathology Atomic Bomb Disease Institute Nagasaki University Graduate School of Biomedical Sciences 1-12-4 Sakamoto Nagasaki 852-8523 Japan Department of Endoscopy Nagasaki University School of Medicine Hospital and Clinics 1-12-4 Sakamoto Nagasaki 852-8523 Japan Department of Digestive Disease the Affiliated Drum Tower Hospital of Nanjing University Medical School Nanjing 210008 Jiangsu Province China Tissue and Histopathology Section Atomic Bomb Disease Institute Nagasaki University Graduate School of Biomedical Sciences 1-12-4 Sakamoto Nagasaki 852-8523 Japan Radiation Biophysics Atomic Bomb Disease Institute Nagasaki University Graduate School of Biomedical Sciences 1-12-4 Sakamoto Nagasaki 852-8523 Japan

AIM: To produce an antibody against rat eosinophil cationic protein (ECP) and to examine the effects of the antibody in rats with dextran sulfate sodium (DSS)-induced ***: An antibody was raised against rat ECP. Rats were treated with 3% DSS in drinking water for 7 d and received the antibody or normal serum. The colons were exarmined histologically and correlated with clinical *** and Western blot analysis were estimated as a grade of ***: The ECP antibody stained the activated eosinophils around the injured crypts in the colonic *** treatment reduced the severity of colonic ulceration and acute clinical symptoms (diarrhea and/or blood-stained stool). Body weight gain was significantly greater and the colon length was significantly longer in anti-ECP-treated rats than in normal serum-treated rats. Expression of ECP in activated eosinophils was associated with the presence of erosions and inflammation. The number of Ki-67-positive cells in the regenerated surface epithelium increased in anti-ECP-treated rats compared with normal serum-treated rats. Western blot analysis revealed reduced expression of macrophage migration inhibitory factor (MIF) in anti-ECP-treated ***: Our results indicate that treatment with ECP antibody, improved DSS-induced colitis in rats, possibly by increasing the regenerative activity of the colonic epithelium and downregulation of the immune response,and suggest that anti-ECP may promote intestinal wound healing in patients with ulcerative colitis (UC).

关键词：嗜曙红细胞抗体硫酸右旋糖苷大肠炎小鼠动物实验

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Impact of continuous local lavage on pancreatic juice-related postoperative complications: Three case reports

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World Journal of Clinical Cases 2019年第17期7卷 2526-2535页

作者： Tomohide Hori Kohei Ogawa Hidekazu Yamamoto Hideki Harada Kazuyoshi Matsumura Michihiro Yamamoto masahiro Yamada Takefumi Yazawa Katsutoshi Kuriyama Masaki Tani Daiki Yasukawa Yasuyuki Kamada Yuki Aisu Ryotaro Tani Ryuhei Aoyama Shinnosuke nakayama Yudai Sasaki Koki Nishimoto Masazumi Zaima Department of Surgery Shiga General HospitalMoriyama 524-8524Japan Department of Hepatobiliary Pancreatic and Breast Surgery Ehime UniversityToon 791-0295Japan Department of Gastroenterology and Hepatology Shiga General HospitalMoriyama 524- 8524Japan Department of Surgery Shiga University of Medical ScienceOtsu 520-2192Japan Department of Surgery Kyoto University Graduate School of MedicineKyoto 606- 8507Japan

BACKGROUND Postoperative pancreatic leakage readily results in intractable pancreatic fistula and subsequent intraperitoneal *** refractory complication can be fatal;therefore,intensive treatment is *** local lavage (CLL) has recently been reevaluated as effective treatment for severe infected pancreatitis,and we report three patients with postoperative intractable pancreatic fistula successfully treated by *** also discuss our institutional protocol for CLL for postoperative pancreatic *** SUMMARY The first patient underwent subtotal stomach-preserving pancreaticoduodenectomy,and pancreatic leakage was observed *** pancreatic fistula led to intraperitoneal abscess,and CLL near the pancreaticojejunostomy site was instituted from postoperative day (POD) *** abscess resolved after 7 d of *** second patient underwent distal *** leakage was observed,and intractable pancreatic fistula led to intraperitoneal abscess near the pancreatic *** was instituted from POD 9,and the abscess resolved after 4 d of *** third patient underwent aneurysmectomy and splenectomy with wide exposure of the pancreatic *** retrograde pancreatic drainage was performed on POD 15 to treat pancreatic fistula;however,intraperitoneal abscess was detected on POD *** performed CLL endoscopically via the transgastric route because the percutaneous approach was *** was instituted from POD 63,and the abscess resolved after 1 wk of *** CLL has therapeutic potential for postoperative pancreatic fistula.

关键词： Surgery Pancreas Pancreatic fistula Pancreatic juice Postoperative complications Case report

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A CIN-like TCP transcription factor(LsTCP4)having retrotransposon insertion associates with a shift from Salinas type to Empire type in crisphead lettuce(Lactuca sativa L.)

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Horticulture Research 2020年第1期7卷 2597-2610页

作者： Kousuke Seki Kenji Komatsu Keisuke Tanaka masahiro Hiraga Hiromi Kajiya-Kanegae Hideo Matsumura Yuichi Uno Nagano Vegetable and Ornamental Crops Experiment Station Tokoo 1066-1SougaShiojiriNagano 399-6461Japan Department of Bioresource Development Tokyo University of AgricultureFunako1737AtsugiKanagawa 243-0034Japan NODAI Genome Research Center Tokyo University of AgricultureSakuragaoka 1-1-1SetagayaTokyo 156-8502Japan Nagano Fruit Tree Experiment Station Ogawara 492SuzakaNagano 382-0072Japan Research Center for Agricultural Information Technology NAROKannondai 3-1-1TsukubaIbaraki 305-8517Japan Gene Research Center Shinshu Seki et al.Horticulture Research(2020)7:15 Page 13 of 14 UniversityTsuneta 3-15-1UedaNagano 386-8567Japan Plant Science Division Department of Bioresource ScienceGraduate School of Agricultural ScienceKobe UniversityRokkodai 1-1NadaKobeHyogo 657-8501Japan

To improve several agronomic traits in crisphead lettuce(Lactuca sativa L.)under high-temperature growth conditions,we investigated the correlation among those traits in multiple cultivars and performed genetic mapping of their causal *** a field cultivation test of Empire type(serrated leaf)and Salinas type(wavy leaf)cultivars,Empire type cultivars showed increased tipburn susceptibility and late bolting compared with Salinas type *** attempted genetic mapping of leaf shape and bolting time by ddRAD-seq using the F2 population derived from a cross between‘VI185’(Empire type)and‘ShinanoGreen’(Salinas type).These analyses suggested that both traits are controlled by a single locus in *** of 51 commercial lettuce cultivars with a tightly linked marker(LG5_v8_252.743Mbp)at this locus showed an association between its genotype and the serrated leaf *** further fine mapping and transcriptome analysis,a gene encoding putative CIN-like TCP transcription factor was determined to be a candidate gene at this locus and was designated as *** insertion of retrotransposable element was found in the allele of‘VI185’,and its transcript level in the leaves was lower than that in‘ShinanoGreen’.Because shapes of leaf epidermal cells in‘VI185’were similar to those in the TCP family mutant of Arabidopsis thaliana,the leaf shape phenotype was likely caused by reduced expression of ***,because it is known that the TCP family protein also controls flowering time via interaction with FT in ***,it was highly possible that LsTCP4 gave pleiotropic effects on both leaf shape and bolting time in lettuce.

关键词： cultivar insertion Lactuca

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Improving recognition of hepatic perivascular epithelioid cell tumor:Case report and literature review

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World Journal of Gastroenterology 2015年第17期21卷 5432-5441页

作者： Toshiya Maebayashi Katsumi Abe Takuya Aizawa Masakuni Sakaguchi Naoya Ishibashi Osamu Abe Tadatoshi Takayama Hisashi nakayama Shunichi Matsuoka Kazushige Nirei Hitomi Nakamura masahiro Ogawa Masahiko Sugitani Department of Radiology Nihon University School of MedicineItabashi-kuTokyo 173-8610Japan Department of Digestive Surgery Nihon University School of MedicineItabashi-kuTokyo 173-8610Japan Department of Gastroenterology and Hepatology Nihon University School of MedicineItabashi-kuTokyo 173-8610Japan Department of Pathology Nihon University School of MedicineItabashi-kuTokyo 173-8610Japan

A 58-year-old man presented with the chief complaint of abdominal bloating and was incidentally found to have a liver *** diagnostic imaging studies could not rule out malignancy,the patient underwent partial resection of segment 3 of the *** lesion pathologically showed eosinophilic proliferation,in addition to immunohistochemical positivity for human melanoma black 45 and Melan-A,thereby leading to the diagnosis of a hepatic perivascular epithelioid cell tumor(PEComa).A PEComa arising from the liver is relatively ***,the name ‘PEComa' has not yet been widely recognized,and the same disease entity has been called epithelioid angiomyolipoma(EAML),further diminishing the recognition of *** addition,PEComa imaging findings mimic those of malignant liver tumors,and clinically,this tumor tends to ***,a PEComa is difficult to *** conducted a systematic review of PEComa and EAML cases and discuss the results,including findings useful for differentiating perivascular epithelioid cell tumors from malignant liver tumors.

关键词： Angiomyolipoma Tuberous sclerosis Melan-A Perivascular epithelioid cell tumor Humanmelanoma black 45 Imaging

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Pluripotent stem cell-derived neural stem cells: From basic research to applications

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World Journal of Stem Cells 2014年第5期6卷 651-657页

作者： masahiro Otsu Takashi nakayama Nobuo Inoue Department of Chemistry Kyorin University School of Medicine Shinkawa Mitaka Tokyo 181-8611 Japan Department of Biochemistry Yokohama City University School of Medicine Fukuura Kanazawa-ku Yokohama 236-0004 Japan Laboratory of Regenerative Neurosciences Department of Frontier Health Sciences Graduate School of Human Health Sciences Tokyo Metropolitan University HigashioguArakawa-ku Tokyo 116-8551 Japan

Basic research on pluripotent stem cells is designed to enhance understanding of embryogenesis, whereas applied research is designed to develop novel therapies and prevent diseases. Attainment of these goals has been enhanced by the establishment of embryonic stem cell lines, the technological development of genomic reprogramming to generate induced-pluripotent stem cells, and improvements in in vitro techniques to manipulate stem cells. This review summarizes the techniques required to generate neural cells from pluripotent stem cells. In particular, this review describes current research applications of a simple neural differentiation method, the neural stem sphere method, which we developed.

关键词： Pluripotent stem cells Embryonic stem cells Neural

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功率波动引起电压波动最小化的风力发电系统无功功率最优控制

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电力电子 2011年第6期9卷 44-47页

作者： Yasuaki nakayama Shinya Oohara Masaya Ichinose Motoo Futami Tsutomu Hasegawa Hitachi Osamu Iso masahiro Orui 胡太元林飞 Kansai Electric Power J 北京交通大学

本文提出了一种新的控制方案,最大限度地减少风力发电系统输出功率产生的电网电压波动。这种控制方案可以使风力发电系统抑制不同的电网条件下电压波动。使用这种控制策略的风力发电系统通过计算其输出功率的波动和电网电压波动之间的... 详细信息

本文提出了一种新的控制方案,最大限度地减少风力发电系统输出功率产生的电网电压波动。这种控制方案可以使风力发电系统抑制不同的电网条件下电压波动。使用这种控制策略的风力发电系统通过计算其输出功率的波动和电网电压波动之间的相关性来在线估计阻抗比R/X。通过输出最佳的无功功率,其值等于阻抗比与发电功率相乘,可有效地抑制电压波动。通过抑制电压波动,使其低于电网规范中所规定的可接受水平,可以提高接入给定电网的风力发电系统容量。仿真及与电网模拟器相连的小功率实验结果验证了所提出的控制方案。

关键词：风力发电系统无功功率控制电网模拟器

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