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Asian Journal of Pharmaceutical Sciences 2016年第5期11卷 662-667页

作者： Atsushi Kawase Hiroyuki Tanaka Toru Otori Kenji Matsuyama masahiro Iwaki Department of Pharmacy Faculty of PharmacyKindai University

Phenytoin(5,5-diphenylhydantoin;DPH) induces expression of cytochromes P450(CYPs). Interactions between DPH and tacrolimus suggested that the persistence of CYP induction after discontinuation of DPH is dependent on the history of administration and dosing period of DPH. However, the relationship between the duration of DPH administration and expression of CYPs in the liver and small intestine of rats is not known. Alterations in levels of P-glycoprotein(P-gp;MDR1;ABCB1) as well as CYPs cause drug interactions in the small intestine. We examined the effects of the duration of DPH administration on expression of CYPs and P-gp in the liver and small intestine of rats. Rats were treated with DPH(100 mg/kg,peroral(p.o.) twice a day(b.d.)) for 2, 4, 8, and 16 d. mRNA levels of CYPs and P-gp were examined using the total RNA extracted from the liver and duodenum 2 h and 24 h after the final administration of DPH. CYP3 A activities were determined using microsomes. DPH administration for 2 d and 4 d markedly increased m RNA levels of CYPs such as CYP3 A1, CYP3 A2,CYP2 B1, and CYP2 B2 in the liver. A relatively long duration of DPH administration(8 d and16 d) resulted in abolition of the induction of hepatic CYP but increased CYP3 A activities were maintained. These results suggest that the duration of DPH administration could be an important determinant of hepatic CYP induction.

关键词： Phenytoin Cytochromes P450 Microsomes mRNA Liver

Improvement in mechanical properties of hypereutectic Al-Si-Cu alloys through sonosolidified slurry

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China Foundry 2014年第4期11卷 396-401页

作者： Yoshiki Tsunekawa Shinpei Suetsugu masahiro Okumiya Naoki Nishikawa Yoshikazu Genma Toyota Technological Institute TenpakuNagoya 468-8511Japan Toyota Motor Corporation Toyota 471-8571Japan

For the wider applications,it is necessary to improve the ductility as well as the strength and wear-resistance of hypereutectic AlSi-Cu alloys,which are typical light-weight wear-resistant *** increase in the amounts of primary silicon particles causes the modified wear-resistance of hypereutectic Al-Si-Cu alloys,but leads to the poor strength and *** is known that dual phase steels composed of hetero-structure have succeeded in bringing contradictory mechanical properties of high strength and ductility *** order to apply the idea of hetero-structure to hypereutectic Al-Si-Cu alloys for the achievement of high strength and ductility along with wear resistance,ultrasonic irradiation of the molten metal during the solidification,which is called sono-solidification,was carried out from its molten state to just above the eutectic *** sono-solidified Al-17Si-4Cu alloy is composed of hetero-structure,which are,hard primary silicon particles,soft non-equilibrium a-Al phase and the eutectic ***-casting was performed at just above the eutectic temperature with sono-solidified slurry to shape a disk *** the rheo-casting with modified sonosolidified slurry held for 45 s at 570 oC,the quantitative optical microscope observation exhibits that the microstructure is composed of 18area%of hard primary silicon particles and 57area%of soft a-Al *** contrast,there exist only 5 area%of primary silicon particles and no a-Al phase in rheo-cast specimen with normally solidified *** the tensile tests of T6 treated rheo-cast specimens with modified sono-solidified slurry exhibit improved strength and 5%of elongation,regardless of having more than 3 times higher amounts of primary silicon particles compared to that of rheo-cast specimen with normally solidified slurry.

关键词： semisolid casting slurry ultrasonic vibration sonosolidification hetero-structure hypereutectic aluminum alloy primary silicon a-Al solid solution

Fabrication of initial trabecular bone-inspired three-dimensional structure with cell membrane nano fragments

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Regenerative Biomaterials 2023年第1期10卷 73-80页

作者： Koichi Kadoya Emilio Satoshi Hara masahiro Okada Yu Yang Jiao Takayoshi Nakano Akira Sasaki Takuya Matsumoto Department of Biomaterials Okayama University Graduate School of MedicineDentistry and Pharmaceutical SciencesOkayama 700-8558Japan Department of Maxillofacial Surgery Okayama University Graduate School of MedicineDentistry and Pharmaceutical SciencesOkayama 700-8558Japan Division of Materials&Manufacturing Science Osaka UniversityOsaka 565-0871Japan

The extracellular matrix of trabecular bone has a large surface exposed to the bone marrow and plays important roles such as hematopoietic stem cell niche formation and *** vitro reproduction of trabecular bone microenvironment would be valuable not only for developing a functional scaffold for bone marrow tissue engineering but also for understanding its biological ***,we analyzed and reproduced the initial stages of trabecular bone formation in mouse femur *** identified that the trabecular bone formation progressed through the following steps:(i)partial rupture of hypertrophic chondrocytes;(ii)calcospherite formation on cell membrane nano fragments(CNFs)derived from the ruptured cells;and(iii)calcospherite growth and fusion to form the initial three-dimensional(3D)structure of trabecular *** reproducing the initial trabecular bone formation in vitro,we collected CNFs from cultured cells and used as nucleation sites for biomimetic calcospherite ***,almost the same 3D structure of the initial trabecular bone could be obtained in vitro by using additional CNFs as a binder to fuse biomimetic calcospherites.

关键词： trabecular bone calcospherites cell membrane nano fragments three dimensionalization bone tissue synthesis

Enzymatic treatment of estrogens and estrogen glucuronide

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Journal of Environmental Sciences 2009年第6期21卷 731-735页

作者： Takaaki Tanaka Toshiyuki Tamura Yuuichi Ishizaki Akito Kawasaki Tomokazu Kawase masahiro Teraguchi Masayuki Taniguchi Department of Materials Science and Technology Niigata University Venture Business Laboratory Niigata University Department of Chemistry and Chemical Engineering Niigata University

Natural and synthetic estrogens from sewage treatment systems are suspected to influence the reproductive health of the animals in the rivers. In this article, we investigated the enzymatic treatment of three estrogens （estrone, 17β-estradiol, and 17α-ethynyletstradiol） by a fungal laccase which oxidize phenolic compounds with dissolved oxygen. The elimination of the estrogenic activities by enzymatic oxidation was demonstrated by medaka vitellogenin assay. In addition, we developed an enzymatic treatment system comprised of β-D-glucuronidase and the laccase for 17β-estradiol 3-（β-D-glucuronide） degradation. The two enzymes eliminated 17β-estradiol 3-（β- D-glucuronide） and the intermediate, 17β-estradiol, efficiently.

关键词： enzymatic treatment laccase estrone estradiol ethynylestradiol glucuronidase glucuronide

The effect of alkyl chain branching positions on the electron mobility and photovoltaic performance of naphthodithiophene diimide(NDTI)-based polymers

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Science China Chemistry 2019年第12期62卷 1649-1655页

作者： Jing Yang Ning An Su Sun Xiangnan Sun masahiro Nakano Kazuo Takimiya Bo Xiao Erjun Zhou CAS Key Laboratory of Nanosystem and Hierarchical Fabrication CAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijing 100190China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China RIKEN Center for Emergent Matter Science(CEMS) 2-1 HirosawaWakoSaitama 351-0198Japan Henan Institutes of Advanced Technology Zhengzhou UniversityZhengzhou 450003China

Conjugated polymers are widely used in organic optoelectronic devices due to their solution processability, thermal stability and structural diversity. Generally, alkyl side chains must be utilized to increase the solubility of final polymers in the processing solvent. However, the effects of different type alkyl chains on the properties of n-type photovoltaic polymers have rarely been investigated. In this article, we synthesized three naphthodithiophene diimide（NDTI） based polymers containing bulky alkyl chains with different branching position, named as NDTI-1, NDTI-2 and NDTI-3, respectively. We systematically investigated the effect of different branching point on the molecular packing, charge transport and photovoltaic performance. When moving the branching point away from the backbone, the intermolecular interaction became stronger, which could be proved by 2D grazing incidence wide angle X-ray scattering（GIWAXS） measurement. Therefore, the electron mobilities in organic field-effect transistors gradually increased from 2.11×10-3 cm2 V/-1 s-1 for NDTI-1 to 4.70×10-2 cm2 V/-1 s-1 for NDTI-2 and 9.27×10-2 cm2 V/-1 s-1 for NDTI-3,which are quite high values for polymers with face-on orientation. In addition, the NDTI-2 and NDTI-3 thin films exhibited redshifted absorption spectra compared with NDTI-1. When blending with three classic donor polymers PBDB-T, PTB7-Th and PE61, NDTI-2 based devices always showed the higher power conversion efficiencies（PCEs） than the other two polymers（beside the comparable result of PTB7-Th:NDTI-3 combination） as a result of the high photocurrent response and high fill factor. Our results indicate that bulky alkyl chain with branching point at 2-position should be a good and safe choice for the design of naphthodithiophene diimide-based and even naphthalene diimide-based n-type photovoltaic polymers.

关键词： all-polymer solar cells branching positions naphthodithiophene diimide(NDTI) PBDB-T PTB7-Th

Left testicular artery arching over the ipsilateral renal vein

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Asian Journal of Andrology 2006年第1期8卷 107-110页

作者： Munekazu Naito Hayato Terayama Yoichi Nakamura Shogo Hayashi Takayoshi Miyaki masahiro Itoh Department of Anatomy Tokyo Medical UniversityTokyo 160-8402Japan

Aim： To report two cases of the left testicular artery arching over the left renal vein （LRV） before running downward to the testis. Methods： The subjects were obtained from two Japanese cadavers. During the student course of gross-anatomical dissection, the anatomical relationship between the testicular vessels and the renal vein was specifically observed. Results： The arching left testicular artery arose from the aorta below the LRV and made a loop around the LRV, which appeared to be mildly compressed between the arching artery and the psoas major muscle. Conclusion： Clinically, compression of the LRV between the abdominal aorta and the superior mesenteric artery occasionally induces LRV hypertension, resulting in varicocele, orthostatic protenuria and hematuria. Considering that the incidence of a left arching testicular artery is higher than that of a right one, an arching left artery could be an additional cause of LRV hypertension. （Asian J Androl 2006 Jan; 8： 107-110）

关键词： anatomy testis blood vessels

Campylobacter jejuni enterocolitis presenting with testicular pain: A case report

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World Journal of Clinical Cases 2020年第15期8卷 3280-3283页

作者： masahiro Sanagawa Tsuneaki Kenzaka Sayaka Kato Ichiko Yamaoka Shouichi Fujimoto Department of Internal Medicine Miyazaki Seikyo HospitalMiyazaki 880-0824Japan Department of Internal Medicine Hyogo Prefectural Tamba Medical CenterHyogo 669-3495Japan Division of Community Medicine and Career Development Kobe University Graduate School of MedicineHyogo 652-0032Japan Department of General Surgery Miyazaki Seikyo HospitalMiyazaki 880-0824Japan Department of Hemovascular Medicine and Artificial Organs Faculty of MedicineUniversity of MiyazakiMiyazaki 889-1692Japan

BACKGROUND Common symptoms of Campylobacter colitis include abdominal pain,vomiting,diarrhea,and fever,among ***,Campylobacter colitis also has a high incidence of extraintestinal *** SUMMARY We report the case of a 51-year-old man who presented with bilateral testicular pain.A scrotal examination failed to reveal any physical findings,but the patient exhibited mild tenderness in the right lower *** tomography revealed ileocecal wall ***-admission,the patient developed diarrhea,and a stool culture was submitted;Campylobacter jejuni infection was *** pain is known to be caused by ***,we suggest that Campylobacter colitis,which causes ileocecal inflammation,caused the testicular pain in this *** In patients with testicular pain and no other objective findings,diseases such as Campylobacter colitis should be considered.

关键词： Campylobacter Colitis Testicular pain Ileocecal inflammation Related pain Case report

H_(∞)control in the frequency domain for a semi-active floor isolation system

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Frontiers of Structural and Civil Engineering 2013年第3期7卷 264-275页

作者： Yundong SHI Tracy C BECKER masahiro KURATA Masayoshi NAKASHIMA Graduate School of Engineering Kyoto UniversityKyoto 611-0011Japan Disaster Prevention Research Institute Kyoto UniversityKyoto 611-0011Japan

A floor isolation system installed in a single floor or room in a fixed base structure is designed to protect *** this configuration,the input motions to the floor isolation from the ground motions are filtered by the structure,leaving the majority of the frequency content of the input motion lower than the predominant frequency of the *** floor isolation system should minimize the acceleration to protect equipment;however,displacement must also be limited to save floor space,especially with long period ***-active control with an H_(∞)control was adopted for the floor isolation system and a new input shaping filter was developed to account for the input motion characteristics and enhance the effectiveness of the H_(∞)control.A series of shake table tests for a semi-active floor isolation system using rolling pendulum isolators and a magnetic-rheological damper were performed to validate the H_(∞)*** control using an oil damper was also tested for *** test results show that the H_(∞)control effectively reduced acceleration for short period motions with frequencies close to the predominant frequency of the structure,as well as effectively reduced displacement for long period motions with frequencies close to the natural frequency of the floor isolation *** H_(∞)control algorithm proved to be more advantageous than passive control because of its capacity to adjust control strategies according to the different motion frequency characteristics.

关键词： semi-active floor isolation H1 control MR damper shaping filter shaking table test

Forming of magnesium alloy by underwater shock wave

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Journal of Magnesium and Alloys 2016年第1期4卷 27-29页

作者： Liqun Ruan Shunsuke Ezaki Fujita masahiro Shirley Shen Yosihito Kawamura Kumamoto University Magnesium Research Center(MRC) Kurokami 2-39-1KumamotoPostcode 860-8555 Japan Department of Mechanical Systems Engineering Graduate School of Science and Technology Kumamoto UniversityKurokami 2-39-1Kumamoto-shi Postcode 860-8555Japan Soujyou University Kumamoto-shiJapan CSIRO Manufacturing Flagship Private Bag 10Clayton South 3149Australia

Magnesium alloys are best known for their light weight and high strength-to-weight *** the forging process of magnesium alloys,hot working of has been often carried ***,the strength of the material is reduced because the material temperature reaches the recrystallization temperature during hot ***,the cold method working is required to maintain or increase the strength of a *** this study,we have designed experimental equipment to examine whether the forming of magnesium alloy is possible in the cold working by utilizing underwater shock wave,and the hardness of the material changes by receiving the underwater shock *** results revealed increase in coefficient of extension and hardness of materials after receiving a shock wave.

关键词： Magnesium alloy Cold working Shock wave Forging Coefficient of extension Vickers hardness

The role of dietary nitrate supplementation in neurovascular function

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Neural Regeneration Research 2021年第7期16卷 1419-1420页

作者： masahiro Horiuchi Gabriella M.K.Rossetti Samuel J.Oliver Division of Human Environmental Science Mount Fuji Research InstituteYamanashiJapan School of Sport Health and Exercise SciencesCollege of Human SciencesBangor UniversityBangorUK

A healthy diet combined with increased physical activity levels may protect against cerebrovascular dysfunction and cognitive impairments(Gorelick et al., 2011).Compared with the number of studies on the effects of physical activity, studies on how diet affects cerebral blood flow(CBF) regulation and cognitive function are relatively ***, we focus on the potential role of dietary nitrate supplementation in CBF regulation and cognitive function under normoxic and hypoxic conditions.

关键词： al. nitrate conditions.