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Efficacy of cytapheresis in patients with ulcerative colitis showing insufficient or lost response to biologic therapy

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World Journal of Gastroenterology 2022年第34期28卷 4959-4972页

作者： masahiro iizuka Takeshi Etou Shiho Sagara Akita Health Care Center Akita Red Cross HospitalAkita 010-0001Japan Department of Gastroenterology Akita Red Cross HospitalAkita 010-1495Japan

For the optimal management of refractory ulcerative colitis(UC),secondary loss of response(LOR)and primary non-response to biologics is a critical *** article aimed to summarize the current literature on the use of cytapheresis(CAP)in patients with UC showing a poor response or LOR to biologics and discuss its advantages and ***,we summarized the efficacy of CAP in patients with UC showing insufficient response to thiopurines or immunomodulators(IM).Eight studies evaluated the efficacy of CAP in patients with UC with inadequate responses to thiopurines or *** were no significant differences in the rate of remission and steroid-free remission between patients exposed or not exposed to thiopurines or *** studies evaluated the efficacy of CAP in patients with UC showing an insufficient response to biologic *** remission rates of biologics exposed or unexposed patients were 29.4%and 44.2%,*** studies evaluated the efficacy of CAP in combination with biologics in patients with inflammatory bowel disease showing a poor response or LOR to *** rates of remission/response and steroid-free remission in patients with UC ranged 32%-69%(mean:48.0%,median:42.9%)and 9%-75%(mean:40.7%,median:38%),*** had the same effectiveness for remission induction with or without prior failure on thiopurines or IM but showed little benefit in patients with UC refractory to *** heterogeneity existed in the efficacy of the combination therapy with CAP and biologics,these combination therapies induced clinical remission/response and steroid-free remission in more than 40%of patients with UC refractory to biologics on *** the excellent safety profile of CAP,this combination therapy can be an alternative therapeutic strategy for UC refractory to *** prospective studies are needed to understand the efficacy of combination therapy with CAP and biologics.

关键词： Ulcerative colitis Inflammatory bowel disease Cytapheresis Granulocyte and monocyte adsorptive apheresis Anti-tumor necrosis factor-αantibody Combination therapy

Acute respiratory distress syndrome associated with severe ulcerative colitis

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World Journal of Gastroenterology 2010年第19期16卷 2440-2442页

作者： Shiho Sagara Yasuo Horie Yumiko Anezaki Hideaki Miyazawa masahiro iizuka Health Care Center Akita Red Cross Hospital Akita 010-0001 Japan Department of Internal Medicine Akita University School of Medicine Akita 010-8543 Japan Department of Surgery Akita University School of Medicine Akita 010-8543 Japan

Various extraintestinal manifestations including pulmonary abnormalities have been reported in patients with ulcerative colitis. Acute respiratory distress syndrome (ARDS) is a serious and fatal pulmonary manifestation. We have experienced a 67-year-old male patient with ARDS associated with a severe type of ulcerative colitis (UC). Severe dyspnea symptoms occurred during the treatment of UC in a previous hospital and the patient was transferred to our hospital on June 27, 2007. Both blood and sputa cultures for bacteria and fungi were negative. Cytomega-lovirus antigenemia was also not detected. From the clinical and radiological [Chest X-ray, computed tomography (CT)] findings, the patient was diagnosed with ARDS on the basis of the def inition of ARDS developed by the European-American Consensus Conference on ARDS. Both colonic inflammations and ARDS symptoms of the patient were resistant to any medical treatment includingcorticosteroids and antibiotics. However, ARDS symptoms were dramatically improved after surgical colectomy. We believe that severe colonic inflammation from UC was closely associated with the onset of ARDS of the patient. Our case report suggests that a severe type of ulcerative colitis might be taken into consideration as one of the predisposing factors of ARDS.

关键词： Acute respiratory distress syndrome Ulcerative colitis Inflammatory bowel disease Extra-intestinal manifestation

Cytapheresis re-induces high-rate steroid-free remission in patients with steroid-dependent and steroid-refractory ulcerative colitis

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World Journal of Gastroenterology 2021年第12期27卷 1194-1212页

作者： masahiro iizuka Takeshi Etou Yosuke Shimodaira Takashi Hatakeyama Shiho Sagara Akita Health Care Center Akita Red Cross HospitalAkita 010-0001Japan Department of Gastroenterology Akita Red Cross HospitalAkita 010-1495Japan Department of Gastroenterology and Neurology Akita University Graduate School of MedicineAkita 010-8543Japan akashi Hatakeyama Department of NephrologyAkita Red Cross HospitalAkita 010-1495Japan

BACKGROUND It is a crucial issue for patients with refractory ulcerative colitis(UC),including steroid-dependent and steroid-refractory patients,to achieve and maintain steroid-free ***,clinical studies focused on the achievement of steroid-free remission in refractory UC patients are ***(CAP)is a non-pharmacological extracorporeal therapy that is effective for active UC with fewer adverse *** study comprised UC patients treated with CAP and suggested the efficacy of CAP for refractory UC *** To clarify the efficacy of CAP in achieving steroid-free remission in refractory UC *** We retrospectively reviewed the collected data from 55 patients with refractory UC treated with *** analyzed the following points:(1)Efficacy of the first course of CAP;(2)Efficacy of the second,third,and fourth courses of CAP in patients who experienced relapses during the observation period;(3)Efficacy of CAP in colonic mucosa;and(4)Long-term efficacy of *** efficacy was evaluated using Lichtiger’s clinical activity index or Sutherland index(disease activity index).Mucosal healing was evaluated using Mayo endoscopic *** primary and secondary endpoints were the rate of achievement of steroidfree remission and the rate of sustained steroid-free remission,*** analysis was performed using the paired t-test and chi-squared *** The rates of clinical remission,steroid-free remission,and poor effectiveness after CAP were 69.1%,45.5%,and 30.9%,*** were no significant differences in rate of steroid-free remission between patients with steroiddependent and steroid-refractory *** mean disease activity index and Lichtiger’s clinical activity index scores were significantly decreased after CAP(P<0.0001).The rates of steroid-free remission after the second,third,and fourth courses of CAP in patients who achieved steroid-free remission after the first course of CAP were 8

关键词： Ulcerative colitis Cytapheresis Steroid-dependent Steroid-refractory Steroid-free remission Inflammatory bowel disease

Typical gastroduodenal endoscopic findings in a Crohn's disease patient in remission stage

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World Journal of Gastrointestinal Endoscopy 2012年第3期4卷 96-98页

作者： masahiro iizuka Taku Harada Hiro-o Yamano Takeshi Etou Shiho Sagara Department of Gastroenterology Akita Red Cross HospitalAkita 010-1495Japan Akita Health Care Center Akita Red Cross Hospital

A 39-year-old patient with Crohn's disease (CD) was referred to our hospital for maintenance treatment of *** was diagnosed as having CD of the small and large intestines at 32 years *** underwent partial resection of the ileum at 35 years old because of ileal *** had received enteral nutritional supplement (1200 kcal/d) and metronidazole preparation (500 mg/d),and was in remission Crohn's disease activity index *** performed a routine gastroduodenal endoscopic examination,which revealed the representative endoscopic findings of gastroduodenal lesions in CD,namely,bamboo-joint-like appearance of the gastric body and cardia and a notched sign in the *** findings were clearly observed by using indigo carmine dye *** our patient,typical gastroduodenal findings were observed even in the remission stage,suggesting that these findings would contribute to the early diagnosis of CD not only in the active stage but also during remission.

关键词： Crohn’s disease Gastroduodenal findings Bamboo-joint-like appearance Notched sign

Transient receptor potential vanilloid 1-immunoreactive signals in murine enteric glial cells

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World Journal of Gastroenterology 2016年第44期22卷 9752-9764页

作者： masahiro Yamamoto Mitsue Nishiyama Seiichi iizuka Shigeaki Suzuki Norihiro Suzuki Sadakazu Aiso Jin Nakahara Tsumura Research Laboratories Tsumura & Co. Department of Neurology Keio University School of Medicine Department of Anatomy Keio University School of Medicine

AIM To investigate the possible involvement of transient receptor potential vanilloid 1(TRPV1) in maturation of enteric glial cells(EGCs).METHODS Immunohistochemical and immunocytochemical techniques were used to analyze EGC markers in myenteric plexus(MP) as well as cultured MP cells and EGCs using TRPV1 knockout(KO) *** We detected TRPV1-immunoreactive signals in EGC in the MP of wild-type(WT) but not KO mice. Expression of glial fibrillary acidic protein(GFAP) immunoreactive signals was lower at postnatal day(PD) 6 in KO mice, though the difference was not clear at PD 13 and PD 21. When MP cells were isolated and cultured from isolated longitudinal muscle-MP preparation from WT and KO mice, the yield of KO EGC was lower than that of WT EGC, while the yield of KO and WT smooth muscle cells showed no difference. Addition of BCTC, a TRPV1 antagonist, to enriched EGC culture resulted in a decrease in the protein ratio of GFAP to S100 B, another EGC/astrocyte-specific marker. CONCLUSION These results address the possibility that TRPV1 may be involved in the maturation of EGC, though further studies are necessary to validate this possibility.

关键词： Enteric glial cells Enteric nervous system Glial fibrillary acidic protein S100B Smooth muscle cells

Laser ion source for heavy ion inertial fusion

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Matter and Radiation at Extremes 2018年第2期3卷 61-66页

作者： masahiro Okamura Collider-Accelerator Department Brookhaven National LaboratoryBuilding 930UptonNY 11973USA

The proposed heavy ion inertial fusion(HIF)scenarios require ampere class low charge state ion beams of heavy *** laser ion source(LIS)is recognized as one of the promising candidates of ion beam providers,since it can deliver high brightness heavy ion beams to *** design of LIS for the HIF depends on the accelerator structure and accelerator complex following the *** this article,we discuss the specifications and design of an appropriate LIS assuming two major types of the accelerators:radio frequency(RF)high quality factor cavity type and non-resonant induction core *** believe that a properly designed LIS would satisfy the requirements of both types,while some issues need to be verified experimentally.

关键词： Inertial fusion Accelerator Ion source Laser ablation Heavy ion source

On a Relation between the Universal Teichmu¨ller Space and the Grunsky Operator

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Acta Mathematica Sinica,English Series 2014年第4期30卷 591-600页

作者： masahiro YANAGISHITA Departments in Fundamental Science and Engineering Waseda University

Being a Strebel point gives a sufficient condition for that the extremal Beltrami coefficient is uniquely determined in a Teichmiiller equivalence class. We consider how Strebel points are characterized. In this paper, we will give a new characterization of Strebel points in a certain subset of the universal Teichmfiller space by a property of the Grunsky operator.

关键词： Quasiconformal mappings Strebel points Grunsky inequalities

An Inverse Problem for Maxwell's Equations in Anisotropic Media

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Chinese Annals of Mathematics,Series B 2007年第1期28卷 35-54页

作者： masahiro YAMAMOTO Graduate School of Mathematical Sciences The University of Tokyo 3-8-1 Komaba Meguro Tokyo 153Japan

The authors consider Maxwell＇s equations for an isomagnetic anisotropic and inhomogeneous medium in two dimensions, and discuss an inverse problem of determining the permittivity tensor （ε1,ε2,ε2,ε3 ） and the permeability μ in the constitutive relations from a finite number of lateral boundary measurements. Applying a Carleman estimate, the authors prove an estimate of the Lipschitz type for stability, provided that ε1,ε2,ε3,μ satisfy some a priori conditions.

关键词： Anisotropic media Inverse problem Maxwell's equations Carleman estimate Lipschitz stability

Recycle for Sludge Scrap of Nd-Fe-B Sintered Magnet as Isotropic Bonded Magnet

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Journal of Rare Earths 2004年第1期22卷 168-171页

作者： masahiro Itoh masahiro Masuda Shunji Suzuki Ken-ichi Machida Collaborative Research Center for Advanced Science and Technology Collaborative Research Center for Advanced Science and TechnologyCollaborative Research Center for Advanced Science and TechnologyCollaborative Research Center for Advanced Science and Technology Osaka University 2-1 Yamadaoka Suita Osaka 565-0871 Osaka University 2-1 Yamadaoka Suita Osaka 565-0871 Osaka University 2-1 Yamadaoka Suita Osaka 565-0871 Osaka University 2-1 Yamadaoka Suita Osaka 565-0871

The reduction diffusion method was performed for the sludge scrap of Nd-Fe-B sintered magnets with adding Ca metal to recover the oxidized Nd-Fe-B phase. After washing the resultant powders to remove Ca metal component, the powders obtained were recycled as an isotropic magnetic powder by the melt spinning method. The magnetic properties of powders as recycled were inferior, especially for the coercivity value, due to the deletion of rare earth metals during the washing process. The adjustment of metal composition, i.e., the addition of Nd metal, at the melt spinning process improved the magnetic properties to be B r=～0.75 T, H cj=～0.93 mA·m -1, and (BH) max=～91 kJ·m -3. The magnetic properties of the bonded magnets prepared from the composition-adjusted powders were B r=～0.66 T, H cj=～0.92 mA·m -1, and (BH) max=～70 kJ·m -3, which are approximately comparable to the commercially available MQPB boned one (B r=～0.73 T, H cj=～0.79 mA·m -1, and (BH) max=～86 kJ·m -3).

关键词： Nd-Fe-B sintered magnet recycling isotropic Nd-Fe-B bonded magnet melt-spinning method sludge scrap rare earths