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Diverse Chromatic Acclimation Processes Regulating Phycoerythrocyanin and Rod-Shaped Phycobilisome in Cyanobacteria

Molecular Plant 2019年第8期12卷 715-725页

作者： Yuu Hirose Song Ghihong Mai Watanabe Chinatsu Yonekawa Kazuyoshi Murata masahiko ikeuchi Toshihiko Eki Department of Environmental and Life Sciences Toyohashi University of Technology1-1 HibarigaokaTempakuToyohashiAichi 441-8580Japan National Institute for Physiological Sciences(NIPS) 38 NishigonakaMyodaijiOkazakiAichi 444-8585Japan Department of Life Sciences(Biology) The University of Tokyo3-8-1 KomabaMeguroTokyo 153-8902Japan

Cyanobacteria have evolved various photoacclimation processes to perform oxygenic photosynthesis under different light *** acclimation(CA)is a widely recognized and ecologically important type of photoacclimation,whereby cyanobacteria alter the absorbing light colors of a supermolecular antenna complex called the *** date,several CA variants that regulate the green-absorbing phycoerythrin(PE)and/or the red-absorbing phycocyanin(PC)within the hemi-discoidal form of phycobilisome have been *** this study,we identified a unique CA regulatory gene cluster encoding yellow-green-absorbing phycoerythrocyanin(PEC)and a rod-membrane linker protein(CpcL)for the rod-shaped form of *** the cyanobacterium Leptolyngbya *** 6406,we revealed novel CA variants regulating PEC(CA7)and the rod-shaped phycobilisome(CAO),which maximize yellowgreen light-harvesting capacity and balance the excitation of photosystems,respective!*** of the distribution of CA gene clusters in 445 cyanobacteria genomes revealed eight CA variants responding to green and red light,which are classified based on the presence of PEC,PE,cpcL,and CA photosensor *** analysis further suggested that the emergence of CA7 was a single event and preceded that of heterocystous strains,whereas the acquisition of CAO occurred multiple *** together,these results offer novel insights into the diversity and evolution of the complex cyanobacterial photoacclimation mechanisms.

关键词： cyanobacteria chromatic acclimation cyanobacteriochrome phycobilisome phycoerythrocyanin

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Breaking the spatial restriction of pluripotency acquisition by environmental stimuli

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Molecular Plant 2023年第2期16卷 301-302页

作者： Momoko ikeuchi Division of Biological Science Graduate School of Science and TechnologyNara Institute of Science and TechnologyIkomaJapan

Plant cells have remarkable developmental plasticity,and many of them have the intrinsic potential to acquire *** some stimuli such as auxin or wounding can trigger cellular pluripotency acquisition,various other envi... 详细信息

关键词： wound al. subsequent

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Color Restoration Method Based on Spectral Information Using Normalized Cut

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International Journal of Automation and computing 2008年第3期5卷 226-233页

作者： Tetsuro Morimoto Tohru Mihashi Katsushi ikeuchi Institute of Industrial Science University of TokyoKoganei Information Technology Research Laboratory Corporate R&D Division Toppan Printing Co.Ltd.

This paper proposes a novel method for color restoration that can effectively apply accurate color based on spectral information to a segmented image using the normalized cut technique. Using the proposed method, we can obtain a digital still camera image and spectral information in different environments. Also, it is not necessary to estimate reflectance spectra using a spectral database such as other methods. The synthesized images are accurate and high resolution. The proposed method effectively works in making digital archive contents. Some experimental results are demonstrated in this paper.

关键词： Spectral information normalized cut digital archive contents digital still camera (DSC) spectrometer.

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Three-dimensionally Perforated Calcium Phosphate Ceramics

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Journal of Wuhan University of Technology(Materials Science) 2005年第B12期20卷 223-225页

作者： Atsuo Ito T Sakurai Y Sogo M ikeuchi H Ohgushi T Mutsuzaki Institute for Human Science and Biomedical Engineering National Institute of Advanced Industrial Science and Technology Central 6 1-1-1 Higashi Tsukuba 305-8566 Japan Research Institute for Cell Engineering National Institute of Advanced Industrial Science and TechnologyAmagasaki Site 3-11-46 Nakouji Amagasaki Hyogo 661-0974 Japan Department of Orthopedic Surgery University of Tsukuba 1-1-1 Tennodai Tsukuba 305-8571 Japan

Porous calcium phosphate ceramics were produced by compression molding using a special mold followed by sintering. The porous calcium phosphate ceramics have three-dimensional and penetrated open pores 380-400μm in diacneter spaced at intervals of 200μm. The layers of the linear penetration pores alternately lay perpendicular to pore direction. The porosity was 59%-65% . The Ca/ P molar ratios of the porous calcium phos phate ceramics range from 1.5 to 1.85. A binder cantaining methyl cellulose was most effective for preparing the powder compact among vinyl acetate, polyvinyl alcohol, starch, stearic acid, methyl cellulose and their mixtures . Stainless steel, polystyrene, nylon and bamboo were used as the long columnar dies for the penetrated open pores. When polystyrene, nylon and bamboo were used as the long columnar male dies, the dies were burned oat during the sintering process. Using stainless steel as the male dies with the removal of the dies before heat treatment resulted in a higher level of densification of the calcium phosphate ceramic.

关键词： calcium phosphate porous ceramic three-dimensionally perforated tissue engineering scaffold tricalcium phosphate

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Long-term efficacy of infliximab maintenance therapy for perianal Crohn’s disease

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World Journal of Gastroenterology 2011年第9期17卷 1174-1179页

作者： Motoi Uchino Hiroki ikeuchi Toshihiro Bando Hiroki Matsuoka Yoshio Takesue Yoshiko Takahashi Takayuki Matsumoto Naohiro Tomita Departments of Lower Gastroenterological Surgery Hyogo College of Medicine Infection Control and Prevention Hyogo College of Medicine Department of Internal Medicine Division of Lower GastroenterologyHyogo College of Medicine

AIM:To assess the long-term efficacy of seton drainage with infliximab maintenance therapy in treatment of stricture for perianal Crohn’s disease(CD). METHODS:Sixty-two patients with perianal CD who required surgical treatment with or without infliximab between September 2000 and April 2010 were identified from our clinic’s *** activities of the perianal lesions were evaluated using the modified perianal CD activity index(mPDAI)*** primary endpoint was a clinical response at 12-15 wk after surgery as a shortterm *** endpoints were recurrence as reflected in the mPDAI score,defined as increased points in every major *** clinical responses were classified as completely healed(mPDAI=0),partially improved(mPDAI score decreased more than 4 points),and failure or recurrence(mPDAI score increased or decreased less than 3 points). RESULTS:There were 43 males and 19 females,of whom 26 were consecutively treated with infliximab after surgery as maintenance *** healing was not *** was seen in 10/36(27.8%) patients without infliximab and 4/26(15.4%)patients with infliximab(P=0.25).Partial improvement was seen in 26/36(72.2%)patients without infliximab and 22/26(88.5%)patients with infliximab(P=0.25). Short-term improvement was achieved in 48/62(77.4%) *** the mPDAI score improved significantly with surgery regardless of infliximab,it decreased more from baseline in patients with infliximab(50.0%) than in those without infliximab(28.6%),(P=0.003). In the long-term,recurrence rates were low regardless of infliximab in patients without anorectal *** patients with anorectal stricture,cumulative recurrence incidences increased gradually and exceeded 40%at 5 years regardless of *** efficacy of infliximab treatment was found(P=0.97).Although the cumulative rate of ostomy creation was also low in patients without stricture and high in patients with stricture,no protective efficacy was found wit

关键词： Crohn’s disease Perianal fistula Infliximab Anorectal stricture Long-term efficacy

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Usefulness of contrast-enhanced ultrasonography in determining treatment efficacy and outcome after pancreatic cancer chemotherapy

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World Journal of Gastroenterology 2008年第47期14卷 7183-7191页

作者： Atsushi Sofuni Takao Itoi Fumihide Itokawa Takayoshi Tsuchiya Toshio Kurihara Kentaro Ishii Syujiro Tsuji Nobuhito ikeuchi Fuminori Moriyasu Department of Gastroenterology and Hepatology Tokyo Medical UniversityTokyo 160-0023Japan

AIM:To investigate if contrast-enhanced ultrasonography(CE-US) is useful for determining treatment efficacy and outcome in the early stages of pancreatic cancer chemotherapy by assessing changes in intratumor hemodynamics using CE-US with a contrast ***:The subjects were 34 patients with unresectable advanced pancreatic cancer treated by ***-US was assessed after every treatment(course) completion under the same conditions,and patients were divided into two groups according to the intratumor enhancement pattern:Vascular rich(R) group and vascular poor(P) ***:After the second course of treatment,R group in intratumor hemodynamics had 18 patients,and P group had 16 *** reduction rates of serum CA19-9 level after chemotherapy which decreased to half or less of the baseline level were 2/15(0.1%) in P group,but 11/16(69%) in R group(P = 0.006).When the mean number of courses of chemotherapy and outcome were compared,P group had a mean number of courses of 4.9(R group,10.2) and mean survival time(MST) of 246 d(R group,402 d),showing that outcome was significantly better in R group(P=0.006).CONCLUSION:CE-US revealed that the change in intratumor blood flow correlated with both serum CA19-9 level and *** with serum CA19-9 that decreased to less than half the baseline level,and patients with an abundant intratumor blood flow,had a significantly better ***,CE-US is potentially useful for evaluating treatment efficacy and outcome in the early stages of pancreatic cancer chemotherapy.

关键词： Pancreatic cancer Chemotherapy Gemcitabine Contrast-enhanced ultrasonography Outcome

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Endoscopic ultrasound-guided choledochoduodenostomy in patients with failed endoscopic retrograde cholangiopancreatography

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World Journal of Gastroenterology 2008年第39期14卷 6078-6082页

作者： Takao Itoi Fumihide Itokawa Atsushi Sofuni Toshio Kurihara Takayoshi Tsuchiya Kentaro Ishii Shujiro Tsuji Nobuhito ikeuchi Fuminori Moriyasu Department of Gastroenterology and Hepatology Tokyo Medical University HospitalTokyo 160-0023Japan

Endoscopic ultrasonography （EUS）-guided biliary drainage was performed for treatment of patients who have obstructive jaundice in cases of failed endoscopic retrograde cholangiopancreatography （ERCP）. In the present study, we introduced the feasibility and outcome of EUS-guided choledochoduodenostomy in four patients who failed in ERCR We performed the procedure in 2 papilla of Vater, including one resectable case, and 2 cases of cancer of the head of pancreas. Using a curved linear array echoendoscope, a 19 G needle or a needle knife was punctured transduodenally into the bile duct under EUS visualization. Using a biliary catheter for dilation, or papillary balloon dilator, a 7-Fr plastic stent was inserted through the choledochoduodenostomy site into the extrahepatic bile duct. In 3 （75%） of 4 cases, an indwelling plastic stent was placed, and in one case in which the stent could not be advanced into the bile duct, a naso-biliary drainage tube was placed instead. In all cases, the obstructive jaundice rapidly improved after the procedure. Focal peritonitis and bleeding not requiring blood transfusion was seen in one case. In this case, pancreatoduodenectomy was performed and the surgical findings revealed severe adhesion around the choledochoduodenostomy site. Although further studies and development of devices are mandatory, EUS-guided choledochoduodenostomy appears to be an effective alternative to ERCP in selected cases.

关键词： Endoscopic ultrasonography-guided fine needle aspiration Biliary drainage Endoscopic retrograde cholangiopancreatography

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Transpapillary incision of refractory circumscript pancreatic duct stricture using wire-guided snare forceps

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World Journal of Gastroenterology 2010年第12期16卷 1541-1544页

作者： Takao Itoi Atsushi Sofuni Fumihide Itokawa Toshio Kurihara Takayoshi Tsuchiya Kentaro Ishii Shujiro Tsuji Nobuhito ikeuchi Fuminori Moriyasu Department of Gastroenterology and Hepatology Tokyo Medical University

Endoscopic therapy of pancreatic duct(PD)strictures using balloon dilation and pancreatic duct stent(PS) placement has been reported to improve the severity of abdominal pain in selected patients with chronic pancreatitis(CP).However,some strictures are refractory and require frequent PS exchange to control *** describe two cases of successful endoscopic PD incision for difficult PD stricture using a wireguided *** snare is partially opened within the strictured pancreatic duct while applying current,thus incising the *** both cases were successful without complications we do not advocate that this method be used routinely because of the potential for severe complications,***,ductal perforation or pancreatic parenchymal *** order to prevent these complications,we developed a wire-guided technique under fluoroscopic *** think this procedure may be useful in patients with short,straight PD *** further study is required,this approach may have potential for selected patients with refractory PD strictures due to CP.

关键词： Chronic pancreatitis Pancreatic duct stricture Pancreatic duct incision

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Impact of preoperative chemoradiotherapy using concurrent S-1 and CPT-11 on long-term clinical outcomes in locally advanced rectal cancer

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World Journal of Gastrointestinal Oncology 2020年第3期12卷 311-322页

作者： Kei Kimura Naohito Beppu Hiroshi Doi Kozo Kataoka Tomoki Yamano Motoi Uchino Masataka Ikeda Hiroki ikeuchi Naohiro Tomita Division of Lower Gastrointestinal Surgery Department of SurgeryHyogo College of MedicineNishinomiyaHyogo 663-8501Japan Department of Radiology Hyogo College of MedicineNishinomiyaHyogo 663-8501Japan Department of Radiation Oncology Kindai University Faculty of MedicineSayamaOsaka 589-8511Japan Department of Inflammatory Bowel Disease Division of SurgeryHyogo College of MedicineNishinomiyaHyogo 663-8501Japan

BACKGROUND Preoperative chemoradiotherapy regimens using a second drug for locally advanced rectal cancer are still under clinical *** To investigate the clinical outcomes of patients with locally advanced rectal cancer treated with preoperative chemoradiotherapy using tegafur/gimeracil/oteracil(S-1)plus irinotecan(CPT-11).METHODS This was a single-center retrospective study of 82 patients who underwent radical surgery for rectal cancer after chemoradiotherapy with S-1(80 mg/m2/d),CPT-11(60 mg/m2/d),and radiation(total 45 Gy)between 2009 and *** median follow-up was 51 mo(range:17–116 mo).RESULTS Twenty-nine patients(35.4%)had T3 or T4 rectal cancer with mesorectal fascia invasion,36(43.9%)had extramural vascular invasion,24(29.8%)had N2 rectal cancer and eight(9.8%)had lateral lymph node *** relative dose intensity was 90.1%for S-1 and 92.9%for ***-nine patients(96.3%)underwent R0 *** regard to pathological response,13 patients(15.9%)had a pathological complete response and 52(63.4%)a good response(tumor regression grade 2/3).The 5-year local recurrence-free survival,relapsefree survival and overall survival rates were 90.1%,72.5%and 91.3%,*** analyzed the risk factors for local recurrence-free survival by Cox regression analysis and none were *** described risk factors such as T4 stage,mesorectal fascia invasion or lateral lymph node swelling were not detected as negative factors for local recurrence-free *** We demonstrated good compliance and favorable tumor regression in patients with locally advanced rectal cancer treated with preoperative S-1 and CPT-11.

关键词： Preoperative chemoradiotherapy Rectal cancer Irinotecan Tegafur/gimeracil/oteracil Neoadjuvant chemoradiotherapy Radiation therapy

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Helicobacter pylori infection and liver diseases: Epidemiology and insights into pathogenesis

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World Journal of Gastroenterology 2018年第32期24卷 3617-3625页

作者： Kazuya Okushin Takeya Tsutsumi Kazuhiko ikeuchi Akira Kado Kenichiro Enooku Hidetaka Fujinaga Kyoji Moriya Hiroshi Yotsuyanagi Kazuhiko Koike Department of Gastroenterology Graduate School of Medicine The University of Tokyo Department of Infection Control and Prevention Graduate School of Medicine The University of Tokyo Division of Infectious Diseases Advanced Clinical Research Center Institute of Medical Science The University of Tokyo Department of Infectious Diseases The University of Tokyo

Both Helicobacter pylori(H. pylori) infection and liver diseases, including nonalcoholic fatty liver disease(NAFLD), viral hepatitis, and hepatocellular carcinoma(HCC), have high prevalences worldwide, and the relationship between H. pylori infection and liver disease has been discussed for many years. Although positive correlations between H. pylori and NAFLD have been identified in some clinical and experimental studies, nega-tive correlations have also been obtained in high-quality clinical studies. Associations between H. pylori and the pathogenesis of chronic viral hepatitis, mainly disease progression with fibrosis, have also been suggested in some clinical studies. Concerning HCC, a possible role for H. pylori in hepatocarcinogenesis has been identified since H. pylori genes have frequently been detected in resected HCC specimens. However, no study hasrevealed the direct involvement of H. pylori in promoting the development of HCC. Although findings regarding the correlations between H. pylori and liver disease pathogenesis have been accumulating, the existing data do not completely lead to an unequivocal conclusion. Further high-quality clinical and experimental analyses are necessary to evaluate the efficacy of H. pylori eradication in ameliorating the histopathological changes observed in each liver disease.

关键词： Helicobacter pylori Nonalcoholic fatty liver disease Nonalcoholic steatohepatitis Hepatitis C virus Hepatitis B virus Viral hepatitis Hepatocellular carcinoma

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