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Clinical usefulness of endoscopic ultrasonography for the evaluation of ulcerative colitis-associated tumors

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World Journal of Gastroenterology 2015年第9期21卷 2693-2699页

作者： Kiyonori kobayashi Kana Kawagishi Shouhei Ooka Kaoru Yokoyama Miwa Sada Wasaburo Koizumi Research and Development Center for New Medical Frontiers Kitasato UniversitySchool of MedicineSagamiharaKanagawa 252-0380Japan Department of Gastroenterology Kitasato UniversitySchool of MedicineSagamihara 252-0380Japan

AIM:To evaluate the clinical usefulness of endoscopic ultrasonography(EUS) for the diagnosis of the invasion depth of ulcerative colitis-associated ***:The study group comprised 13 patients with 16 ulcerative colitis(UC)-associated tumors for which the depth of invasion was preoperatively estimated by *** lesions were then resected endoscopically or by surgical colectomy and were examined *** mean age of the subjects was 48.2 ± 17.1 years,and the mean duration of UC was 15.8 ± 8.3 *** lesions were treated by endoscopic resection and the other 14 lesions by surgical *** depth of invasion of UCassociated tumors was estimated by EUS using an ultrasonic probe and was evaluated on the basis of the deepest layer with narrowing or rupture of the colonic ***:The diagnosis of UC-associated tumors by EUS was carcinoma for 13 lesions and dysplasia for 3 *** invasion depth of the carcinomas was intramucosal for 8 lesions,submucosal for 2,the muscularis propria for 2,and subserosal for ***(69%) of the 16 lesions arose in the *** macroscopic appearance was the laterally spreading tumor-non-granular type for 4 lesions,sessile type for 4,laterally spreading tumor-granular type for 3,semipedunculated type(Isp) for 2,type 1 for 2,and type 3 for *** depth of invasion was correctly estimated by EUS for 15 lesions(94%) but was misdiagnosed as intramucosal for 1 carcinoma with high-grade submucosal *** 2 lesions treated by endoscopic resection were intramucosal carcinoma and dysplasia,and both were diagnosed as intramucosal lesions by ***:EUS provides a good estimation of the invasion depth of UC-associated tumors and may thus facilitate the selection of treatment.

关键词： Ulcerative colitis Colitis-associated tumor Diagno

Acquired amegakaryocytic thrombocytopenia previously diagnosed as idiopathic thrombocytopenic purpura in a patient with hepatitis C virus infection

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World Journal of Gastroenterology 2017年第35期23卷 6540-6545页

作者： Shojiro Ichimata Mikiko kobayashi Kohei Honda Soichiro Shibata Akihiro Matsumoto Hiroyuki Kanno Department of Pathology Shinshu University School of Medicine Department of Medicine Shinshu University School of Medicine

We report the first case of a patient with hepatitis C virus(HCV) infection and idiopathic thrombocytopenic purpura(ITP), who later developed acquired amegakaryocytic thrombocytopenia(AAMT), with autoantibodies to the thrombopoietin(TPO) receptor(c-Mpl). A 64-year-old woman, with chronic hepatitis C, developed severe thrombocytopenia and was diagnosed with ITP. She died of liver failure. Autopsy revealed cirrhosis and liver carcinoma. In the bone marrow, a marked reduction in the number of megakaryocytes was observed, while other cell lineages were preserved. Therefore, she was diagnosed with AAMT. Additionally, autoantibodies to c-Mpl were detected in her serum. Autoantibodies to c-Mpl are one of the causes of AAMT, acting through inhibition of TPO function, megakaryocytic maturation, and platelet formation. HCV infection induces several autoantibodies. HCV infection might also induce autoantibodies to c-Mpl, resulting in the development of AAMT. This mechanism may be one of the causes of thrombocytopenia in patients with HCV infection.

关键词： Hepatitis C virus Acquired amegakaryocytic thrombocytopenia Anti-thrombopoietin receptor(c-Mpl) autoantibodies Idiopathic thrombocytopenic purpura Thrombocytopenia

Primary hepatic neuroendocrine neoplasm diagnosed by somatostatin receptor scintigraphy:A case report

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World Journal of Clinical Cases 2022年第7期10卷 2222-2228页

作者： Miho Akabane Yuta kobayashi Keiichi Kinowaki Satoshi Okubo Junichi Shindoh Masaji Hashimoto Division of Hepatobiliary-pancreatic Surgery Department of Gastroenterological SurgeryToranomon HospitalTokyo 105-8470Japan Department of Diagnostic Pathology Toranomon HospitalTokyo 105-8470Japan

BACKGROUND Primary hepatic neuroendocrine neoplasm(NEN)is a rare condition,and it is difficult to differentiate between primary and metastatic hepatic ***,we report a case of primary hepatic NEN that initially mimicked a hemangioma but showed a gradual increase in size on long-term careful *** SUMMARY A 47-year-old woman was incidentally diagnosed with a 12-mm liver mass,suspected to be a *** then,regular follow-up had been carried *** years later,she was referred to our institute due to the tumor(located in segment 4)having increased to 20 *** imaging studies depicted no apparent extrahepatic *** emission tomography(PET)/computed tomography exhibited significant accumulation in the mass lesion,which made us consider the possibility of *** hepatectomy was *** histopathological diagnosis was neuroendocrine tumor grade 2,with somatostatin receptor 2 a/5 *** somatostatin receptor scintigraphy(SRS)showed no other site,leading to the diagnosis of NEN of primary hepatic *** gradual growth of the hepatic NEN over 10 years suggested that it was likely to be a primary liver *** In this case,positivity on PET and postoperative SRS may have helped determine whether the tumor was primary or metastatic.

关键词： Hepatic neoplasm Scintigraphy Surgery Positron-emission tomography Clinical decision-making Case report

Heat and mass transfer through spiral tubes in absorber of absorption heat pump system for waste heat recovery

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Propulsion and Power Research 2017年第2期6卷 140-146页

作者： Yoshinori Itaya Masatoshi Yamada Kenji Marumo Nobusuke kobayashi Environmental and Renewable Energy System Division.Graduate School of Engineering.Gifu University 501-1193 GifuJapa Research and Development Section Morimatsu Research Institute Co.Ltd.1057-1 Yai501-0417 MotosuJapan

Heat and mass transfer of a LiBr/water absorption heat pump system(AHP)was experimentally studied during working a heating-up *** examination was performed for a single spiral tube,which was simulated for heat transfer tubes in an *** inside and outside of the tube were subjected to a film flow of the absorption liquid and exposed to the atmosphere,*** maximum temperature of the absorption liquid was observed not at the entrance but in the region a little downward from the entrance in the *** steam absorption convective heat transfer coefficient between the liquid film flowing down and the inside wall of the temperature and the film temperature at the maximum temperature location and the *** film heat and mass transfer coefficients rose with increasing Reynolds number of the liquid film *** coefficients showed opposite trend to the empirical correlation reported for laminar film flow on a straight smooth tube in a refrigeration mode in the past *** fact can be caused due to a turbulent promotion effect of the liquid in a spiral tube.

关键词： Absorption heat pump A single spiral tube Heat and mass transfer Lithium bromide/water Film heat transfer coefficient Mass transfer coefficient Waste heat recovery

Pitfalls and promises of bile duct alternatives:A narrative review

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World Journal of Gastroenterology 2022年第39期28卷 5707-5722页

作者： Mitsuo Miyazawa Masayasu Aikawa Junpei Takashima Hirotoshi kobayashi Shunsuke Ohnishi Yoshito Ikada Department of Surgery Teikyo University Mizonokuch HospitalKanagawa 213-8507Japan Department of Surgery Saitama Medical University International Medical CenterSaitama 350-1298Japan Department of Gastroenterology and Hepatology Hokkaido University Faculty of Medicine and Graduate School of MedicineSapporo 060-8638Japan Department of Bioenvironmental Medicine Nara Medical UniversityNara 634-8521Japan

Biliodigestive anastomosis between the extrahepatic bile duct and the intestine for bile duct disease is a gastrointestinal reconstruction that abolishes duodenal papilla function and frequently causes retrograde *** chronic inflammation can cause liver dysfunction,liver abscess,and even bile duct *** research has been conducted for over 100 years to directly repair bile duct defects with alternatives,no bile duct substitute(BDS)has been *** narrative review confirms our understanding of why bile duct alternatives have not been developed and explains the clinical applicability of BDSs in the near *** searched the PubMed electronic database to identify studies conducted to develop BDSs until December 2021 and identified studies in *** independent reviewers reviewed studies on large animals with 8 or more *** types of BDSs prevail:Autologous tissue,non-bioabsorbable material,bioabsorbable material,and others(decellularized tissue,3D-printed structures,etc.).In most studies,BDSs failed due to obstruction of the lumen or stenosis of the anastomosis with the native bile *** has not been developed primarily because control of bile duct wound healing and regeneration has not been elucidated.A BDS expected to be clinically applied in the near future incorporates a bioabsorbable material that allows for regeneration of the bile duct outside the BDS.

关键词： Bile duct alternative Bile duct substitute Biliary regeneration Bile duct reconstruction Peribiliary gland Bioabsorbable polymer

Eustachian tube involvement in a patient with relapsing polychondritis detected by magnetic resonance imaging:A case report

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World Journal of Clinical Cases 2022年第4期10卷 1441-1446页

作者： Daisuke Yunaiyama Akiko Aoki Hiroshi kobayashi Miwako Someya Mitsuru Okubo Kazuhiro Saito Department of Radiology Tokyo Medical University HospitalShinjuku-ku 160-0023TokyoJapan Department of Radiology Tokyo Medical University Hachioji Medical CenterHachioji-shi 193-0998Japan Department of Rheumatology Tokyo Medical University Hachioji Medical CenterHachioji-shi 193-0998Japan Department of Otorhinolaryngology Head and Neck SurgeryTokyo Medical University Hachioji Medical CenterHachioji-shi 193-0998Japan

BACKGROUND Relapsing polychondritis(RP)is a rare inflammatory disease involving the systemic cartilage,such as the auricle,trachea,and bronchiole,among others.A patient with RP shows variable symptoms based on the involved *** SUMMARY A 72-year-old Japanese woman with a history of redness of the bilateral auricles for 3 d was referred to a *** clinician prescribed antibiotics to the patient;however,the symptoms worsened;thus,she was referred to our *** and neck magnetic resonance imaging(MRI)showed edematous auricle with remarkable contrast,fluid collection in the bilateral mastoid cells,suggesting otitis *** eustachian tube(ET)on the right side was also edematous with contrast *** patient was suspected of RP according to the diagnostic criteria.A biopsy of the auricular cartilage was performed by an otorhinolaryngologist,confirming pathological proof of *** with steroids were immediately administered *** We highlight a rare case of RP with radiologically confirmed involvement of ET in the MRI.

关键词： Relapsing polychondritis Magnetic resonance imaging Contrast enhancement Otitis media with effusion Eustachian tube Case report

Surface‑applied or incorporated biochar and compost combination improves soil fertility,Chinese cabbage and papaya biomass

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Biochar 2021年第2期3卷 213-227页

作者： Justine Cox Nguyen V.Hue Amjad Ahmad Kent D.kobayashi Tropical Plant and Soil Sciences University of Hawaii3190 Maile WayHonoluluHI 96822USA Present Address:NSW Department Primary Industries 1243 Bruxner HighwayWollongbarNSW 2477Australia

Many Hawaiian agricultural soils are acidic with low-nutrient retention;therefore,organic soil amendments are often used to improve soil properties and increase *** can be incorporated for annual crops,but perennial orchards need surface application to avoid damaging surface *** trials compared responses to incorporated(IBC)or surface-applied(SBC)combination of hardwood biochar and chicken manure compost(4%v/v of each amendment)added to an Andisol and *** pH was increased by 0.4-1.1 units in IBC and by 0.2-0.5 for SBC in the 0-10 cm soil *** SBC and IBC increased soil total N,extractable P,Ca and Mg in the 0-10 cm soil *** pH,total C and extractable Ca were also higher in the 10-20 cm soil layer for IBC soil,indicating movement and/or leaching of *** cabbage biomass was 18-70%higher in the IBC and 14-47%higher in the SBC than that in the unamended soil,while papaya biomass was 23%and 19%higher in SBC and IBC,*** was a greater response in the more acidic Andisol soil,with larger improvements in soil pH,plant nutrient uptake and root biomass than the *** application was as effective in increasing plant growth as the incorporated amendment,providing evidence for farm scale *** and compost are recommended for use in tropical soils,and surface application may be beneficial to annual and perennial crops.

关键词： Surface-applied Andisol Oxisol Carica papaya Brassica rapa chinensis Biochar

Are angiographic culprit lesions true?Disagreement between angiographic and optical coherence tomographic detection

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Journal of Geriatric Cardiology 2021年第10期18卷 844-846页

作者： Osamu Kurihara Masamichi Takano Yusaku Shibata Nobuaki kobayashi Yasushi Miyauchi Kuniya Asai Cardiovascular Center Nippon Medical School Chiba Hokusoh HospitalInzaiChibaJapan Division of Intensive Care Unit Nippon Medical School Chiba Hokusoh HospitalInzaiChibaJapan

Coronary angiography provides a two-dimensional silhouette of the vascular *** is the gold standard for the dia-gnosis of coronary artery disease and is essential during percutaneous coronary intervention(PCI).

关键词： coronary lesions Coronary

Clinical management for malignant afferent loop obstruction

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World Journal of Gastrointestinal Oncology 2021年第7期13卷 684-692页

作者： Arata Sakai Hideyuki Shiomi Atsuhiro Masuda Takashi kobayashi Yasutaka Yamada Yuzo Kodama Division of Gastroenterology Department of Internal MedicineKobe University Graduate School of MedicineKobe 650-0017HyogoJapan

Afferent loop obstruction(ALO)is defined as duodenal or jejunal mechanical obstruction at the proximal anastomosis site of a *** advances in chemotherapy,the incidence of malignant ALO is *** ALO can be complicated by ischemia,gangrenous bowel,pancreatitis,and ascending ***,the general condition of patients with recurrent cancer is often ***,accurate and rapid diagnosis and minimally invasive treatments are ***,no review articles on the diagnosis and treatment of malignant ALO have been *** literature searching,we reviewed related articles published between 1959 and 2020 in the PubMed ***,we present recent advances in the diagnosis and treatment of malignant ALO and describe future *** transluminal self-expandable metal stent(SEMS)placement is considered the standard treatment for malignant ALO,as this procedure is well established and less ***,with the development of interventional endoscopic ultrasound(EUS)in recent years,the usefulness of EUS-guided gastrojejunostomy has been ***,through indirect comparison,this approach has been reported to be superior to transluminal SEMS *** is expected that a safer and less invasive treatment method will be established through the continued advancement and innovation of interventional endoscopy techniques.

关键词： Malignant afferent loop obstruction Endoscopic self-expandable metal stent placement Endoscopic ultrasound guided gastrojejunostomy Lumen-apposing metal stent