5′-Hydroxyzearalenol,a new β-resorcylic macrolide from Fusarium sp. 05ABR26

作     者：Ling Ling Zhao Yue Gai Hisayoshi Kobayashi Chang Qi Hu Hui Ping Zhang 

作者机构：Department of Natural Products Chemistry School of Pharmacy Fudan University Shanghai 200032 China Institute of Molecular and Cellular Biosciences The University of Tokyo Tokyo 113-0032 Japan 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2008年第19卷第9期

页      面：1089-1092页

核心收录：

学科分类：081702[工学-化学工艺] 081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：the National Natural Science Foundation(No.30371680)of the People's Republic of China 

主　　题：5'-Hydroxyzearalenol Fusarium sp. X-ray diffraction data Pyricularia oryzae 

摘      要：A new β-resorcylic macrolide, 5＇-hydroxyzearalenol （1）, was isolated from the culture broth of a marine-derived fungus Fusarium sp. 05ABR26. Three known compounds, zearalenone （2）, 8＇-hydroxyzearalenone （3） and zearalenol （4） were also isolated. The structure and relative stereochemistry of 1 were elucidated on the basis of spectroscopic data and single-crystal X-ray diffraction data. Compound 2 displayed potent inhibitory activity against Pyricularia oryzae with a MIC value of 6.25 μg/mL, while compound 3 was much less active; however, 1 and 4 showed no obvious activity.