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Impact of age on feasibility and short-term outcomes of ERAS after laparoscopic colorectal resection

World Journal of Gastrointestinal Surgery 2019年第10期11卷 395-406页

作者： Corrado Pedrazzani Cristian Conti Giulia Turri Enrico Lazzarini marzia tripepi Giovanni Scotton Matteo Rivelli Alfredo Guglielmi Division of General and Hepatobiliary Surgery Department of Surgical Sciences Dentistry Gynecology and Pediatrics University of Verona Hospital Trust

BACKGROUND There is still large debate on feasibility and advantages of fast-track protocols in elderly population after colorectal *** To investigate the impact of age on feasibility and short-term results of enhanced recovery protocol(ERP)after laparoscopic colorectal *** Data from 225 patients undergoing laparoscopic colorectal resection and ERP between March 2014 and July 2018 were retrospectively *** groups were considered according to patients’age:Group A,65 years old or less,Group B,66 to 75 years old and Group C,76 years old or *** and pathological data were compared amongst groups together with post-operative outcomes including post-operative overall and surgery-specific complications,mortality and readmission *** in post-operative length of stay and adherence to ERP’s items were evaluated in the three study *** Among the 225 patients,112 belonged to Group A,57 to Group B and 56 to Group ***-day overall morbidity was 32.9%whilst mortality was *** the percentage of complications progressively increased with age(25.9%vs 36.8%vs 42.9%),no differences were observed in the rate of major complications(4.5%vs 3.5%vs 1.8%),prolonged post-operative ileus(6.2%vs 12.2%vs 10.7%)and anastomotic leak(2.7%vs 1.8%vs 1.8%).Significant differences in recovery outcomes between groups were observed such as delayed urinary catheter removal(P=0.032)and autonomous deambulation(P=0.013)in elderly *** discharge criteria were achieved later in older patients(3 d vs 3 d vs 4 d,P=0.040),post-operative length of stay was similar in the 3 groups(5 d vs 6 d vs 6 d).CONCLUSION ERPs can be successfully and safely applied in elderly undergoing laparoscopic colorectal resection.

关键词： Colorectal surgery Laparoscopic surgery Enhanced recovery protocol Age Elderly

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Post Cryopreservation Growth Kinetic and Photosynthetic Assessment of an Acid Tolerant Strain of Stichococcus bacillaris

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Natural Resources 2024年第5期15卷 130-148页

作者： marzia Licata Luigi Marra Nunzia Nappi Elena Aurino Feliciana Oliva Antonino De Natale Donato Giovannelli Antonino Pollio Department of Biology University of Naples &#8220Federico II&#8221 Naples Italy ACUF Algal Collection of University of Naples &#8220Federico II&#8221 Naples Italy Department of Chemical Materials and Industrial Production Engineering University of Naples &#8220Federico II&#8221 P.le V. Tecchio Naples Italy Institute for Marine Biological Resources and Biotechnologies Italian National Research Council CNR-IRBIM Ancona Italy Earth-Life Science Institute ELSI Tokyo Institute of Technology Tokyo Japan Marine Chemistry and Geochemistry Department Woods Hole Oceanographic Institution Woods Hole MA USA Department of Marine and Coastal Science Rutgers University New Brunswick NJ USA

Preserving microbial diversity has become a strategic undertaking. Thus, ex situ microalgal culture conservation results in strategic and functional resource in both biodiversity protection and application domains. Cryopreservation of microalgae has been practiced since the 1960s and is now considered the optimal preservation strategy. Furthermore, the overall monitoring during growth of cultures after freezing/thawing protocols was hardly investigated and there is poor evaluation related to preserve especially the photosystem apparatus. The present study focuses on Stichococcus bacillaris as case study for short-term cryopreservation at −80 °C storage. Various freezing pretreatments using cryoprotective agents, and two thawing methods were compared introducing a novel variable to evaluate viability recovery and assessing growth kinetics of cultures immediately after thawing and after a series batch cultivation. Photosynthetic rate and pigments assessment were proposed to evaluate hidden metabolic cell damage. Results underline cryoprotective agents can increase the kinetic recovery of preserved cells in terms of reduction of lag phase during batch cultivation tests: the use of dimethyl sulfoxide and glycerol granted a growth comparable to unpreserved cells when sudden thawing occurs after 24 hours of storage, but recovery after preservation is less sensitive to cryoprotective agents when gradual thawing and 1 month of storage is considered. However, cells are always able to restore their physiological pathways even without agents, so their kinetic effect has been proved and quantified. Interestingly, both the photosynthetic efficiency and the ratio between total chlorophyll and carotenoids are comparable (0.75 Fv/Fm, 2.2 ± 0.25 g/g) to unpreserved cells and they are unsensitive to chosen agents, but the ratio between chlorophyll a and chlorophyll b was clearly altered (up to 10 times), suggesting that photoactive pigments relative proportions

关键词： Microalgae Stichococcus bacillaris Cryopreservation Growth Kinetic Photosynthetic Rate

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Heart failure with preserved ejection fraction

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Journal of Geriatric Cardiology 2013年第4期10卷 369-376页

作者： marzia Rigollil Gillian A Whalley Awhina Health Campus Waitakere Hospital Waitemata District Health Board Private Bag93-503 Auckland New Zealand Division of Cardiology University of Verona Ospedale Maggiore Pie Stefani 1 37126 Verona Italy Faculty of Social and Health Sciences Unitec Institute of Technology Private Bag92025 Auckland NewZealand

Progressive aging of the population and prolonga tion of life expect ancy have led to the ris ng prevalence of heart failure (HF)。Despitethe improvements in medical therapy，the mortality rate of this condition has remained unaccept ably high，becoming t heprimary cause ofdeath in the elderly popul at ion。Almost half of patient swith signs and symptoms of HF are f ound to have a nearly normal ejection fraction，which delineates a distinctclinical syndrome 。known as HF with preserved ejection fraction(HF-PEF) 。While early research focused on the importance of diastolicdys function，more recent studies reported the pathophysological compl exity of the disease with multiple cardiovas 。cular abnormalities contributing to its development and progression。HF-PEF is a challenging maj or health problem with yet no solution as there is no evidence。Based treatment which improves clinical out comes。This review summarizes the state of current knowledge on diagnosis，prognosis and treatment of HF。PEF，with particul ar insights on the pathological characteristics in the elderly population。

关键词： Diastole Echocardiography Heart failure Mortality Preserved ejection fraction

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Biliverdin Reductase-A correlates with inducible nitric oxide synthasein in atorvastatin treated aged canine brain

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Neural Regeneration Research 2013年第21期8卷 1925-1937页

作者： Fabio Di Domenico marzia Perluigi Eugenio Barone Department of Chemistry Center of Membrane Sciences and Sanders-Brown Center on Aging University of Kentucky Department of Biochemical Sciences Sapienza University of Rome Brain Mind Institute School of Life Sciences Swiss Federal Institute of Technology (EPFL)

Alzheimer’s disease is a neurodegenerative disorder characterized by progressive cognitive impairment and neuropathology. Recent preclinical and epidemiological studies proposed statins as a possible therapeutic drug for Alzheimer’s disease, but the exact mechanisms of action are still unknown. Biliverdin reductase-A is a pleiotropic enzyme involved in cellular stress responses. It not only transforms biliverdin-IX alpha into the antioxidant bilirubin-IX alpha but its serine/threonine/ tyrosine kinase activity is able to modulate cell signaling networks. We previously reported the beneficial effects of atorvastatin treatment on biliverdin reductase-A and heme oxygenase-1 in the brains of a well characterized pre-clinical model of Alzheimer’s disease, aged beagles, together with observed improvement in cognition. Here we extend our knowledge of the effects of atorvastatin on inducible nitric oxide synthase in parietal cortex, cerebellum and liver of the same animals. We demonstrated that atorvastatin treatment （80 mg/day for 14.5 months） to aged beagles selectively increased inducible nitric oxide synthase in the parietal cortex but not in the cerebellum. In contrast, inducible nitric oxide synthase protein levels were significantly decreased in the liver. Significant positive correlations were found between biliverdin reductase-A and inducible nitric oxide synthase as well as heme oxygenase-1 protein levels in the parietal cortex. The opposite was observed in the liver. Inducible nitric oxide synthase up-regulation in the parietal cortex was positively associated with improved biliverdin reductase-A functions, whereas the oxidative-induced impairment of biliverdin reductase-A in the liver negatively affected inducible nitric oxide synthase expression, thus suggesting a role for biliverdin reductase-A in atorvastatin-dependent inducible nitric oxide synthase changes. Interestingly, increased inducible nitric oxide synthase levels in the parietal cortex were not assoc

关键词： neural regeneration age Alzheimer’s disease atorvastatin biliverdin reductase-A cell stress-response cognitive function 4-hydroxy-2-nonenal heme oxygenase-1 inducible nitric oxide synthase oxidative stress neuroregeneration.

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Intranasal nerve growth factor for prevention and recovery of the outcomes of traumatic brain injury

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Neural Regeneration Research 2023年第4期18卷 773-778页

作者： Luigi Manni Giorgio Conti Antonio Chiaretti marzia Soligo Institute of Translational Pharmacology National Research Council of Italy(CNR)RomeItaly Intensive Pediatric Therapy and Pediatric Trauma Center Department of EmergencyAnesthesiological and Reanimation SciencesFondazione Policlinico Universitario A.Gemelli IRCCSRomeItaly Institute of Pediatrics Department of Woman and Child HealthFondazione Policlinico Universitario A.Gemelli IRCCSRomeItaly

Traumatic brain injury is one of the main causes of mortality and disability *** brain injury is characterized by a primary injury directly induced by the impact,which progresses into a secondary injury that leads to cellular and metabolic damages,starting in the first few hours and days after primary mechanical *** date,traumatic brain injury is not targetable by therapies aimed at preventing and/or limiting the outcomes of secondary damage but only by palliative *** growth factor is a neurotrophin targeting neuronal and non-neuronal cells,potentially useful in preventing/limiting the outcomes of secondary damage in traumatic brain *** potential has further increased in the last two decades since the possibility of reaching neurotrophin targets in the brain through its intranasal delivery has been ***,molecules intranasally delivered to the brain parenchyma may easily bypass the blood-brain barrier and reach their therapeutic targets in the brain,with favorable kinetics,dynamics,and safety *** the first part of this review,we aimed to report the traumatic brain injury-induced dysfunctional mechanisms that may benefit from nerve growth factor *** the second part,we then exposed the experimental evidence relating to the action of nerve growth factor(both in vitro and in vivo,after administration routes other than intranasal)on some of these *** the last part of the work,we,therefore,discussed the few manuscripts that analyze the effects of treatment with nerve growth factor,intranasally delivered to the brain parenchyma,on the outcomes of traumatic brain injury.

关键词： intranasal delivery nerve growth factor pharmacology traumatic brain injury

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圆形画、椅子和围巾——《椅中圣母》的一种线索式解读

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艺术工作 2024年第3期 4-16页

作者： [意]玛琪雅·费埃王钰(译) 张鹏(校) 不详

当恩斯特·贡布里希[Ernst Gombrich]参观皮蒂宫(Palazzo Pitti)帕拉蒂纳画廊(Galleria Palatina)时,他亲自观察了《椅中圣母》(Madonna della seggiola)~([1]),意在为1955年11月的会议做准备~([2])。关于这幅画的起源,当地导游之间流传着一个奇特的传说。有关这幅画最初的说法可以追溯到恩斯特·冯·胡瓦尔德[Ernst von Houwald]写于1820年的一本儿童读物,贡布里希本人在次年出版的《拉斐尔的椅中圣母》(Raphael’s Madonna della Sedia)一文中向我们讲述了这一点~([3])。关于这个故事的回忆,一方面是一次营救(一位隐士为了躲避一群狼的攻击,躲在一棵橡树上,被一位酒商勇敢的女儿所救),另一方面是一则预言(隐士心存感激,预言这位女子和这棵橡树都将获得不朽的生命)。许多年后,拉斐尔才出现在这一故事情节中:在此期间,橡树被砍伐,木头变成了酒桶,而那位年轻女子也已经结婚,成为两个孩子的母亲。

关键词：拉斐尔贡布里希儿童读物瓦尔德隐士恩斯特圣母

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Association between orofacial granulomatosis and Crohn's disease in children:Systematic review

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World Journal of Gastroenterology 2014年第23期20卷 7497-7504页

作者： marzia Lazzerini Matteo Bramuzzo Alessro Ventura Institute for Maternal and Child Health IRCCS Burlo Garofolo34137 TriesteItaly University of Trieste 34137 TriesteItaly

AIM: To review pediatric cases of orofacial granulomatosis (OFG), report disease characteristics, and explore the association between OFG and Crohn’s disease.

关键词： Orofacial granulomatosis Melkersson-Rosenthal syndrome Cheilitis granulomatosa Crohn’ s disease Children Systematic review

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Assessment and impact of diastolic function by echocardiography in elderly patients

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Journal of Geriatric Cardiology 2016年第3期13卷 252-260页

作者： Clementina Dugo marzia Rigolli Andrea Rossi Gillian A Whalley Awhina Health Campus Waitemata District Health Board Auckland New Zealand Section of Cardiology Department of Medicine University of Verona Italy Institute of Diagnostic Ultrasound Australasian Sonographers Association Melbourne Australia

Doppler echocardiography is the gold standard for assessment of diastolic dysfunction, which is increasingly recognised as a cause of heart failure, especially in the elderly. Using a combination of Doppler echocardiography techniques, it is possible to identify grades of dia- stolic dysftmction, estimate left ventricular filling pressures and establish the chronicity of diastolic dysfunction. These physiologi- cally-derived measures have been widely validated against invasive measurements of left heart pressures and have been shown to be prog- nostically valuable in a wide range of clinical settings. This review explores the mechanisms, and approaches to the assessment of diastolic dysfunction in the elderly. The challenge for clinicians is to identify pathophysiological changes from those associated with normal ageing. When used in combination, and taking age into account, Doppler echocardiographic parameters are helpful in the assessment of dyspnoea in older patients and provide prognostic insights.

关键词： Diastolic dysfunction Doppler Echocardiography

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Interaction of cetyltrimethylammonium bromide with cefixime trihydrate drug at different temperatures and compositions: Effect of different electrolytes

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Chinese Journal of Chemical Engineering 2019年第8期27卷 1895-1903页

作者： marzia Rahman Md.Anamul Hoque Malik Abdul Rub Mohammed Abdullah Khan Department of Chemistry Jahangirnagar UniversitySavarDhaka 1342Bangladesh Chemistry Department Faculty of ScienceKing Abdulaziz UniversityJeddah 21589Saudi Arabia Center of Excellence for Advanced Materials Research King Abdulaziz UniversityJeddah 21589Saudi Arabia

Herein,conductivity measurements have been carried out to explore the interaction between cetyltrimethylammonium bromide(CTAB,a cationic surfactant) and antibiotic drug(cefixime trihydrate(CMT)) in water and also in occurrence of inorganic salts(NaCl,Na2 SO4 and Na3 PO4) over the temperature range of 303.15-323.15 K with an interval of 5 *** all cases,two critical micelle concentrations(c^*) were achieved for the CMT-surfactant *** of CMT drug to CTAB solution decreases the values of c^* which indicates the interaction between CMT and *** values of c^* for CMT-CTAB mixture in the presence of salts are lower in magnitude compared to the aqueous medium which indicates that micellization of the CMT-CTAB mixed system is favorable in salt *** values of △Gm^0 were obtained to be negative indicating the spontaneity of the micellization process and the extent of spontaneity further increases by means of rising *** obtained outcomes from the ΔHm^0 and ΔSm^0 values disclose that the interactions between CMT and CTAB are mostly electrostatic along with hydrophobic in *** thermodynamic parameters of transfer and enthalpy-entropy compensation phenomenon were also determined and discussed in detail.

关键词： Cefixime trihydrate CTAB Critical micelle concentration Compensation temperature Free energy of transfer

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Intranasal nerve growth factor bypasses the blood-brain barrier and affects spinal cord neurons in spinal cord injury

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Neural Regeneration Research 2014年第10期9卷 1025-1030页

作者： Luigi Aloe Patrizia Bianchi Alberto De Bellis marzia Soligo Maria Luisa Rocco Cellular Biology and Neurobiology Institute National Research Council(CNR) Maria Rosaria Maglione Foundation Onlus NapoliItaly Intitute of Translational Pharmacology National Research Council(CNR)

The purpose of this work was to investigate whether, by intranasal administration, the nerve growth factor bypasses the blood-brain barrier and turns over the spinal cord neurons and if such therapeutic approach could be of value in the treatment of spinal cord injury. Adult Sprague-Dawley rats with intact and injured spinal cord received daily intranasal nerve growth factor administration in both nostrils for 1 day or for 3 consecutive weeks. We found an in-creased content of nerve growth factor and enhanced expression of nerve growth factor receptor in the spinal cord 24 hours after a single intranasal administration of nerve growth factor in healthy rats, while daily treatment for 3 weeks in a model of spinal cord injury improved the deifcits in locomotor behaviour and increased spinal content of both nerve growth factor and nerve growth factor receptors. These outcomes suggest that the intranasal nerve growth factor bypasses blood-brain barrier and affects spinal cord neurons in spinal cord injury. They also suggest exploiting the possible therapeutic role of intranasally delivered nerve growth factor for the neuroprotection of damaged spinal nerve cells.

关键词： nerve regeneration spinal cord injury nerve growth factor intranasal delivery blood-brain barrier motor function leptin neuroprotection rats neural regeneration

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