Heart failure with preserved ejection fraction

作     者：Marzia Rigollil Gillian A Whalley 

作者机构：Awhina Health Campus Waitakere Hospital Waitemata District Health Board Private Bag93-503 Auckland New Zealand Division of Cardiology University of Verona Ospedale Maggiore Pie Stefani 1 37126 Verona Italy Faculty of Social and Health Sciences Unitec Institute of Technology Private Bag92025 Auckland NewZealand 

出 版 物：《Journal of Geriatric Cardiology》 (老年心脏病学杂志（英文版）)

年 卷 期：2013年第10卷第4期

页      面：369-376页

核心收录：

学科分类：1002[医学-临床医学] 10[医学] 

主　　题：Diastole Echocardiography Heart failure Mortality Preserved ejection fraction 

摘      要：Progressive aging of the population and prolonga tion of life expect ancy have led to the ris ng prevalence of heart failure (HF)。Despitethe improvements in medical therapy，the mortality rate of this condition has remained unaccept ably high，becoming t heprimary cause ofdeath in the elderly popul at ion。Almost half of patient swith signs and symptoms of HF are f ound to have a nearly normal ejection fraction，which delineates a distinctclinical syndrome 。known as HF with preserved ejection fraction(HF-PEF) 。While early research focused on the importance of diastolicdys function，more recent studies reported the pathophysological compl exity of the disease with multiple cardiovas 。cular abnormalities contributing to its development and progression。HF-PEF is a challenging maj or health problem with yet no solution as there is no evidence。Based treatment which improves clinical out comes。This review summarizes the state of current knowledge on diagnosis，prognosis and treatment of HF。PEF，with particul ar insights on the pathological characteristics in the elderly population。