检索结果-南通市图书馆

Stable mechanical fixation in a bionic osteochondral scaffold considering bone growth

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Rare Metals 2022年第8期41卷 2711-2718页

作者： Jian Zhou Hao Huang Li-Jing Wang maryam tamaddon Chao-Zong Liu Zi-Yu Liu Teng-Bo Yu Ying-Ze Zhang Department of Orthopaedic Surgery Qingdao Municipal HospitalQingdao UniversityQingdao266071China Department of Sports Medicine Affiliated Hospital of Qingdao UniversityQingdao266000China Division of Surgery&Interventional Science University College LondonRoyal National Orthopaedic HospitalLondonHA74LPUK School of Aeronautic Science and Engineering Beihang UniversityBeijing100191China School of Engineering Medicine Beihang UniversityBeijing100191China

In the field of tissue engineering,there is significant subsidence of the porous design scaffold several months after *** avoid stress shielding and stimulate bone and cartilage ingrowth,high scaffold porosity is needed to diminish the mechanical properties of the *** closer the mechanical properties of the scaffold are to those of surrounding tissues,the better biological properties it will ***,adequate mechanical stability is needed as the scaffold needs to be well fixed in the target area and it will endure load after *** the mechanical fixation of the scaffold at the initial stage and the long-term performance of a scaffold for in vivo study is hard,as no facility can be put into the target area for the friction *** study investigated the mechanical stability of the biomimetic scaffold at the initial stage of implantation by finite element analysis(FEA).According to in vivo study,scaffold could not maintain its original position and would sink 1-2 mm in the target *** simulation results suggested that mechanical loading is not the main reason for scaffold subsidence.

关键词： Osteochondral scaffold Mechanical fixation Scaffold subsidence Bone ingrowth

In vivo evaluation of additively manufacturedmulti-layered scaffold for the repair of large osteochondral defects

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Bio-Design and Manufacturing 2022年第3期5卷 481-496页

作者： maryam tamaddon Gordon Blunn Rongwei Tan Pan Yang Xiaodan Sun Shen-Mao Chen Jiajun Luo Ziyu Liu Ling Wang Dichen Li Ricardo Donate Mario Monzón Chaozong Liu Institute of Orthopaedic and Musculoskeletal Science Royal National Orthopaedic HospitalUniversity College LondonStanmore HA74LPUK School of Pharmacy and Biomedical Sciences University of PortsmouthPortsmouth PO12DTUK Guangdong Engineering Research Center of Implantable Medical Polymer Shenzhen Lando Biomaterials Co.Ltd.Shenzhen 518107China School of Materials Science and Engineering Tsinghua UniversityBeijing 100084China State Key Laboratory for Manufacturing System Engineering School of Mechanical EngineeringXi’an Jiaotong UniversityXi’an 710054China Departamento de Ingeniería Mecánica Grupo de Investigación en Fabricación Integrada y AvanzadaUniversidad de Las Palmas de Gran CanariaCampus Universitario de Tafira s/n35017 Las PalmasSpain

The repair of osteochondral defects is one of the major clinical challenges in ***-established osteochondral tissue engineering methods have shown promising results for the early treatment of small ***,less success has been achieved for the regeneration of large defects,which is mainly due to the mechanical environment of the joint and the heterogeneous nature of the *** this study,we developed a multi-layered osteochondral scaffold to match the heterogeneous nature of osteochondral tissue by harnessing additive manufacturing technologies and combining the established art laser sintering and material extrusion *** developed scaffold is based on a titanium and polylactic acid matrix-reinforced collagen“sandwich”composite *** microstructure and mechanical properties of the scaffold were examined,and its safety and efficacy in the repair of large osteochondral defects were tested in an ovine condyle *** 12-week in vivo evaluation period revealed extensive and significantly higher bone in-growth in the multi-layered scaffold compared with the collagen–HAp scaffold,and the achieved stable mechanical fixation provided strong support to the healing of the overlying cartilage,as demonstrated by hyaline-like cartilage *** histological examination showed that the regenerated cartilage in the multi-layer scaffold group was superior to that formed in the control *** genes such as aggrecan and collagen-II were upregulated in the scaffold and were higher than those in the control *** findings showed the safety and efficacy of the cell-free“translation-ready”osteochondral scaffold,which has the potential to be used in a one-step surgical procedure for the treatment of large osteochondral defects.

关键词： Osteochondral scaffold Large animal Additive manufacturing Porous titanium

Translation through collaboration:practice applied in BAMOS project in in vivo testing of innovative osteochondral scaffolds

在线全文

学校读者我要写书评

暂无评论

Biomaterials Translational 2022年第2期3卷 102-104页

作者： Ricardo Donate maryam tamaddon Viviana Ribeiro Mario Monzón J.Miguel Oliveira Chaozong Liu Departamento de Ingeniería Mecánica Grupo de Investigación en Fabricación Integrada y AvanzadaUniversidad de Las Palmas de Gran CanariaLas PalmasSpain Division of Surgery&Interventional Science University College LondonRoyal National Orthopaedic HospitalStanmoreUK B’s Research Group I3B’s-Research Institute on BiomaterialsBiodegradables and BiomimeticsUniversity of MinhoBarcoGuimarãesPortugal ICVS/3B’s-PT Government Associated Laboratory BragaGuimarãesPortugal.

Osteoarthritis is the most common chronic degenerative joint disease,recognized by the World Health Organization as a public health problem that affects millions of people *** project Biomaterials and Additive Manufacturing:Osteochondral Scaffold(BAMOS)innovation applied to osteoarthritis,funded under the frame of the Horizon 2020 Research and Innovation Staff Exchanges(RISE)program,aims to delay or avoid the use of joint replacements by developing novel cost-effective osteochondral scaffold technology for early intervention of *** multidisciplinary consortium of BAMOS,formed by international leading research centres,collaborates through research and innovation staff *** project covers all the stages of the development before the clinical trials:design of scaffolds,biomaterials development,processability under additive manufacturing,in vitro test,and in vivo *** paper reports the translational practice adopted in the project in in vivo assessment of the osteochondral scaffolds developed.

关键词： bone cartilage in vivo evaluation regenerative medicine tissue engineering

Osteochondral tissue repair in osteoarthritic joints： clinical challenges and opportunities in tissue engineering

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Bio-Design and Manufacturing 2018年第2期1卷 101-114页

作者： maryam tamaddon Ling Wang Ziyu Liu Chaozong Liu Institute of Orthopaedic and Musculoskeletal Science Division of Surgery and Interventional Science University College London Royal National Orthopaedic Hospital Stanmore HA7 4LP UK School of Mechanical Engineering Xi'an Jiaotong University Xi'an 710049 People's Republic of China

Osteoarthritis (OA), identified as one of the priorities for the Bone and Joint Decade, is one of the most prevalent joint diseases, which causes pain and disability of joints in the adult population. Secondary OA usually stems from repetitive overloading to the osteochondral (OC) unit, which could result in cartilage damage and changes in the subchondral bone, leading to mechanical instability of the joint and loss of joint function. Tissue engineering approaches have emerged for the repair of cartilage defects and damages to the subchondral bone in the early stages of OA and have shown potential in restoring the joint's function. In this approach, the use of three-dimensional scaffolds (with or without cells) provides support for tissue growth. Commercially available OC scaffolds have been studied in OA patients for repair and regeneration of OC defects. However, none of these scaffolds has shown satisfactory clinical results. This article reviews the OC tissue structure and the design, manufacturing and performance of current OC scaffolds in treatment of OA. The findings demonstrate the importance of biological and biomechanical fixations of OC scaffolds to the host tissue in achieving an improved cartilage fill and a hyaline-like tissue formation. Achieving a strong and stable subchondral bone support that helps the regeneration of overlying cartilage seems to be still a grand challenge for the early treatment of OA.

关键词：骨性关节炎生物技术生物设计设计方案

基于选择性激光熔化技术的骨缺损修复用梯度多孔钛支架的研制与表征

在线全文

学校读者我要写书评

暂无评论

Transactions of Nonferrous Metals Society of China 2023年第6期33卷 1755-1767页

作者：于爱华徐伟路新 maryam tamaddon 刘博文田世伟张策 Muhammad Arif MUGHAL 张嘉振 Chao-zong LIU 北京科技大学工程技术研究院高效轧制与智能制造国家工程研究中心北京100083 北京科技大学顺德创新学院佛山528399 北京科技大学新金属材料国家重点实验室北京材料基因工程高精尖创新中心北京100083 Institute of Orthopaedic&Musculoskeletal Science University College LondonRoyal National Orthopaedic HospitalStanmore HA74LPUK 北京科技大学工程技术研究院国家板带生产先进装备工程技术研究中心北京100083 北京科技大学人工智能研究院北京100083

为提高骨缺损修复的治疗效果,设计孔隙率为78.8%、70.8%、62.6%和54.4%的梯度多孔钛支架(分别表示为P1,P2,P3和P4),并通过选择性激光熔化技术进行制备。通过模拟和实验方法研究支架的成形性、显微组织、力学性能和渗透性能。模拟结果表... 详细信息

为提高骨缺损修复的治疗效果,设计孔隙率为78.8%、70.8%、62.6%和54.4%的梯度多孔钛支架(分别表示为P1,P2,P3和P4),并通过选择性激光熔化技术进行制备。通过模拟和实验方法研究支架的成形性、显微组织、力学性能和渗透性能。模拟结果表明,4种梯度结构的最大等效应力和渗透性分别在569.1~1469.0MPa和(21.7~54.6)×10^(−9)m^(2)范围内,并且P3和P4具有更小的最大等效应力,表明P3和P4具有更高的强度。P3和P4结构支架的显微组织为α'马氏体,屈服强度和弹性模量分别为185.3~250.8MPa和6.1~9.7GPa。相比于P3结构支架,P4结构支架展现出更高的强度和与皮质骨更加匹配的弹性模量,并且其渗透性(18.6×10^(−9)m^(2))在人体骨组织渗透性范围内。因此,具有P4结构支架有望被应用于骨科植入领域。

关键词：梯度多孔钛骨植入体选择性激光熔化力学性能渗透性

Improving the fretting biocorrosion of Ti6Al4V alloy bone screw by decorating structure optimised TiO2 nanotubes layer

在线全文

学校读者我要写书评

暂无评论

Journal of Materials Science & Technology 2020年第14期47卷 47-55页

作者： Jiajun Luo maryam tamaddon Changyou Yan Shuanhong Ma Xiaolong Wang Feng Zhou Chaozong Liu Institute of Orthopaedic&Musculoskeletal Science Division of Surgery&Interventional ScienceUniversity College LondonRoyal National Orthopaedic HospitalStanmoreHA74LPUnited Kingdom State Key Laboratory of Solid Lubrication Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhou730000China

TiO2 nanotubes(NT)has been demonstrated its potential in orthopaedic applications due to its enhanced surface wettability and ***,the fretting biocorrosion is the main concern that limited its successfully application in orthopaedic *** this study,a structure optimised thin TiO2 nanotube(SONT)layer was successfully created on Ti6Al4V bone screw,and its fretting corrosion performance was investigated and compared to the pristine Ti6Al4V bone screws and NT decorated screw in a bone-screw fretting simulation *** results have shown that the debonding TiO2 nanotube from the bone screw reduced significantly,as a result of structure *** SONT layer also exhibited enhanced bio-corrosion resistance compared pristine bone screw and conventionally NT modified bone *** is postulated that interfacial layer between TiO2 nanotube and Ti6Al4V substrate,generated during structure optimisation process,enhanced bonding of TiO2 nanotube layer to the Ti6Al4V bone screws that leading to the improvement in fretting corrosion *** results highlighted the potential SONT in orthopaedic application as bone fracture fixation devices.

关键词： Bone implant interface Bone screws Biomedical materials TiO2 nanotubes Fretting corrosion

On the mechanical aspect of additive manufactured polyether-ether-ketone scaffold for repair of large bone defects

在线全文

学校读者我要写书评

暂无评论

Biomaterials Translational 2022年第2期3卷 142-151页

作者： Seyed Ataollah Naghavi Changning Sun Mahbubeh Hejazi maryam tamaddon Jibao Zheng Leilei Wang Chenrui Zhang Swastina Nath Varma Dichen Li Mehran Moazen Ling Wang Chaozong Liu Institute of Orthopaedic&Musculoskeletal Science University College LondonRoyal National Orthopaedic HospitalLondonUK State Key Laboratory for Manufacturing Systems Engineering School of Mechanical EngineeringXi’an Jiaotong UniversityXi’anShaanxi ProvinceChina Department of Mechanical Engineering University College LondonLondonUK.

Polyether-ether-ketone(PEEK)is widely used in producing prosthesis and have gained great attention for repair of large bone defect in recent years with the development of additive *** is due to its excellent biocompatibility,good heat and chemical stability and similar mechanical properties which mimics natural *** this study,three replicates of rectilinear scaffolds were designed for compression,tension,three-point bending and torsion test with unit cell size of 0.8 mm,a pore size of 0.4 mm,strut thickness of 0.4 mm and nominal porosity of 50%.Stress-strain graphs were developed from experimental and finite element analysis *** Young’s modulus and yield strength of the scaffolds were measured from the slop of the stress-strain graph to be 395 and 19.50 MPa respectively for compression,427 and 6.96 MPa respectively for tension,257 and 25.30 MPa respectively for three-point bending and 231 and 12.83 MPa respectively for torsion *** finite element model was found to be in good agreement with the experimental *** fracture of the struct subjected to tensile strain was the main failure mode of the PEEK scaffold,which stems from the low crystallinity of additive manufacturing *** mechanical properties of porous PEEK are close to those of cancellous bone and thus are expected to be used in additive manufacturing PEEK bone implants in the future,but the lower yield strength poses a design challenge.

关键词： additive manufacturing bone scaffold finite element analysis mechanical behaviour lattice structure PEEK scaffold

Osteochondral scaffolds for early treatment of cartilage defects in osteoarthritic joints:from bench to clinic

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Biomaterials Translational 2020年第1期1卷 3-17页

作者： maryam tamaddon Helena Gilja Ling Wang JMiguel Oliveira Xiaodan Sun Rongwei Tan Chaozong Liu Institute of Orthopaedic&Musculoskeletal Science University College LondonRoyal National Orthopaedic HospitalLondonUK State Key Laboratory for Manufacturing System Engineering School of Mechanical EngineeringXi’an Jiaotong UniversityXi’anShaanxi ProvinceChina B’s Research Group I3Bs–Research Institute on BiomaterialsBiodegradables and BiomimeticsUniversity of MinhoHeadquarters of the European Institute of Excellence on Tissue Engineering and Regenerative MedicineAveParkPortugal ICVS/3B’s-PT Government Associate Laboratory Braga/GuimarãesPortugal The Discoveries Centre for Regenerative and Precision Medicine Headquarters at University of MinhoAveparkPortugal School of Materials Science and Engineering Tsinghua UniversityBeijingChina Shenzhen Lando Biomaterials Co.Ltd.Merchants Guangming Science Park ShenzhenGuangdong ProvinceChina

Osteoarthritis is a degenerative joint disease,typified by the loss in the quality of cartilage and bone at the interface of a synovial joint,resulting in pain,stiffness and reduced *** current surgical treatment for advanced stages of the disease is joint replacement,where the non-surgical therapeutic options or less invasive surgical treatments are no longer *** are major surgical procedures which have a substantial impact on patients’quality of life and lifetime risk of requiring revision *** using regenerative methods such as tissue engineering methods have been established and are promising for the early treatment of cartilage degeneration in osteoarthritis *** this approach,3-dimensional scaffolds(with or without cells)are employed to provide support for tissue ***,none of the currently available tissue engineering and regenerative medicine products promotes satisfactory durable regeneration of large cartilage ***,we discuss the current regenerative treatment options for cartilage and osteochondral(cartilage and underlying subchondral bone)defects in the articulating *** further identify the main hurdles in osteochondral scaffold development for achieving satisfactory and durable regeneration of osteochondral *** evolution of the osteochondral scaffolds–from monophasic to multiphasic constructs–is overviewed and the osteochondral scaffolds that have progressed to clinical trials are examined with respect to their clinical performances and their potential impact on the clinical *** of an osteochondral scaffold which bridges the gap between small defect treatment and joint replacement is still a grand *** scaffold could be used for early treatment of cartilage and osteochondral defects at early stage of osteoarthritis and could either negate or delay the need for joint replacements.

关键词： cartilage injury osteoarthritis osteochondral scaffold regenerative medicine subchondral defect tissue engineering

Design and performance evaluation of additively manufactured composite lattice structures of commercially pure Ti(CP-Ti)

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Bioactive Materials 2021年第5期6卷 1215-1222页

作者： Wei Xu Aihua Yu Xin Lu maryam tamaddon Mengdi Wang Jiazhen Zhang Jianliang Zhang Xuanhui Qu Chaozong Liu Bo Su Beijing Advanced Innovation Center for Materials Genome Engineering Institute for Advanced Materials and TechnologyState Key Laboratory for Advanced Metals and MaterialsUniversity of Science and Technology BeijingBeijing100083China Institute of Orthopaedic&Musculoskeletal Science University College LondonRoyal National Orthopaedic HospitalStanmore HA74LPUK Bristol Dental School University of BristolBristol BS12LYUK School of Physiology Pharmacology and NeuroscienceUniversity of BristolBristolBS81TDUK School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing100083China

Ti alloys with lattice structures are garnering more and more attention in the field of bone repair or regeneration due to their superior structural,mechanical,and biological *** this study,six types of composite lattice structures with different strut radius that consist of simple cubic(structure A),body-centered cubic(structure B),and edge-centered cubic(structure C)unit cells are *** designed structures are firstly simulated and analysed by the finite element(FE)*** pure Ti(CP-Ti)lattice structures with optimized unit cells and strut radius are then fabricated by selective laser melting(SLM),and the dimensions,microtopography,and mechanical properties are *** results show that among the six types of composite lattice structures,combined BA,CA,and CB structures exhibit smaller maximum von-Mises stress,indicating that these structures have higher *** on the fitting curves of stress/specific surface area versus strut radius,the optimized strut radius of BA,CA,and CB structures is 0.28,0.23,and 0.30 mm *** corresponding compressive yield strength and compressive modulus are 42.28,30.11,and 176.96 MPa,and 4.13,2.16,and 7.84 GPa,*** CP-Ti with CB unit structure presents a similar strength and compressive modulus to the cortical bone,which makes it a potential candidate for subchondral bone restorations.

关键词： Composite lattice structure Finite element modelling Selective laser melting(SLM) CP-Ti