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Chinese Chemical Letters 2014年第2期25卷 313-316页

作者： Hamzeh Kiyani maryam ghiasi School of Chemistry Damghan University

An efficient synthesis of Biginelli-type compounds using potassium phthalimide as a green, mild, and commercially available organocatalyst in a one-pot, multi-component cyclocondensation reaction of cyclopentanone, aldehydes, and urea/thiourea is reported. The present methodology is a green approach to access 4-aryl-7-（aryImethylene）-3,4,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-2（5H）-ones/thiones. It offers several merits such as simple operational procedures, no use of hazardous organic solvents, and cheap and environmentally friendly solid basic catalyst.

关键词： Organocatalyst Potassium phthalimide Biginelli reaction PyrimidinoneSolvent-free

Kink-band Kinematic Analysis and its Implications for Late-stage Deformation in the Internal Parts of the Zagros Collision(Sanandaj–Sirjan Zone) in West Iran

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Acta Geologica Sinica(English Edition) 2024年第4期98卷 921-935页

作者： maryam HEYDARI Mahdi BEHYARI Department of Geology Faculty of SciencesUrmia University57153165 UrmiaIran

In the internal parts of the Zagros collision zone, several deformation phases have been superimposed. The early deformation phase caused the development of a penetrative foliation. The late-stage deformation phase was preferentially accommodated within shear zones and caused the generation of shear bands, implying a non-coaxial component of deformation, the end of this stage deformation was marked by the development of kink-bands. In the vicinity of Zagros suture zone, the kink angle increased from 40° to 60°, and the kink-bands was converted to chevron folds. In this region, the external(α) and internal(β) angular ratio is α/β ≠ 1 and kink angle increased, and deformation occurred with 10% to 30% volume loss. Farther from the suture zone in the east, α/β = 1;and total volume was constant or increased by 5% to 10%. Kink-bands kinematic analysis in the study area revealed this structures were sensitive to deformation conditions and components such that, with decreasing distance to the Zagros suture zone, shearing and rotation increased, a high kinematic vorticity dominated, and volume loss occurred during deformation.

关键词： kink-band shear zone strain vorticity Zagros Iran

Quantum speedup and non-Markovianity of an atom in structured reservoirs:pseudomodes as a good description of environmental memory

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Communications in Theoretical Physics 2024年第8期76卷 60-66页

作者： maryam Hadipour Soroush Haseli Saeed Haddadi Faculty of Physics Urmia University of TechnologyUrmiaIran School of Physics Institute for Research in Fundamental Sciences(IPM)PO Box 19395-5531TehranIran Faculty of Physics Semnan UniversityPO Box 35195-363SemnanIran

Following the recent paper(Teittinen et al 2019 New J. Phys. 21 123041), one can see that in general there is no simple relation between non-Markovianity and quantum speed limit. Here, we investigate the connection between quantum speed limit time and non-Markovianity of an atom in structured environments(reservoirs) whose dynamics is governed by an exact pseudomode master equation(Garraway 1997 Phys. Rev. A 55 2290). In particular, we find an inverse relation between them, which means that the non-Markovian feature of the quantum process leads to speedup of evolution. Thus, there is a link between quantum speedup and memory effects for specific cases of dynamical evolution. Our results might shed light on the relationship between the speedup of quantum evolution and the backflow of information from the environment to the system.

关键词： quantum speed limit non-Markovianity pseudomode method structured environments

Improving mobile mass monitoring in the IoT environment based on Fog computing using an improved forest optimization algorithm

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Journal of Control and Decision 2024年第1期11卷 36-49页

作者： Tahere Motedayen Mahdi Yaghoobi maryam Kheirabadi Department of Computer Engineering Neyshabur BranchIslamic Azad UniversityNeyshaburIran

In the IoT-based users monitor tasks in the network environment by participating in the data collection process by smart *** monitor their data in the form of fog computing(mobile mass monitoring).Service providers are required to pay user rewards without increasing platform *** of the NP-Hard methods to maximise the coverage rate and reduce the platform costs(reward)is the Cooperative Based Method for Smart Sensing Tasks(CMST).This article uses chaos theory and fuzzy parameter setting in the forest optimisation *** proposed method is implemented with *** average findings show that the network coverage rate is 31%and the monitoring cost is 11%optimised compared to the CMST scheme and the mapping of the mobile mass monitoring problem to meta-heuristic *** using the improved forest optimisation algorithm can reduce the costs of the mobile crowd monitoring platform and has a better coverage rate.

关键词： Internet of Things mobile mass monitoring forest optimization algorithm chaos theory fuzzy system

Suspended particulate matter promotes epithelial-to-mesenchymal transition in alveolar epithelial cells via TGF-β1-mediated ROS/IL-8/SMAD3 axis

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Journal of Environmental Sciences 2024年第7期141卷 139-150页

作者： Shahrzad Molavinia Dian Dayer Mohammad Javad Khodayar Gholamreza Goudarzi maryam Salehcheh Cellular and Molecular Research Center Medical Basic Sciences Research InstituteAhvaz Jundishapur University of Medical SciencesAhvazIran Department of Toxicology School of PharmacyAhvaz Jundishapur University of Medical SciencesAhvazIran Student Research Committee Ahvaz Jundishapur University of Medical SciencesAhvazIran Toxicology Research Center Medical Basic Sciences Research InstituteAhvaz Jundishapur University of Medical SciencesAhvazIran Air Pollution and Respiratory Diseases Research Center Ahvaz Jundishapur University of Medical SciencesAhvazIran Iranian Scientific Association of Clean Air TehranIran

Epidemiological evidence presents that dust storms are related to respiratory diseases,such as pulmonary fibrosis(PF).However,the precise underlying mechanisms of SPM-elicited adverse effects still need to be ***-mesenchymal transition(EMT)process is a characteristic of *** discussed whether suspended particulate matter(SPM)is involved in EMT induction via transforming growth factor-β1(TGF-β1).In this study,a detailed elemental analysis(55 elements),particle size,and morphology were *** investigate the toxicity of SPM,an MTT test was performed to detect cell ***,A549cells were exposed to selected concentrations of SPM(20 and 40μg/mL)for single and repeated *** DCFH-DA assay showed that exposure to SPM could produce reactive oxygen species(ROS).The ELISA assay demonstrated increased levels of interleukin-8(IL-8)and TGF-β1 in the *** blot was used to detect the expression of proteins associated with EMT and the SMAD3-dependent *** of western blot demonstrated that E-cadherin was reduced,whereas p-SMAD3,vimentin,andα-smooth muscle actin were *** findings indicated that SPM triggered EMT by induction of oxidative stress,inflammation,and the TGF-β1/SMAD3 pathway activation.

关键词： Particulate matter TGF-β1 Oxidative stress Epithelial-mesenchymal transition Pulmonary fibrosis Cells

Evolution of biomass particles during pelletization process

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Particuology 2024年第3期86卷 182-187页

作者： Hamid Rezaei maryam Tajilrou Jun Sian Lee Kanages Singaraveloo Anthony Lau Shahab Sokhansanj Biomass and Bioenergy Research Group Department of Chemical and Biological EngineeringUniversity of British ColumbiaVancouverCanada

Pulverizing is an essential unit operation in co-firing biomass with *** are only compatible with pellet forms of fibrous biomass materials and crush them down to their original forming particle *** is why the data on the size distribution of the particles forming a biomass pellet is crucial to achieving optimum combustion *** current study determines the internal particle size distribution of pellets after wet disintegration,following Iso 17830 standard,and aims to suggest improvements to the mentioned standard based on new measured *** were carried out on white wood pellets(no bark)and brown wood pellets containing bark at four water temperatures:20,40,60,and 95℃,with or without *** particle size distribution of the pre-pelletizer wood particles was also measured and compared with particles in the formed *** water temperature of 20℃ was found to be adequate for the complete disintegration of pellets,and no mechanical stirring was *** 30% of particles in the disintegrated pellets were 0.5-1.0 *** changes the particle size distribution to smaller *** disintegrated bark pellets contained more fines than white pellets.

关键词： Wood pellets Particle sizes distribution Wet disintegration Stirring Water temperature

Cancer cell cycle heterogeneity as a critical determinant of therapeutic resistance

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Genes & Diseases 2024年第1期11卷 189-204页

作者： Ebrahim H.Maleki Ahmad Reza Bahrami maryam M.Matin Department of Biology Faculty of ScienceFerdowsi University of Mashhad*** MashhadIran Jagiellonian Centre for Experimental Therapeutics(JCET) Jagiellonian University31-007 KrakowPoland Doctoral School of Exact and Natural Sciences Jagiellonian University30-348 KrakowPoland Industrial Biotechnology Research Group Institute of BiotechnologyFerdowsi University of Mashhad*** MashhadIran Novel Diagnostics and Therapeutics Research Group Institute of BiotechnologyFerdowsi University of Mashhad***MashhadIran Stem Cell and Regenerative Medicine Research Group Iranian Academic Center for EducationCulture and Research(ACECR)Khorasan Razavi Branch917751376 MashhadIran

Intra-tumor heterogeneity is now arguably one of the most-studied topics in tumor biology,as it represents a major obstacle to effective cancer *** tumor cells are highly diverse at genetic,epigenetic,and phenotypic levels,intra-tumor heterogeneity can be assumed as an important contributing factor to the nullification of chemotherapeutic effects,and recurrence of the *** on the role of heterogeneous subpopulations of cancer cells with varying cell-cycle dynamics and behavior during cancer progression and treatment;herein,we aim to establish a comprehensive definition for adaptation of neoplastic cells against *** discuss two parallel and yet distinct subpopulations of tumor cells that play pivotal roles in reducing the effects of chemotherapy:"resistant"and"tolerant"***,this review also highlights the impact of the quiescent phase of the cell cycle as a survival mechanism for cancer *** understanding the mechanisms under-lying the quiescence,it provides an insightful perspective on cancer stem cells(CsCs)and their dual and intertwined functions based on their cell cycle state in response to ***-over,CSCs,epithelial-mesenchymal transformed cells,circulating tumor cells(CTCs),and disseminated tumor cells(DTCs),which are mostly in a quiescent state of the cell cycle are proved to have multiple biological links and can be implicated in our viewpoint of cell cycle heterogeneity in ***,increasing our knowledge of cell cycle heterogeneity is a key to identifying new therapeutic solutions,and this emerging concept may provide us with new opportunities to prevent the dreadful cancer recurrence.

关键词： Cancer stem cells(CSCs) Carcinoma Cell cycle heterogeneity Quiescence Therapy resistance Therapy tolerance Tumor dormancy

Boron Nitride-Integrated Lithium Batteries:Exploring Innovations in Longevity and Performance

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Energy & Environmental Materials 2024年第6期7卷 13-40页

作者： Shayan Angizi Sayed Ali Ahmad Alem Mahdi Torabian maryam Khalaj Dmitri Golberg Amir Pakdel Department of Chemical Engineering McMaster University1280 Main St WHamiltonONL8S 4L7 Canada Institute of Chemistry of Polymeric Materials Montanuniversität LeobenOtto-Glöckel-Strasse 2A-8700 LeobenAustria Department of Chemistry Materials and Chemical EngineeringPolitecnico di MilanoPiazza Leonardo da Vinci 3220133 MilanItaly Department of Materials Science and Engineering Northwestern UniversityEvanstonIL60208 USA Centre for Materials Science and School of Chemistry and Physics Queensland University of Technology(QUT)2 GeorgeBrisbaneQLD4000 Australia Research Centre for Materials Nanoarchitectonics(MANA) National Institute for Materials Science(NIMS)Namiki 1Ibaraki3050044 Japan Department of Mechanical Manufacturing and Biomedical EngineeringTrinity College DublinThe University of DublinDublinD02PN40 Ireland

The current global warming,coupled with the growing demand for energy in our daily lives,necessitates the development of more efficient and reliable energy storage *** batteries(LBs)are at the forefront of emerging power sources addressing these *** studies have shown that integrating hexagonal boron nitride(h-BN)nanomaterials into LBs enhances the safety,longevity,and electrochemical performance of all LB components,including electrodes,electrolytes,and separators,thereby suggesting their potential value in advancing eco-friendly energy *** review provides an overview of the most recent applications of h-BN nanomaterials in *** begins with an informative introduction to h-BN nanomaterials and their relevant properties in the context of LB ***,it addresses the challenges posed by h-BN and discusses existing strategies to overcome these limitations,offering valuable insights into the potential of BN *** review then proceeds to outline the functions of h-BN in LB components,emphasizing the molecular-level mechanisms responsible for performance ***,the review concludes by presenting the current challenges and prospects of integrating h-BN nanomaterials into battery research.

关键词： electrode electrolyte hexagonal boron nitride lithium battery separator

Role of Fibrinogen-like Protein 1 in Tumor Recurrence Following Hepatectomy

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Journal of Clinical and Translational Hepatology 2024年第4期12卷 406-415页

作者： Zahra Shafieizadeh Zohreh Shafieizadeh maryam Davoudi Reza Afrisham Xiaolei Miao Department of Medical Laboratory Sciences School of Allied Medical SciencesTehran University of Medical SciencesTehranIran School of Pharmacy Xianning Medical CollegeHubei University of Science and TechnologyXianningHubeiChina

Partial hepatectomy is a first-line treatment for hepatocellular *** 2 weeks following partial hepatectomy,specific molecular pathways are activated to promote liver ***,residual microtumors may also exploit these pathways to reappear and *** targeting molecules that are differentially regulated between normal cells and malignancies,such as fibrinogen-like protein 1(FGL1),appears to be an effective *** potential functions of FGL1 in both regenerative and malignant cells are discussed within the ambit of this *** FGL1 is normally elevated in regenerative hepatocytes,it is normally downregulated in malignant *** does indeed upregulate FGL1 by increasing the release of transcription factors that promote FGL1,including HNF-1α and STAT3,and inflammatory effectors,such as TGF-β and ***,in turn,stimulates certain proliferative pathways,including EGFR/Src/*** alters the phase transition of highly differentiated hepatocytes from G0 to G1,thereby transforming susceptible cells into cancerous *** of the PI3K/Akt/mTOR pathway by FGL1 allele loss on chromosome 8,a tumor suppressor area,may also cause hepatocellular ***,FGL1 is specifically expressed in the liver via HNF-1α histone acetylase activity,which triggers lipid metabolic reprogramming in ***1 might also be involved in other carcinogenesis processes such as hypoxia,epithelial-mesenchymal transition,immunosuppression,and sorafenib-mediated drug *** study highlights a research gap in these disciplines and the necessity for additional research on FGL1 function in the described processes.

关键词： Fibrinogen-like protein 1 FGL1 Hepatocellular carcinoma Liver regeneration Hepatectomy Lipogenesis Recurrence

Metaheuristic-Driven Two-Stage Ensemble Deep Learning for Lung/Colon Cancer Classification

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Computers, Materials & Continua 2024年第9期80卷 3855-3880页

作者： Pouyan Razmjouei Elaheh Moharamkhani Mohamad Hasanvand maryam Daneshfar Mohammad Shokouhifar Department of Electrical&Computer Engineering Valie-e-Asr University of RafsanjanKerman***Iran International Academic Relations Office(IRO) Computer Science DepartmentUniversity of HalabjaHalabja46018Iraq Department of Computer Engineering University of Mohaghegh ArdabiliArdabil***Iran Department of Biomedical Engineering Islamic Azad University of MashhadMashhad***Iran Department of Electrical&Computer Engineering Shahid Beheshti UniversityTehran***Iran

This study investigates the application of deep learning,ensemble learning,metaheuristic optimization,and image processing techniques for detecting lung and colon cancers,aiming to enhance treatment efficacy and improve survival *** introduce a metaheuristic-driven two-stage ensemble deep learning model for efficient lung/colon cancer *** diagnosis of lung and colon cancers is attempted using several unique indicators by different versions of deep Convolutional Neural Networks(CNNs)in feature extraction and model constructions,and utilizing the power of various Machine Learning(ML)algorithms for final ***,we consider different scenarios consisting of two-class colon cancer,three-class lung cancer,and fiveclass combined lung/colon cancer to conduct feature extraction using four *** extracted features are then integrated to create a comprehensive feature *** the next step,the optimization of the feature selection is conducted using a metaheuristic algorithm based on the Electric Eel Foraging Optimization(EEFO).This optimized feature subset is subsequently employed in various ML algorithms to determine the most effective ones through a rigorous evaluation *** top-performing algorithms are refined using the High-Performance Filter(HPF)and integrated into an ensemble learning framework employing weighted *** findings indicate that the proposed ensemble learning model significantly surpasses existing methods in classification accuracy across all datasets,achieving accuracies of 99.85%for the two-class,98.70%for the three-class,and 98.96%for the five-class datasets.

关键词： Lung cancer colon cancer feature selection electric eel foraging optimization deep learning ensemble learning